• Journal of Gastric Cancer
• /
• v.16 no.3
• /
• pp.177-181
• /
• 2016

Purpose: The International Organization for Standardization-5fluorouracil (FU) 10 trial found that bolus 5-FU and l-leucovorin was not inferior to S-1 in the treatment of gastric cancer (GC). Continuous 5-FU and the rapid injection of 5-FU have different anti-cancer effects. Thus, bolus 5-FU and l-leucovorin treatment might be useful for oral FU-resistant GC. Materials and Methods: We retrospectively analyzed the medical records of all patients with S-1 or capecitabine-resistant, unresectable, or recurrent GC treated with bolus 5-FU and l-leucovorin between January 2010 and December 2015 at Hokkaido University Hospital. The bolus 5-FU and l-leucovorin regimen consisted of intravenous l-leucovorin ($250mg/m^2/2h$) and bolus 5-FU ($600mg/m^2$) administered once weekly followed by a 2-week rest period; each cycle was repeated every 8 weeks. Results: A total of 14 patients were identified. The disease control rate was 35.7%. The median progression-free survival was 1.6 months (95% confidence interval [CI], 1.3~2.0 months), and the median overall survival was 6.3 months (95% CI, 4.7~7.9 months). No patient died from treatment-related causes. The most common severe adverse event associated with bolus 5-FU and l-leucovorin was neutropenia, which occurred in 21.4% of patients. Conclusions: Bolus 5-FU and l-leucovorin treatment might be useful for oral FU-resistant GC. We are planning a multi-center prospective phase II trial to evaluate the efficacy and safety of bolus 5-FU and l-leucovorin treatment for pre-treated unresectable or recurrent GC to confirm the results of this limited, retrospective study.

• Journal of the Korea Institute of Building Construction
• /
• v.13 no.6
• /
• pp.557-564
• /
• 2013

Unsafe and dangerous factors or environments on building construction sites often cause safety accidents. Sometimes, accidents happen despite the existence of warning and caution signs. Such warning signs are likely to be hidden by stacked materials or temporary facilities on site. If workers cannot see the signs when moving or working, they could be injured, sometimes fatally. Many studies have focused on each worker's position, and various systems have been developed using GPS signals and sensors. This paper suggests a method for identifying the problem of worker inability to see the unsafe factors, to manage the problem in the construction planning phase by considering things from the worker's perspective. The method uses CAD software to investigate the relation between the height of stacked materials and the visible ratio of the unsafe factor. The results of a sample project show that the changes in the height and location of stacked materials make the site safer.

• Korean Journal of Construction Engineering and Management
• /
• v.12 no.1
• /
• pp.133-140
• /
• 2011

Recently, the demolition industry is becoming more important than ever for formulating reuse and recycling of a construction waste with the current trend in pursuing a sustainable development. As considering the situation of a domestic housing construction and an existing house, a scale of a demolition market is expected to increase continually. Therefore, for a sustainable development, it is needed to forecast and manage rightly the demolition waste producted in a demolition phase. But, because most of a demolition company is very small and the investment in a technology development is not enough, the effort to develope a system and to make a standard for managing righly a demolition waste is also not sufficient. Therefore, this study develops a system to automatize quantifying a demolition waste. This system makes it possible to manage the planning of demolition works and the quantifying, disposal, reusing and recycling of a demolition waste in one system by integrating all the activities related with demolition works. 3D drawings of each element for demolition works will manage by being linked to its schedule for visualizing 3D object. Also, this study presents methods for quantifying easily a demolition waste by using 3D object.

• Journal of The Korean Digital Architecture Interior Association
• /
• v.11 no.3
• /
• pp.5-16
• /
• 2011

This study aims for improvement and rebuilding of the 'Green Building Certification Criteria Information System;GBCCIS'. To achieve this, improved information system has developed self-assessment program available on the web and to provide data about the target of Green Building Certification based on the 2010 revised criteria. The target building of Green Building Certification is Apartment, Office, Mixed-Use Building, School, property for sale, accommodation, and other facilities. Also, the information system about the Green building related technologies and techniques to take advantage of offer a variety of information was built. Green Building Certification Criteria web-site Established in this study has information and each menu and contents are linked to organic and high-utilization. Each menu is organized according to the used frequency and the group. Also this web-site is composed of information guide field, core service field, and other field. These improvement of Green Building Certification Criteria Information System can be a positive incentive measures for the activation of Green Building Certification Criteria easily by taking advantage of relevant information by users. And these will be possible to planning development of Green building technologies by introducing the latest Green building construction techniques applicable building. Also, to assess in advance by using self-assessment program in the design phase of building will lead to Green building design and provide the convenience of the application process and through database construction and share information of building assessment resources certified Green Building Certification Criteria will lead to the containment and fair assessment between cation authorities.

• KIEAE Journal
• /
• v.17 no.1
• /
• pp.23-28
• /
• 2017

Purpose: Many design index that are using in planning phase have been developed. The most popular things among them are Window to Wall Ratio and Surface to Volume Ratio. However there are some limits. Window to Wall Ratio cannot consider building size and Surface to Volume Ratio cannot do Window to Wall Ratio. Accordingly, in this paper, the Window to Floor Ratio was proposed that it can be considered both building size and Window to Wall Ratio. And analyzed correlation of energy demand. Method: For the test, 16 modules with the size of $6m{\times}6m{\times}4m$ were used to make 35 models with the same volume. The simulation was conducted to 945 cases using the window-to-wall ratio of 30, 50 and 70 % in three areas such as Seoul, Gwangju and Jeju and three kinds of windows. And IES_VE was used. Result: The findings above show that the Window to Floor Ratio that can be considered both building size and Window area have to become as design index. It was found out that design criteria with SHGC is necessary, not with the thermal performance (U-value). It is needed to additional analysis about residential building and the effect of 24-hours heating and cooling condition. It plans to carry out research to establish design indicators for climatic conditions in the country and building applications.

• Proceedings of the Korean Institute Of Construction Engineering and Management
• /
• 2004.11a
• /
• pp.145-152
• /
• 2004

Many construction companies have developed many kinds of information system to integrate the information created in the phase of planning, design, procurement, construction, and maintenance of construction project. However, the previous researches for the state of applying information technologies and the efforts of the analysis of the present information system launched in domestic construction industry is very rare. There also has been short of research on the construction decision-making support theory in construction business and industry. Hence this paper would contribute in identifying the state of information technologies and the theory of decision-making support of the information system in general construction company. and suggest the characteristic model on the information system for the construction decision-making support. The model consists of the two dimensions; (1) organizational hierarchy (2) data analyzing technology. This research, especially, can be expected to initiate the discussion on framework for understanding the construction decision-making support system in construction industry. The model is nut a practical methodology, but a window that offers a new perspective un sources of information system in each construction company, and thus can provide a clue of the useful guide to construction information system development.

• Korean Journal of Construction Engineering and Management
• /
• v.11 no.6
• /
• pp.3-13
• /
• 2010

The purpose of this research is to develop a conceptual model that establishes a new approach for functional area cost estimating in the schematic design phase. A cost estimating model should consider not only the estimate accuracy, but also the flexibility to the design alternatives and user-oriented serviceability. Therefore, this research uses the method that classifies various facilities of a building according to its functions by analyzing historical data. After setting the functional area as cost parameter, a formula which can estimate functional area cost is derived from statistical analysis. Finally, to validate the proposed conceptual model, it is applied to historical data of a military barrack project. It enables customized space planning reflecting client's needs and compares the cost of various design alternatives as well as improves estimate accuracy.

• 한국벤처창업학회:학술대회논문집
• /
• 2009.10a
• /
• pp.51-78
• /
• 2009

Nowaday, management of research and development(R&D) projects is focused on promotion of performance-centric R&D by market and customer-oriented R&D and commercialization, and this tendency is also appeared in national R&D projects. For the commercialization of R&D outcomes, market demand-centric R&D, establishment of commercialization plan in R&D planning and carrying out phase, and communication with external stakeholders are needed, and these activities can be performed more effectively by developing business model. However, systematical procedure for developing business model in national R&D environment haven't suggested by prior researches. Therefore, we propose a business model development system that is reflect characteristics of national R&D environment and perspectives of technology researchers and commercialization experts. Research result is expected to be usefully applied as a guideline for developing business model in national R&D projects.

• Journal of the Korean Society of Propulsion Engineers
• /
• v.24 no.2
• /
• pp.35-42
• /
• 2020

Recently the reusable launch vehicle is being a major trend in the worldwide space market, because a few commercial companies, especially SpaceX, are trying to cut down the launch price through developing and succeeding the reusable launch vehicles. However, there is still a big controversy about whether in view point of the launch cost which is more favorable between expendable and reusable. Therefore, a study and close examination is required for the launch cost in the early development phase of the reusable launch vehicle. In this study the sensitivity analysis is performed with respect to the major cost parameters which have great effects on the launch cost and price. The standard vehicle of this sensitivity analysis is the expendable vehicle having a payload 20 tons. The cost estimation relationships used in this calculation are referred from the commonly proven cost models such as TRANSCOST. The major cost parameters chosen in this study are as follows: development cost, production cost, refurbishment cost, and maximum reusable number.

• Transactions of the Korean hydrogen and new energy society
• /
• v.20 no.1
• /
• pp.22-30
• /
• 2009

Energy environment has been changing rapidly such as the fluctuation of oil prices and the effect on UNFCCC. Oil price change affects Korea's economy heavily due to her poor natural resources and large dependence of consumed energy resources. Korea takes the 4th place of importing the crude oil and 9th place in $CO_2$ emissions with the 1st place of $CO_2$ emissions increasing rate. Considering the current statue of Korea including oil price change and UNFCCC, Korea will be expected to be the Annex I nation due to Korean energy environments and the quantity of $CO_2$ emission. Energy technology development is a crucial key to cope with Korea's national energy security and environments. In this study, we establish the framework, which allocates the relative weights of assessment criteria and sub-criteria, for assessing and selecting R&D programs of energy technologies strategically. We integrated fuzzy theory and analytic hierarchy process (AHP) approach since the fuzzy AHP approach reflects the vagueness of human thoughts and perception effectively as making pairwise comparisons of criteria and alternatives. The fundamental data of this research results will support R&D planning phase for policy-makers and the production of well focused R&D outcomes.