• International journal of steel structures
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• v.18 no.4
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• pp.1191-1199
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• 2018

Concepts of submerged floating tunnels (SFTs) for land connection have been continuously suggested and developed by several researchers and institutes. To maintain their predefined positions under various dynamic environmental loading conditions, the submerged floating tunnels should be effectively moored by reasonable mooring systems. With rational mooring systems, the design of SFTs should be confirmed to satisfy the structural safety, fatigue, and operability design criteria related to tunnel motion, internal forces, structural stresses, and the fatigue life of the main structural members. This paper presents a feasibility study of a submerged floating tunnel moored by an inclined tendon system. The basic structural concept was developed based on the concept of conventional cable-stayed bridges to minimize the seabed excavation, penetration, and anchoring work by applying tower-inclined tendon systems instead of conventional tendons with individual seabed anchors. To evaluate the structural performance of the new type of SFT, a hydrodynamic analysis was performed in the time domain using the commercial nonlinear finite element code ABAQUS-AQUA. For the main dynamic environmental loading condition, an irregular wave load was examined. A JONSWAP wave spectrum was used to generate a time-series wave-induced hydrodynamic load considering the specific significant wave height and peak period for predetermined wave conditions. By performing a time-domain hydrodynamic analysis on the submerged floating structure under irregular waves, the motional characteristics, structural stresses, and fatigue damage of the floating tunnel and mooring members were analyzed to evaluate the structural safety and fatigue performance. According to the analytical study, the suggested conceptual model for SFTs shows very good hydrodynamic structural performance. It can be concluded that the concept can be considered as a reasonable structural type of SFT.

• Journal of Digital Convergence
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• v.19 no.6
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• pp.343-353
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• 2021

The beauty industry of China POP-UP store service, has entered the peak development period. This paper takes China Estee Lauder POP-UP store as an example, based on the user experience of interactive marketing mode in Beauty POP-UP store under the new retailing model. The paper aims to establish a system interaction design process integrating online and offline to help enterprises complete the sustainable development of marketing services. To achieve this goal, this study uses questionnaires to investigate the key elements of user experience, customer journey map to determine the user pain points, and completes the design of the new system process. This process can provide designers with a new perspective through experimental verification, with high timeliness and practicability. It also promotes the collaborative optimisation and upgrading of physical retail and online retail and provides theoretical support and practical basis for other enterprises.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.54 no.3
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• pp.329-339
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• 2021

The monthly variation in species composition of fishes in the Gujora and Mangchi coastal waters in Geoje, Korea, was investigated between June 2018 and May 2019 through monthly fish collections using a gill net. A total of 46 species, numbering 410 individuals weighing a total of 96,645.0 g, were collected during the study period. The dominant species in terms of numbers were Chelidonichthys spinosus, Stephanolepis cirrhifer, Ditrema temmincki, Sillago japonica, Sebastes inermis, and Paraplagusia japonica. The number and biomass of fishes peaked in July. The peak in species diversity indices occurred in September. The cluster analysis revealed that there were four groups of fishes depending on the season. In addition, subtropical fishes were recorded in the study area, indicating the gradual subtropicalization of the coast of Geoje. Furthermore, the need to understand the changes in marine ecosystems owing to subtropicalization through continuous monitoring is emphasized.

• Journal of Genetic Medicine
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• v.17 no.2
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• pp.73-78
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• 2020

Purpose: Congenital myasthenic syndrome (CMS) is a clinically and genetically heterogeneous group of disorders characterized by impaired neuromuscular transmission. This study aims to provide the clue for early diagnosis and improved therapeutic strategies in CMS. Materials and Methods: Through the targeted panel sequencing including twenty CMS causative genes, eleven patients were genetically confirmed and enrolled in this study. A retrospective medical record review was carried out for the clinical and laboratory data analysis. Results: The age of patients ranged from 5 to 23 years, with the median age of 16 years. The peak age at onset of symptoms was the neonatal period. Seven out of the eleven patients were symptomatic at birth. The most commonly reported initial finding was generalized hypotonia with poor sucking and crying. Mean time to accurate diagnosis was 9.3±5.0 years. Total fifteen different variants in seven genes associated with CMS (DOK7, AGRN, RAPSN, CHRNE, COLQ, SLC5A7, and GFPT1) were identified. Conclusion: We describe the clinical and genetic characteristics of CMS patients and treatment outcome in a single tertiary center. High clinical suspicion and timely molecular diagnosis is particularly important for the tailored therapy to maximize clinical improvement in CMS.

• Journal of Ocean Engineering and Technology
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• v.35 no.4
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• pp.273-286
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• 2021

In recent years, as human casualties and property damage caused by hazardous waves have increased in the East Sea, precise wave prediction skills have become necessary. In this study, the Simulating WAves Nearshore (SWAN) third-generation numerical wave model was calibrated and optimized to enhance the accuracy of winter storm wave prediction in the East Sea. We used Source Term 6 (ST6) and physical observations from a large-scale experiment conducted in Australia and compared its results to Komen's formula, a default in SWAN. As input wind data, we used Korean Meteorological Agency's (KMA's) operational meteorological model called Regional Data Assimilation and Prediction System (RDAPS), the European Centre for Medium Range Weather Forecasts' newest 5th generation re-analysis data (ERA5), and Japanese Meteorological Agency's (JMA's) meso-scale forecasting data. We analyzed the accuracy of each model's results by comparing them to observation data. For quantitative analysis and assessment, the observed wave data for 6 locations from KMA and Korea Hydrographic and Oceanographic Agency (KHOA) were used, and statistical analysis was conducted to assess model accuracy. As a result, ST6 models had a smaller root mean square error and higher correlation coefficient than the default model in significant wave height prediction. However, for peak wave period simulation, the results were incoherent among each model and location. In simulations with different wind data, the simulation using ERA5 for input wind datashowed the most accurate results overall but underestimated the wave height in predicting high wave events compared to the simulation using RDAPS and JMA meso-scale model. In addition, it showed that the spatial resolution of wind plays a more significant role in predicting high wave events. Nevertheless, the numerical model optimized in this study highlighted some limitations in predicting high waves that rise rapidly in time caused by meteorological events. This suggests that further research is necessary to enhance the accuracy of wave prediction in various climate conditions, such as extreme weather.

• The Korean Journal of Pain
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• v.35 no.1
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• pp.14-21
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• 2022

The coronavirus disease 2019 (COVID-19) pandemic, which has been rampant since the end of 2019, has evidently affected pain management in clinical practice. Fortunately, a COVID-19 vaccination program is currently in progress worldwide. There is an ongoing discussion that pain management using steroid injections can decrease COVID-19 vaccine efficacy, although currently there is no direct evidence to support this statement. As such, the feeling of pain in patients is doubled in addition to the co-existing ill-effects of social isolation associated with the pandemic. Thus, in the COVID-19 era, it has become necessary that physicians be able to provide high quality pain management without negatively impacting COVID-19 vaccine efficacy. Steroids can alter the entire process involved in the generation of adaptive immunity after vaccination. The period of hypophysis-pituitary-adrenal axis suppression is known to be 1 to 4 weeks after steroid injection, and although the exact timing for peak efficacy of COVID-19 vaccines is slightly different for each vaccine, the average is approximately 2 weeks. It is suggested to avoid steroid injections for a total of 4 weeks (1 week before and after the two vaccine doses) for the double-shot vaccines, and for 2 weeks in total (1 week before and after vaccination) for a single-shot vaccine. This review focuses on the basic concepts of the various COVID-19 vaccines, the effect of steroid injections on vaccine efficacy, and suggestions regarding an appropriate interval between the administration of steroid injections and the COVID-19 vaccine.

• Journal of the Earthquake Engineering Society of Korea
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• v.26 no.3
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• pp.105-116
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• 2022

Seismic demand on nonstructural components (NSCs) is highly dependent on the coupled behavior of a combined supporting structure-NSC system. Because of the inherent complexities of the problem, many of the affecting factors are inevitably neglected or simplified based on engineering judgments in current seismic design codes. However, a systematic analysis of the key affecting factors should establish reasonable seismic design provisions for NSCs. In this study, an idealized 2-DOF model simulating the coupled structure-NSC system was constructed to analyze the parameters that affect the response of NSCs comprehensively. The analyses were conducted to evaluate the effects of structure-NSC mass ratio, structure, and NSC nonlinearities on the peak component acceleration. Also, the appropriateness of component ductility factor (R_p) given by current codes was discussed based on the required ductility capacity of NSCs. It was observed that the responses of NSCs on the coupled system were significantly affected by the mass ratio, resulting in lower accelerations than the floor spectrum-based response, which neglected the interaction effects. Also, the component amplification factor (a_p) in current provisions tended to underestimate the dynamic amplification of NSCs with a mass ratio of less than 15%. The nonlinearity of NSCs decreased the component responses. In some cases, the code-specified R_p caused nonlinear deformation far beyond the ductility capacity of NSCs, and a practically unacceptable level of ductility was required for short-period NSCs to achieve the assigned amount of response reduction.

• Structural Engineering and Mechanics
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• v.83 no.2
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• pp.153-166
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• 2022

Structural pounding due to strong seismic excitations can result in severe damage or even collapse of colliding structures. Many researchers focused on studying the mutual pounding between two adjacent structures while very few researches were concerned with the pounding of a series of structures. This paper aims to study the pounding effect on a series of four buildings having different natural frequencies. The paper also investigates the effect of different arrangements of the four buildings on their pounding response. For this, a mathematical model was constructed using Matlab code where, pounding was modeled using a contact force-based approach. A Non-Linear viscoelastic (Hertzdamp) contact element was used and activated only during the approach period of collision. The mathematical model was validated by comparing its prediction versus experimental results on three adjacent buildings. Then the model was used to study the pounding between four adjacent structures arranged in different sequences according to their natural frequencies. The results revealed that increasing the gap distance generally led to decrease the peak responses of the towers. Such response is somehow different from that predicted earlier by the authors for the case of three adjacent buildings. Moreover, the arrangement of towers has a significant effect on their pounding response. Significant difference between the natural frequencies of adjacent structures increases the pounding forces especially when the more flexible buildings are located at the outer edge of the series. The study points out the need for further researches on buildings in series to gain a better understanding of such complex phenomena.

• Safety and Health at Work
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• v.11 no.4
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• pp.509-516
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• 2020

Background: Meta-analyses have shown firefighters to be at an increased risk of several cancer types. Occupational carcinogen exposure may explain these increased risks. This study aims to describe Norwegian fire departments' work conditions from 1950 until today, focusing on factors relevant for potential occupational carcinogen exposure. Methods: With the help of a reference group, we developed a questionnaire on topics related to occupational exposure to carcinogens for the period 1950-2018. Selected Norwegian fire departments provided department-specific responses. Results: Sixteen departments, providing fire services for 48% of the Norwegian population as of 2019 and mainly consisting of professional firefighters, responded to our questionnaire. The introduction of synthetic firefighting foams, more regular live fire training, the introduction of chemical diving, and a higher number of diesel-driven fire service vehicles were identified as changes thought to increase exposure to occupational carcinogens. Changes thought to decrease exposure included the switch from negative to positive pressure self-contained breathing apparatuses, the use of self-contained breathing apparatuses during all phases of firefighting, the use of ventilating fans during firefighting, increased attention to flammable materials used during live fire training, increased attention to handling and cleaning of turnout gear and other equipment, and installment of exhaust removal systems in apparatus bays. Conclusion: Norwegian fire departments' work conditions have seen several changes since 1950, and this could influence firefighters' occupational carcinogen exposure. A peak of carcinogen exposure may have occurred in the 1970s and 1980s before recent changes have reduced exposure.

• Journal of the Korean Society of Food Culture
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• v.37 no.6
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• pp.519-528
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• 2022

The Cheonggukjang used in this study was made with four soybean cultivars grown and harvested at the National Agrobiodiversity Center of the National Academy of Agricultural Sciences: C1 (KLS87248), C2 (Nongrim 51), C3 (GNU-2007-14613), and C4 (Daewon). The soybeans were inoculated with Bacillus subtilis AFY-2 and fermented for 0, 12, 21, 36, 45, and 60 h in a culture room at 35℃. ABTS and DPPH radical scavenging activities were significantly increased upon fermentation for 12 hours in all samples and maintained or decreased after 21 hour The inhibition of NO production was significantly increased compared to the LPS-treated group, and the C2 sample showed inhibition of NO production at 12 hours of fermentation, and the C3 sample showed inhibition at 21 hours of fermentation. PCA analysis revealed that the ABTS and DPPH radical scavenging activity and NO production inhibitory activity reached peak levels around 12 h fermentation time for all samples. Our results indicate that the optimal fermentation time of the Cheonggukjang sample is 12 hours, confirming the high correlation of all experiments.