• Title/Summary/Keyword: Petussis toxin PMA

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EFFECT OF PERTUSSIS TOXIN ON THE SECRETION OF $[MET^5]$-ENKEPHALIN AND EXPRESSION OF PROENKEPHALIN A mRNA INDUCED BY NICOTINE, ANGIOTENSIN II, AND PHORBOL MYRISTATE ACETATE IN BOVINE ADRENAL MEDULLARY CHROMAFFIN CELLS

  • Hong W. Suh;Kim, Yung H.
    • Toxicological Research
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    • v.9 no.2
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    • pp.187-194
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    • 1993

  • [Met5]-Enkephalin (ME) secretion and the expression of proenkephalin A (proENK) mRNA were studied following long-term exposure of bovine adrenal medullary chromaffin (BAMC) cells to pertussis toxin. Prolonged (24 hr) stimulation of BAMC cells with pertussis toxin increased the secretion of ME as well as proENK gene expression. BAMC cells were also incubated with pertussis toxin in the presence or absence of other secretagogues such as nicotine, angiotensin II and phorbol myristate acetate.

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