• Title/Summary/Keyword: Phase I study

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Epidemiologic Changes in Over 10 Years of Community-Acquired Bacterial Enteritis in Children

  • Yang, Jae Jin;Lee, Kunsong
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.25 no.1
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    • pp.41-51
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    • 2022
  • Purpose: Community-acquired bacterial enteritis (CABE) is a common problem in developed countries. It is important to understand the epidemiologic changes in bacterial pathogens for prevention and treatment. Therefore, we studied the epidemiologic changes in CABE in Korean children. Methods: A total of 197 hospitalized pediatric patients aged <19 years that presented with dysentery symptoms and showed positive polymerase chain reaction results for bacterial species in stool samples, were enrolled in this study for 10 years (June 2010 to June 2020). We classified patients in phase I (06, 2010-06, 2015) and phase II (07, 2015-06, 2020) and analyzed their epidemiologic and clinical characteristics. Results: The most common pathogens were Campylobacter species (42.6%) and Salmonella species were the second most common pathogens (23.9%). The abundance of pathogens decreased in the following order: Clostridium difficile (9.6%), Shigella (5.6%), and Clostridium perfringens (5.6%). Escherichia coli O157:H7 was found to be the rarest pathogen (2.0%). Campylobacter species showed an increase in the infection rate from 32.1% in phase I to 49.6% in phase II (p=0.0011). Shigella species showed a decline in the infection rate in phase I from 14.1% to 0.0% in phase II (p<0.001). C. difficile and C. perfringens showed an increase in infection rate in phase II compared to phase I, but the difference was not statistically significant. Conclusion: The infection rate of Campylobacter species in CABE has been rising more recently, reaching almost 50%. This study may help establish policies for prevention and treatment of CABE in Korean children.

Experimental Study on Accelerating Phase Change Heat Transfer (상변화 물질의 상변이 촉진에 관한 실험적 연구)

  • 박설현;오율권;차경옥
    • Journal of Advanced Marine Engineering and Technology
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    • v.26 no.1
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    • pp.23-29
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    • 2002
  • Solid-liquid phase change (i.e. melting or solidification) occurs in a number of situations of practical interest. Some common examples include the melting of edible oil, metallurgical process such as casting and welding, and materials science applications such as crystal growth. Therefore, due to the practical importance of the subject, there have been a large number of experimental and numerical studies of problems involving phase change during the past few decades. Also, this study presented the effective way to enhance phase change heat transfer.

Effects of Dietary Lysine and Energy Levels on Growth Performance and Apparent Total Tract Digestibility of Nutrients in Weanling Pigs

  • Kim, Y.W.;Ingale, S.L.;Kim, J.S.;Kim, K.H.;Chae, B.J.
    • Asian-Australasian Journal of Animal Sciences
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    • v.24 no.9
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    • pp.1256-1267
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    • 2011
  • Two experiments were conducted to determine the effects of dietary lysine and energy level on performance and apparent total tract digestibility (ATTD) of nutrients in weanling pigs. In Exp. 1, a total of 288 weaned pigs (initial BW $5.77{\pm}0.85\;kg$) were randomly allotted to 4 treatments (4 replicates per treatment with 18 pigs in each replicate). Experimental diets were fed in the 3 phases: phase I (d 0 to 7), phase II (d 8 to 14) and phase III (d 15 to 28). Isocalorific diets (3,450 kcal/kg) with incremental lysine levels (Phase I: 1.51, 1.61, 1.71 and 1.81; Phase II: 1.35, 1.46, 1.56 and 1.66; Phase III: 1.18, 1.28, 1.39 and 1.49% lysine respectively for T1, T2, T3 and T4) were used as treatments. An increase in the dietary lysine levels linearly improved (p<0.05) the ADG and G:F during phases I, II and III as well as overall study period. The ATTD of DM (d 7 and 28) and CP (d 7, 14 and 28) were linearly improved (p<0.05) with increasing dietary lysine levels. ATTD of ash, Ca and P were not affected by dietary lysine level. In Exp. 2, 64 weanling pigs (initial BW $4.79{\pm}0.79\;kg$) were randomly allotted to 4 treatments (4 replicates per treatment with 4 pigs in each replicate) in a $2{\times}2$ factorial arrangement on the basis of BW. Effects of two levels of energy (high, 3,450 or low, 3,350 kcal/kg) and lysine (high or low; 1.70 or 1.50, 1.55 or 1.35 and 1.40 or 1.20% in phase I, II and III diets, respectively) on performance and ATTD of nutrients were investigated. High energy and lysine diets improved ADG (p<0.05) in pigs during phase I, II and III and overall period (p<0.001), while G:F increased (p<0.05) during phase I and overall period. Pigs fed high lysine diets consumed more (p<0.05) feed during phase III and overall period. Additionally, pigs fed high energy diets had greater (p<0.05) ATTD of GE (d 7 and 14), CP (d 7 and 28) and DM (d 28); whereas, pigs fed high lysine diets had greater (p<0.05) ATTD of GE and CP during d 7, 14 and 28. ATTD of ash, Ca and P remained unaffected (p>0.05) by dietary energy and lysine level. However, there was no energy${\times}$lysine interaction for any of the measured variables. Results obtained in present study suggested that high energy and lysine level improve the growth performance and ATTD of nutrients in weanling pigs.

Study on the Phases and Testing Standard of Standing to Squatting Position (쭈그려 앉기의 단계화와 표준화된 검사에 대한 연구)

  • Chung, Hyung-Kuk
    • The Journal of Korean Physical Therapy
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    • v.19 no.6
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    • pp.11-15
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    • 2007
  • Purpose: This study examined the various patterns of standing to squatting activities, and reports the testing standard and phases for examining the standing to squatting position. Methods: One thousand, normal college students (500 males, 500 females) volunteered for this study. The patterns are performed by naked eye analysis with two video cameras. Results: The patterns from the standing to squatting position are as follows 1. parallel with the heel on the pattern: 2. parallel with the heel off the pattern: 3. closed with the heel on the pattern: 4. closed with the heel on the pattern: 5. open with the heel on the patternand 6. open with the heel on the pattern. Conclusion: The phases of the standing to squatting position are as follows: phase I from standing to the anterior parts of the knees reaching the anterior limit of the BOS, phase II from phase I until the height of the hip and knee joints are the same, phase III from phase II until there was no full squatting and the heels broke contact with the floor and phase IV from phase III full squatting on the heels in contact with the floor.

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The Development of an ADDIE Based Instructional Model for ELT in Early Childhood Education

  • MARIAM, Nuzhat;NAM, Chang-woo
    • Educational Technology International
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    • v.20 no.1
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    • pp.25-55
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    • 2019
  • The core purpose of the study is to develop and validate an ADDIE model based instructional model for English Language Teaching (ELT) in early childhood classroom in Bangladesh as an aid to teachers to reconstruct their knowledge and experience more strategically, and for them to design and implement their instruction more structurally. This study is developmental in nature which has been divided in five phases as follows. Phase I: Existing methods and instructional strategy review, Phase II: Instructional model development, Phase III: Delphi 1st round, Phase IV: Delphi 2nd round and Phase V: Model validation. After reviewing relevant literature and existing strategy in phase I, the 1st version of instructional model is made phase II. Next in phase III and phase IV, two rounds of Delphi have been conducted where experts related to different concerning areas of this study reviewed the 1st version and gradually the final version of the instructional model is made. Finally, the instructional model for English teachers of early childhood classroom in Bangladesh got validated by the same Delphi panelists in Phase V. In respect with each phases of ADDIE, the instructional model elaborates the 1) representative key points, 2) instructors' activities prescribed for the instructors, 3) supporting strategies. Both the conceptual and procedural models are included in this study for clearer identification of the whole process. Lastly the study provides some recommendations for instructors and practitioners on choosing the instructional model like doing prior need analysis, incorporating teacher training programs, training students, keeping on researching for finding effective teaching technique and tools and being open to changes etc. In addition, the study also acknowledges its limitations like not being able to consider the psychological factors due to time limitation. Finally, at the end the study points out the areas that welcome further research.

Nurses단 Role Models, Perceptions Toward Occupation, Self-Actualization Value and the Phases of Socialization Process (임상간호원의 사회화과정단계에 있어서의 역할모델, 직업에 대한 지각향성 및 자아실현성간의 관계)

  • 한윤복;강윤숙
    • Journal of Korean Academy of Nursing
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    • v.17 no.1
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    • pp.24-32
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    • 1987
  • This study was designed to investigate the changes of nurses' role model, perceptions toward occupation, and self actualization value in terms of the phases of socialization process. Two hundred and sixty nine nurses working in clinical settings were randomly selected from 15 general hospitals despersed over Seoul and Kyungki province. Data were gathered by the standardized Perceptual Orientation Test, the Self-actualization Test, and Questionnaires on role models and phases of socialization process developed by the investigators from October 1985 to March 1986. The data were analysed by ANOVA and Pearson's Correlation Coefficient. The results were as follows: 1. The average time period required for the shift of phases of socialization process were; phase Ⅰ, role adjustment, took average 10 months of employment: Phase Ⅱ, interpersonal adjustment, 12 months: and Phase Ⅲ, role conflict, 15 months respectively. Conflict resolution, phase Ⅳ, began to take place 18 months of employment; and shifted to phase V, internalization and self-actualization at 25 months of employment. 2. Throughout 5 consecutive phase, the number of immediate superior nurse model was dominantly the highest among the role models. The number of head nurse role model increased at phase Ⅱ, phase Ⅲ, and phase Ⅳ. Respondents with school model in phase I tended to transfer to work model at phase Ⅱ. 3. The perceptions toward occupation were not significantly influenced by the Phases of socialization process. 4. The score of self-actualization value was not significantly influenced by the phases of socialization process. 5. In regard to perceptions toward occupation, nursing director model group showed significantly lower score in phase I (p<.01). 6. The comparison of self-actualization value between the 5 phases revealed significant difference in phase I: in particular among respondents with school model at p<.05. To conclude: 1. The phase Ⅲ of socialization process is the period of role conflict which occur at 15 months of employment, an6 conflict resolution, phase Ⅳ, begins at 18 months of employment on the average in clinical settings. 2. The immediate superior nurse and the head nurse are important role models for nurses all through their socialization process.

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Changes of Surface Electromyography on Frontalis Muscle during Electro-Acupuncture Stimulation of Abdomen or Legs - A Pilot Study for Clinical Approach to Autonomic Nervous System Changes - (복부 및 사지 부위의 전기침 자극이 전두근에서 측정한 SEMG 변화에 미치는 영향 - 자율신경계의 변화에 대한 임상적 접근을 위한 사전 연구 -)

  • Je, Jun-Tae;Choi, San-Ho;Shin, Sun-Ho;Lim, Jin-Young;Lee, Sang-Kwan
    • The Journal of Internal Korean Medicine
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    • v.33 no.1
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    • pp.14-25
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    • 2012
  • Objectives : To observe physiological changes during clinical acupuncture treatment. Methods : We recruited 40 healthy volunteers who had experienced an acupuncture treatment at least once within the past three years. The experimental group was divided into four groups according to the needling site and frequency of electrical stimulation. Sites consisted of abdomen and legs. Frequencies consisted of 100 Hz and 2 Hz. The procedures of experimental treatment consisted of seven phases, Resting I phase (Resting I), Needle insertion phase (Insertion), Maintenance of needle insertion I phase (Maintain I), Electrical stimulation phase (ES), Maintenance of needle insertion II phase (Maintain II), Needle removal phase (Removal) and Resting II phase (Resting II). We measured the surface electromygraphy (SEMG) through an electrode on the frontalis muscle during all phases consecutively. Results : When SEMGs of all seven phases were analyzed, they significantly increased or decreased according to phases. SEMGs of Insertion, Maintain I, ES and Maintain II phase significantly increased more than RestingI in abdomen and legs groups. SEMGs of the abdomen group were measured as being $4.78{\pm}0.74{\mu}V$ on Resting I, $16.48{\pm}3.97{\mu}V$ on Insertion, $46.31{\pm}10.56{\mu}V$ on Maintain I, $45.88{\pm}9.72{\mu}V$ on ES, $45.56{\pm}9.69{\mu}V$ on Maintain II, $18.76{\pm}3.05{\mu}V$ on Removal, and $3.75{\pm}0.65{\mu}V$ on Resting II. SEMGs of the legs group were measured as being $3.34{\pm}0.35{\mu}V$ on Resting I, $12.11{\pm}1.76{\mu}V$ on Insertion, $36.74{\pm}6.99{\mu}V$ on Maintain I, $33.57{\pm}6.30{\mu}V$ on ES, $32.66{\pm}6.03{\mu}V$ on Maintain II, $14.08{\pm}2.15{\mu}V$ on Removal, and $2.88{\pm}0.32{\mu}V$ on Resting II. Conclusions : SEMG changed differently according to processes of acupuncture. Electrical stimulation showed different change of SEMG. Thus, acupuncture treatment may change the status of the autonomic nervous system.

Solvent-localized in-situ NMR Monitoring by Intermolecular Single-quantum Coherence Study

  • Cha, Jin Wook;Park, Sunghyouk
    • Journal of the Korean Magnetic Resonance Society
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    • v.24 no.4
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    • pp.96-103
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    • 2020
  • A new NMR method to monitor solvent-localized NMR signals in the two-phase liquid system is suggested. This method based on intermolecular single-quantum coherence (iSQC). Here, we exploited the feature of the local action of distant dipolar field (DDF) effect in order to filter out specific NMR signals dissolved in different solvents. This solvent specific iSQC spectroscopy was carried out on a model two-phase liquid system (D-glucose in water/palmitic acid in chloroform), and showed solvent-localized NMR signals. We believe our approaches might be useful in metabolic analysis such as two-phase liquid extraction scheme for labile chemical species.

Improvement of catheter-related outcomes after application of tunneled cuffed hemodialysis catheter insertion without fluoroscopy

  • Kang, Seok Hui;Do, Jun Young
    • Journal of Yeungnam Medical Science
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    • v.37 no.3
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    • pp.186-193
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    • 2020
  • Background: Non-tunneled catheters (NTCs) are used for hemodialysis (HD) in many centers in which fluoroscopy is not easily accessed despite high complication rates and conditions requiring long-term HD. Therefore, here we aimed to evaluate the superiority of catheter-related outcomes after the application of tunneled cuffed catheter (TCC) without fluoroscopy versus unconditioned NTC insertion. Methods: We divided the participants into two phases: those receiving NTCs between March 2010 and February 2011 (phase I), and those receiving TCCs or NTCs between March 2011 and February 2012 (phase II). Catheter survival, nurse satisfaction, and reasons for catheter removal were analyzed. Results: Two hundred and sixty patients in phase I and 300 patients in phase II were enrolled in this study. The success rate of TCC insertion was 99.2%. The catheter survival rate in phase I was 65.5% at 1 month, while that in phase II was 74.9% at 1 month (p=0.023). We compared catheter survival between TCCs and NTCs for all periods regardless of phase. The TCC survival rate was higher than the NTC survival rate (p<0.001). Catheter-associated problems led to catheter removal in 97 patients (26.6%) in phase I and 68 patients (18.5%) in phase II (p=0.009). Among 14 HD nurses, all reported being satisfied with manipulation during pre-/post-HD, manupulation during HD, and overall. Eleven HD nurses (78.6%) reported being satisfied with the workload. Conclusion: Compared with unconditional NTC insertion for HD, TCC insertion without fluoroscopy improved the overall catheter survival and nurse satisfaction rates.

High Pressure Phase Transition Study of ${\alpha}$-cristobalite $GaPO_4$ (${\alpha}$-크리스토발라이트 구조의 $GaPO_4$에 대한 고압 상변이 연구)

  • Hwang, Gil-Chan;Kim, Young-Ho
    • Journal of the Mineralogical Society of Korea
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    • v.23 no.3
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    • pp.267-272
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    • 2010
  • High pressure x-ray diffraction patterns of ${\alpha}$-cristobalite gallium phosphate ($GaPO_4$) were acquired up to 8.9 GPa at room temperature using Mao-Bell type diamond anvil cell with high flux synchrotron radiation. Starting orthorhombic phase (phase-I) shows the splitting of peak which is possibly resulted from the pressure induced orientation disorder of the framework structure of tetrahedra. This is designated as phase-I'. This phase transforms to the orthorhombic high pressure phase-III between 2 and 3 GPa. Present phase transition sequence is not in accord with the recent high pressure X-ray diffraction results performed on the same starting sample (Ming et al., 2007). X-ray pattern of the unloaded sample to ambient pressure shows that the structure retains that of the high pressure phase prior to decompression.