• The Korean Journal of Physiology and Pharmacology
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• 제7권1호
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• pp.33-37
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• 2003

Oxidative damage to mitochondria is a critical mechanism in necrotic or apoptotic cell death induced by many kinds of toxic chemicals. Thioredoxin (Trx) family proteins are known to play protective roles in organisms under oxidative stress through redox reaction by using reducing equivalents of cysteines at a conserved active site, Cys-X-X-Cys. Whereas biological and physiological properties of Trx1 are well characterized, significance of mitochondrial thioredoxin (Trx2) is not well known. Therefore, we addressed physiological role of Trx2 in PC12 cells under oxidative stress. In PC12 cells, transiently overexpressed Trx2 significantly reduced cell death induced by hydrogen peroxide, whereas mutant Trx2, having serine residues instead of two cysteine residues at the active site did not. In addition, stably expressed Trx2 protected PC12 cells from serum deprivation. These results suggest that Trx2 may play defensive roles in PC12 cells by reducing oxidative stress to mitochondria.

• Journal of Ginseng Research
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• 제18권3호
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• pp.204-211
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• 1994

Three unknown ninhydrin positive substances (UK-I, UK-II and UK-III) were detected with an amino acid analyzer in a water extract of Korean red ginseng. One of them (UK-II) was isolated and determined to be maltulosyl arginine (Arg-Fru-Glc) on the basis of chemical and spectroscopic evidence. Another one (VK-III) was identified as Arg-Fru. Maltulosyl arginine, but not Arg-Fru, is a newly identified amino acid derivative. The Korean red ginseng was shown to contain more amount of maltulosyl arginine than the white ginseng. Maltulosyl arginine was found to be produced by the Mallard reaction of maltose with arginine during the heating process involved in preparation of the red ginseng. Maltulosyl arginine was found to inhibit maltase activity. Based on these results, the physiological significance of this new compound is discussed.

• 복식문화연구
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• 제12권2호
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• pp.279-289
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• 2004

This study was conducted to compare the hunting reaction of finger in the cold water. Finger skin temperature is measured the left middle finger tip immersion in cold water of 5℃ for 30 minutes and measurements were made on finger skin temperature(Ts), thermal comfort, and cold pain sensations during the experiment at the spring (March) and Winter(December). Results were follows. Is before immersion was at the highest in spring and at the lowest in winter and was closely related to the indoor temperature Ts during immersion and recovery. Mean of finger skin temperature(MST), the skin temperature at the first rise(TTR) and amplitude of finger skin temperature reaction during immersion(AT) were significant higher in spring than that in winter(P＜.01). The lowest skin temperature(LST) during the cold water immersion were significantly higher in spring than that in winter (P＜.05). The frequency of the appearance of cold-Induced vase dilation(CIVD) was higher in spring than that in winter. However, time for the first temperature(TTR) and recovery time(RT) had no seasonal variation. In addition, cold pains during immersion were felt more strongly in spring than in winter. Local thermal sensation, finger thermal sensation in dynamic state during hand immersion was different from that in the Winter. Spring was slowly cold in cold water immersion.

• 한국수정란이식학회지
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• 제26권4호
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• pp.287-296
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• 2011

Mammalian fertilization is a complex cascade process consisting of sperm migration through the female reproductive tract, physiological changes to sperm such as sperm capacitation and acrosome reaction, and sperm-egg interaction in the oviduct in vivo. On the other hand, in vitro fertilization (IVF) is a process by which egg cells are fertilized by sperm outside the body: in vitro. IVF has been used for a variety of purposes in reproductive biotechnology for human and animals. The discovery of sperm capacitation in 1951 promoted the development of IVF technology. In the initial stage of IVF, sperm capacitation in preincubation medium was shown to be essential to fuse with eggs. Besides, sperms should detour some of the in vivo regulations for IVF. This review introduces a general mammalian fertilization process, including sperm capacitation, removal of cumulus matrix, acrosome reaction, and sperm-egg fusion and focuses on the roles of key biochemical molecules, signal mechanisms, and genes involved during IVF and novel results of sperm-oocyte interaction elucidated in various gene-knockout mice models.

• 동의생리병리학회지
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• 제18권6호
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• pp.1896-1903
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• 2004

Anglicae dahuricae Radix (ADR), the dried roots of Angelica Dahurica Benth et Hook (Umbelliferae), is a traditional herbal medicine used to treat colds, headache, skin diseases such as acne and possess analgesic, antipyretic and drainage effects. In the present study, the author evaluated the effect of ADR on regulation of inflammatory reaction. ADR reduced the ear-swelling responses derived from compound 48/80 in dose-dependent manner significantly. ADR inhibited the PMA plus A23187-induced productions of IL (Interleukin)-8, IL-1β, granulocyte macrophage-colony stimulating factor (GM-CSF) and tumor necrosis factor (TNF)-α from human mast cells (HMC)-1. In addition, ADR blocked PMA plus A23187-induced ERK1/2 phosphorylation. Ⅰ suggest that ADR regulates inflammatory reaction through inhibition of inflammatory cytokines such as IL-8, IL-1β and GM-CSF.

• 대한치과의사협회지
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• 제9권5호
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• pp.235-239
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• 1971

The effects of folic acid on the oral mucosa of albino rats were histochemically studied in the twenty four male rats, weighing abut 100gm. Seven groups of 3 each were injected with 0.2ml folic acid (folic acid 0.5mg. was dissolved in physiological saline 0.2ml) subcutaneously, during 1,2,3,5,7,10 and 14 days respectively. Oral mucosa of rats sere removed from upper molar region and fixed in 10% formalin, cold absolute alcohol, Carnoy's solution and acetone. The serial sections were histochemically stained by McManu's PAS reaction, Mowry's metachromasia, alloxan-Schiff reaction, and azo dye method for alkaline phosphatase. The comparative staining method was hematoxylin-eosin stain. The results were as follows: 1) Alkaline phosphatase reaction of stratum spinosum and stratum granulosum tended to increase after 7 and 10 days of folic acid administration. 2) PAS reactions of basement membrane and lamina propria increased after folic acid administration. 3) Metachromasia of stratum spinosum and stratum granulosum were slightly increased after 3,5 and 7days of folic acid administration and returned to the level of Control after 10 days. 4) In the oral mucosa, alloxan-Schiff reaction increased after 7 days of folic acid administration.

• 전자공학회논문지CI
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• 제48권1호
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• pp.65-71
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• 2011

현대 사회에서 자동차는 가장 중요한 이동수단으로써 사용되고 있다. 그로 인해 교통사고 또한 증가되고 있는 추세이다. 교통사고의 가장 큰 요소는 운전자이다. 그렇기 때문에 운전자에 대한 연구는 반응속도, 심리상태, 생체 선호, 연령, 주행패턴 등으로 다양하게 진행되고 있다. 본 논문에서는 운전자의 숙련도에 따른 장애물 인식 반응속도를 측정하기 위한 임베디드 시스템을 설계하였다. 본 논문에서 제안된 시스템은 브레이크 측정 모듈과 OBD-2 스캐너, 블루투스 전송 모듈로 구성되어있다. 또한, 측정된 데이터를 저장하고 분석하기 위해 GUI 프로그램과 데이터베이스를 구축하였다. 제안된 시스템을 통해 운전자의 반응 속도를 측정한 결과, 운전 숙련도를 판단할 수 있었다.

• 한국콘텐츠학회논문지
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• 제12권6호
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• pp.371-379
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• 2012

본 연구는 부산 경남지역의 치과내원환자를 대상으로 주관적 구강건강인식과 상태 그리고, 치과진료 분야에 치과공포수준을 파악하여 추후 치과진료 시 치과공포를 줄일 수 있는 방안을 마련하여, 구강건강의 향상과 더불어 삶의 질 향상에 기초자료로 개발하고자 한다. DFS의 전체 문항에서 100점 만점에 남자(44.9점)보다 여자(53.1점)에서 공포감이 모두 높게 나타났다. 치료종류에 따른 공포수준은 임플란트 치료 치료회피요인(p=0.015), 교정치료 치료회피요인(p=0.002), 생리적 반응요인(p=0.009), 보철치료 치료회피요인(p=0.014), 신경치료 치료회피요인(p=0.005), 생리적 반응요인(p=0.017), 치주치료 치료회피요인(p=0.013), 생리적 반응요인(p=0.004), 정기검진을 받지 않는 경우 치료회피요인(p=0.027)이 높았다. 구강증상에 대하여 인지하고 있는 개수가 많을수록 치료회피요인(p=0.001), 자극반응요인(p=0.002), 생리적반응요인(p=0.005)로 높았다. 이상의 결과에서 치과공포를 줄이기 위해서는 정기검진과 예방적 처치를 위한 다양한 프로그램개발 및 구강보건교육을 실시해야 할 것이다.

• 한국산림과학회지
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• 제110권2호
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• pp.189-197
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• 2021

본 연구는 다양한 효능·효과가 최근에 입증된 상동나무를 대상으로 다목적 수용성 복합비료를 농도(0.5 g·L^-1, 1.0 g·L^-1, 1.5 g·L^-1, 2.0 g·L^-1)처리에 따른 생장특성(간장, 근원경 및 H/D율)과 생리특성(광합성, 엽록소 함량 및 형광반응)을 정량화하여 적정 시비 수준을 알아보고자 실시하였다. 간장생장은 시비농도가 1.5 g·L^-1까지 높아짐에 따라 생장량이 증가했으나 2.0g·L^-1 시비처리에서는 낮아졌다. 근원경 생장은 시비농도가 높아짐에 따라 생장량은 유의하게 낮아졌다. 광합성 반응은 1.5 g·L^-1 시비처리에서 엽육세포 내 CO₂ 반응곡선, 최대광합성효율, 최대 카르복실화 속도가 가장 높았다. 엽록소 형광반응과 엽록소 지수는 무처리구에 비해 시비처리구에서 유의적으로 광합성 기구의 효율을 높이고 있음을 확인하였다. 따라서 우량한 묘목품질의 상동나무를 생산하기 위한 시비 수준은 1.0~1.5 g·L^-1 농도라고 판단된다.

• 산업경영시스템학회지
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• 제33권1호
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• pp.108-113
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• 2010

The purpose of this study was to investigate the differences of driving performance and physiological responses between young male and female drivers for unexpected situation using a graphic vehicle simulator. The participants included 20 college graduates; 23 males aged $24.3\;{\pm}\;1.4$ with $2.3\;{\pm}\;1.5$ years of driving experiences and 23 females aged $23.2\;{\pm}\;2.1$ with $2.2\;{\pm}\;1.7$ years of driving experience. The participants were instructed to drive the vehicle simulator which was programed unexpected situation for two minutes. The physiological measurements used were autonomic responses of electrocardiogram (ECG) and skin conductance response (SCR), and the driving performance measurements used were the reaction time of break and the rate of collision for unexpected situation. Results showed that there were no significant differences between male and female drivers in the reaction time of break and the rate of collision for unexpected situation. Averaged R-R interval decreased and LF IHF and SCL amplitude increased for unexpected situation. There were no significant differences between male and female in the averaged R-R interval and LF/HF for unexpected situation. On the other hand, SCL amplitude of female was higher than male. Rising time to maximum SCL amplitude of female was longer than male.