• Bulletin of the Korean Chemical Society
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• v.30 no.10
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• pp.2318-2328
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• 2009

Massive deadenylation of adenine based-nucleosides induced by halogenated alkanes at the physiological condition have been observed. For the study of deadenylation effects by the different substituents and/or functionality in halogenated alkanes, diverse kinds of halogenated alkanes were incubated with adenine based-nucleosides (ddA, dA and adenosine) for 48 h at the physiological condition (pH 7.4, $37\;{^{\circ}C}$), which were analyzed by HPLC and further confirmed by LC-MS. Among the sixteen different halogenated alkanes, we observed massive deadenylation of nucleosides by 2-bromo-2-methylpropane, 2,3-dibromopropene, 2-bromopropane, bromoethane and 2-iodopropane. The order of deadenylation rate was highest in 2-bromo-2-methylpropane followed by 2,3-dibromopropene, 2-bromopropane, bromoethane and 2-iodopropane. In addition, time and dose response relationship of deadenylation in adenine based-nucleosides induced by 2-bromo-2-methylpropane, 2,3-dibromopropene, 2-bromopropane, bromoethane and 2-iodopropane at the physiological condition were investigated. In addition, deadenylation of calf thymus DNA induced by halogenated alkanes was also investigated. These results suggest that the toxic effect of certain halogenated alkanes might be from the depurination of nucleosides.

• Preventive Nutrition and Food Science
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• v.13 no.3
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• pp.176-181
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• 2008

This study analyzed the some of the physiological activities of 70% ethanol extracts of specialty rough rice ('Goami2', 'Keunnunbyeo', and 'Heugkwangbyeo' rough rice cultivars) before and after germination. The physiological activities of the extracts were analyzed for their inhibition of linoleic acid peroxidation, hydrogen peroxide radical scavenging activity, superoxide dismutase-like activity, xanthine oxidase inhibitory activity, and nitrite scavenging effects. The most active rough rice cultivar was 'Heugkwangbyeo' and germinated 'Heugkwangbyeo' rough rice was more effective than ungerminated rough rice, having higher inhibition activity of linoleic acid peroxidation (1.2-fold), hydrogen peroxide radical scavenging activity (1.4-fold), superoxide dismutase-like activity (1.2-fold), and xanthine oxidase inhibitory activity (1.1-fold). The nitrite scavenging effect was increased after germination (2.1-fold) and decreased as pH increased. According to the results obtained in this study, 70% ethanol extracts from germinated 'Heugkwangbyeo' rough rice can be used for industrial applications such as the functional food materials.

• Bulletin of the Korean Chemical Society
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• v.30 no.12
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• pp.2949-2958
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• 2009

Massive deguanylation of guanine based-nucleosides induced by halogenated alkanes at the physiological condition have been observed. For the study of deguanylation effects by the different substituents and/or functionality in halogenated alkanes, diverse kinds of halogenated alkanes were incubated with guanine based-nucleosides (ddG, dG and guanosine) for 48 h at the physiological condition (pH 7.4, 37$^{\circ}C$), which were analyzed by HPLC and further confirmed by LC-MS. Among the sixteen different halogenated alkanes, we observed massive deguanylation of nucleosides by 2-bromo-2-methylpropane, 2,3-dibromopropene, 2-bromopropane, bromoethane and 2-iodopropane. The order of deguanylation rate was highest in 2-bromo-2-methylpropane followed by 2,3-dibromopropene, 2-bromopropane, bromoethane and 2-iodopropane. In addition, time and dose response relationship of deguanylation in guanine basednucleosides induced by 2-bromo-2-methylpropane, 2,3-dibromopropene, 2-bromopropane, bromoethane and 2-iodopropane at the physiological condition were investigated. Deguanylation of calf thymus DNA induced by halogenated alkanes was also investigated. These results suggest that the toxic effect of certain halogenated alkanes might be from the depurination of nucleosides.

• Child Health Nursing Research
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• v.18 no.4
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• pp.164-169
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• 2012

Purpose: The purpose of this study was to compare the effectiveness for infants of antifebrile therapy using a hypothermia blanket or rectal antipyretics following open heart surgery. Methods: This was a retrospective study and 174 infants who had open heart surgery at P University Hospital, and whose body temperature body temperature exceeded $37.2^{\circ}C$ were included in the study. The assessment tool was composed of 32 items was used for assessment of fever therapy, physiological indexes and antifebrile duration. Physiological indexes included systolic blood pressure, diastolic blood pressure, heart rate, pH, $PaCO_2$, $PaO_2$, $HCO_3{^-}$, $SaO_2$, and $K^+$ and the antifebrile duration was minutes from having a fever until BT returned to normal levels. Results: The antifebrile duration with the hypothermia blanket was shorter than with rectal antipyretics. There were significant differences in the physiological indexes with either type of antifebrile therapy, but drop in BT was greater with the hypothermia blanket than rectal antipyretics. Conclusion: The results of this study indicate that a hypothermia blanket is a non-invasive, non-drug and safe antifebrile therapy. Therefore, a hypothermia blanket can be applied to infants with a fever following open heart surgery.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 1999.11a
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• pp.211-215
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• 1999

It is well known that a long-term exposure to a loud noise environment affects performance, since it distracts attention, and also is able to evoke stress accompanied by negative emotional states. The purpose of this study was to analyze dynamics of subjective and physiological variables during long-lasting (30 min) exposure to intensive white noise (85 dB[A]). Physiological signals on 23 college students were recorded by BIOPAC, Grass Neurodata systems and AcqKnowledge 3.5 software. Autonomic variables, namely skin conductance level (SCL), non-specific SCR number (N-SCR), inter-beat intervals in ECG (RR intervals), heart rate variability index (HF/LF ratio of HRV), respiration rate (RESP), and skin temperature (SKT) were analyzed on 5 min epoch basis. Psychological assessment (subjective rating of stress level) was also repeated on every 5 min basis. Regression and correlation analyses were employed to trace the time course of the dynamics of the subjective and autonomic physiological variables and their relationship. Results showed that intense noise evokes subjective stress with associated autonomic nervous system responses. However, it was shown that physiological variables endure specific changes in the process of exposure to loud white noise. Discussed are probable psychophysiological mechanisms mediating reactivity to long-term auditory stimulation of high intensity.

• Journal of the Korean Institute of Landscape Architecture
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• v.43 no.5
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• pp.1-12
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• 2015

This study analyzes the physiological healing effects on users according to forest types. Forest types are classified into Chamaecyparis obtusa, Quercus serrata and Pinus densiflora and the subjects of this study, 64 hypertensives, 59 diabetics and 59 ordinary people, were tested to observe their physiological effects. The index of physiological reaction comprises electroencephalogram(EEG), heart rate variability(HRV), blood pressure and cortisol level. An analysis of the stress-buffering effect from the physiological reactions of the overall subjects indicates that Quercus serrata forests have a higher stress-buffering effect than others in terms of central nervous, endocrine and autonomic nervous systems. Chamaecyparis obtusa forests are contributory to soothing stress in the central nervous and endocrine systems. Pinus densiflora forests contribute in some indexes of the endocrine and autonomic nervous systems. In contrast, Pinus densiflora forests are less influential on a stress-buffering effect than the other two. In the level of the effect for lowering blood pressure, Chamaecyparis obtusa and Quercus serrata forests are more effective than Pinus densiflora forests. Therefore, staying in the first two forests can heighten the healing effect of the lowering of blood pressure for hypertensive patients. Every forest is efficacious to lowering diabetic blood glucose levels. Spending time in Quercus serrata forests is more effective for hypoglycemic.

• Proceedings of the KSCN Conference
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• 1999.05a
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• pp.87-87
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• 1999

• 대한동의생리학회:학술대회논문집
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• 2005.07a
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• pp.18-18
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• 2005

• 대한약리학회:학술대회논문집
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• 2006.10a
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• pp.75-75
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• 2006

• The Journal of the Korean dental association
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• v.10 no.7
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• pp.417-428
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• 1972