• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.1
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• pp.149-153
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• 2011

In this study, we structuralized the diagnostic indices used for pattern identification (PI) of stroke, and suggested an AHP method to obtain the weights of PI indices. AHP of the subjects under consistency ratio 0.1 showed that the critical indices for stroke PI consists of 9 for Qi-deficiency, 13 for Phlegm/dampness, 7 for blood stagnation, 12 for Yin-deficiency and 16 for Fire/heat. Furthermore, AHP analysis rendered the weights of indices of each PI that will be useful for oriental medical experts to perform objective PI.

• Journal of Physiology & Pathology in Korean Medicine
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• v.36 no.2
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• pp.73-78
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• 2022

Since Traditional Korean medicine (TKM) doctors use various knowledge systems during treatment, diagnosis results may differ for each TKM doctor. However, it is difficult to explain all the reasons for the diagnosis because TKM doctors use both explicit and implicit knowledge. In this study, an upgraded random forest (RF)-based evaluation tool was proposed to extract clinical knowledge of TKM doctors. Also, it was confirmed to what extent the professor's clinical knowledge was delivered to the trainees by using the evaluation tool. The data used to construct the evaluation tool were targeted at 106 people who visited the Sasang Constitutional Department at Kyung Hee University Korean Medicine Hospital at Gangdong. For explicit knowledge extraction, four TKM doctors were asked to express the importance of symptoms as scores. In addition, for implicit knowledge extraction, importance score was confirmed in the RF model that learned the patient's symptoms and the TKM doctor's constitutional determination results. In order to confirm the delivery of clinical knowledge, the similarity of symptoms that professors and trainees consider important when discriminating constitution was calculated using the Jaccard coefficient. As a result of the study, our proposed tool was able to successfully evaluate the clinical knowledge of TKM doctors. Also, it was confirmed that the professor's clinical knowledge was delivered to the trainee. Our tool can be used in various fields such as providing feedback on treatment, education of training TKM doctors, and development of AI in TKM.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.6
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• pp.1460-1464
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• 2009

In spite of many studies on statistical model for pattern identifications (PIs), little attention has been paid to the complexity of pattern diagnosis processed by oriental physicians. The aim of this study is to develop a statistical diagnostic model which discriminates four PIs using multiple indicators in stroke. Clinical data were collected from 981 stroke patients and 516 data of which PIs were agreed by two independent physicians were included. Discriminant analysis was carried out using clinical indicators such as symptoms and signs which referred to pattern diagnosis, and applied to validation samples which contained all symptoms and signs manifested. Four Fischer's linear discriminant models were derived and their accuracy and prediction rates were 93.2% and 80.43%, respectively. It is important to consider the pattern diagnosis processed by oriental physicians in developing statistical model for PIs. The discriminant model developed in this study using multiple indicators is valid, and can be used in the clinical fields.

• Journal of Physiology & Pathology in Korean Medicine
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• v.28 no.2
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• pp.233-237
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• 2014

This case report that the therapeutic effects of traditional Korean medicine(TKM) treatment on the tumor response in a diffuse large B-cell lymphoma(DLBL) patient. A patient was treated by acupuncture, pharmacopuncture, moxibustion, cupping and herbal medicine once a week at least for 12 months. we evaluated the grade of chief complaints and performed blood tests and sonography, abdominal CT periodically. After 1 month administration with TKM treatment, the symptoms of the patient vanished obviously. the size of inguinal lymphoma decreased gradually through 3 months. then from 3 to 10 months, the size of inguinal lymphoma remained as it is. TKM treatment was maintained continuously. in the abdomino-pelvic CT performed after 12 months, the patient didn't complain any symptom and the size of inguinal lymphoma decreased a little again. This case study supports that TKM treatments may have a efficacy in treating diffuse large B-cell lymphoma(DLBL) patients.

• The Journal of Korean Medical History
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• v.24 no.2
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• pp.17-24
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• 2011

Cho Heon Yeong's 'Tongsokanuihagwollon' is an introductory and essential book on Traditional Korean Medicine(TKM), and now we can nearly take it as classic. It contains almost whole contents of TKM : physiology, pathology, herbology, meridian & acupoint, internal medicine, diagnostics, formula science, etc. He wanted to help people get TKM services easily on their own through this book. In the first chapter following the introduction, he inserted Yin-Yang theory, and his lecture on Yin-Yang theory continues for 88 pages, taking 17% of the whole book. Yin-Yang theory chapter is composed of 14 parts which tells about concept, definition and meaning of Yin-Yang, change of Yin-Yang according to time, season, constitution, body region, meridian, herb, etc. Last part refers to disharmony & dysfunction of Yin-Yang in body, so he showed both theoretical and clinical view of Yin-Yang theory. He wrote some quotations from the book 'Complete Works of Jingyue(景岳全書)', 'Huangdi's Internal Classic(黃帝內徑)', 'Introduction to Medicine(醫學入門)', etc. He tried to explain easily about Yin-Yang theory with modern but rough language of science. He seemed to already know clearly that without modern science TKM cannot progress and will soon be overwhelmed by western medicine, and acted his own way to spread spirit of TKM in the period of rapid change & conflict between two civilizations.

• Journal of Physiology & Pathology in Korean Medicine
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• v.38 no.5
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• pp.187-195
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• 2024

Bones and teeth impact quality of life and serve as important indicators of overall health, and diseases such as osteoporosis and periodontitis are emerging as increasingly significant health issues in aging societies. In traditional Korean medicine(TKM), bones and teeth are classified under the kidneys, explaining their interrelationship, and biomedical studies have been published on this connection. This study aims to compare the perspectives of TKM and biomedicine on the relationship between the kidneys, bones, and teeth, focusing on similarities between the two disciplines. The fact that the kidneys produce active vitamin D, which contributes to skeletal formation, and that sex hormones, which influence the lifespan of osteoclasts and osteoblasts, resemble the role of the kidneys(腎) in TKM, which are associated with growth and reproduction, aligns with the TKM concept that "the kidneys govern the bones" (腎主骨). Furthermore, the histological similarity between bones and teeth, as well as the metabolic parallels involving osteoclast metabolism, retinoic acid metabolism, and vitamin D, support the idea that "teeth are the surplus of bones" (齒者骨之餘). In addition to the kidneys acting on the shared pathways of bones and teeth, the pathological link between kidney deficiency(腎虛) and dental diseases-caused by aging, overwork, or congenital deficiencies-explains the concept that "the kidneys govern the teeth"(腎主齒). This study contributes to an integrated understanding of both disciplines by comparing the TKM concept with biomedical explanations concerning the kidneys, bones, and teeth. Through this approach, it can be demonstrated that TKM concepts remain valid in modern contexts, while also suggesting the potential to explain less clearly understood TKM theories in this manner.

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.5
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• pp.894-899
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• 2011

Traditional Korean Medicine (TKM) has been actively researched through various approaches, including computational methods. This paper aims at providing an overview of domestic studies using the computational techniques in TKM field. A literature search was conducted in Korean publications using OASIS system, and major studies of data mining in TKM were identified. A review was presented in six diagnosis fields, including sasang constitution diagnosis, eight constitution diagnosis, tongue diagnosis, pattern diagnosis for stroke, diagnosis based on ontology, diagnosis for cause of disease. They collect clinical data themselves for experiments and primarily applied a algorithm of decision tree, SVM, neural network, case-based reasoning, ontology reasoning, discriminant analysis. In the future, there needs to identify which algorithm is suitable to diagnosis or other fields of TKM.

• Herbal Formula Science
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• v.32 no.3
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• pp.311-324
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• 2024

Objectives : Human body keeps balance through the interaction of various organs, especially the lungs and kidneys are closely connected in maintaining health and preventing disease. This study explores how the lungs and kidneys interact in terms of breathing and fluid balance and aims to find common ground between Eastern and Western medical practices. Methods : Similar explanations related to the interaction between the lungs and kidneys in the physiology and pathology of Traditional Korean Medicine(TKM) and biomedicine were compared. Results : In breathing, the lungs and kidneys work together by adjusting abdominal pressure with the diaphragm and maintaining acid-base balance, and hormones and enzymes secreted from the kidneys significantly affect lung function. This process corresponds to the concept of TKM that the kidneys control the reception of qi (腎主納氣). For fluid balance, the lungs help manage fluid levels through evaporation and sweating, interacting with the kidneys via the Renin-Angiotensin System (RAS), ACE, ACE2 enzymes, and antidiuretic hormone (ADH). This is similar to the theory in TKM that the lungs regulate human fluid (肺主通調水道). Conclusions : This research shows that by looking at the same physiological and pathological processes from different angles, we can reduce misunderstandings between Eastern and Western medicine. It helps improve the understanding of TKM's theories and supports building a unified framework for both medical traditions. Future work should focus on developing compatible theoretical systems across these fields.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.6
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• pp.1486-1490
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• 2009

To develop the diagnostic tool for Fire-heat pattern, we analyzed sensitivity and specificity of symptom signs to diagnose the Fire-heat pattern in stroke patients. Korean medicine doctor surveyed Fire-Heat of the symptoms for the Stroke(KSDS) case report form in stroke patients within 1 month of onset. The sensitivity of "more 1/5 in major sings and 2/11 in helpful sings", "more 2/5 in major sings and 2/11 in helpful sings", "more 3/5 in major sings and 2/11 in helpful sings", "more 1/5 in major sings and 3/11 in helpful sings" "more 2/5 in major sings and 3/11 in helpful sings" "more 3/5 in major sings and 3/11 in helpful sings" are respectively 93%, 59%, 33%, 80%, 53%, 32%. The specificity are respectively 93%, 59%, 33%, 80%, 53%, 32%. The sensitivity(59%) and specificity(80%) of "more 2/5 in major sings and 2/11 in helpful sings" that to be implanted.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.5
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• pp.938-941
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• 2009

In spite of abundant clinical resources of stroke patients, the objective and logical data analyses or diagnostic systems were not established in oriental medicine. In the present study we tried to develop the statistical diagnostic tool discriminating the subtypes of oriental medicine diagnostic system, syndrome differentiation (SD). Discriminant analysis was carried out using clinical data collected from 1,478 stroke patients with the same subtypes diagnosed identically by two clinical experts with more than 3 year experiences. Numerical discriminant models were constructed using important 61 symptom and syndrome indices. Diagnostic accuracy and prediction rate of 5 SD subtypes: The overall diagnostic accuracy of 5 SD subtypes using 61 indices was 74.22%. According to subtypes, the diagnostic accuracy of "phlegm-dampness" was highest (82.84%), and followed by "qi-deficiency", "fire/heat", "static blood", and "yin-deficiency". On the other hand, the overall prediction rate was 67.12% and that of qi-deficiency was highest (73.75%). Diagnostic accuracy and prediction rate of 4 SD subtypes: The overall diagnostic accuracy and prediction rate of 4 SD subtypes except "static blood" were 75.06% and 71.63%, respectively. According to subtypes, the diagnostic accuracy and prediction rate was highest in the "phlegm-dampness" (82.84%) and qi-deficiency (81.69%), respectively. The statistical discriminant model of constructed using 4 SD subtypes, and 61 indices can be used in the field of oriental medicine contributing to the objectification of SD.