• Journal of Genetic Medicine
• /
• v.19 no.2
• /
• pp.57-62
• /
• 2022

Systemic autoinflammatory diseases (SAIDs) are characterized by unprovoked inflammatory episodes such as recurrent/periodic fever, serositis, skin lesions, abdominal symptoms, arthritis/arthralgia, and central nervous system involvement. Genetic diagnosis of SAIDs has been challenging because disease manifestations overlap among themselves and with other immunological disease categories, such as infection and autoimmune diseases. However, the advent of next-generation sequencing (NGS) technologies and expanding knowledge about the innate immunity and inflammation have made the routine genetic diagnosis of SAIDs possible. Here, we review the recurrent/periodic fevers, other recently identified autoinflammatory diseases, and type I interferonopathies, and discuss the clinical usefulness of NGS targeted sequencing for SAIDs, and recent advance of understandings for this heterogeneous disease group as for underlying primary immunodeficiency.

• International Journal of Naval Architecture and Ocean Engineering
• /
• v.10 no.2
• /
• pp.153-169
• /
• 2018

A submarine has a pressure hull that can withstand high hydraulic pressure and therefore, requires the use of highly advanced shipbuilding technology. When producing a pressure hull, periodic inspection, repair, and maintenance are conducted to maintain its soundness. Of the maintenance methods, Non-Destructive Testing (NDT) is the most effective, because it does not damage the target but sustains its original form and function while inspecting internal and external defects. The NDT process to detect defects in the welded parts of the submarine is applied through Magnetic particle Testing (MT) to detect surface defects and Ultrasonic Testing (UT) and Radiography Testing (RT) to detect internal defects. In comparison with RT, UT encounters difficulties in distinguishing the types of defects, can yield different results depending on the skills of the inspector, and stores no inspection record. At the same time, the use of RT gives rise to issues related to worker safety due to radiation exposure. RT is also difficult to apply from the perspectives of the manufacturing of the submarine and economic feasibility. Therefore, in this study, the Phased Array Ultrasonic Testing (PAUT) method was applied to propose an inspection method that can address the above disadvantages by designing a probe to enhance the precision of detection of hull defects and the reliability of calculations of defect size.

• Journal of the Korean Society for Nondestructive Testing
• /
• v.12 no.1
• /
• pp.9-15
• /
• 1992

Ultrasonic spectroscopy is likely to become a very powerful NDE method for detection of microfects and thickness measurement of thin film below the limit of ultrasonic distance resolution in the opaque materials, provides a useful information that cannot be obtained by a conventional ultrasonic measuring system. In this paper, we considered a thin film below the limit of ultrasonic distance resolution sandwitched between two substances as acoustical analysis model, demonstrated the usefulness of ultrasonic spectroscopic analysis technique using information of ultrasonic frequency for measurements of thin film thickness, regardless of interference phenomenon and phase reversion of ultrasonic waveform. By using frequency intervals(${\triangle}f$) of periodic minima from the ratio of reference power spectrum of reflective waveform obtained a sample to power spectrum of multiple reflective waves obtained interference phenomenon caused by ultrasonic waves reflected at the upper and lower surfaces of a thin layer, can measured even dimensions of interest are smaller than the ultrasonic wave length with simplicity and accuracy.

• Journal of the Korean Society for Nondestructive Testing
• /
• v.28 no.2
• /
• pp.199-204
• /
• 2008

The generation of axisymmetric Lamb waves and interaction with wall thinning (corrosion) defects in hollow cylinders are simulated using the finite element method. Guided wave interaction with defects in cylinders is challenged by the multi-mode dispersion and the mode conversion. In this paper, two longitudinal, axisymmetric modes are generated using the concept of a time-delay periodic ring arrays (TDPRA), which makes use of the constructive/destructive interference concept to achieve the unidirectional emission and reception of guided waves. The axisymmetric scattering by the wall thinning extending in full circumference of a cylinder is studied with a two-dimensional FE simulation. The effect of wall thinning depth, axial extension, and the edge shape on the reflections of guided waves is discussed.

• Journal of the Korean Society for Nondestructive Testing
• /
• v.14 no.4
• /
• pp.219-227
• /
• 1995

A two-dimensional photoacoustic microscope utilizing photoacoustic signals generated by periodic heating of specimen surface with Argon ion laser and measured by accelerometer has been developed. Several aluminum specimens with various defects have been examined, characteristics of the microscope have been evaluated and optimal experimental conditions have been determined by examining the dependence on several experimental conditions including the modulation frequency and the beam width of laser.

• Journal of Korean Society for Quality Management
• /
• v.39 no.2
• /
• pp.170-178
• /
• 2011

In general, a software fault detection phenonenon is described by a software reliability model based on a nonhomogeneous Poisson process(NHPP). In this paper, we propose a software reliability growth model considering the differences of the software environments in both the testing phase and the operational phase. Also, we consider the problem of determining the optimal release time and the optimal warranty period that minimize the total expected software cost which takes account of periodic software maintenance(e.g. patch, update, etc). Finally, we analyze the sensitivity of the optimal release time and warranty period based on the fault data observed in the actual testing process.

• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.sup3
• /
• pp.17-22
• /
• 2016

Colorectal cancer is a major cause of mortality worldwide. Fecal occult blood testing has proven a very effective screening tool for early detection and mortality reduction. The aim of this study was to determine predictors factors related to fecal occult blood testing using the Health Belief Model method among residents of Bushehr, Iran. A cross sectional study was performed on a sample of 600 men and women more than 50 years of age. The sample was selected by a convenience method from patients referred to public and private laboratories throughout the city. Each subject filled out a questionnaire which was designed and developed based on Health Belief Model constructs. Statistical analysis was conducted using ANOVA, T-test, chi-square test, and logistic regression. Fecal occult blood tests were performed on 179 (29.8%) out of 600 subjects, of which 95 patients (58.1%) did a periodic examination test and 84 patients (46.9%) had a doctor's advice for testing. According to the logistic regression model, the perceived barriers (P=0.0, Exp(B)= 0.3), perceived benefits (P<0.01, Exp(B)= 1.9) and self-efficacy (P<0.01, Exp(B)= 1.6) were predictive factors related to occult blood testing among subjects. The results showed that reducing people's perception of barriers to testing, increasing perceived benefits of screening, and reinforcing self efficacy can have major effect in increasing the rate of fecal occult blood screening for colorectal cancer prevention.

• Transactions of the Korean Society of Pressure Vessels and Piping
• /
• v.11 no.1
• /
• pp.74-78
• /
• 2015

Nuclear power plant steam generator that is one of the main component has several thousands of thin tubes. And the steam generator tube is subject to damage because of the severe operation conditions such as the high temperature and pressure. Therefore periodic inspections are conducted to ensure the integrity of steam generator component. Hanul unit 3 also has been inspected in accordance with in-service inspection program and is scheduled to be replaced for exceeding the plugging rate which was recommended by manufacturer. During the steam generator replacement activity, we found several clustered porosity on inner surface of main feed water pipe. Additionally crack-like indications were found at weld interface between base material and weld of main feed water pipe. This paper describes the field experience and visual testing results for inner surface of main feed water pipes. The destructive test result had shown that these indications were porosities which were caused by manufacturing process not by operation service.

• Korean Journal of Digital Imaging in Medicine
• /
• v.9 no.1
• /
• pp.53-65
• /
• 2007

PACS has been run at the Kyung Hee University Medical Center(KHMC) since 2001, and the installation and operation of PACS have contributed to automation and quantification of KHMC's medical environment During these five years our greatest concern is how to make our own guiding principle of diagnostic monitor QA which is adapted to international standards. In accordance with the terms of 'KHMC QA Guideline', 'AAPM TG18', 'SMPTE RP133', 'DICOM Part14', 'DIN V 6868-57', 'JESRA X-0093', 'JIS Z4752-2-5' and 'KCARE', concern about quality assurance of medical images are on the increase. With the investigation of acceptance testing and quality control of international standards for medical display devices, and data collection and analysis for recommended guideline, it is reported that acceptance testing(quality control), including geometrical distortion, display reflection, luminance response, luminance uniformity, display resolution, display noise, veiling glare and color chromaticity being adequate and effective to domestic hospital environments for medical display devices and assessment methods according to each performance. Accordingly, KHMC classified the checkpoint items by period, at the time of monitor setting, monthly, quarterly, half-yearly and annually. Periodic classification of checkpoint items for monitor QA makes a good guideline for image QA/QC and useful guideline for persistent good quality of monitor.

• Journal of the Korean Society for Nondestructive Testing
• /
• v.31 no.2
• /
• pp.127-133
• /
• 2011

A LabVIEW program has been developed together with simple infrared thermography(IRT) system to control the lock-in conditions of the system efficiently. The IR imaging software was designed to operate both of infrared camera and halogen lamp by synchronizing them with periodic sine signal based on thyristor(SCR) circuits. LabVIEW software was programmed to provide users with screen-menu functions by which it can change the period and energy of heat source, operate the camera to acquire image, and monitor the state of the system on the computer screen. In experiment, lock-in IR image for a specimen with artificial hole defects was obtained by the developed IRT system and compared with optical image.