• Journal of Pharmaceutical Investigation
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• v.29 no.4
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• pp.315-321
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• 1999

Poly (lactide-co-glycolide) (PLGA) microspheres containing ovalbumin (OVA) as a model protein drug were prepared by double emulsification method, and various conditions such as mixing rate, volume of outer phase and isopropyl alcohol concentration in outer phase during secondary emulsification were observed to control the size of microspheres. In addition, entrapment efficiency of OVA and protein denaturation were also evaluated. As the rate of stirring was increased, the size of particles was decreased. But excessive stirring increased the particle size of microspheres. In a preparation condition of small volume of outer phase, the particle size was decreased but the entrapment efficiency was increased. Adding isopropyl alcohol to outer phase decreased the size of particles, but increased the entrapment efficiency. Microparticles should have smaller size than $10\;{\mu}m$ to be uptaked by Peyer's patch in small intestine. High speed of mixing and relatively small volume of outer phase are needed to reduce the size. In addition, appropriate amount of isopropyl alcohol in outer phase also plays an important role in size reduction of PLGA microspheres.

• Proceedings of the KSME Conference
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• 2008.11b
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• pp.2688-2691
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• 2008

This study addresses a microfluidic method to uniformly form diacetylene (DA) liposomes and control their size. DA liposomes are biochemical sensor materials with a unique property such that when they are polymerized to polydiacetylene (PDA) they exhibit non-fluorescent blue to fluorescent red phase transition upon chemical or thermal stress. The liposome size and distribution are important because they significantly affect the phase transition. So far, DA Liposomes, have been prepared by mixing of bulk phases leading to heterogeneous, polydisperse distribution in size. Therefore, additional post-processes are required such as sonication or membrane extrusion to obtain an appropriate size of liposomes. Here, we report a novel strategy using a microfluidic chip and hydrodynamic focusing to form DA liposomes and control their size. Preliminary results obtained by scanning electron microscope (SEM) and dynamic light scattering (DLS) show that the microfluidic strategy generates more monodispersed liposomes than a bulk method.

• The Transactions of the Korean Institute of Power Electronics
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• v.23 no.2
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• pp.94-100
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• 2018

Generally, in a single-phase energy storage system (ESS) for households, AC ripple component with twice the fundamental frequency exists inevitably in the DC link voltage of single-phase PCS. In the grid-connected mode of a single-phase inverter, the AC ripple component in the DC link voltage causes low-order harmonics on grid-side current that deteriorates power quality on an AC grid. In this work, a control system adopting a feedforward controller is established to eliminate the AC ripple interference on the DC link side. Optimal battery nominal voltage design method is also proposed by considering the voltage loss and AC ripple voltage on DC link side in a single-phase ESS. Finally, the control system and battery nominal voltage design method are verified through simulations and experiments.

• Journal of Physiology & Pathology in Korean Medicine
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• v.19 no.4
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• pp.993-999
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• 2005

This research was peformed to investigate protective effect of Sophora Subprostrata fractions against focal ischemic brain damage after middle cerebral artery(MCA) occlusion using intraluminal suture. Rats were divided into six groups: MCA-occluded group(Control): each administered groups with Sophora Subprostrata total phase(Total), Sophora Subprostrata Aqueous phase (Aqueous), Sophora Subprostrata BuOH phase(BuOH), and Sophora Subprostrata Alkaloid phase(Alkaloid) after MCA-occlusion; sham-operated group(Sham). The right MCA was occluded by A poly-L-lysine coated 4-0 nylon suture thread through the internal carotid artery permanently. Sophora Subprostrata and fractions were administered orally(Smg/ml) for 7 days after MCA-occlusion. The Drain tissue was stained with $2\%$ triphenyl tetrazolium chloride on ischemic brain tissue(2mm section). The results showed that 1) Sophora Subprostrata total phase reduced infarct size and total infarct volume compared to the control group at 24 hours after MCA-occlusion, 2) Sophora Subprostrata Aqueous phase reduced infarct size and total infarct volume compared to the control group at 24 hours after MCA-occlusion, 3) Sophora Subprostrata Alkaloid phase reduced infarct size compared to the control group at 24 hours after MCA-occlusion, but 4) at 7 days after MCA-occlusion, Sophora Subprostrata did not show effective recovery compared with control group. Sophora Subprostrata has protective effects against brain damage at the early stage of focal cerebral ischemia. Sophora Subprostrata total and Aqueous phase produced more pronounced protective effect against focal ischemic brain damage.

• Proceedings of the KIEE Conference
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• 1996.07b
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• pp.949-952
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• 1996

The ultrasonic motor(USM) has good characteristics such as compact size, silent motion, low speed, high torque and high speed response. The USM is driven by 2-phase AC electricity. The control parameters of USM are voltage, phase difference, frequency of input power, etc. In this paper, we propose voltage difference control. And we designed USM controller to adjust voltage and phase using pLSI(programmable Large Scale Integration). Voltage difference control has many advantages that are lower current, lower power than phase difference control. Especially there is nearly zero ampere at the zero point of speed and torque. we can apply this voltage difference control to the compliance control of DD manipulator.

• Journal of Drive and Control
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• v.17 no.4
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• pp.1-7
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• 2020

In orchard or crop-growing environments, pesticides are sprayed using various nozzles to prevent pests and improve productivity. Nozzles currently in use are restricted for use in multi-purpose environments, thus, it is necessary to develop new nozzles. In this study, new two-phase nozzles are proposed to improve the performance of the nozzle (flow rate, spray angle, spray particle size). The performance of the two-phase nozzles are predicted through the CFD analysis and the performance of the nozzles is compared with the experiment. The experimental results showed that the proposed two-phase nozzles are available at relatively low operating pressure condition and are capable of extensive spray particle size control. Thus, the proposed nozzles are expected to be available in various orchard environments.

• Journal of the Korean Ceramic Society
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• v.42 no.8 s.279
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• pp.542-547
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• 2005

Keys to the attainment of tailored properties in SiC ceramics are microstructure control and judicious selection of the sintering additives. In this study, three different strategies for controlling microstructure of liquid-phase-sintered SiC ceramics (LPS-SiC) have been suggested: control of the initial $\alpha-SiC$ content in the starting powder, a seeding technique, and a post-sintering heat treatment. The strategies suggested offer substantial flexibility for producing toughened SiC ceramics whereby grain size, grain size distribution, and aspect ratio can be effectively controlled. The present results suggest that the proposed strategies are suitable for the manufacture of toughened SiC ceramics with improved toughness.

• Proceedings of the KIEE Conference
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• 1994.07a
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• pp.328-330
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• 1994

The Ultrasonic motor(USM) has many good characteristics such as high torque at low speed range, large holding torque based upon frictional force, high speed response, flexible free ferns, compactness in size, low magnetic noise and silentness in motion. Because of having low speed rotation, USM is good as an actuator of a small size direct drive (DD) manipulator. The acturators for the DD manipulators must have good controllability on the speed and torque from zero to maximum value continuously. New method was developed for speed and torque control by the phase difference control of the two-phase driving signals of the motor. Then rule adjustable compliant and dumped motion was realized on the output shaft of the motor by PD control of the output shaft angle.

• Proceedings of the Membrane Society of Korea Conference
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• 1996.04a
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• pp.55-56
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• 1996

Heterophase polymer system has been attractive for a potential applicability to gas separation membrane material. It has been known that there is a trade-off between gas permeability and its selectivity in common polymers. Therefore, the heterophase polymer can be an alternative for a gas separation membrane material because its transport properties can be readily controlled by blending of two different polymers. The transport properties of immiscible polymer blends strongly depend upon the intrinsic transport properties of corresponding polymers. Another important factor to determine the transport properties is their morphology: volume fraction, size and shape of dispersed phase. Although the effect of the volume fraction of the dispersed phase on the transport properties has been widely investigated, the size and shape effects have been paid attention very much. In an immiscible polymer blend of two polymers, its morphology is primarily controlled by its volume fraction of dispersed phase. Therefore, the effect of the size of the dispersed phase can be hardly seen. Therefore, a block copolymer has been commonly employed to control their morphology when each block is miscible with one or the other phase. In this work, gas transport properties will be measured by varying the morphology of the heterophase polymer membrane. The transport properties will be interpreted in terms of their morphology. The effect of the volume fraction of the PI phase and, in particular, its size effect will be investigated experimentally and theoretically.

• Proceedings of the KSME Conference
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• 2000.11b
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• pp.180-185
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• 2000

Nano crystalline or non-crystalline particles have been widely used in various industrial area, such as ceramics, catalysis, electronics, metallurgy and optic device. In all applications, synthesizing the particles as small as possible and controlling the crystalline phase according to its purpose are necessary for the enhancement of processing performance. In some cases, non-agglomerated particles may be necessary for solving the packing problems. This motivates our attempt of controlling size, morphology, phase of nano titania and silica particles. If one can enhance sintering rate of small aggregates independently of collision rate, one may expect that original aggregates can be changed into volume equivalent spheres and thereby the decrease of collision frequency due to the change leads to much smaller rate of growth of the particles. This is the basic idea of our control strategy.