• Journal of Photoscience
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• 제9권2호
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• pp.240-242
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• 2002

In Drosophila melanogaster, it is known that the circadian clock consists of an autoregulatory feedback loop, which includes so-called clock genes, such as per, tim, dClk and cyc and produces periodical expression of per. It is recently suggested, however, that the circadian oscillation without the rhythmical expression of per is involved in the regulation of circadian locomotor rhythms. In the present study, we examined the existence and the property of the possible per-less oscillation using arrhythmic clock mutant flies carrying per$^{01}$, tim$^{01}$, dClk$^{Jrk}$ or cyc$^{01}$. When temperature cycles consisting of 25$^{\circ}$Ｃ and 30$^{\circ}$Ｃ with varying periods (T = 8~32 hr) were given, they showed rhythms synchronizing with the given cycle under constant darkness (DD). per$^{01}$ and tim$^{01}$ flies always showed a peak around 7 hr after the onset of thermophase irrespective of Ts of temperature cycles, while dClk$^{Jrk}$ and cyc$^{01}$ flies did not. In addition, several days were necessary to establish a clear temperature entrainment in per$^{01}$ and tim$^{01}$ flies, when they were transferred from a constant temperature to a temperature cycle under DD. These results suggest that per$^{01}$ and tim$^{01}$ flies have a temperature-entrainable weak oscillatory mechanism. The fact that dClk$^{Jrk}$ and cyc$^{01}$ flies did not show any sign of the endogenous oscillation suggests that the per-less oscillatory mechanism may require CLK and CYC.

• 한국태양에너지학회 논문집
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• 제23권1호
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• pp.1-8
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• 2003

Various efforts to combine new high-tech materials with solar system have been progressed nowadays in order to improve the performance of the existing passive solar system. TIM(Transparent Insulation Material) replacing the conventional outer building envelope glazing as well as the wall is good example for this trend. TI integrated wall is a thermal mass wall with a special shaped TIM instead of using typical envelope materials The tested TIM type is a small(diameter 4mm and thickness 50mm) capillary tube of Okalux model and cement brick(density 1500kg/m3). The purpose of this study was to analyze the thermal performance through the actual measurements performed in a test cell. This study was carried out to justify the following issues. 1) the impact of Tl-wall over the temperature variations 2) the impact of mass wall surface absorptance over the transient thermal behavior and 3) the impact of thermal mass wall thickness over the temperature variations. Finally, as results indicated that the peak time of room temperature was shifted about one hour early when absorptance of thermal mass wall changed from 60% to 95% for the 190mm thickness thermal mass wall test case. the temperature difference of both surfaces of thermal mass wall surface showed about $23^{\circ}C$ during a day of March for the 380mm thickness thermal mass wall case. However, the thermal mass wall was over-heated by outside temperature and solar radiation in a day of May the temperature difference of both surfaces of thermal mass wall surface was indicated $10^{\circ}C$ and inside temperature was observed more than average 22C.

• 전력전자학회논문지
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• 제14권5호
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• pp.415-422
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• 2009

본 논문은 기존의 시스템에 비해 시스템의 전력회로 구조의 큰 변경 없이 밧데리와 같은 전력저장 장치 디바이스의 추가와 개선된 운용방법을 적용한 첨두부하 삭감효과를 갖는 계통연계형 태양광발전시스템(UIPV)을 제안하였다. 개선된 운용방법과 에너지 저장장치의 추가로 기존 시스템에 비해 PV-array 용량을 작게 설치하여도 첨두부하 삭감효과를 크게 할 수 있으며, 가격 및 설치공간 등의 면에서 평가하여 기존시스템보다 더 나아짐을 확인하였다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제23권6호
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• pp.539-547
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• 2020

Purpose: Pediatric acute liver failure (PALF) is a serious condition; however, data on PALF in developing countries are sparse, particularly concerning molecular diagnosis and liver transplantation (LT). This study aimed to determine the causes, outcomes, and prognostic factors of PALF. Methods: We retrospectively reviewed the medical records of children (age <15 years) with PALF diagnosed using the American Association for the Study of Liver Diseases criteria at our center from 2011 to 2016. The collected data included laboratory results, complications, outcomes, and potential factors associated with death and LT. Results: We included a total of 27 patients, with a median age of 2 years (interquartile range, 3 months to 4 years). Viral infection was the most common etiology (n=8, 30%), predominantly dengue infection (n=4). A total of 16 patients (59%) died and 11 patients survived (3 patients with LT). The prognostic factors associated with death or LT requirement were grade IV hepatic encephalopathy (p<0.01), hypotension (p=0.02), gastrointestinal bleeding (p=0.03), increased intracranial pressure (p=0.04), and higher peak serum lactate level (p=0.01). Peak serum lactate ≥6 mmoL/L had a sensitivity of 79% and a specificity of 88% for predicting mortality or the necessity of LT. Conclusion: Viral infection was the most common cause of PALF. The mortality rate remained high, and a considerable number of patients required LT. In addition to several clinical factors, peak serum lactate could be a potential marker for predicting poor outcomes in PALF.

• Parasites, Hosts and Diseases
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• 제60권5호
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• pp.345-352
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• 2022

Chitinase AO-801 is a hydrolase secreted by Arthrobotrys oligospora during nematode feeding, while its role remained elusive. This study analyzed the molecular characteristics of recombinant chitinase of Arthrobotrys oligospora (reAO-801). AO-801 belongs to the typical glycoside hydrolase 18 family with conserved chitinase sequence and tertiary structure of (α/β)₈ triose-phosphate isomerase (TIM) barrel. The molecular weight of reAO-801 was 42 kDa. reAO-801 effectively degraded colloidal and powdered chitin, egg lysate, and stage I larval lysate of Caenorhabditis elegans. The activity of reAO-801 reached its peak at 40℃ and pH values between 4-7. Enzyme activity was inhibited by Zn2⁺, Ca2⁺, and Fe3⁺, whereas Mg2⁺ and K⁺ potentiated its activity. In addition, urea, sodium dodecyl sulfate, and 2-mercaptoethanol significantly inhibited enzyme activity. reAO-801 showed complete nematicidal activity against C. elegans stage I larvae. reAO-801 broke down the C. elegans egg shells, causing them to die or die prematurely by hatching the eggs. It also invoked degradation of Haemonchus contortus eggs, resulting in apparent changes in the morphological structure. This study demonstrated the cytotoxic effect of reAO-801, which laid the foundation for further dissecting the mechanism of nematode infestation by A. oligospora.

• 대한방사선기술학회지:방사선기술과학
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• 제39권1호
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• pp.51-57
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• 2016

뇌 자기공명영상(Magnetic Resornance Imaging; MRI)에서 검사 중 발생되는 소음을 줄이기 위한 기법으로 경사 파형을 변경한 Quiet $T_2$-weighted Turbo Spin-Echo(이하 Q-$T_2$)와 일반적으로 사용되는 $T_2$-weighted Turbo Spin-Echo(이하 $T_2$) 영상의 소음수준 및 영상의 질을 비교하여 그 유용성을 알아보고자 하였다. 3.0T MR 기기로 뇌 MR 검사를 받은 60명(남자 29명, 여자 31명, 평균 연령 60.1세)의 환자를 대상으로 하였다. Q-$T_2$와 $T_2$ 각각의 영상에서 소음 및 심박동수를 측정하였다. 정량적 분석은 Q-$T_2$와 $T_2$의 SNR, CNR, SIR 값을 측정한 뒤 독립표본 T검정을 이용하여 통계적 분석을 하였다. 정성적 분석은 Q-$T_2$와 $T_2$의 전체적인 영상의 질에 대하여 육안으로 평가하였다. 평가는 5점 척도로서 우수(excellent) 5점, 양호(good) 4점, 보통(fair) 3점, 불량(poor) 2점, 평가불가(unacceptable) 1점으로 평가하였다. Q-$T_2$와 $T_2$ 검사 중 평균소음과 peak소음은 Q-$T_2$가 기존 $T_2$에 비해 각각 $15dB_A$, $10dB_A$ 감소하였다. 또한 각각의 검사 중 120초 동안 심박동수의 평균값은 Q-$T_2$에서 더 낮은 값으로 나타났지만 통계적인 유의성은 없었다. 정량적 분석의 결과 CNR과 SIR은 유의한 차이가 없었으며, SNR은 Q-$T_2$가 더 낮은 평균값을 보임으로서 유의한 차이를 보였다(p<0.05). 정성적 분석은 59개의 Q-$T_2$와 $T_2$ 영상의 질이 동일하게 우수(excellent) 5점으로 평가되었으며, 1개의 영상에서 모션 아티팩트로 인해 양호(good) 4점으로 평가되었다. Q-$T_2$는 기존의 $T_2$와 같이 검사시간 및 진단의 정확도는 동일하지만 소음을 효과적으로 감소시킬 수 있으며, 이로인하여 환자 편의를 향상시킬 수 있을 것으로 사료된다.