• Proceedings of the PSK Conference
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• 2003.04a
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• pp.256.1-256.1
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• 2003

As a part of our ongoing research to discover novel monamine oxidase (MAO) inhibitors of plant origin, we found that a MeOH extract from the whole plant of Cayratia japonica (Vitaceae) strongly inhibited the MAO activity in mouse brain. The EtOAc-soluble fraction was. therefore, subjected to the bioactivity-guided fractionations to isolate the active compounds. (omitted)

• Proceedings of the PSK Conference
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• 2001.10a
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• pp.307.1-307.1
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• 2001

• Bulletin of the Korean Chemical Society
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• v.29 no.4
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• pp.749-754
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• 2008

To increase the solubility of sibutramine freebase, the solid dispersion was prepared using a fluid-bed granulator. The solid dispersion containing sibutramine freebase was characterized by differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD). After filling the sibutramine solid dispersion in the gelatin hard capsule, we performed in vitro dissolution test, the stability test under accelerated conditions and pharmacokinetic study in beagle dogs. The DSC and XRD data showed that sibutramine solid dispersion would be amorphous state. The dissolution rate of sibutramine solid dispersion was significantly increased about 70% than sibutramine freebase. The stability of sibutramine solid dispersion capsules was equivalent or above to commercial product of sibutramine. In beagle dogs, the sibutramine solid dispersion showed equivalent pharmacokinetic behavior with commercial product of sibutramine hydrochloride. In conclusion, the solid dispersion system provided a possible way to overcome the low solubility of sibutramine freebase, and the sibutramine solid dispersion can be a bioequivalent with the commercial product in humans.

• Biomolecules & Therapeutics
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• v.12 no.4
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• pp.195-197
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• 2004

• Proceedings of the Korean Society of Applied Pharmacology
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• 2004.04a
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• pp.53-57
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• 2004

• YAKHAK HOEJI
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• v.58 no.6
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• pp.405-412
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• 2014

The history of pharmaceutical service system in Korea originated from the beginning of Korean people was reviewed with focus on the pharmaceutical administration and laws after the Liberation from Japan in 1945.

• Proceedings of the PSK Conference
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• 2000.04a
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• pp.196.1-196.1
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• 2000

• Proceedings of the PSK Conference
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• 2000.04a
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• pp.196.2-196.2
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• 2000

• Proceedings of the PSK Conference
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• 2001.04a
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• pp.216.3-217
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• 2001

• Natural Product Sciences
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• v.12 no.3
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• pp.119-121
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• 2006

Four 3,4-seco-lupane trierpenoids were isolated from the MeOH extract of the leaves of Acanthopanax divaricatus forma flavi-flos Yook by using various column chromatography. The chemical structures of isolates were identified as chiisanogenin, chiisanoside, isochiisanoside and 11-deoxyisochiisanoside on the basis of physico-chemical and spectroscopic date($^1H-NMR,\;^{13}C-NMR$M$, 2D-NMR and FAB-MS). These compounds were isolated for the first time from A. divaricatus forma flavi-flos.