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Disturbed Functional Asymmetry of Sensorimotor Cortex in Schizophrenia: A Study with Functional Magnetic Resonance Imaging (정신분열증에서 감각운동피질의 기능적 비대칭성의 장애: 기능적 자기공명영상을 이용한 연구)

  • Ahn, Kook-Jin;Chae, Jeong-Ho;Kim, Tae;Kim, Euy-Neyng;Lee, Jee-Mun;Choi, Kyu-Ho;Hahn, Seong-Tai
    • Investigative Magnetic Resonance Imaging
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    • v.4 no.1
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    • pp.52-57
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    • 2000
  • Purpose : The purpose of this study was to investigate the pattern of cerebral response to motor tasks in patients with schizophrenia compared with normal subjects using functional MRI. Materials and methods ; Nine right handed-schizophrenic patients and six right-handed normal subjects were included. We used right hand movement as task. Series of 120 consecutive echo-planar images per section were acquired during three cycles of task and rest activations. Lateralization index of cortical response was measured and compared between patients and normal subjects. Results ; Right hand motor task was associated with greater activation in left sensorimotor cortex than the right in normal subjects. Schizophrenia patients showed relatively decreased activation in left cortex and increased activation in right cortex compared with normal subjects. In one patient, reversed lateralization was noted. Conclusion : Normal hemispheric asymmetry of cortical response to motor task was found in different pattern in schizophrenia. Our result is consistent with functional disturbance of motor circuitry in this disorder. Functional MRI will play an important role in diagnosis and research of this disorder.

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Functional-Magnetic Resonance Imaging and Transcranial Magnetic Stimulation in a Case of Schizencephaly (뇌열 1예의 기능적 자기공명영상과 경두부 자기자극)

  • 변우목;한봉수;이재교;장용민
    • Investigative Magnetic Resonance Imaging
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    • v.4 no.1
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    • pp.14-19
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    • 2000
  • Purpose : This study was to present the functional brain mapping of both functional magnetic resonance imaging(MRI) and transcranial magnetic stimulation(TMS) in a case of schizencephaly. Materials and methods : A 28-year-old man, who had left hemiplegia and schizencephaly in right cerebral hemisphere, was exacted with both functional MRI and TMS. Motor function of left hand was decreased whereas right hand was within normal limit. For functional MRI, gradient-echo echo planar imaging($TR/TE/{\alpha}$=1.2 sec/90 msec/90) was employed. The paradigm of motor task consisted of repetitive self-paseo hand flexion-extension exercises with 1-2 Hz periods. An image set of 10 slices was repetitively acquired with 15 seconds alternating periods of task performance and rest and total 6 cycles (three ON periods and three OFF periods) were performed. In brain mapping, TMS was performed with the round magnetic stimulator (mean diameter; 90mm). The magnetic stimulation was done with 80% of maximal output. The latency and amplitude of motor evoked potential(MEP)s were obtained from both abductor pollicis brevis(APB) muscles. Results : Functional MRI revealed activation of the left primary motor cortex with flexion-extension exercises of healthy right hand. On the other hand, the left primary motor cortex, left supplementary motor cortex, and left promoter areas were activated with flexion-extension exercises of left hand. In TMS, magnetic evoked potentials were induced in no areas of right cerebral hemisphere, but in 5 areas of left corebral hemisphere from both abductor pollicis brevis. Latency, amplitude, and contour of response of the magnetic evoked potentials in both hands were similar. Conclusion : Functional MRI and TMS in a patient with schizencephaly were successfully used to localize cortical motor function. Ipsilateral motor pathway is thought to be secondary to reinforcement of the corticospinal tract of the ipsilateral motor cortex.

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Assessment of Posterior Globe Flattening: Two-Dimensional versus Three-Dimensional T2-Weighted Imaging

  • Ann, Jun Hyung;Kim, Eung Yeop
    • Investigative Magnetic Resonance Imaging
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    • v.19 no.3
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    • pp.178-185
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    • 2015
  • Purpose: To compare the frequency of posterior globe flattening between two-dimensional T2-weighted imaging (2D T2WI) and three-dimensional (3D T2WI). Materials and Methods: Sixty-nine patients (31 female; mean age, 44.4 years) who had undergone both 5-mm axial T2WI and sagittal 3D 1-mm isovoxel T2WI of the whole brain for evaluation of various diseases (headache [n = 30], large hemorrhage [n = 19], large tumor or leptomeningeal tumor spread [n = 15], large infarct [n = 3], and bacterial meningitis [n = 2]) were used in this study. Two radiologists independently reviewed both sets of images at separate sessions. Axial T2WI and multi-planar imaging of 3D T2WI were visually assessed for the presence of globe flattening. The optic nerve sheath diameter (ONSD) was measured at a location 4 mm posterior to each globe on oblique coronal imaging reformatted from 3D T2WI. Results: There were significantly more globes showing posterior flattening on 3D T2WI (105/138 [76.1%]) than on 2D T2WI (27/138 [19.6%], P = 0.001). Inter-observer agreement was excellent for both 2D T2WI and 3D T2WI (Cohen's kappa = 0.928 and 0.962, respectively). Intra-class correlation coefficient for the ONSD was almost perfect (Cohen's kappa = 0.839). The globes with posterior flattening had significantly larger ONSD than those without on both 2D and 3D T2WI (P < 0.001; $6.14mm{\pm}0.44$ vs. $5.74mm{\pm}0.44$ on 2D T2WI; $5.90mm{\pm}0.47$ vs. $5.56mm{\pm}0.34$ on 3D T2WI). Optic nerve protrusion was significantly more frequent on reformatted 1-mm 3D T2WI than on 5-mm 2D T2WI (8 out of 138 globes on 3D T2WI versus one on 2D T2WI; P = 0.018). Conclusion: Posterior globe flattening is more frequently observed on 3D T2WI than on 2D T2WI in patients suspected of having increased intracranial pressure. The globes with posterior flattening have significantly larger ONSD than those without.

Artifacts Improvement by using the Echo Planar Imaging and Pre-Saturation Pulse Band techniques of Reduced Field-Of-View in Breast Magnetic Resonance Imaging Examination (유방 자기공명영상검사에서 감소된 영상영역의 에코평면영상기법과 사전포화기법 사용에 의한 인공물 개선)

  • Lee, Jaeheun;Kim, Hyunjin;Im, Inchul
    • Journal of the Korean Society of Radiology
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    • v.9 no.5
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    • pp.307-314
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    • 2015
  • This study was conducted in reducing the involuntary motion artifacts because of lungs and heart movements as well as the aliasing artifacts generated during the use of the reduced-FOV EPI technique while performing breast MRI. Performed on a total of 38 obesity female subjects who visited the clinic for pre-examination before surgery within the period from August 1 to November 30, 2014. The 3.0T MRI scanner equipped with a breast scanning coil. Qualitative and quantitative analyses were each used for the evaluation of the acquired images while an Paired T-test and Wilcoxon rank test were performed to check the statistical significance. The variation ratio rose by 15.69% with the additional application of a pre-saturation pulse in the lesion, by 13.72% near the lesion, and 20.63% in the fat and the contrast-to-noise ratio rose by 10.58% in and near the lesion and by 12.03% in the lesion and fat, respectively. there were increases of 22.05% and 21.42% at 0 and 1000 respectively in qulitative evaluation and growth of 16.10% in apparent diffusion coefficient. it showed a statistically significant result(p<0.05) in signal to noise ratio, contrast to noise ratio, diffusion slope coefficient and apparent diffusion coefficient. The involuntary movements artifacts that occur in the phase encoding direction and the aliasing artifacts are considered to be reduced to obtain the best image in the additional use of the pre-saturation pulse as DWI is acquired.

A Pulse-Echo Testing Model for Partially Damaged Ultrasonic Transducers (부분 손상을 입은 초음파 탐촉자의 펄스-에코 시험 모델)

  • Song, Sung-Jin
    • Journal of the Korean Society for Nondestructive Testing
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    • v.16 no.2
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    • pp.95-108
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    • 1996
  • In ultrasonic testing, flaw signal from which quantitative information on flaws is determined is influenced by 3 factors : (1) the incident wavefield.produced by the transducer, (2) the scattered waves produced by flaws, and (3) the reception of the scattered waves back at the transducer. So even small changes in transducer performance due to aging or unexpected damages can produce the changes in the characteristics of flaw signal and finally the changes in the quantitative information on flaws. Thus a reliable calibration method of transducer performance is desired. Recently, theoretical models for ultrasonic testing have been employed as reference standards for the calibration of transducers which are considered as circular planar piston sources in the most of cases. But this simplification cannot be applied to partially damaged transducer which has lost their symmetry in performance, even not in appearance. Unfortunately there has been no reliable practical model which can be used for the calibration of partially damaged transducers. Here a pulse-echo testing model for partially damaged ultrasonic transducers was developed with experimental verification. The experimental responses agree very well with the theoretical prediction. So we expect that this model can be served as a theoretical reference standards for transducer calibration.

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The Crystal and Molecular Structure of p-Phenylenediamine Dihydroperchlorate (p-Phenylenediamine Dihydroperchlorate의 결정 및 분자구조)

  • Ahn Choong Tai
    • Journal of the Korean Chemical Society
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    • v.21 no.5
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    • pp.320-329
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    • 1977
  • p-Phenylenediamine dihydroperchlorate, $C_6H_4N_2H_4{\cdot}2HC1O_4$, crystallizes in space group $P\={1}$ with $a=4.79{\pm}0.02,\;b=9.03{\pm}0.02,\;c=7.12{\pm}0.03{\AA},\;{\alpha}=109.4{\pm}0.2,\;{\beta}=79.6{\pm}0.2,\;r=104.6{\pm}0.2^{\circ},\;Z=1$. The structure has been solved by the Patterson and Fourier methods. The refinement by block-diagonal least-squares cycles gives R = 0.13 for 387 observed reflexions collected on equi-inclination Weissenberg photographs with CuK${\alpha}$ radiation. There are two different types of five hydrogen bonds. The first type consists of one trifurcated N${\cdot}{\cdot}{\cdot}$O hydrogen bond and the second of two normal N${\cdot}{\cdot}{\cdot}$O hydrogen bonds, both of which exist between the amino group and the perchlorate, groups. A p-phenylenediamine group is approximately planar within an experimental error and bonded to twelve perchlorates: ten perchlorates forming hydrogen bonds and two being contacted with the van der Waals forces. A perchlorate group is surrounded by six p-phenylenediamines and four perchlorates; among the six p-phenylenediamines, five of them are hydrogen-bonded, and the rest contacted with the van der Waals force.ce anaysis of our samples and investigated the variarions in the values of parameters obtained through fitting the theoretical impedance to the experimental impedance. The characters of the dielectric constant and the impedance showed abnormal variations for the 0.2 at K-doped NSBN ceramics, which we were able to interpret in terms of the variations in the number A-site vacancies with the K doping ratio. From these results, A-site vacancies are thought to be space charges that influence the ferroelectric properties of NSBN ceramics.

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The Crystal Structure of Thiourea of Derivatives(I) (Thiourea Deirvatives의 결정과 분자구조 (제1보))

  • Park Young Ja;Suh Chung Sun;Koo, Chung Hoe
    • Journal of the Korean Chemical Society
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    • v.21 no.5
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    • pp.307-319
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    • 1977
  • The crystal structure of $N-({\alpha}-dimethyl\;{\beta}-hydroxy)ethyl\;N'-cyclohexyl\;thiourea,\;C_{ll}H_{22}N_2OS)$, has been determined by X-ray diffraction method. The compound crystallizes in the orthorhombic space group Pbca with a = 10.33(3), b = 11.82(3), c = 22.57(4)${\AA}$ and Z = 8. A total of 1414 observed reflections collected by the Weissenberg photographs and was solved by heavy atom method and refined by block diagonal least-squares methods to the R value of 0.13. The cyclohexane ring has a normal chair conformation and the thiourea unit is planar. The primary alcoholic group O-H bonded to C(l) makes an intramolecular hydrogen bond with N(2), which leads to stablize the molecule. There are two independent hydrogen bonds in the structure. One of them is of the type N-H${\cdot}{\cdot}{\cdot}$O intramolecular hydrogen bond with the length 2.71${\AA}$, another is of the type O-H${\cdot}{\cdot}{\cdot}$S intermolecular hydrogen bond with the length 3.21${\AA}$ parallel to the b axis. Apart from the hydrogen bonding system the molecules are held together by van der Waals forces in the crystal.

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Molecular Theory of Plastic Deformation (I). Theory (소성변형의 분자론 (제1보). 이론)

  • Kim Chang Hong;Ree Taikyue
    • Journal of the Korean Chemical Society
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    • v.21 no.5
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    • pp.330-338
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    • 1977
  • In order to elucidate the plastic deformation of solids, the following assumptions were made: (1) the plastic deformation of solids is classified into two main types, the one which is caused by dislocation movement and the other caused by grain boundary movement, each movement being restricted on a different shear surface, (2) the dislocation movement is expressed by a mechanical model of a parallel connection of various kinds of Maxwell dislocation flow units whereas the grain boundary movement is also expressed by a parallel connection of various kinds of Maxwell grain boundary flow units; the parallel connection in each type of movements indicates that all the flow units on each shear surface flow with the same shear rate, (3) the latter model for grain boundary movement is connected in series to the former for dislocation movement, this means physically that the applied stress distributes homogeneously in the flow system while the total strain rate distributes heterogeneously on the two types of shear planes (dislocation or grain boundary shear plane), (4) the movement of dislocation flow units and grain boundary units becomes possible when the atoms or molecules near the obstacles, which hinder the movement of flow units, diffuse away from the obstacles.Using the above assumptions in conjunction with the theory of rate processes, generalized equations of shear stress and shear rate for plastic deformation were derived. In this paper, four cases important in practice were considered.ted N${\cdot}{\cdot}{\cdot}$O hydrogen bond and the second of two normal N${\cdot}{\cdot}{\cdot}$O hydrogen bonds, both of which exist between the amino group and the perchlorate, groups. A p-phenylenediamine group is approximately planar within an experimental error and bonded to twelve perchlorates: ten perchlorates forming hydrogen bonds and two being contacted with the van der Waals forces. A perchlorate group is surrounded by six p-phenylenediamines and four perchlorates; among the six p-phenylenediamines, five of them are hydrogen-bonded, and the rest contacted with the van der Waals force.

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Characteristics of Beam-tilting Slot Array Waveguide Antennas for DBS Reception (DBS 수신용 빔 틸트형 슬롯 어레이 도파관 안테나의 특성)

  • Min, Gyeong-Sik;Kim, Dong-Cheol;Arai, Hiroyuki
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.39 no.3
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    • pp.140-149
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    • 2002
  • This paper describes the characteristics of beam-tilting slot away waveguide antennas for mobile DBS reception. As a basic study of slotted waveguide array, design for 16 slot elements located on a broad-wall waveguide is considered. Design parameters such as slot length, space between each slot and cross slot angle of antennas with the beam-tilting characteristics are calculated by method of moments. Based on these results, the radiation waveguide antennas with 16-element $\times$16-array are designed and fabricated. The measured main beam direction angles of the fabricated antennas are 48$^{\circ}$to 50$^{\circ}$depending on the measured frequencies and it shows good agreement with prediction. The measured 3 dB beam width of elevation pattern is about 13$^{\circ}$, and the axial ratio and the gain measured at DBS band are observed 2.8 dB below and 24 dBi above, respectively. In order to evaluate a performance of the fabricated waveguide planar antenna, it is combined with the satellite tracking control system and the field performance test of antenna mounted on a mobile vehicle is carried out at highway. During the measurement, it was possible to watch television without a break signal in a driving vehicle and an excellent performance of the proposed antennas was demonstrated.

SAR analysis with variety of the antenna structures on PCS handset (PCS 전화기의 안테나 구조에 따른 SAR 분석)

  • Kim, Hyoun-Kyoung;Park, Ju-Deok;Kim, Jin-Seok;Kim, Nam
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.37 no.11
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    • pp.8-16
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    • 2000
  • In this paper, on calculating SARs on human head using computer simulation, SARs caused by PCS handsets are calculated and compared, and the design parameters that affect SAR values are analyzed. Is and 10 g peak averaged SARs are calculated as the type of antenna, the location of antenna, and the type of handset are changed and SAR distributions as depth of human head are shown. Among the antennas on flip type handsets, side mounted PIFA has the lowest SARs 1g and 10g peak averaged SARs are 0.686W/kg and 0.353W/kg. The SARs caused by monopole antenna on folder type handset are 1.133W/kg and 0.709W/kg. and are about 30% lower than monopole 1.759W/kg and 0.978W/kg, respectively. SAR distributions as depth of human head of side mounted PIFA and monopole antenna on folder-type handset are more slowly changed than those of top mounted PIFA and monopole antenna on flip-type handset.

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