• Title/Summary/Keyword: Patient-tailored therapy

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Design of 3-Sectored Oxygen Chamber with Automatic Control Function based on Embedded System (임베디드시스템 기반 자동제어 기능의 삼단분리형 산소챔버 설계)

  • Cho, Myeon-gyun
    • Journal of Convergence for Information Technology
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    • v.8 no.3
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    • pp.71-77
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    • 2018
  • In this paper, considering the oxygen sensitivity and preference pattern of the patient, the profile of the oxygen therapy of the individual is specified. And, we design a three-compartment, single compartment oxygen chamber that automatically adjusts the oxygen pressure according to the specified profile. Hyperbaric oxygen therapy is a method of providing patients with 100% oxygen higher than atmospheric pressure for therapeutic purposes. However, there is a disadvantage that the ear pain is caused by the pressure difference depending on the individual. Based on the embedded system, the proposed system creates a patient-tailored oxygen therapy profile by DB of patient's preference patterns and treatment records of oxygen therapy. If only the patient's name is entered, the oxygen chamber system can adjust the oxygen pressure automatically according to the profile pattern to maximize the oxygen treatment effect.

High Frequency Circuit Design using Feedback Control with Body Load Fluctuation for Pain Relief Therapy (통증 완화 치료기용 인체 부하 변동에 따른 피드백 제어가 가능한 고주파 회로 설계)

  • Park, Chul-Won;Won, Chul-Hee
    • The Transactions of the Korean Institute of Electrical Engineers P
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    • v.62 no.1
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    • pp.45-49
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    • 2013
  • High frequency system has been used for the purpose of skin care and obesity treatment, by high-frequency energy is applied to the human body generates deep heat. Conventional high frequency system could not selection control by depending on the body load fluctuations. Such as burns and side effects have been reported by system instability and then therapeutic effect is insufficient. During treatment, objective information about the status of the patient was no. Because of treatment methods are subjective, and so tailored treatments were impossible. In this paper, high frequency medical system with sinusoidal frequency characteristics without distortion of the Push pull switching scheme for pain relief therapy was designed. And control circuit that was designed by feedback using the output changes according to the body-load fluctuation. Last, power circuit for efficient control the heat generated from the hardware was proposed.

Diagnostic and management challenge of concurrent tongue squamous cell carcinoma with an unknown parapharyngeal mass

  • Raymond Shupak;Roderick Kim;Jun Hyuk Huh
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.50 no.1
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    • pp.56-59
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    • 2024
  • There are very few case reports of the diagnosis and management of concurrent oral cavity and parapharyngeal space tumors. We present a case involving a 49-year-old female who presented with oral cavity squamous cell carcinoma confirmed by biopsy. Initial diagnostic workup revealed a concurrent parapharyngeal mass. Diagnostic studies and surgical therapy were tailored to account for both pathological entities. The patient was treated with a combination of surgery and adjuvant therapy. The surgical strategy was designed to address both lesions simultaneously. One year post-surgery, the patient had good response to therapy with no evidence of persistent or recurrent disease. This report discusses the outcome and treatment of a rare case of concurrent squamous cell carcinoma with a complicating parapharyngeal space tumor. It explores the diagnostic process, comprehensive workup, and the surgical management.

Overview of chronic fatigue syndrome (만성 피로 증후군)

  • Sin, Ho-Cheol
    • Journal of Korea Association of Health Promotion
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    • v.3 no.1
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    • pp.97-109
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    • 2005
  • Chronic fatigue syndrome(CFS) is a complex, debilitating disorder characterized by at least 6 months of severe persistent of relapsing fatigue and a group of characteristic but nonspecific symptoms. Many researchers have proposed that CFS has a specific cause. However currently no evidence exists that proves either a specific cause of CFS. And there is no diagnostic test for CFS. The diagnosis of chronic fatigue syndrome is based on the patient's history, excluding other illnesses In the absence of consistent biological markers, the diagnosis of CFS arises from operational criteria that do not afford validity. The prognosis is poor and often disability and impairment of daily function and performance are prolonged. A limited understanding of the CFS has complicated the management of this disorder. Therefore, treatment of CFS may be variable and should be tailored to each patient. Therapy should include exercise, diet, good sleep hygiene, antidepressants, and other medications, depending on the patient's presentation. Regular follow-up is key to continue to exclude other medical problems and provide support for patients. Chronic fatigue syndrome is a challenging illness to manage and requires a team approach of caring providers. For the majority of patients this is a chronic illness with the goals of therapy being to improve functional status and to prevent disability. Further understanding of the etiology and pathogenesis of this illness should lead to better specific therapy.

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Patients' Knowledge and Medication Adherence to Adjuvant Hormonal Therapy for Breast Cancer Treatment (유방암 환자의 호르몬치료에 대한 지식과 약물복용이행에 관한 연구)

  • Jo, Yeong Mi;Kwon, In Gak
    • Journal of Korean Clinical Nursing Research
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    • v.21 no.2
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    • pp.234-242
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    • 2015
  • Purpose: The purpose of this study was to investigate the levels of knowledge and medication adherence to hormonal therapy (HT) and to identify the factors influencing medication adherence for patients with breast cancer. Methods: Data were collected from 136 patients undergoing adjuvant HT for breast cancer in 3 general hospitals from July 1 to August 14 in 2014 using self-report questionnaires. Data were analyzed using descriptive statistics, independent t-test, ANOVA, $Scheff{\grave{e}}$ test, and multiple regression. Results: The average of knowledge about HT was $5.15{\pm}2.22$ (Max 9), and that of medication adherence was $5.76{\pm}1.65$ (Max 8). Younger age, shorter duration of HT, more active participation in decision making for treatment, positive perception for impacts of HT, and stronger belief in cure were influencing factors on higher adherence level. Age, duration of HT, and perception on the impacts of hormonal therapy, and belief in cure explained 25.2% of the adherence. Conclusion: To improve the treatment adherence to hormonal therapy, patient education and involvement in decision making, and the tailored intervention for the patients with older age, and long treatment period of HT are needed. Additionally, the strategies for diminishing unintentional forgetting is necessary to be developed.

Surgical Management of Intracranial Aneurysms in the Endovascular Era : Review Article

  • Mason, Alexander M.;Cawley, C. Michael III;Barrow, Daniel L.
    • Journal of Korean Neurosurgical Society
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    • v.45 no.3
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    • pp.133-142
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    • 2009
  • The advent of endovascular therapy for intracranial aneurysms and the rapid advances in that field have supplanted microsurgical treatment for many intracranial aneurysms. Applying current outcome data and other parameters, nuances of selecting the modality of treatment for intracranial aneurysms are reviewed. Patient factors, such a age, co-morbidities, vasospasm and other medical conditions, are addressed. A custom-tailored multimodality treatment paradigm for the management of ruptured and unruptured aneurysms will maximize the favorable results seen in this difficult patient population.

Nursing Genetics in 'Postgenome' Era ('포스트 게놈' 시대에서 간호학의 과제)

  • ChoiKwon, S-Mi
    • Journal of Korean Biological Nursing Science
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    • v.7 no.1
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    • pp.5-14
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    • 2005
  • Since the Human Genome Project(HGP) has begun in the mid 1980s, the sequencing of the human genome has been finally completed in 2001. The knowledge developed from the HGP has revolutionized how health care professionals think about patient care, mandating a new paradigm of patient care in totally inconceivable ways from the past. For instance, the patients at risk for disease can be identified early enough for intervention; the medicine can be tailored for individual patients based on their own genetic information ; the gene therapy could be a common procedure in the near future. The advancement in genetics, therefore, requires the shift of paradigm not only in nursing education, practice, but also in nursing research. It is attempted, in this article to introduce briefly the basic knowledge of genetics, the pharmacogenomics, and the overview of national genetic research initiated and organized by the Center for Functional Analysis of Human Genome in Korea. The current state of nursing genetic knowledge and its implications on nursing education, practice, and research has examined. Furthermore, the visions and the opportunities for nursing science and practice to participate in this genetic revolution were also explored.

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Development of Drugs and Technology for Radiation Theragnosis

  • Jeong, Hwan-Jeong;Lee, Byung Chul;Ahn, Byeong-Cheol;Kang, Keon Wook
    • Nuclear Engineering and Technology
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    • v.48 no.3
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    • pp.597-607
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    • 2016
  • Personalized medicine is tailored medical treatment that targets the individual characteristics of each patient. Theragnosis, combining diagnosis and therapy, plays an important role in selecting appropriate patients. Noninvasive in vivo imaging can trace small molecules, antibodies, peptides, nanoparticles, and cells in the body. Recently, imaging methods have been able to reveal molecular events in cells and tissues. Molecular imaging is useful not only for clinical studies but also for developing new drugs and new treatment modalities. Preclinical and early clinical molecular imaging shows biodistribution, pharmacokinetics, mechanisms of action, and efficacy. When therapeutic materials are labeled using radioisotopes, nuclear imaging with positron emission tomography or gamma camera can be used to treat diseases and monitor therapy simultaneously. Such nuclear medicine technology is defined as radiation theragnosis. We review the current development of drugs and technology for radiation theragnosis using peptides, albumin, nanoparticles, and cells.

Radiologic Evaluation for Resectability of Pancreatic Adenocarcinoma (췌장 선암의 절제 가능성 평가)

  • Shin Hye Hwang;Mi-Suk Park
    • Journal of the Korean Society of Radiology
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    • v.82 no.2
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    • pp.315-334
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    • 2021
  • Imaging studies play an important role in the detection, diagnosis, assessment of resectability, staging, and determination of patient-tailored treatment options for pancreatic adenocarcinoma. Recently, for patients diagnosed with borderline resectable or locally advanced pancreatic cancers, it is recommended to consider curative-intent surgery following neoadjuvant or palliative therapy, if possible. This review covers how to interpret imaging tests and what to consider when assessing resectability, diagnosing distant metastasis, and re-assessing the resectability of pancreatic cancer after neoadjuvant or palliative therapy.

Antiepileptic Drugs in Children : Current Concept

  • Lee, Jeehun
    • Journal of Korean Neurosurgical Society
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    • v.62 no.3
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    • pp.296-301
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    • 2019
  • An epileptic seizure is defined as the transient occurrence of signs and/or symptoms due to abnormally excessive or synchronous neuronal activity in the brain. The type of seizure is defined by the mode of onset and termination, clinical manifestation, and by the abnormal enhanced synchrony. If seizures recur, that state is defined as epilepsy. Antiepileptic drugs (AEDs) are the mainstay of treatment. Knowledge about initiating and maintaining adequate AEDs is beneficial for the clinician who treats children with epilepsy. This article will delineate the general principles for selecting, introducing, and discontinuing AEDs and outline guidelines for monitoring adverse effects. In general, AED therapy following a first unprovoked seizure in children is not recommended. However, treatment should be considered after a second seizure. In children and adolescents, if they are seizure-free for at least 2 years, attempts to withdraw medication/s should be made, taking into account the risks vs. benefits for the individual patient. The decision on when and what AED to use should be tailored according to the patient. For optimal treatment, the selection of adequate AEDs can be achieved by considering the precise definition of the patient's seizure and epilepsy syndrome. Continuous monitoring of both therapeutic and adverse effects is critical for successful treatment with AEDs.