• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제11권sup1호
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• pp.149-152
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• 2008

비만으로 인해 체지방이 증가하면 증가된 지방에서 분비되는 여러 가지 사이토카인과 지방산에 의해 인슐린 저항성을 유발시키며, 인슐린 저항성으로 인해 이상지혈증, 고혈압, 심혈관계 질환, 제 2형 당뇨, 비알코올성 지방간염, 다낭성 난소 증후군 등이 발생한다.

• 한국조사연구학회지:조사연구
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• 제12권2호
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• pp.159-173
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• 2011

The goal of this study is to identify and compare predictors of smoking initiation, persistence and smoking status among Hispanics and Whites. The sample includes 1,410 Hispanic and non-Hispanic White adults living in El Paso, TX, USA and Do$\tilde{n}$a Ana and Otero counties, NM, USA from the Paso del Norte 2002 BRFSS. Whites reported higher rates of cigarette smoking and became regular smokers earlier than Hispanics. Males were twice more likely to initiate cigarette smoking and progress to regular smoking than females among Hispanics, but this gender difference among Whites was not significant. Childhood exposure to drinkers or alcoholics was an important predictor of smoking initiation and becoming a regular smoker, but only among Hispanics. Few identified ethnic differences in predictors of smoking were found. The findings underscore the importance of Hispanic norms on smoking behaviors. Prevention efforts need to address the culture as one of the important components relevant to smoking.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2002년도 봄 학술발표회 논문집
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• pp.501-508
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• 2002

The percentage of a mountainous district in our country is comparatively high but the concern for rock mass has been disregarded for a long time. Especially for rock slope, the most important factors are geometric characteristics and their shear strength parameter. In this paper, parametric studies are performed using the distinct element computer program UDEC-BB for rock slopes. Parameters adopted in this paper are joint angle, spacing, persistence, aperture and shear strength parameters (JRC, JCS, basic friction angle). To estimate slope stability, shear strength reduction method is used. The most important factors affecting rock slope stability are joint angle and spacing. The relationship between average displacement calculated by UDEC-BB and safe factor by shear strength reduction method is researched.

• 국제학술발표논문집
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• The 6th International Conference on Construction Engineering and Project Management
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• pp.138-141
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• 2015

The South Korean construction industry has shown a high proportion of industrial accidents (approximately 28% of whole injuries) and the continuously increasing accident rate. Although many safety research emphasized that the 3E (Enforcement, Education, and Engineering) approach is a potential solution to enhance workplace safety, there should be benefits to consider psychological (i.e., Emotional) effects on the safety performance since most construction works are human-oriented. Thus, understanding construction workers' psychological conditions can be a priority. This research studied the relationships between psychological conditions-which cover stress, personal temperament, emotional disturbance, and drinking habit-and specific safety-related factors including safety motivation and knowledge, and safety performance of individual workers at a construction site. This study conducted a survey of 430 respondents and analyzed the data with the multiple linear regressions. The results imply persistence, trait anxiety, and problem-focused coping style are the critical factors that should be controlled for enhancing jobsite safety. Finally, the research outcomes could be applied to build a strategic safety management plan for a construction manager.

• 한국대기환경학회지
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• 제28권2호
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• pp.172-181
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• 2012

Mercury is one of the most hazardous air pollutants. Recently, mercury has been a concern in domestic and overseas because it has lethal toxicity, long distance transport, persistence and bioaccumulation in the environment. Stationary combustion sources such as coal-fired power plants, waste incinerators, and cement kilns are the major sources of mercury emissions. The objectives of this study were to measure the concentration for mercury from coal-fired power plants and to calculate emission factor to estimate its emission. The results showed that the mercury concentrations in the flue gas were 1.63-3.03 mg/$Sm^3$ in anthracite-fired power plants (average 2.32 mg/$Sm^3$) and 1.95-3.33 mg/$Sm^3$ in bituminous-fired power plants (average 2.6 mg/$Sm^3$). Mercury emission factor was estimated as 25.74 mg/ton for anthracite-fired power plants and 12.48 mg/ton for bituminous-fired power plants. Because actual measurements are limited in quantity, it is desirable to refine our estimates by extending the actual measurements.

• 대한수학교육학회지:학교수학
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• 제18권3호
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• pp.691-709
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• 2016

수학 예비교사의 신념을 이해하는 것은 효과적인 교사교육 프로그램을 시행하고 설계하기 위하여 필수적이다. 본 연구에서는 초등 예비교사의 수학적 신념에 대해 분석하였다. 연구결과는 다음과 같다. 첫째, 수학문제해결에 대한 신념인 끈기 요인, 수학학습에 대한 신념인 교사주도 요인, 활동참여 요인, 자아개념에 대한 신념인 흥미 요인은 다른 수학적 신념요인들과 관련성이 많았다. 둘째, 수학교과에 대한 신념인 고정관념 요인이 교사주도 요인에 영향을 주고 있고, 수학문제해결에 대한 신념인 과정 요인이 활동참여 요인에 영향을 주고 있었다. 셋째, 학년별 수학적 신념 비교에서는 수학교과에 대한 신념인 고정관념, 유용성 요인과 자아개념에 대한 신념인 유익성 요인만이 통계적으로 유의미한 차이가 있었다. 넷째, 전공별 수학적 신념비교에서는 자아개념에 대한 신념인 유익성 요인과 자신감 요인을 제외한 나머지 수학적 신념에서 모두 유의미한 차이가 있었다. 본 연구결과를 토대로 초등 예비교사가 지녀야 할 수학적 신념이 무엇인지를 정립하고, 예비교사교육과정, 교수 학습 방법등 다양한 방안을 마련해야 할 것이다.

• Clinical and Experimental Pediatrics
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• 제57권5호
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• pp.211-216
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• 2014

Asthma comprises a heterogeneous group of disorders characterized by airway inflammation, airway obstruction, and airway hyperresponsiveness (AHR). Airway inflammation, which induces AHR and recurrence of asthma, is the main pathophysiology of asthma. The fractional exhaled nitric oxide (FeNO) level is a noninvasive, reproducible measurement of eosinophilic airway inflammation that is easy to perform in young children. As airway inflammation precedes asthma attacks and airway obstruction, elevated FeNO levels may be useful as predictive markers for risk of recurrence of asthma. This review discusses FeNO measurements among early-childhood wheezing phenotypes that have been identified in large-scale longitudinal studies. These wheezing phenotypes are classified into three to six categories based on the onset and persistence of wheezing from birth to later childhood. Each phenotype has characteristic findings for atopic sensitization, lung function, AHR, or FeNO. For example, in one birth cohort study, children with asthma and persistent wheezing at 7 years had higher FeNO levels at 4 years compared to children without wheezing, which suggested that FeNO could be a predictive marker for later development of asthma. Preschool-aged children with recurrent wheezing and stringent asthma predictive indices also had higher FeNO levels in the first 4 years of life compared to children with wheezing and loose indices or children with no wheeze, suggesting that FeNO measurements may provide an additional parameter for predicting persistent wheezing in preschool children. Additional large-scale longitudinal studies are required to establish cutoff levels for FeNO as a risk factor for persistent asthma.

• 생명과학회지
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• 제13권1호
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• pp.99-104
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• 2003

Aromatic compounds are of major concern among environmental pollutants due to their toxicity and persistence. To monitor aromatic compounds in a real time with a better sensitivity, a new method of SPR (surface plasmon resonance) based on DNA chip (Biacore 3000) was developed here. It is thought that CapR regulatory protein as a complex with phenol, could bind to their corresponding promoter, Po. Biotinylated DNA oligomers for the promoter was synthesized by PCR and coupled onto streptoavidin-linked CM5-chip. CapR regulatory proteins were purified after cloning their genes in pET21a (+) vector and expressing proteins. The interaction was assessed by the system where the regulatory proteins flowed with or without phenol through the cells of DNA chip. CapR regulatory protein even in the presence of phenol had no response to its promoter, Po, suggesting that other factor(s) might be required for the activation of Po promoter. The present work reveals a promising possibility of the SPR-based DNA chip in monitoring specific environmental pollutants in a real time.

• 자원환경지질
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• 제33권1호
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• pp.77-88
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• 2000

The goal of this study is to assess the spatial distribution of natural slopes and cutting slopes under would-be development. For this goal, a quantitative slope stability analysis method using GIS integrated with a computer program was developed. Through field investigations, the discontinuity parameters were collected such as orientation of discontinuity, persistence, spacing, JRC, JCS, and water depth. The distributions were interpolated from the ordinary kriging method in ARC/INFO GIS after variogram analysis. The layers showing all parameters needed for limit equilibrium analysis were constructed. The final layer using GIS works composed of 162,352 polygons, that is, unit slopes. The rock slope stability analysis program was coded by C++ language. This program can calculate geometrical vectors related to rock block failures using input orientation data and direction and dimension of strength to occur failure. Also, this can calculate shear strength of joints through empirical equations and quantitative factors of safety. This methodology was applied to the study area which is located in Jaecheon city and Danyang-gun of the northeastern Keumsu is about 135$km^2$. As a result, the study area was entirely stable but unstable, that is, factor of safety less than 1.0dominantly at the slopes near Keumsil, Daejangri, Keumsungmyun and Sojugol, Mt. Dongsan, Juksongmyun by the natural slope stability analysis. Assuming the cutting slope showing the same direction immediate, and quantitative analysis of factors of safety for a regional area could be conducted through GIS integrated with a computer program of limit equilibrium.

• BMB Reports
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• 제44권4호
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• pp.217-231
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• 2011

T cell exhaustion develops under conditions of antigen-persistence caused by infection with various chronic pathogens, such as human immunodeficiency virus (HIV) and myco-bacterium tuberculosis (TB), or by the development of cancer. T cell exhaustion is characterized by stepwise and progressive loss of T cell function, which is probably the main reason for the failed immunological control of chronic pathogens and cancers. Recent observations have detailed some of the intrinsic and extrinsic factors that influence the severity of T cell exhaustion. Duration and magnitude of antigenic activation of T cells might be associated with up-regulation of inhibitory receptors, which is a major intrinsic factor of T cell exhaustion. Extrinsic factors might include the production of suppressive cytokines, T cell priming by either non-professional antigenpresenting cells (APCs) or tolerogenic dendritic cells (DCs), and alteration of regulatory T (Treg) cells. Further investigation of the cellular and molecular processes behind the development of T cell exhaustion can reveal therapeutic targets and strategies for the treatment of chronic infections and cancers. Here, we report the properties and the mechanisms of T cell exhaustion in a chronic environment.