• 제목/요약/키워드: Pharmacy

검색결과 16,826건 처리시간 0.052초

Ddt Increase Aromatase Gene Expression and Activity in Leydig Cells

  • Lee, Kyung-Jin;Kim, Ji-Young;Shin, Dong-Weon;Cho, Young-Rhan;Jung, Kyung-Sik;You, Ho-Jin;Jeong, Hye-Gwang
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2003년도 추계학술대회
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    • pp.137-137
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    • 2003
  • Dichlorodiphenyltrichloroethane (DDT) is a widespread environmental pollutant. Earlier reports have demonstrated that DDT is an endocrine-active compound capable of affecting early-stage sexual differentiation in male rats. Experiments based on receptor binding affinity and receptor-mediated transcriptional activation have identified DDE as an androgen receptor antagonist.(omitted)

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Up-regulation of inducible nitric oxide synthase expression and inflammatory cytokines by collagen and gelatin in murine macrophages

  • Kim, Ji-Young;Lee, Kyung-Jin;Oh, Duk-Hee;Jung, Kyung-Sik;Shin, Dong-Weon;Cho, Young-Rhan;Jeong, Hye-Gwang
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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    • pp.121.2-121.2
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    • 2003
  • Synthetic polymers, biological polymer such as collagen and gelatin are employed extensively as backbones in the construction of hydrogels or cell/tissue scaffoldings for various biomedical applications. In the present study, we investigated the effect of collagen and gelatin on the inducible nitric oxide synthase (iNOS) gene expression in the mouse macrophage cell line RAW 264.7. The production of nitric oxide and expression level of iNOS mRNA were induced by both of collagen and gelatin in dose-dependent manner. (omitted)

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In vitro neural differentiation of human embryonic stem cells

  • Park, Jae-Hyun;Shin, Hwa-Yean;Kang, Yun-Hee;Kang, Young-Kook;Lee, Jung-Bok;Yoon, Hyun-Soo;Ryu, Chun-Jeih;Myung, Pyung-Keun;Hong, Hyo-Jeong
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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    • pp.164.2-164.2
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    • 2003
  • Human embryonic stem (ES) cell lines derived from the inner cell mass of human blastocysts have potential to differentiate into any cell types. We have established in vitro neural differentiation of human ES cells. After the formation of embroid bodies (EBs), the differentiating EBs formed neural tube-like rosettes in the presence of basic fibroblast growth factor (bFGF). The rosettes were selectively isolated by the treatment of dispase and cultured in a medium for human neural precursors in the presence of bFGF. (omitted)

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Acanthoic acid blocks production of pro-inflammatory mediators by inhibiting the ERK activation in trypsin-stimulated human leukemic mast cells

  • Kang, Ok-Hwa;Tae, Jin;Choi, Yeon-A;Kwon, Dong-Yeul;Kim, Yun-Kyung;Cai, Xing-Fu;Kim, Young-Ho;Bae, Ki-Hwan;Lee, Young-Mi
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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    • pp.88.3-89
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    • 2003
  • Acanthoic acid (AA) is a pimaradiene diterpene isolated from the Korean medicinal plant, Acanthopanax koreanum (Araliaceae), which has been traditionally used as a tonic and sedative as well as in the treatment of rheumatism and diabetes in korea. Proteinase-activated receptor-2 (PAR-2) agonist trypsin plays a role in inflammation, and human leukemic mast cells (HMC-l) express PAR-2. In the present study, the effect of acanthoic acid on production of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and tryptase in trypsin-stimulated HMC-1 was examined. (omitted)

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한국약학사 (The History for Pharmacy in Korea)

  • 심창구;남영희;정성욱;황성미
    • 약학회지
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    • 제51권6호
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    • pp.361-382
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    • 2007
  • The history of pharmacy in Korea from the era of 'Dangun Mythology' to today was reviewed briefly with special emphases on the beginning of pharmacy education, introduction of modern pharmacy education, establishment of modern educational institutions, and the evolution of the education system to a new 6-year pharmacy program.