• Asian Journal of Atmospheric Environment
• /
• 제2권1호
• /
• pp.47-53
• /
• 2008

In this study, we analyzed how ozone pollution could be differently measured and how these different measures varied year to year and across the ten most populated cities in the United States, from 1980 to 2000. Although peak values of ozone concentration have been significantly reduced in most polluted U.S. cities for the last 20 years, the annual average values of ozone concentration have not been lowered as much as peak values. Ozone concentration data for each city shows a unique pattern of distribution, central tendency, and also there is a wide variation among different ozone measures. Two different cities with the same annual mean concentration of ozone can experience very different distributions of ozone concentration within a year. Ozone measures also show a wide margin of variability as they are estimated from different ozone monitoring sites within each city. Ozone pollution statistics can be largely varied depending on the choice of measures, monitoring sites, and averaging time period. EPA's new ozone standard of 0.08 ppm averaged over an eight-hour appears to be more stringent than the current maximum ozone standard of 0.12 ppm averaged over one hour.

• Journal of Pharmaceutical Investigation
• /
• 제33권1호
• /
• pp.51-53
• /
• 2003

This study was conducted to compare the bioavailability of a generic product of Sinil Atenolol Tablets (Sinil Pharmaceutical Co., Ltd., Korea) with the innovator product, $Tenormin^{\circledR}$ Tablets in 20 healthy Korean volunteers. The volunteers received a single 50 mg dose of each atenolol formulation according to a randomized, two-way crossover design. Plasma samples were obtained over a 24-hour interval, and atenolol concentrations were determined by HPLC with a fluorescence detector. From the plasma atenolol concentration vs time curves, the following parameters were compared: area under the plasma concentration-time curve (AUC), peak plasma concentration $(C_{max})$, time to reach peak plasma concentration $(T_{max})$, and terminal first order elimination half-life $(t_{1/2})$. No statistically significant difference was obtained between the $T_{max}$ values, and the logarithmic transformed AUC and $C_{max}$ values of the two products. The 90% confidence for the ratio of the logarithmically transformed AUC and $C_{max}$ values of Sinil Atenolol Tablets over those of $Tenormin^{\circledR}$ Tablets were calculated to be between 0.99 and 1.07, and 1.04 and 1.16, respectively; both were within the bioequivalence limit of 0.80-1.25. The mean of $T_{max}$ in $Tenormin^{\circledR}$ Tablet group was 3.68 hour, and that in Sinil Atenolol Tablet group was 3.65 hour. The values of $t_{1/2}$ between the two products were found comparable, and the mean $t_{1/2}$ values of $Tenormin^{\circledR}$ Tablets and Sinil Atenolol Tablets were 5.9 and 6.0 hour, respectively. Based on these results, it was concluded that Sinil Atenolol Tablets were comparable to $Tenormin^{\circledR}$ Tablets in both the rate and extent of absorption, indicating that Sinil Atenolol Tablets were bioequivalent to the reference product, $Tenormin^{\circledR}$ Tablets

• Biomolecules & Therapeutics
• /
• 제15권3호
• /
• pp.187-191
• /
• 2007

This study was conducted to compare the bioavailability of two brands of atenolol (50 mg) tablets, which are a generic product of $Ditent^{\circledR}$ (Daewon Pharmaceutical Co., Ltd., Korea) and an innovator product $Tenormin^{\circledR}$ (Hyundai Pharm. Ind. Co., Ltd., Korea), in 20 healthy Korean male volunteers. The volunteers received a single 50 mg dose of each atenolol formulation according to a randomized, two-way cross-over design. The washout period between treatments was 1 week. Plasma samples were obtained over a 24-hour interval, and atenolol concentrations were determined by HPLC with a fluorescence detector. From the plasma atenolol concentration vs. time curves, the following parameters were compared: area under the plasma concentration-time curve ($AUC_{0-24}$), peak plasma concentration ($C_{max}$), time to reach peak plasma concentration ($T_{max}$), and terminal first order elimination half-life ($t_{1/2}$). No statistically significant difference was obtained between the $T_{max}$ values, and the logarithmic transformed $AUC_{0-24}$ and $C_{max}$ values of the two products. The 90% confidence interval for the ratio of the logarithmically transformed AUC and $C_{max}$ values of $Ditent^{\circledR}$ over those of $Tenormin^{\circledR}$ were calculated to be between 0.85 and 1.04, and 0.89 and 1.07, respectively; both were within the bioequivalence limit of 0.80-1.25. The mean of $T_{max}$ in $Tenormin^{\circledR}$ group was 3.1 hour, and that in Ditent$^{\circledR}$ group was 3.2 hour. The values of $t_{1/2}$ between the two products were found comparable, and the mean values were 5.2 hour in the both products. Based on these results, it was concluded that $Ditent^{\circledR}$ was comparable to $Tenormin^{\circledR}$ in both the rate and extent of absorption, indicating that $Ditent^{\circledR}$ was bioequivalent to the reference product, $Tenormin^{\circledR}$.

• Asian Journal of Atmospheric Environment
• /
• 제7권2호
• /
• pp.114-119
• /
• 2013

The characteristics of Asian dust (AD) in Korea between 1997 and 2005 were investigated, focusing on peak 1-hour $PM_{10}$ concentrations during AD events at seven cities over the Korean Peninsula. The frequency of AD events decreased from Seoul to Busan, indicating the major pathway of AD in Korea was from northwest to southeast. AD events were most frequent in 2001 while peak concentrations during AD events were much higher in 2002. Recent works show that the trajectories from northerly directions increased during the 2000s and later (Chun, 2009; Kim, 2008). In this work, the fraction of trajectories from the northwest was the largest on the whole, although trajectories from each direction varied by city and year. It is presumed that high concentrations of $PM_{10}$ during AD events are generally associated with trajectories from the northwest rather than from the source region.

• Journal of Forest and Environmental Science
• /
• 제10권1호
• /
• pp.57-65
• /
• 1994

본(本) 연구(硏究)는 강원대학교(江原大學校) 임과대학(林科大學) 부속연습림(附屬演習林)의 임도개설유역(林道開設流域)을 중심으로 우기(雨期)의 계류수(溪流水)에 함유되어 있는 부유토사량(浮遊土砂量)을 측정하므로써 임도개설(林道開設)에 따른 토사유출(土砂流出) 변화(變化)를 파악하고자 진행하였다. 이를 위해 임도개설유역(林道開設流域)의 강우량(降雨量)과 유출량(流出量), 유출량(流出量)과 부유토사량(浮遊土砂量)의 관계를 규명하였으며, 아울러 임도개설유역(林道開設流域)과 미개설유역(未開設流域)의 강우량(降雨量)에 따른 부유토사량(浮遊土砂量)의 변화에 대하여 비교, 분석하였다. 1. 임도개설유역(林道開設流域)에 있어서 우기(雨期)의 강우량(降雨量)과 유출량(流出量)의 관계는 Table 3 및 Fig. 3와 같이 수문곡선(水文曲線)의 Peakpoint는 강우강도(降雨强度) 및 전강우량(前降雨量) 등에 따라 형성시간(形成時間)과 높이가 상이하였다. 즉 6월(月)12일(日)의 강우(降雨)(a)(20mm이상이 4시간 지속)에서는 3시간 경과 후에 $1514m^3/hour$, 8월(月) 8일(日)의 강우(降雨)(b)(최대(最大) 시우량(時雨量) 40mm)경우는 동일(同一) 시간대(時間帶)에서 $1246m^3/hour$, 그리고 8월(月) 20일(日)의 강우(降雨)(c)(최대(最大) 시우량(時雨量) 17.2mm)의 경우는 2시간 경과 후에 $1245m^3/hour$의 Peak point가 형성되었다. 2. 임도개설유역(林道開設流域)에서 유출량(流出量)과 부유토사량(浮遊土砂量)의 관계는 유출량(流出量)에 비례하여 부유토사량(浮遊土砂量)도 증가하였다(Table 4 및 Fig. 4). 즉 강우(降雨)(a)는 최대유출량(最大流出量)이 $1514m^3/hour$일 때 부유토사량(浮遊土砂量) 1261mg/l가 1시간 후에 나타났고, 강우(降雨)(b) 및 (c)는 각각 최대유출량(最大流出量) $1246m^3/hour$과 $1245m^3/hour$일 때 최대부유토사량(最大浮遊土砂量) 4952mg/l와 472mg/l가 동일시간대(同一時間帶)에서 나타났다. 3. 강우중(降雨中)의 부유토사량(浮遊土砂量)의 농도(濃度)는 강우강도(降雨强度)에 강하게 영향받고 있으며, 특히 강우강도(降雨强度)가 강할수록 곡선회귀(曲線回歸)의 형태(形態)로 증가하였다. 임도개설유역(林道開設流域)에서의 부유토사농도(浮遊土砂濃度)의 Peak point는 강우(降雨)(a)의 경우 1261mg/l와 125mg/l, 강우(降雨)(b)는 4952mg/l와 44mg/l, 그리고 강우(降雨)(c)는 472mg/l와 4mg/l로서 유역간(流域間)에 현격한 차이가 나타났다.

• Asian-Australasian Journal of Animal Sciences
• /
• 제9권6호
• /
• pp.711-714
• /
• 1996

The present study investigated the hypophysial responsiveness in terms of GnRH induced LH and FSH release in cycling buffalo during the tropical summer and winter climatic conditions (seasons). Peripheral plasma LH and FSH levels were measured at 1 hour before and 6 hours subsequent to the administration of GnRH (1 ug/kg body weight) or saline on Day 14 of oestrous cycle in 2 groups of buffalo (n = 6 each) during summer and winter seasons. Although GnRH induced LH peak concentrations did not differ during the two seasons, time to attain LH peak concentration was shorter (p < 0.05) and the area under LH peak was 39% higher (p < 0.05) during winter season in comparison to summer season. However, season had no effect on GnRH induced peak FSH concentration, time to attain peak FSH concentration and the area under FSH peak. Pretreatment basal LH and FSH levels did not differ during the two seasons. The present study suggests that the summer season adversely affects the GnRH stimulated release of LH in buffalo.

• 한국대기환경학회지
• /
• 제12권1호
• /
• pp.55-66
• /
• 1996

One-hour average concentrations of ground-level ozone from around 80 monitoring stations in Korea during 1991 to 1993 were analyzed to examine characteristics of the ozone concentration variations. Two types of variations were observed: one was for the Capital area typified by Kwanghwmun, and the other was for the south and east seashore region typified by Tongkwangyang. In the Capital area including Seoul, Inchon, Kyonggi-do and Chunchon, mean daily 1-hout maximum was the highest in June following high monthly averages in spring. But frequent precipitation prevented further rise of daily maximum in July and August even though there were frequent episodes of high concentration exceeding 100ppb. In the south and east seashore region, average concentration was the highest throughout the year, and daily maximum and minimum simultaneously changed owing to small contributions from photochemical reactions. The typical annual variation was spring peak, summer down, and fall rise. Spring peak accompanied an usual observations of background variations at remote sites in the Northern Hemisphere. Riess of average and daily maximum with lower daily minimum in fall were attributable to photochemical reactions.

• 한국환경과학회지
• /
• 제32권5호
• /
• pp.285-301
• /
• 2023

This study analyzed characteristics of ozone (O₃) formation regimes in Busan over a period of recent five years (2015~2019) and compared the findings with those obtained in Seoul. We employed four observed variations: early morning commuting-hour (i.e., 06:00-09:00 LST) nitrogen dioxide (NO₂), peak-hour (i.e., 12:00-16:00 LST) O₃, 8-hour average O₃ (MDA8 O₃), and △O₃ (=O_{3_max}- O_{3_min}) in Busan and Seoul. In addition, the NO₂-O₃ relation was assessed to interpret which of NOx-limited or volatile organic compound (VOC)-limited was dominant. In Busan, the annual mean O₃ concentration was relatively higher than in Seoul, whereas there were fewer high-concentration days. The Pearson correlation coefficients (R) between Early morning-hour NO₂ and the Peak-hour O₃ was positive (but close to zero) in Busan and negative in Seoul. Likewise, the R between the Early morning-hour NO₂ and the △O₃ showed a relatively considerable positive correlation (R=+0.4~0.5)(R=+0.4~0.5) in Busan, while a weak positive correlation (R=+0.1~0.2) in Seoul. From this result, it can be inferred that the O₃ formation regime in Busan was intrepreted to be nearly neutral or relatively closer to the NO_x-limited regime than Seoul, while Seoul to the VOC-limited regime. The study findings imply that O₃ control strategies should be applied differently in Busan and Seoul. The results here were inferred from surface NO₂ and O₃ observations, and the varification studies based on in-situ VOCs measurements would be needed.

• 약학회지
• /
• 제23권2호
• /
• pp.81-94
• /
• 1979

Rifampicin-polyvinylpyrrolidone coprecipitates were prepared by the solvent method to increase the solubility and dissolution rate, thereby improving absorption of rifampicin. It was found that the solubility and dissolution rate were greater with the 1 : 5 (w/w) coprecipitate than with the pure drug, physical mixtures or coprecipitates of any other ratio of the two components. The blood concentration data in non-fasted rats showed that the extent of absorption of rifampicin were significantly enhanced following the oral administration of the 1 : 5 coprecipitate; The area under the serum concentration curve (0-8hr) was 1.3 times greater with the 1 : 5 coprecipitate than with the pure drug. The blood concentration reached its peak (4. 38$\pm$1.36mcg/ml) within two hours in the case of oral administration of the 1 : 5 coprecipitate and, on the other hand, it reached the maximum (3.77$\pm$0.90mcg/ml) after four hours of oral administration of the pure drug. It was observed that there was no significant difference between the 1 : 5 coprecipitate and the pure drug in the extent and rate of absorption of rifampicin when fasted rats were used. When the 1 : 5 coprecipitate was orally administered to human subjects 20 minutes after meal, it was found that the blood concentration reached the maximum after one hour; in the case of the pure drug, it reached its peak after four hours.

• 한국습지학회지
• /
• 제11권2호
• /
• pp.47-54
• /
• 2009

본 논문은 부산지역의 지역용도별 PM10(입경 10 ${\mu}m$미만의 크기를 가진 먼지입자) 농도의 특성을 고찰하기 위해 수행되었다. 미세먼지는 배출량, 지형조건 그리고 기상인자에 의해 영향을 받는다. 공업지역의 경우, 내륙인 감전동의 PM10농도는 여름철을 제외한 모든 계절에서 해안인 녹산동보다 높았으며, 1차 peak가 가을철과 겨울철에 명확하게 나타났다. 녹지지역인 경우, 내륙인 대저동의 PM10농도는 해안인 동삼동보다 모든 계절에서 높은 농도를 나타내었다. 상업지역의 경우, 내륙인 전포동에서 primary peak를 나타내는 시각이 계절에 따라 1 시간씩 지연되었으며, 해안인 광복동은 전포동보다 봄철에 높은 농도를 나타내었다. 주거지역의 경우, 내륙인 덕천동과 용수리에서 봄철에 고농도의 PM10(80~90 ${\mu}g/m^3$)이 6시간동안 지속되어 나타났다.