• Title/Summary/Keyword: Pilot protocol study

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CLINICAL STUDY OF THE SKELETAL CL III MALOCCLUSION PATIENTS AFTER 2-PHASE SURGICAL-ORTHODONTIC TREATMENT (골격성 제III급 부정교합 환자의 2단계 치료후 경과에 대한 임상적 연구)

  • Cho, Yun-Ju;Kim, Sang-Jung;Kim, Dong-Ryul;Suk, Geon-Jung;Hong, Kwang-Jin;Lee, Jeong-Gu;Sohn, Hong-Bum
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.26 no.6
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    • pp.628-635
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    • 2000
  • The purpose of this study was to evaluate the result after 2-phase surgical-orthodontic treatment without preoperative orthodontic treatment for the skeletal Cl III malocclusion patient and to obtain an adequate protocol on the bases of this result. This retrospective study of ten patients who underwent 2-phase treatment were done to evaluate 1) the surgical stability and relapse pattern 2) the facial esthetics 3) the TMJ problem 4) the total time of the treatment. Results were followed : 1) The horizontal relapse of the mandible was 26.8% and didn't show significant differences compared to the conventional 3-phase treatment. But, it was considered that this amount of relapse was the sum of true relapse and autoratation of mandible due to decreased vertical dimension during orthodontic treatment. 2) It was estimated that there's no difference on the ratio of anterior facial height between the subjects and the normal patients. On the horizontal analysis, the mandible of the subjects was located more anteriorly than that of the normal patients. This result showed that there was a need for the accurate preoperative esthetic evaluation and the additional methods for reducing the relapse due to the occlusal interference. 3) Wide variation was noted on the TMJ symptoms of the subjects, however, it was estimated that there's no significant differencees of symptoms compared to that of the conventional 3-phase treatment on literatures. 4) The average of the overall period of treatment was 20.8 months and we obtained reduction of the treatment time compaired to 3-phase treatment on many literatures. Most of the results of this study were similar to the findings of the 3-phase treatment(preoperative orthodontic-orthognathic surgery-postoperative orthodontic), but total time of the treatment was shorter in patients with 2-phase treatment than in those with the conventional 3-phase treatment. With 2-phase treatment, we experienced many advantages compared to the conventional method considering that it was favarable conditions for the teeth, it had the flexibility for the treatment, and it could be the adequate treatment approach for the stomatognathic system. Although this retrospective pilot study had some limitations, due to small samples, the authors would hope that it could serve as a guide for the future researches, and the clinical applications.

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Clinical Research of Warm Needle Acupuncture for Chronic Low Back Pain: A Protocol for Randomized, Controlled Pilot Study (온침이 만성요통에 미치는 효과에 대한 무작위배정 대조군 예비 임상연구 프로토콜)

  • Seo, Yeonho;Kim, Taeoh;Cho, Whisung;Ko, Junhyuk;Ahn, Jonghyun;Kim, Soo Jeon;Lee, Hansol;Chang, Hokyung;Kim, Hyungsuk;Kim, Koh-Woon;Cho, Jae-Heung;Chung, Wonseok;Song, Mi-Yeon
    • Journal of Korean Medicine Rehabilitation
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    • v.30 no.4
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    • pp.155-164
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    • 2020
  • Objectives This study is aimed to evaluate the feasibility of further clinical research of warm needle acupuncture as an effective and safe treatment for chronic low back pain. Methods Thirty participants will be randomly assigned to the Warm needle acupuncture group (n=15) and Dry needle acupuncture group (n=15). All patients will receive acupuncture therapy twice a week for 6 weeks, but only the experimental group will receive thermal stimulation. The primary outcome will be measured using the visual analogue scale for bothersomeness of low back pain, and the secondary outcome will be measured using the VAS for pain intensity, Oswestry disability index, 36-Item Short Form Health Survey, Beck's depression inventory, and amount of analgesics used. Conclusions The results of this study will be used to determine the feasibility of a future large-scale randomized controlled trial that provides clinical evidence for the efficacy and safety of warm needle acupuncture in the treatment of patients with chronic low back pain.

Effects of Occupation-Based Bilateral Upper Extremity Training for Chronic Stroke: Pilot Study (뇌졸중 환자의 작업기반 양측성 상지훈련 효과: 예비연구)

  • Kim, Sun-Ho;Park, Ji-Hyuk
    • Therapeutic Science for Rehabilitation
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    • v.6 no.2
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    • pp.47-58
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    • 2017
  • Objective : The purpose of this study is to observe effects of Occupation-Based bilateral UE training for chronic stroke. Methods : 4 patients with hemiplegic stroke were divided into two groups: experimental group and control group. From May to August 2016, we conducted a occupation - based bilateral UE training and a traditional bilateral UE training for 5 weeks, 3 times a week, and 60 minutes per session for each subject. EMG, accelerometer, ARAT, Y-BAT, SIS, and COPM were performed before and after the intervention. Results : The experimental group showed a large changes before and after intervention in ECR, DA and all items except for hand function and memory of SIS, compared with the control group. Also, the experimental group showed a large change before and after the intervention compared to the control group in the accelerometer measuring the amount used of bilateral hand and grasp, pinch, and gross movement items of ARAT and COPM, Y-BIT. Conclusions : Occupation-based bilateral upper extremity training was effective in the recovery of upper limb function and social participation through neurological changes. Future research will be required development studies to ensure a high content validity of the Occupation-based bilateral upper extremity training protocol.

Study Protocol for the Most Effective Recall Method in a Cervical Cancer Screening Program in Klang, Malaysia

  • Rashid, Rima Marhayu Abdul;Dahlui, Maznah
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.10
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    • pp.5867-5870
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    • 2013
  • Background: Cervical cancer is the second most common cancer among Malaysian women with an ASR of 17.9 and a mortality rate of 5.6 per 100,000 population in 2008 (GLOBOCAN, 2008). The 5 year prevalence was estimated to be 14.5 per 100,000 population. As the second most common cancer affecting productive females, cervical cancer imposes an impact to the socioeconomic aspect of the country. However, the poor uptake of cervical cancer screening is a major problem in detecting early pre-cancerous lesions and thus, delay in initiating treatment for cervical cancer. Realizing the urgency to increase the uptake of PAP smear, besides enhancing the promotion of PAP smear screening for women above 35 years old, the call-recall system for pap smear screening had been piloted in one of the suburban districts which aimed to improve regular participation of women for cervical and breast cancer screening. This is of public health importance as identifying the best feasible option to increase patient's respond to participate in the screening program effectively in our setting will be helpful in implementing an organized regular population based screening program tailored to our setting. The pilot program of cervical cancer screening in Klang was an opportunity to assess different options in recalling patients for a repeat pap smear to increase their participation and adherence to the program. Methods and Results: This was a population based randomized control trial. Women aged 20-65 years in the population that matched the inclusion and exclusion criteria were re-called for a repeat smear. There are four different intervention groups; letter, registered letters, short messages services (SMS) and phone calls where 250 subjects were recruited into each group. Samples were generated randomly from the same population in Klang into four different groups. The first group received a recall letter for a repeat smear similar to the one that has been given during the first invitation. The intervention groups were either be given a registered letter, an SMS or a phone call to re-call them. The socio-demographic data of the patients who came for uptake were collected for further analysis. All the groups were followed up after 8 weeks to assess their compliance to the recall. Conclusions: The study will provide recommendations about the most effective methods for recall in a population based pap smear screening program on two outcomes: i) patients response; ii) uptake for repeat pap smear.

Anthropometric Analysis of Korean Helicopter Pilots for Helicopter Cockpit Design (헬리콥터 조종실 설계를 위한 헬리콥터 조종사 인체측정 및 분석)

  • Jung, Kih-Yo;Jo, Ja-Young;Jeong, Jeong-Rim;Park, Ji-Eun;Lee, Won-Sup;Uem, Joo-Ho;Lee, Joung-Hyo;Kang, Byung-Gil;Kim, Hee-Eun;Park, Sei-Kwon;You, Hee-Cheon
    • Journal of the Ergonomics Society of Korea
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    • v.27 no.4
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    • pp.37-44
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    • 2008
  • To design the cockpit of Korean helicopter, anthropometric data for Korean helicopter pilots as a target population is necessary. The present study measured the body sizes of Korean helicopter pilots to design the cockpit of Korean helicopter, and compared the measurements with those of Korean civilian and the US Army. The sample size was 100 which determined by a statistical analysis. Anthropometric measurements were collected for 100 samples (male = 94, female = 6; age group = 20~40) of Korean helicopter pilots by applying standard measurement protocol. To compare three anthropometric data, Korean civilian and US Army data were controlled by considering age group (20~40) and gender ratio (male: female = 9:1) of Korean helicopter pilots. The average body sizes of Korean helicopter pilots were mostly similar to those of Korean civilian, however, lower limb related variables (hip breadth, popliteal height and thigh clearance) and shoulder-to-elbow length were significantly greater (1~7%) at α=0.05. Furthermore, the average body sizes for Korean helicopter pilots regarding lower limb length and thickness were significantly smaller than those of the US Army (1~12%); however, the average body sizes for Korean helicopter pilots regarding upper body related variables (sitting height, sitting eye height, and acromial height) and hip breadth were significantly greater (0.7~1.9%). Lastly, size variability for Korean helicopter pilots was significantly smaller than those of Korean civilian and the US Army. Anthropometric data for Korean helicopter pilots of the present study was applied to design and evaluate a Korean helicopter cockpit.

Influence of Rotation Number in the Effect of PC6 on the Heart Rate: A Pilot Study (내관 자침 시 염전 횟수가 심박 변이도에 미치는 영향: 예비연구)

  • Lee, Bong Hyo;Chung, Jae Hwan;Son, Jigook;Heo, Jeong Hyeon;Park, Ji Ha;Kim, Hee Young;Lee, Sang Nam;Lee, Young Joon;Kim, Mi Ryeo;Lim, Sung Chul;Kim, Jae Su;Lee, Yun Kyu;Lee, Hyun Jong;Jung, Hyun Jung;Jung, Tae Young
    • Korean Journal of Acupuncture
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    • v.30 no.2
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    • pp.88-96
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    • 2013
  • Objectives : In the acupuncture treatment of Korean Medicine, the Tonifying or Purging depending on how many times the needle is rotated has been used widely. However, there is little evidence about the optimal number of rotation. This study, therefore, was aimed to investigate the optimal number of rotation. Methods : Heart rate variation was measured before and after exercise in 20 healthy adults. Acupuncture was performed at PC6 immediately after exercise according to the protocol of each group without remaining. Pre-exercise and post-exercise measurements were compared and the rotation number that produced statistically significant difference was investigated. Results : Significant differences were found in the heart rate variation and R-R interval Average, between non-rotation group (control) and both of 15 times rotation group of tonifying and 6 times rotation group of purging. Conclusions : Significantly effective number of rotation in the effect of PC6 on the HR and RRAv was 15 times in the tonifying and 6 in the purging respectively.

Acupuncture for Prehypertension and Stage 1 Hypertension in Postmenopausal Women: Protocol for a Randomized Controlled Pilot Trial (폐경 후 여성의 전단계 및 1기 고혈압에 대한 침 치료: 다기관 무작위 대조 예비연구)

  • Kim, Jung-Eun;Choi, Jin-Bong;Kim, Hyeong-Jun;Kang, Kyung-Won;Liu, Yan;Jung, Hee-Jung;Lee, Min-Hee;Shin, Mi-Suk;Kim, Jae-Hong;Choi, Sun-Mi
    • Korean Journal of Acupuncture
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    • v.31 no.1
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    • pp.5-13
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    • 2014
  • Objectives : This study aims to evaluate the effectiveness and safety of acupuncture and explore the appropriate number of treatment for postmenopausal women diagnosed with prehypertension and stage 1 hypertension. Methods : A 4-arm randomized open label pilot trial will be performed at 2 centers. Sixty participants will be divided into 2 treatment groups and 2 control groups. Treatment groups will receive acupuncture at 8 points(bilateral GB20, LI11, ST36, SP6) for 4 weeks(treatment group A, 10 total sessions) or 8 weeks(treatment group B, 20 total sessions), while maintaining usual care. Control groups will not receive acupuncture but will be under usual care for 16 weeks(control group C) or 20 weeks(control group D). Each patient's living habits will be corrected and drugs that may affect blood pressure(BP) will be prohibited. Treatment group A and control group C will be evaluated at 4, 8, 12, and 16 weeks after randomization, while treatment group B and control group D will be evaluated at 4, 8, 12, 16, and 20 weeks after randomization. The major outcome variable is the magnitude of change in diastolic BP levels at 4 weeks after randomization; auxiliary outcome variables are (1) diastolic BP change at 8, 16, and 20 weeks, (2) systolic BP change, (3) BP control rate, (4) lipid profiles, and (5) high-sensitivity C-reactive protein. Patient safety will be assessed at every visit. Results and Conclusions : The study findings may help develop evidence for the effectiveness and safety of acupuncture for BP control.

Preliminary Results of Concurrent Radiation Therapy and Chemotherapy in Locally Advanced Cervical Carcinoma (국소적으로 진행된 자궁 경부암에서 방사선과 항암화학요법 병행치료의 예비적 결과)

  • Yang KM;Ahn SD;Choi EK;Chang HS;Kim YT;Nam JH;Mok JE
    • Radiation Oncology Journal
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    • v.11 no.2
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    • pp.355-361
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    • 1993
  • Since May 1991, authors have conducted a pilot study to determine the feasibility and evaluate the effect of concurrent radiation therapy and chemotherapy with 5-FU and Cis-platinum for locally advanced cervical cancer (stage IIB-IVA). Radiation therapy consisted of external irradiation to whole pelvis (4140 cGy/23 fx) in 4.5 weeks followed by high dose rate intracavitary radiation therapy (HDR ICRT) to deliver a dose of 30 to 35 Gy to A point in 6 to 7 fractions. After the intracavitary radiation therapy, parametrial boost was delivered for B point dose of 60 Gy in Stage IIB and 65 Gy in stage IIIB. 5-FU (1000 $mg/m^2/24hr$ for 96 hour iv infusion) and Cis-platinum (20 $mg/m^2/day$ IV bolus for 3 days) were given during the second week of external RT and the second course chemotherapy administered at the first HDR ICRT with the same method as the first chemotherapy. Sixteen patients (10 stage IIB,4 stage IIIB,2 stage IVA) were registered to this protocol. Among these 16 patients, two refused treatment after 2 fractions of external irradiation, and one could not continue intracavitary irradiation because of treatment related genitourinary toxicity. So 14 patients were evaluated for toxicity and 13 patients were evaluated for response analysis. Five of 14 patients developed grade 3 gastrointestinal toxicity but 4 of them recovered at the completion of treatment. One stage IIIB patient with inguinal lymph node metastasis who received higher dose of radiation in spite of initial poor performance status did not recover from gastrointestinal toxicity at the completion of treatment. And she died of distant metastasis at one month after the completion of treatment. Two of 14 evaluable patients showed weight loss, more than $10\%$ of initial weight. One patient developed grade 3 leukopenia. In this study, the average total treatment period of completely treated patients was 75 days and three of them took more than 80 days (84, 84, 89 days). Toxicities were generally acceptable and there were no treatment related death. At the last follow-up, complete response was achieved in $62\%(8/13)$ and especially of nine patients with stage IIB, eight patients showed complete response. This study suggests that concurrent radiation therapy and chemotherapy (5-FU and Cis-platinum) is tolerable and effective. Further follow-up is needed to determine whether this protocol will have a favorable impact on survival and to evaluate the late effect on normal tissues. In future, prospective randomized trials are needed to compare the standard radiation therapy alone with concurrent chemotherapy and radiation therapy for locally advanced cervical carcinoma.

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A Study on change from an RTU-based substation to IEC 6 1850-based SA substation (RTU 기반 변전소의 IEC 61850 기반 SA 변전소로의 전환에 대한 실증 연구)

  • Yuk, Sim-Bok;Lee, Sung-Hwan;Kim, Chong-il
    • The Journal of Korea Institute of Information, Electronics, and Communication Technology
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    • v.11 no.4
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    • pp.436-444
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    • 2018
  • Currently, the new substation automation uses the international standard IEC 61850 communication protocol. KEPCO is also constructing a new substation based on IEC 61850 from 2013 through the pilot application and research and development starting from 2007. However, there are few cases where existing substations(Transformer, T/L GIS, D/L GIS, etc.) have been used, and RTU based substations operating systems have been changed to SA substations based on IEC 61850. Therefore, the introduction of IEC 61850 in existing substation facilities has the advantage of enhancing the substantiality of the substation by reusing existing facilities, improving the interoperability with the latest substations introduced, and converting existing substations into systems suitable for unmanned operation. In this paper, we introduce a case of changing the existing RTU based substation operation system to digital substation using IEC 61850 field information processor, Ethernet switch and SA operation system. Also, IEC 61850 client authentication program and Wireshark, which is a packet analysis tool, verify IEC 61850 conformance and its feasibility.

An Experimental Study for RFID Application of Construction Materials in an Apartment House Construction Site (건설자재의 공동주택 현장 적용을 위한 RFID 부착 및 인식에 관한 실험적 연구)

  • Ju, Ki-Beom;Han, Choong-Han
    • Korean Journal of Construction Engineering and Management
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    • v.10 no.5
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    • pp.67-75
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    • 2009
  • While the trend of all industries recently lies in combination, construction industry is much interested in enhancing efficiency and competitiveness in the aspect of site control by adopting RFID. Though RFID has been applied to diverse areas thus far, it cannot be easily applied to construction industry due to diverse physical, chemical and use-environmental properties of construction materials. Furthermore, it is rarely applied to the site because of many problems in its application. It is required to prepare RFID code issuance and system that can systematically control the code as well as to research the standardization of frequency, specification, protocol, package method, recognition method, etc in order to apply RFID to construction industry. In this research, RFID code issuance and management program are proposed as a part of program research to apply RFID. Furthermore, the restricted matters of existing RFID tag are drawn to produce pilot product of RFID tag that can solve it so as to perform site application test. According to the experiment, effective recognition distance varies depending on material/environmental property and control efficiency changes depending on attachment method and application method. Thus, preparing diverse restrictive factors and solutions by systematically analyzing control method(medium, process) of current architecture materials and applying it to construction site can be the way to successfully apply RFID.