• Journal of Veterinary Clinics
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• v.22 no.4
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• pp.322-327
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• 2005

DLA class I complement-dependent cytotoxicity (CDC) cross-match method was established to control hyperacute rejections in organ transplantation. The aim of the present study is to investigate if DLA class 1 CDC corssmatch method is effective to prevent hyperacute rejections in canine renal allografts. Seven mongrel dogs of similar age and weight were used. Erythrocyte crossmatch was first performed and only the negatives were used. Among the same blood types, CDC cross-match was performed. Anti-dog serum, Hank's balanced salt solution(HBSS), and tile self-serum was used as a positive-, a negative-, and all auto-control respectively. After the reaction with class I complement, it was stained with eosin and scored by international cytotoxicity scoring system under inverted phase microscope. According to these results, kidneys oi CDC negatives among same blood types were cross-transplanted to observe the incidence of hyperacute rejections. One of four 1.2 B blood type dogs had autoantibodies. here were negative CDC results among each blood type, and also there were negative results between different blood types. Two pairs with the same blood types and negative CDC results underwent allo-transplantation each other. There were no hyperacute rejections. DLA cross-match method studied in this experiment for canine renal allograft can be effective to prevent hyperacute rejections. it may be applicable for the future studies of histocompatibility testing in canine renal allografts.

• Korean Journal of Construction Engineering and Management
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• v.14 no.5
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• pp.35-43
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• 2013

Nowadays the widely used media in architecture include visualizations, animations and three-dimensional models. 3D digital methods using active CAM(Computer Aided Manufacturing) and CNC(Computerized Numerical Control) imaging have been developed for accurate shape and 3D measurements in freeform buildings. In contrast to a conventional building using auto CAD system and others, the proposed digital optimization method is based on a combination of 3D numerical data and parametric 3D model for design and construction. The objective of this paper is therefore to present digital optimization process for constructability of freeform building. The method can be useful in the effective implementation of an error-proofing process of freeform building during design and construction phase. 3D digital coordinate data can be used effectively to identify correct size of structural and finish members and installation location of each members in construction field. In addition, architects, engineers and contractors can evaluate design, materials, constructability and identify error-proofing opportunities. Other project participants can also include representatives from all levels of management, departments as well as workers and key subcontractors' personnel, if necessary. The 3D digital optimization process is therefore appropriate to serious variations in freeform shape. For future study, the developed digital optimization method is necessary to be carried out to verify the robustness and accuracy for constructability in construction field.

• Korean Journal of Applied Biomechanics
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• v.12 no.2
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• pp.159-177
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• 2002

The purpose of this study was to investigate the relations between the segments of the body, the three dimensional anatomical angle and the angular velocity of the air born phase and understand the control mechanism of the high-bar movement, the somersault, the double somersault, the double somersault with full twist. For this study seven well trained university gymnastic volunteered, Zatsiorky and Seluyanov(1983, 1985)'s sixteen segment system anatomical model was used for this study. For the movement analysis three dimensional cinematographical method(Arial Performance Analysis System : APAS) was used and for the calculation of the kinematic variables a self developed program was used with the LabVIEW 5.1 graphical profromming(Johnson, 1999) program. By using Eular's equations the three dimensional anatomical Cardan angles of the joint and angular velocity were defined. As a result of this study 1. As the rotation of the body increased in the air born phase the projection angle of the CM of the total increased, this resulted the increased of the max hight of the CM. 2. In three dimensional angular velocity the Z axis(vertical direction) projection angular velocity increased as the rotation of the body increased in the airborn phase, but the Y axis and the X axis projection angular velocity did not show significant differences. 3. As the rotation of the body increased in the air born phase the angular movement of the shoulder and the hip showed significant change. These movement act as the starter in the preparation phase. 4. The somersault angle, the twist angle, the tilt angle of the upper body related to the global reference frame in the releas phase the average somersault angle of the three types of high-bar movement was $57.7^{\circ}$, $38.8^{\circ}$, $39.7^{\circ}$, the average tilt angle was $-1.5^{\circ}$, $-5.4^{\circ}$, $-8.4^{\circ}$, the average twist angle was $13.4^{\circ}$, $10.6^{\circ}$, $23.3^{\circ}$. This result showed that the somersault with full twist had the largest movement.

• Journal of Radiation Protection and Research
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• v.33 no.1
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• pp.13-20
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• 2008

The flow rate measurements in a multi-phase flow pipeline were evaluated quantitatively by means of a clamp-on sealed radioisotope based on a cross correlation signal processing technique. The flow rates were calculated by a determination of the transit time between two sealed gamma sources by using a cross correlation function following FFT filtering, then corrected with vapor fraction in the pipeline which was measured by the ${\gamma}$-ray attenuation method. The pipeline model was manufactured by acrylic resin(ID. 8 cm, L=3.5 m, t=10 mm), and the multi-phase flow patterns were realized by an injection of compressed $N_2$ gas. Two sealed gamma sources of $^{137}Cs$ (E=0.662 MeV, ${\Gamma}$ $factor=0.326\;R{\cdot}h^{-1}{\cdot}m^2{\cdot}Ci^{-1}$) of 20 mCi and 17 mCi, and radiation detectors of $2"{\times}2"$ NaI(Tl) scintillation counter (Eberline, SP-3) were used for this study. Under the given conditions(the distance between two sources: 4D(D; inner diameter), N/S ratio: $0.12{\sim}0.15$, sampling time ${\Delta}t$: 4msec), the measured flow rates showed the maximum. relative error of 1.7 % when compared to the real ones through the vapor content corrections($6.1\;%{\sim}9.2\;%$). From a subsequent experiment, it was proven that the closer the distance between the two sealed sources is, the more precise the measured flow rates are. Provided additional studies related to the selection of radioisotopes their activity, and an optimization of the experimental geometry are carried out, it is anticipated that a radioisotope application for flow rate measurements can be used as an important tool for monitoring multi-phase facilities belonging to petrochemical and refinery industries and contributes economically in the light of maintenance and control of them.

• Structural Engineering and Mechanics
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• v.58 no.3
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• pp.515-532
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• 2016

The elastoplastic response of functionally graded material (FGM) beams resting on a nonlinear elastic foundation to an eccentric axial load is investigated by using the finite element method. The FGM is assumed to be formed from ceramic and metal phases with their volume fraction vary in the thickness direction by a power-law function. A bilinear elastoplastic behavior is assumed for the metallic phase, and the effective elastoplastic properties of the FGM are evaluated by Tamura-Tomota-Ozawa (TTO) model. Based on the classical beam theory, a nonlinear finite beam element taking the shift in the neutral axis position into account is formulated and employed in the investigation. An incremental-iterative procedure in combination with the arc-length control method is employed in computing the equilibrium paths of the beams. The validation of the formulated element is confirmed by comparing the equilibrium paths obtained by using the present element and the one available in the literature. The numerical results show that the elastoplastic post-buckling of the FGM beams is unstable, and the post-buckling strength is higher for the beams associated with a higher ceramic content. Different from homogeneous beams, yielding in the FGM beam occurs in the layer near the ceramic layer before in the layer near metal surface. A parametric study is carried out to highlight the effect of the material distribution, foundation support and eccentric ratio on the elastoplastic response of the beams.

• Korean Journal of Materials Research
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• v.22 no.12
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• pp.711-716
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• 2012

Tungsten bronze structure $Sr_{1-x}Ba_xNb_2O_6$ (SBN) single crystals were grown primarily using the Czochralski method, in which several difficulties were encountered: striation formation and diameter control. Striation formation occurred mainly because of crystal rotation in an asymmetric thermal field and unsteady melt convection driven by thermal buoyancy forces. To optimize the growth conditions, bulk SBN crystals were grown in a furnace with resistance heating elements. The zone of $O_2$ atmosphere for crystal growth is 9.0 cm and the difference of temperature between the melt and the top is $70^{\circ}C$. According to the growth conditions of the rotation rate, grown SBN became either polycrystalline or composed of single crystals. In the case of as-grown $Sr_{1-x}Ba_xNb_2O_6$ (x = 0.4; 60SBN) single crystals, the color of the crystals was transparent yellowish and the growth axis was the c-axis. The facets of the crystals were of various shapes. The length and diameter of the single crystals was 50~70 mm and 5~10 mm, respectively. Tungsten bronze SBN growth is affected by the temperature profile and the atmosphere of the growing zone. The thermal expansion coefficients on heating and on cooling of the grown SBN single crystals were not matched. These coefficients were thought to influence the phase transition phenomena of SBN.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.11
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• pp.5903-5908
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• 2012

Objective: The purpose of this study is to investigate the combined effects of exemestane and aspirin on MCF-7 human breast cancer cells. Methods: Antiproliferative effects of exemestane and aspirin, alone and in combination, on growth of MCF-7 human breast cancer cells were assessed using the MTT assay. Synergistic interaction between the two drugs was evaluated in vitro using the combination index (CI) method. The cell cycle distribution was analyzed by flow cytometry and Western blotting was used to investigate the expression of cyclooxygenase-1, cyclooxygenase-2 and Bcl-2. Results: MTT assays indicated that combination treatment obviously decreased the viability of MCF-7 human breast cancer cells compared to individual drug treatment (CI<1). In addition, the combination of exemestane and aspirin exhibited a synergistic inhibition of cell proliferation, significantly arrested the cell cycle in the $G_0/G_1$ phase and produced a stronger inhibitory effect on COX-1 and Bcl-2 expression than control or individual drug treatment. Conclusion: These results indicate that the combination of exemestane and aspirin might become a useful method to the treatment of hormone-dependent breast cancer. The combination of the two inhibitors significantly increased the response as compared to single agent treatment, suggesting that combination treatment could become a highly effective approach for breast cancer.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.2
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• pp.578-584
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• 2013

Ice slurry that is a mixture of fine ice crystals and liquid water is a widely used working fluid in the ice thermal energy storage system due to its flowability and large latent heat of fusion. Generally ice slurry is made from supercooled water. But the excessive supercooling causes the water to freeze even worse to block the pipe. Additionally large degree of supercooling of water degrades the efficiency of the ice thermal energy storage system. Therefore the effective method to control the phase change from supercooled water to ice slurry is needed. In this paper we experimentally studied a novel method to generate the ice slurry from the supercooled water using the ultrasonic vibration. It was found that the cavitation impact of supercooled water by ultrasonic vibration can help the generation of ice slurry.

• Journal of the Korean Society of Safety
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• v.21 no.3 s.75
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• pp.53-58
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• 2006

Following a Mediterranean fruit fly outbreak in South Australia, a bait spray program involving the pesticides like malathion(MAL) was carried out. During the application, dermal exposure was considered for the pest controllers wearing PVC gloves. However there is a lack of information about PVC glove performance like break through times and permeation rates with MAL, therefore, a new analytical method for HPLC-UV was developed. A standard permeation test cell was used in this study. From the results of this study, more than 96% solubility of MAL was provided at 30% isopropyl alcohol in distilled water as a collecting media. However, there was significant decomposition of MAL when the solutions were kept at over $50^{\circ}C$ for 2-3 hours. As a mobile phase, 50% acetonitrile water solution (pH 6.0) gave the greater sensitivity compared with other compositions of acetonitrile solution. The arm section of the gloves had shorter breakthrough times and higher permeation rates compared with the palm. There was no malathion solution breakthrough up to 24 hours using the 1% MAL working strength solution. When the temperature was changed from $22{\pm}1^{\circ}C\;to\;37{\pm}1^{\circ}C$, the breakthrough times were decreased by 14.5% on palm and 37.5% on arm, and permeation rates were increased significantly. The findings of this study indicate that further investigations on used gloves, periods of use and varying working conditions like tasks and seasons should be carried out to assess potential worst case scenarios.

• Journal of Powder Materials
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• v.21 no.5
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• pp.371-376
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• 2014

In this study, modified catalytic chemical vapor deposition (CCVD) method was applied to control the CNTs (carbon nanotubes) growth. Since titanium (Ti) substrate and iron (Fe) catalysts react one another and form a new phase ($Fe_2TiO_5$) above $700^{\circ}C$, the decrease of CNT yield above $800^{\circ}C$ where methane gas decomposes is inevitable under common CCVD method. Therefore, we synthesized CNTs on the Ti substrate by dividing the tube furnace into two sections (left and right) and heating them to different temperatures each. The reactant gas flew through from the end of the right tube furnace while the Ti substrate was placed in the center of the left tube furnace. When the CNT growth temperature was set $700/950^{\circ}C$ (left/right), CNTs with high yield were observed. Also, by examining the micro-structure of CNTs of $700/950^{\circ}C$, it was confirmed that CNTs show the bamboo-like structure.