• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제12권1호
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• pp.75-78
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• 2009

복강내 유리소체는 epiploic appendage의 염전과 분리로 인해 생성 되며 대개 증상이 없고 간혹 수술이나 검시에서 우연히 발견 된다. 대부분 중년이상의 연령에서 발견되며 소아에서는 극히 드물며, 특히 국내 소아 연령에서는 보고가 없다. 저자들은 10세 여아가 4일 동안의 빈뇨와 하복부 동통으로 개인의원에서 시행한 복부 단순 X-ray 촬영에서 복강 내 종괴가 있어 전원 되어 복강경 수술 후 복강내 유리소체로 진단되었던 1예를 경험하였기에 보고하는 바이다.

• 동의생리병리학회지
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• 제37권1호
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• pp.1-8
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• 2023

The aim of this study is to evaluate the antidiabetic effect of the water extract of Aurantii fructus immaturus (WAF), in diabetic models using enzyme, cells and mice, and to suggest a putative mechanism explaining its antidiabetic effect. In an enzyme model using the enzyme α-glucosidase, WAF had no significant effect on α-glucosidase, as compared with acarbose, an antidiabetic drug. Nonetheless, WAF was capable of reducing the blood glucose levels during oral sucrose tolerance test and oral glucose tolerance test, implying that there would be other antidiabetic pathways in no relation to inhibition of α-glucosidase. In cell models using RIN-m5f β-cells and L6 myotubes, WAF, at its non-cytotoxic doses, augmented the secretion of insulin in RIN-m5f β-cells stimulated with 5 mM glucose. In addition, it enhanced the cellular uptake of glucose in L6 myotubes stimulated with deprivation of glucose for 12 h. Therefore, it is most likely that WAF may exert its antidiabetic effects, at least in part, by enhancing insulin secretion and glucose uptake. Meanwhile, in diabetic mice induced with peritoneal injection of streptozotocin (STZ), WAF significantly improved fast blood glucose levels, glycosylated hemoglobin levels, body weight loose, blood pressure, and diabetic adverse effects on functions of the kidney and the liver. Taken together, the water extract of Aurantii fructus immaturus may ameliorate diabetes in mice injected with STZ, at least in part, by enhancing insulin secretion and glucose uptake.