• 제목/요약/키워드: Phenanthrene lactam

검색결과 2건 처리시간 0.016초

삼백초의 세포독성 성분연구 (Studies on the Cytotoxic Constituent of Saururus chinensis$(L_{OUR.})\;B_{AILL.}$)

  • 박시경;오갑진;배춘일;김현종;환완식;정순간;조의환
    • 약학회지
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    • 제41권6호
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    • pp.704-708
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    • 1997

  • In our search for bioactive natural products with antitumor activity, we have valuated various extracts of Saururi Herba (Saururaceae), which has been used in traditional medici ne for edema, beriberi, jaundice, turbid urine, carbuncle and furuncle. The hexane extract of the aerial part of this plant was found to show a potent cytotoxicity against several kinds of cultured human solid tumor cell lines (AGS, A549, HCT15, SKOV3, HEP-3B) in vitro. Using cytotoxicity-guided chromatographic separation of the hexane extract, cytotoxic constituent: 10-aminomethyl-3-hydroxy-4-methoxyphenanthrene-carboxylic acid lactam, was isolated and structurally identified by physico-chemical properties and spectroscopic evidences.

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