• Archives of Pharmacal Research
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• 제9권3호
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• pp.175-181
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• 1986

Four technical grade organophosphate pesticides (Fenitrothion, Fenthion, Dizninon and EPN) were investigated for their effects on the murine immune function. Among the immunotoxicological assay parameters of NIEHS, humoral immune parameter and pathotoxicological indicators were examined in this study. Subchronic exposure of rodents to these pesticides resulted in marked suppression of humoral immune function and moderate histological changes of lymphoid organ any significant alterations of clinical status.

• 한국식품위생안전성학회지
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• 제2권4호
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• pp.191-196
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• 1987

Erythrosine used as a colouring agent in drugs, cosmetics and foods in Korea, was examined for its effects on murine immune system and methemoglobin formation. As immunotoxicologic assay parameters, we adopted circulating leukocytes and immunoorgan weights for pathotoxicology, IgM plaque forming cells and arthus reaction for humoral immunity, delayed hypersensitivity reaction of cell mediated immunity and carbon clearacnce for macrophage function. Erythrosine's effects were observed as follows; 1. Ery throsine showed no significant effects on circulating leulocyte counts and relative immunoorgan weight. 2. Erythrosine diminished IgM plaque forming cells. 3. Erythrosine decreased arthus reaction, in the dose dependent manner. 4. Erythrosine had no significant effect on delayed hypersensitivity. 5. Phagocytic and corrected phagocytic index were not affected. 6. Methemoglobin content was similar in the test and control groups.

• 한국식품위생안전성학회지
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• 제7권2호
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• pp.91-97
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• 1992

Diazinon which is one of the most beavily used organophosphate pesticide in Korea, was examined for its effects on the murine host defense system. Immunotoxicological assay parameters adopted in this study were carbon clearance for macrophage function, susceptibility to tumor challenge, and pathotoxicological indicators, Subchronic exposure of pesticide to rodents resulted in the suppression of immune functions, enhancement of susceptibility to tumor challenge, and moderate histological changes of lymphoid organ without any significant alteration of clinical status.

• 한국식품위생안전성학회지
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• 제5권1호
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• pp.41-48
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• 1990

황산화제인 Propyl gallate가 in vivo에서 정상 웅성 마우스이 세포 면역기능에 미치는 영향에 관한 실험 결과, 1. Propyl gallate는 지연형과민증을 용량의존적으로 감소시켰다. 2. Phagocitic index와 corrected phagocytic index는 Propyl gallate의 영향을 볼수 없었다. 3. Propyl gallate는 혈중 백혈구 수를 용량의존적으로 감소시켰다.