• 경영과정보연구
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• 제35권3호
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• pp.195-212
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• 2016

이 연구는 1분 단위의 거래량가중평균가격(VWAP)을 이용하여 한국 유가증권시장에 상장된 기업을 대상으로 특허권 취득 공시의 초과수익률 및 누적초과수익률 및 이벤트 차익거래 전략을 이용하였을 경우의 실현수익률을 분석하였다. 이상의 연구목표에 대한 결과는 다음과 같다. 첫째, 연구결과 특허권 취득공시 후 1분 뒤 평균 0.92%의 누적초과수익률이 유의하게 발생하여 한국유가증권시장이 실시간으로 효율적인 준강형 시장임을 확인하였다. 또한 기업규모(size)에 따라 3개 패널로 분류하여 연구한 결과, 소형주의 초과수익률이 중형주보다 적어 한국유가증권시장에서 규모효과가 더 이상 존재하지 않는다는 최근의 자산가격결정모형과 관련한 연구결과를 부분적으로 지지하였다. 둘째, 공시 시점에 매입하는 이벤트 차익거래 전략의 실현수익은 마켓 메이킹 전략이 가장 우수한 실현수익률을 보였으며 시장가로 매수 매도하는 전략은 음(-)의 수익률을 실현하였다. 이와 같은 결과는 즉각적으로 시장가 매수주문을 하는 전략보다 시장가주문과 지정가주문의 유입률, 주문의 취소율과 같은 주문흐름(order flow)과 체결확률을 고려한 마켓 메이킹 전략을 병행할 때 실현수익률이 향상될 수 있음을 시사한다.

• 경영과정보연구
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• 제35권2호
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• pp.221-254
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• 2016

인구 고령화로 건강에 대한 관심이 증가함에 따라, 의료기기산업은 성장 가능성이 매우 높은 미래 먹거리 산업으로 부각되고 있다. 하지만, 국내 의료기기산업은 협소한 내수시장과 영세한 기업구조로 인해 해외 글로벌 기업에 비해 시장경쟁력이 부족한 실정이다. 이에 국내기업이 국제경쟁력을 확보하기 위한 의료기기의 핵심기술이 무엇인지 도출하고 이의 흐름에 대해 파악해야 할 필요성이 대두되고 있다. 본 연구의 목적은 특허 네트워크분석을 통해 의료기기분야에서의 핵심기술을 예측하는 것이다. 핵심기술이란 해당 기술 분야에서 많은 기술들과 연결되어 있는 기술로써 현재 또는 미래시장에서 경제적 가치를 창출할 수 있는 기술, 조직의 생존과 관련된 전략적 가치를 가진 기술, 해당 분야의 기술전개 과정에서 중심적 역할을 하는 기술을 의미한다. 실증분석을 위해, Jun(2012)이 제안한 방법론을 활용하여 특허 IPC코드 간의 공분산 및 상관계수 값으로 소셜네트워크분석을 실시하였다. 또한, 보건산업통계의 의료기기 산업데이터를 활용하여 도출된 핵심기술의 해당 의료기기 품목에 대한 생산액을 검토함으로써 연구방법론의 타당성을 확보하고자 하였다. 분석결과, 중분류별로 선정된 핵심기술과 관련된 품목이 국내 의료기기 생산액 상위 품목에 부합되는 결과를 도출하였다. 국가 R&D 방향이 기술사업화라는 측면에서 볼 때 의료기기 핵심기술을 파악함으로써 미래 먹거리 기술을 도출하고 이에 대한 R&D 개발전략에 도움을 줄 수 있을 것으로 판단된다.

• Clinical and Experimental Pediatrics
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• 제65권4호
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• pp.188-193
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• 2022

Background: Respiratory distress syndrome (RDS) is a common cause of hospitalization and death in preterm infants who require surfactant treatment and respiratory support. Purpose: This study aimed to compare the clinical outcomes of minimally invasive surfactant therapy (MIST) and the INtubation, SURfactant administration, and Extubation (INSURE) technique in preterm infants with RDS. Methods: In this clinical trial, 112 preterm infants born at 28-36 weeks of gestation and diagnosed with RDS randomly received 200-mg/kg surfactant by MIST or the INSURE method. In the MIST group, surfactant was administered using a thin catheter (5F feeding tube); in the INSURE group, surfactant was administered after intubation using a feeding tube and the tracheal tube was removed after positive pressure ventilation was started. Nasal continuous positive airway pressure was applied in both groups for respiratory support and the postprocedure clinical outcomes were compared. Results: The mean hospitalization time was shorter for infants in the MIST group than for those in the INSURE group (9.19±1.72 days vs. 10.21±2.15 days, P=0.006). Patent ductus arteriosus was less frequent in the MIST group (14.3% vs. 30.4%, P=0.041). Desaturation during surfactant administration occurred less commonly in the MIST group (19.6% vs. 39.3%, P=0.023). There were no significant intergroup differences in other early or late complications. Conclusion: These results suggest that surfactant administration using MIST could be a good replacement for INSURE in preterm infants with RDS since its use reduced the hospitalization time and the number of side effects.

• The Journal of Asian Finance, Economics and Business
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• 제6권3호
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• pp.141-149
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• 2019

The paper proposes a knowledge innovation performance model by the dynamic data envelopment analysis with slacks-based measure approach for evaluating the effectiveness of 30 regional knowledge innovation activities in China from 2010 to 2016. In recent years, China has paid more attention to knowledge innovation activities, as central and local governments have pushed on with their innovation projects by lots of investment whatever the difficulties may be. Decision-maker is usually interested in judge its knowledge innovation performance relative to target benchmark by exploring whether one provincial administration region performs better among others and/or if the growth of economy will be benefited greatly by the knowledge innovation activities. To acquire the managerial insight about this issue from a comprehensively designed performance evaluation model, knowledge innovation activity is conceptualized as an intertemporal production process. Invention patent and regional gross product are imposed on desirable outputs, highlighting the need for knowledge economy. The empirical result shows that knowledge innovation has a positive effect on economic development. At the same time, decision-maker should be interest in the economic effect of patents' type and quality. The government should then encourage new technical applications with greater commercial value from a market-oriented perspective, in order to benefit the most from the innovation process in the short-run.

• 대한안전경영과학회지
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• 제17권4호
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• pp.343-352
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• 2015

This study analyzes the business performance of research and development(R&D) and especially studies the effect of technology management activity and technology innovation competency on commercialization performance. According to previous studies, the technology management activity can be composed of technological innovativeness, analysis of market, R&D method, and appropriateness for commercialization plan. Also, the technology innovation can be divided into patent, R&D manpower, R&D investment ratio, production capability, and marketing capability. On the result of the analysis, all the components of technology management activity are positively related with commercialization performance. In case of technology innovation competency, however, only production and marketing capabilities have influence on the business performance. Especially, marketing capability controls the effect of technology management activities on the commercialization performance. Consequently, technology management is very important activity for SMEs to succeed commercialization and SMEs should collaborate with production and marketing departments from the early stage of R&D.

• 산업경영시스템학회지
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• 제44권3호
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• pp.192-206
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• 2021

The pharmaceutical industry is an industry that provides medicines related to the health and life of the people. The pharmaceutical industry is a traditional regulation industry with the characteristics of R&D(Research and Development), purchasing, manufacturing, distribution and consumption under strict government management. Until now, pharmaceutical companies have continued to make efforts to maintain competitiveness through patent management, new product development, and marketing. However, industries are rapidly changing, including rising costs for developing new products and expanding generic markets. As these changes and uncertainties in the management environment increase, efforts are required to improve the competitiveness of the pharmaceutical industry from a new perspective. In this study, we intend to examine the impact of SCM(Supply Chain Management) dynamic capability of pharmaceutical companies on corporate performance through partnerships to respond to market changes and uncertainties. It was determined that the agility, visibility and flexibility that constitutes the SCM dynamic capabilities would affect the performance of pharmaceutical companies. In this study, the importance of SCM dynamic capabilities and cooperative relationships was identified through surveys by SCM managers of pharmaceutical companies. Consequently, in the pharmaceutical industry, which is a regulatory industry, we have identified that SCM dynamic capabilities and cooperative relationships with partner companies have a significant impact on corporate performance.

• 한국임상약학회지
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• 제27권2호
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• pp.63-68
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• 2017

Neonates have large inter-individual variability in pharmacokinetic parameters of many drugs due to developmental differences. The aim of this study was to investigate the factors affecting the pharmacokinetic parameters of drugs, which are commonly used in critically ill neonates. Factors that reflect physiologic maturation such as gestational age, postnatal age, postconceptional age, birth weight, and current body weight were correlated with pharmacokinetic parameters in neonates, especially preterm infants. Comorbidity characteristics affecting pharmacokinetics in critically ill neonates were perinatal asphyxia, hypoxic ischemic encephalopathy, patent ductus arteriosus (PDA), and renal dysfunction. Administration of indomethacin or ibuprofen in neonates with PDA was associated with the reduced clearance of renally excreted drugs such as vancomycin and amikacin. Therapeutic hypothermia and extracoporeal membrane oxygenation were influencing factors on pharmacokinetic parameters in critically ill neonates. Dosing adjustment and careful monitoring according to the factors affecting pharmacokinetic variability is required for safe and effective pharmacotherapy in neonatal intensive care unit.

• Journal of Chest Surgery
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• 제8권1호
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• pp.69-74
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• 1975

Twenty-nine cases of ventricular septal defect operated in this department during the period from 1969 to May 1975 were presented. Out of 29 cases, there were 20 cases of type II defects, 8 cases of type I, and one case of type III, and the last case was multiple defect. The anomalies associated with ventricular septal defect were eight in all; three patent ductus arteriosus, one atrial septal defect, one tricuspid insufficiency and an aortic insufficiency. Over all mortality was 17%. The causes of death were complete heart block in a case, respiratory distress due to excessive administration of morphine in one, low cardiac output in two and perforation of the aortic annulus after repair of the ventricular septal defect associated with aortic insufficiency.

• Journal of Chest Surgery
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• 제34권8호
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• pp.634-639
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• 2001

중추성 항콜린성 증후군(Central Anticholinergic Syndrome)은 중추신경계에서 콜린성 신경전달 활성도의 감소로 인하여 다양한 임상 양상을 보이는 질환이다. 이 증후군은 주로 마취시에 사용되는 약제와 연관되며 Physostigmine의 투여 후 증상이 반전되는 것으로 확진된다. 저자들은 뇌혈관 질환의 원인으로 생각되는 난원공 개존증에 대해 개심술을 시행한 후 발생한 중추성 항콜린성 증후군을 Physostigmine의 투여로 확진한 1례에 대하여 보고하는 바이다.

• 동아시아경상학회지
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• 제6권4호
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• pp.47-57
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• 2018

Purpose - This paper aims to analyze the determinants of licensing behaviors of manufacturing firms empirically in non-advanced exporting countries. Research design and methodology - We try to approach licensing behavior from the perspective of innovation strategy and open innovation, and deal with two activities composing licensing, i.e. licensing-in and licensing-out using the result of Korean Innovation Survey Results - Firstly, Organizational characteristic factors, particularly the size and size related factors influence the firm behavior of licensing-out, but not in case of licensing-in. Secondly, innovation strategy influences the firm behavior of licensing-in, but not in case of licensing-out. Lastly, the determinants of licensing-in and that of licensing-out are different. Conclusions - In general, firms doing licensing-out have many complementary assets and orientation for global markets. Meanwhile, firms doing licensing-in are innovative firms utilizing patent as an appropriation mechanism. Licensing-out have relevance with product market-related factors and licensing-in have more relevance with technology market-related factors