• Journal of the Economic Geographical Society of Korea
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• v.23 no.3
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• pp.334-348
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• 2020

Recently, the demand for corporate location in the city is increasing. Due to the difficulty of finding a large site in the city, the small-scale 'mini-industrial complex' would be appropriate as a future industrial complex type. In response to this, site suitability indicators was prepared and applied to the metropolitan area as a pilot. To this end, the under-utilized site were assumed as potential candidates for development. After analyzing the importance among indicators through a questionnaire from experts and companies, this was applied as a weight. As a result, candidate sites ranging from Grade 1 to Grade 4 were derived. The indicators that had a great influence on the location identified as a Grade 1 were transport accessibility and urban service conditions when the company weight was applied, whereas advanced knowledge industry and university/research center when applying expert weight. The Seoul-south axis and southwest axis of Gyonggi-Do were identified as the most excellent mini-industrial complex locations among the Seoul metropolitan areas. It means that the already formed knowledge industry clusters will be recognized as competitive future industrial locations.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.17
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• pp.7619-7625
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• 2015

Background: Aberrant microRNA expression has been associated with the pathogenesis of a variety of human malignancies including oral squamous cell carcinoma (SCC). In this study, we examined primary oral SCCs for the expression of 6 candidate miRNAs, of which five (miR-34a, miR-143, miR-373, miR-380-5p, and miR-504) regulate the tumor suppressor TP53 and one (miR-99a) is involved in AKT/mTOR signaling. Materials and Methods: Tumor tissues (punch biopsies) were collected from 52 oral cancer patients and as a control, 8 independent adjacent normal tissue samples were also obtained. After RNA isolation, we assessed the mature miRNA levels of the 6 selected candidates against RNU44 and RNU48 as endogenous controls, using specific TaqMan miRNA assays. Results: miR-34a, miR-99a, miR-143 and miR-380-5p were significantly down-regulated in tumors compared to controls. Moreover, high levels of miR-34a were associated with alcohol consumption while those of miR-99a and miR-143 were associated with advanced tumor size. No significant difference was observed in the levels of miR-504 between the tumors and controls whereas miR-373 was below the detection level in all but two tumor samples. Conclusions: Low levels of miR-380-5p and miR-504 that directly target the 3'UTR of TP53 suggest that p53 may not be repressed by these two miRNAs in OSCC. On the other hand, low levels of miR-34a or miR-143 may relieve MDM4 and SIRT1 or MDM2 respectively, which will sequester p53 indicating an indirect mode of p53 suppression in oral tumors.