• Title/Summary/Keyword: Pharmacy

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OXIDATIVE DAMAGE, DNA REPAIR AND SIGNAL TRANSDUCTION IN CHEMICAL TERATOGENESIS.

  • Peter G Wells;Yadvinder Bhuller;Connie S Chen;Jeffrey T Henderson;Winnie Jeng;Sonja Kasapinovic;Julia C Kennedy;Rebecca R Laposa;Christopher J Nicol;Toufan Parman;Michael J Wiley;Louise M Winn;Andrea W Wong
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2002.05a
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    • pp.44-64
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    • 2002
  • Embryonic prostaglandin H synthases (PHSs) and lipoxygenases bioactivate xenobiotics (phenytoin, thalidomide, benzo[a]pyrene) to free radical intermediates that initiate reactive oxygen species (ROS) formation, which oxidatively damage cellular macromolecules and/or alter signal transduction.(omitted)

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A New Stilbene Glucoside from the Roots of Polygonum multiflorum Thunb.

  • Xu, Ming-Lu;Zheng, Ming Shan;Lee, Yeon-Kyong;Moon, Dong-Cheol;Lee, Chong-Soon;Woo, Mi-Hee;Jeong, Byeong-Seon;Lee, Eung-Seok;Jahng, Yurng-Dong;Chang, Hyeun-Wook;Lee, Seung-Ho;Son, Jong-Keun
    • Archives of Pharmacal Research
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    • v.29 no.11
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    • pp.946-951
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    • 2006
  • One new stilbene glucoside (6), along with five known compounds (1-5), were isolated from the roots of Polygonum multiflorum Thumb., and their chemical structures established based on physicochemical and spectroscopic data. Of the compounds, compound 3 showed DNA topoisomerase I and II inhibitory activities.

Biochemical analysis of a high-molecular-weight protease from Streptomyces tendae JC412

  • Seong, Chi-Nam;Nam, Doo-Hyun;Kim, Sung-Jun;Cho, Sueung-Sik;Han, Ji-Man;Kim, Joon-Ho;Lee, Hyo-Jung;Yoo, Jin-Cheol
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.333.1-333.1
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    • 2002
  • Streptomyces tendae JC412 secreted two forms of protease(ST -1 and ST -2) when grown in OSY medium (oatmeal 1.5%. soybean meal 2%. dried yeast 1 %) supplemented with glucose(0.5%) and KH2PO4(0.05%). Initial pH of the culture medium was adjusted to 10.0 with NaOH and incubated at $27^{\circ}C$ on a rotary shaking incubator (180rpm). High- molecular-weight protease ST-1 was heat labile. whereas low molecular protease ST-2(22.000 Da) was reported to be heat stable. (omitted)

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Sesquiterpenes and Sterols from Aster glehni

  • Min, Yong-Deuk;Kwon, Hak-Cheol;Choi, Sang-Zin;Lee, Sung-Ok;Kim, Soo-Hak;Lee, Won-Bin;Yang, Min-Cheol;Chung, Ae-Kyung;Lee, Kyu-Ha;Nam, Kyu-Ha;Lee, Kang-Ro
    • Proceedings of the PSK Conference
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    • 2002.04a
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    • pp.200.2-200.2
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    • 2002
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