• Journal of Yeungnam Medical Science
• /
• 제35권2호
• /
• pp.156-164
• /
• 2018

Environmental contaminants are one of the important causal factors for development of various human diseases. In particular, the perinatal period is highly vulnerable to environmental toxicants and resultant dysregulation of fetal development can cause detrimental health outcomes potentially affecting life-long health. Perfluoroalkyl compounds (PFCs), emerging environmental pollutants, are man-made organic molecules, which are widely used in diverse industries and consumer products. PFCs are non-degradable and bioaccumulate in the environment. Importantly, PFCs can be found in cord blood and breast milk as well as in the general population. Due to their physicochemical properties and potential toxicity, many studies have evaluated the health effects of PFCs. This review summarizes the epidemiological and experimental studies addressing the association of PFCs with neurotoxicity and immunotoxicity. While the relationships between PFC levels and changes in neural and immune health are not yet conclusive, accumulative studies provide evidence for positive associations between PFC levels and the incidence of attention deficit hyperactivity disorder and reduced immune response to vaccination both in children and adults. In conclusion, PFCs have the potential to affect human health linked with neurological disorders and immunosuppressive responses. However, our understanding of the molecular mechanism of the effects of PFCs on human health is still in its infancy. Therefore, along with efforts to develop methods to reduce exposure to PFCs, studies on the mode of action of these chemicals are required in the near future.

• International Journal of Advanced Culture Technology
• /
• 제9권2호
• /
• pp.47-55
• /
• 2021

The coronavirus disease 2019 (COVID-19) pandemic continuously influences on the health and well-being of people and communities worldwide. The purpose of this study was to explore the published research articles in the fields of nursing and health during the COVID-19 pandemic. The research design is an exploratory study. Samples are the abstracts of the articles from a literature database, PubMed, that were published from January 1st, 2020 to April 15th, 2021. We used a MeSH term, 'nursing' and "COVID-19" to retrieve articles that are related to COVID-19. Five hundred and fifty-five articles were retrieved. Two hundred and sixteen articles were excluded as they were not met the inclusion criteria. The total number of articles used in this study was three hundred and thirty-nine. The average number of articles published during the data collection period was 21.9. Seven topics were discovered from the abstracts of the articles: COVID-19 management and guidance; Perinatal COVID-19 and breastfeeding; Nurse; Health service and support; Patient care; Research; and Education and experience. This study revealed some interesting topics from the articles related to COVID-19 and provided some sense of research areas that may be interesting and allow us to develop important research questions about nursing science and nursing practice.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권6호
• /
• pp.3469-3472
• /
• 2013

Extract of Lentinula edodes mycelia (LEM) is currently utilized as an oral biological response modifier (BRM) medicine for cancer patients. However, its effectiveness for breast cancer patients with postoperative adjuvant hormone therapy has not yet been scientifically verified. In this study, we investigated the influence of LEM on the quality of life (QOL) and immune response in breast cancer patients undergoing postoperative adjuvant hormone therapy. Twenty patients were studied in total. They received only hormone therapy in the first 4 weeks followed by hormone therapy and LEM during the next 8 weeks. Laboratory tests, QOL score and peripheral blood cytokine production levels were evaluated during the study period. No changes in QOL or cytokines were noted after the first 4 weeks. In contrast, during the following combined therapy period, improvements were noted in QOL and cytokine levels. Although a future large-scale investigation is necessary to confirm these results, these data suggest that the concomitant use of LEM with postoperative adjuvant hormone therapy improves the QOL and immune function of patients.

• Advances in pediatric surgery
• /
• 제10권2호
• /
• pp.107-111
• /
• 2004

Recently, the incidence of perinatally detected asymptomatic adrenal gland masses has increased because of widespread use of radiological diagnostic tools. However, optimal treatment of these masses has not been determined. The aim of this study is to elucidate the treatment guideline of perinatally diagnosed adrenal gland masses. The authors retrospectively reviewed the medical records of the 11 patients with asymptomatic adrenal gland mass, detected perinatally, between 1999 and 2004. Six cases were detected by prenatal ultrasound and 5 cases were incidentally detected by postnatal ultrasound. Six patients (surgery group) underwent mass excision. The pathologic diagnoses were neuroblastoma (n=4), adrenocortical adenoma (n=1) and adrenal pseudocyst (n=1). The indications for operation were suspicion of neuroblastoma (n=5) or absence of size decrease during observation (n=1). Three of the 5 suspicious cases of neuroblastoma and one case under observation were proven to be neuroblastoma. There was no surgical complication in the urgery group. All neuroblastoma patients have been well during the follow up period ($24.4{\pm}14.4$ month) without evidence of recurrence. Five cases (observation group) were closely observed because of the benign possibility or size decrease in follow up ultrasound. During the observation period ($39{\pm}21$ week), 4 cases showed complete spontaneous resolution and 1 case showed markedly decreased size of the mass but could not be followed up completely. Surgical resection of the perinatally diagnosed asymptomatic adrenal gland mass is a safe treatment method especially in case of suspicion of neuroblastoma, but closed observation can be applied.

• 여성건강간호학회지
• /
• 제1권1호
• /
• pp.28-43
• /
• 1995

The relationship between perceived social support and adaptation to maternal role for first-time mothers was investigated in this descriptive correlational study. A nonprobable sample of 90 first-time mothers were selected, who had uncomplicated perinatal experiences and delivered healthy and term newborns as well. The data was collected during a home interview at 4-6weeks postpartum. The outcome of adaptations was defined as the level of sensitivity in parent-infant interactions and of the self confidence in infant care. The perception of social support in the primiparous was assessed by the NSSQ during the postpartum. The results obtained from this study are summarized as follows : 1. The mean score of the perceived total functional support was $116.6{\pm}37.5$ points (affective : 38.1 affirmative : 39.3, aid : 39.3), and the score of the total network support was $45.2{\pm}13.9$ points (size : 4.9, duration :19.8 frequency : 20.4). These scores tended to be slightly low. 2. The mean score of the self confidence on the infant care activity as the subjective aspect of the maternal role adaptation (MRA) was 56.5 points (86.9%), whereas that of the sensitivity of the mother-infant interaction of the MRA was 78.9 points (63.2%). 3. The subjective aspect of the MRA has showed a positive relation ship with the aid dimension of the functional support. And the objective aspect of the MRA also showed a positive relationship with the total functional support and the total network support. However the correlating degrees were slightly low. In conclusion, the primiparous mothers perceived that they had received a small amount of social support during the postpartum period, suggesting the need of various kinds of social support to promote the MRA for the primiparous.

• 여성건강간호학회지
• /
• 제27권4호
• /
• pp.326-336
• /
• 2021

Purpose: This study explored the prevalence of prenatal and postpartum depression in Korea and its influencing factors from 20 weeks of pregnancy to 12 weeks postpartum. Methods: Using a prospective cohort study design, data on women's depression and its influencing factors were collected at 20, 28, and 36 weeks of pregnancy and at 2, 6, and 12 weeks postpartum. The participants were 219 women and 181 spouses during pregnancy; and 183 mothers and 130 spouses after childbirth. Depressive symptoms were assessed by the Edinburgh Postnatal Depression Scale and influencing factors were measured by the Postpartum Depression Predictors Inventory-Revised, parity, and spousal depression. Results: The prevalence of maternal depression was 10.5% to 21.5% before birth, and it was 22.4% to 32.8% postpartum. The prevalence slightly decreased during the prenatal period but peaked at 2 weeks postpartum. Antenatal depression was influenced by low socioeconomic status, lower self-esteem, having experienced prenatal depression, having experienced prenatal anxiety, a previous history of depression, lower social support, lower marital satisfaction, and higher life stress. The factors influencing postpartum depression were lower self-esteem, having experienced prenatal depression, having experienced prenatal anxiety, lower social support, lower marital satisfaction, and higher life stress, as well as infant temperament and maternal blues. Parity and spousal depression had no impacts. Conclusion: The prevalence and influencing factors of maternal depression changed over time. Nurses need to screen women accordingly during the perinatal period and should provide education or counseling to prevent depression and promote adjustment to parenthood.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권11호
• /
• pp.6227-6231
• /
• 2013

In the past, hepatitis B virus (HBV) infection was endemic in the general Korean population. The association of HBV infection with the occurrence of liver cancer has been well demonstrated in several epidemiologic studies. While the mortality rates of liver cancer in Korea have decreased steadily over the last decade, the presence of hepatitis B surface antigen (HBsAg) in mothers remains high at 3-4%, and 25.5% of these HBsAg positive mothers are positive for hepatitis B e antigen (HBeAg). HBV infection caused almost a quarter of hepatocellular carcinoma (HCC) cases and one-third of deaths from HCC. These aspects of HBV infection prompted the Korean government to create a vaccination program against HBV in the early 1980s. In 1995, the Communicable Disease Prevention Act (CDPA) was reformed, and the government increased the number of HBV vaccines in the National Immunization Program (NIP), driving the vaccination rate up to 95%. In 2000, the National Health Insurance Act (NHIA) was enacted, which provided increased resources for the prevention of perinatal HBV infection. Then in 2002, the Korean government, in conjunction with the Korean Medical Association (KMA), launched an HBV perinatal transmission prevention program. The prevalence of HBsAg in children had been high (4-5%) in the early 1980s, but had dropped to below 1% in 1995, and finally reached 0.2% in 2006 after the NIP had been implemented. After the success of the NIP, Korea finally obtained its first certification of achievement from the Western Pacific Regional Office of the World Health Organization (WPRO-WHO) for reaching its goal for HBV control. An age-period-cohort analysis showed a significant reduction in the liver cancer mortality rate in children and adolescents after the NIP had been implemented. In addition to its vaccination efforts, Korea launched the National Cancer Screening Program (NCSP) for 5 leading sites of cancer, including the liver, in 1999. As a consequence of this program, the 5-year liver cancer survival rate increased from 13.2% (1996-2000) to 23.3% (2003-2008). The development of both the primary and secondary prevention for liver cancer including HBV immunization and cancer screening has been of critical importance.

• Clinical and Experimental Pediatrics
• /
• 제48권12호
• /
• pp.1324-1329
• /
• 2005

목 적 : 최근 1,000 g 미만의 초극소 미숙아의 생존율이 괄목할 만큼 향상되었고 이는 또한 신생아 집중치료술 평가의 지표로 간주되고 있어 초극소 미숙아의 생존율이 얼마나 향상되었는 지를 평가하고 생존율 향상과 연관된 주산기 및 치료인자를 알아보고자 하였다. 방 법 : 본원 신생아 중환자실에 입원한 출생 체중 1,000 g 미만의 초극소 미숙아들을 대상으로 1994년부터 1999년까지를 1기(n=100)로, 2000년부터 2004까지를 2기(n=166)로 분류하여 후향적 의무기록 분석을 통해 두 시기의 임상양상을 비교하였다. 결 과 : 1기에 비해 2기에서 평균 재태연령과 출생 체중($27{\pm}2$주, $841{\pm}121g$ vs. $26{\pm}2$주, $794{\pm}143g$)이 유의하게 낮았으나 생존율이 60%에서 75%로 현저히 향상되었다. 또한 재태연령과 출생 체중을 보정한 분석에서 두 시기간 유의한 차이를 보인 합병증으로는 기관지폐이형성증, 균혈증이 확인된 패혈증과 3도 이상의 뇌실내 출혈로 2기에서 낮은 빈도를 보였다. 대상 환아들의 생존율 향상과 연관된 주산기 및 치료인자를 확인하기 위해 두 시기 간 유의한 차이를 보인 임상인자를 로짓회귀분석을 한 결과 산전 스테로이드 치료, 비강 지속성 기도 양압 치료기간과 3도 이상의 뇌실내 출혈의 부재가 포함되었다. 결 론 : 본원의 초극소 미숙아들의 생존율이 최근 향상된 것은 덜 침습적인 치료 방법을 중요시 여겼던 신생아 중환자실팀의 임상적 관리의 향상을 바탕으로 산전 스테로이드 치료 증가, 비강 지속성 양입기도 사용 증가와 3도 이상의 뇌실내 출혈감소에 기인한 것으로 사료된다.

• 여성건강간호학회지
• /
• 제13권4호
• /
• pp.245-253
• /
• 2007

Purpose: The purpose of this study was to measure the effects of a breastfeeding management program for promotion of breastfeeding. Method: The study design was a non-equivalent control group pre-post test. The study subjects were pregnant women receiving a breastfeeding education class in one hospital in Ilsan. The total number of study subjects was 153 pregnant women, namely 75 mothers in the experimental group and 78 in the control group. Data was collected between June and November, 2006. A breastfeeding management program was provided to the experimental group while admitted for delivery, and in weeks 2, 4, 8, 12, 16, 20, and 24 of the postpartum period. The rates of breastfeeding were measured in weeks 2, 4, 8, 12, 16, 20, and 24 of the postpartum period. Result: There were significant differences in the scores of rate of breastfeeding between the two groups(all cases), which were 93.1 in the experimental group and 85.8 in the control group at week 4; 88.1 vs 71.8 at week 8; 83.4 vs 56.7 at week 12; 71.4 vs 53.9 at week 16; and 65.7 vs 48.4 at week 20 respectively. However, there were not significant differences in the scores of rate of breast-feeding between the two groups, which were 97.7 in the experimental group and 96.0 in the control group in the early postpartum period at week 2, and 59.6 vs 45.3 at week 24. Add to this, the study analyzed only people who had jobs. As a result, the scores of rate of breastfeeding were 94.8 in the experimental group which were significantly higher than 88.5 in the control group at week 4; 93.2 vs 73.3 at week 8; 89.6 vs 57.2 at week 12; and 75.0 vs 46.0 at week 20 respectively. However, there were not significant differences at week 2, week 16 and week 24. Conclusion: The results of this study suggest that a breastfeeding management program during the last trimester of the perinatal period and postpartum period may increase the duration of breastfeeding in postpartum clients who intend to breastfeed. This study supports the literature which found that prenatal education and postpartum support are important to the outcome of breastfeeding.

• 한국인구학
• /
• 제24권1호
• /
• pp.67-90
• /
• 2001

통계청에서는 출생 및 사망 신고가 동시에 누락되는 영아사망 미신고분을 감안하여 기간 출생률 및 사망률, 생명표상의 기간 영아사망확률을 추정하여 왔다. 보건복지부의 93년 및 96년 출생 코호트 영아사망조사 결과가 발표됨에 따라 통계청이 1971년-1997년 영아사망확률을 재추정하였다. 자료원은 사망신고 자료, 보건복지부 조사. 선진국의 사망신고 자료, 모델생명표 및 일본생명표이었으며, 17가지 방법으로 시산하였다. 최종 방법은 1993년 보건복지부 조사의 사망확률과 사망신고 자료의 1∼4세 사망 확률 관계에 의존하여 1971-1991년 영아사망확률을 추정하였고, 93년은 93년 보건 복지부 조사의 영아사망확률을 사용하였으며, 95년과 97년에 대해서는 93년과 96년 보건복지부 조사에 나타난 영아사망확률 감소율을 적용하였다. 영아사망확률은 Coale-Demeny North Model 을 활용하여 영아사망률로 전환하였다. 통계청이 수집한 98년 화장장 자료로 영아사망 미신고를 보완하여 영아사망률을 추정해 본 결과 화장장 자료는 영아사망수준 추정을 위한 중요한 자료원이 될 뿐만 아니라 신생아사망을 크게 보완하고, 태아사망 및 주산기사망 통계 생산도 가능한 것으로 나타났다.