• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.7 no.3
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• pp.104-109
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• 1998

This document is a experimental study on fatigue life of brace mounting weld joint. A brace is used to put sub-frame together on the main frame with high strength bolts. It has low fatigue life so a patch is in need for improving a fatigue characteristics of welded joint in brace mounting This paper presents the most pertinent patch size for truck. For this, a critical stress is computed at the point of fatigue crack occurred on truck frame by finite Element Analysis. Using by this critical stress. Designers are able to determin whether fatigue crack is occurred and are able to select a pertinent patch type. And then, with a selected patch type, structural joint stiffness was estimated to compare to the conventional and other patch type or brace mounting Finally, fatigue test were performed to prove a suitability of selected prototype compare with the conventional and other patch type or brace mounting.

• Journal of Pharmaceutical Investigation
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• v.29 no.4
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• pp.343-348
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• 1999

The purpose of this study is to prepare the controlled release adhesive patch containing naproxen. Pressuresensitive adhesive (PSA)-type patch was fabricated by casting of polyisobutylene (PIE.) and mineral oil in toluene. Membrane-controlled release (MCR)-type patch was prepared by the attachment of the controlled release membrane on the PSAtype patch. The membrane was mainly composed of Eudragit, polyethylene glycol(PEG) and glycerin. The drug release profile and skin permeation test with various patches were evaluated in vitro. The release of naproxen from PIE-based PSAtype patch with various loading doses fitted Higuchi's diffusion equation. However, the permeation of naproxen through hairless mouse skin from PSA-type patch followed zero-order kinetics. In MCR-type patch, thickness of controlled release membrane affected on the drug release rate highly. In the composition of membrane, the release rate was decreased as the ratio of Eudragit increased. The drug release from the MCR-type patch followed zero order kinetics. The permeation of naproxen through hairless mouse skin from MCR-type patch showed lag time for the intial release period and didn't fit the zero-order kinetics

• Journal of Pharmaceutical Investigation
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• v.25 no.1
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• pp.47-54
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• 1995

Transdermal patch formulations of estradiol to treat post-menopausal symptoms and prevent osteoporosis in women were developed and evaluated for the permeation characteristics through the excised hairless mouse abdorminal skin and the uterotropic effect on the ovariectomized rabbits. The design of patch formulations was optimized by varying several formulation parameters, such as type of enhancers, amount of enhancers, amount of drug loading and coating thickness. Compared to a commercially available transdermal product, several patch formulations showed the similar skin permeation profiles (following zero-order kinetics), but their skin permeation rates were lasted for the longer period (a week). In one-week uterotropic efficacy test in the ovariectimized rabbits, the selected patch formulations showed the positive effect in atrophy of the urogenital epithelium. The mean values of uterus weight in rabbits after application of patches containing estradiol were much higher than those in control group (containing no drug).

• Journal of the Korean Society of Safety
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• v.38 no.3
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• pp.20-26
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• 2023

Fiber-reinforced composite materials with carbon, glass, and aramid fibers are widely applied to industrial field structures due to their excellent properties. However, carbon fibers are vulnerable to external impacts, whereas aramid fibers degrade when exposed to water. This study evaluated carbon/aramid fiber composites degraded and damaged by high-temperature saline environments using acoustic emission (AE). The test specimen was molded using an autoclave and immersed in seawater at 70 ℃ for 224 days. In order to imitate the damage, a 3-mm-diameter hole was drilled using a diamond drill. Additionally, the specimen with the perforation was repaired by patch attachment processing. Three-point bending was used to conduct the flexural experiment, and an AE sensor with a 150-kHz resonance frequency was attached to evaluate the damage and the effect of patch attachment. AE accumulative counts obtained at the maximum load were 69.2, 67.1, and 91.2 for a high-temperature seawater deteriorated condition, a hole specimen, and a repaired patch specimen, respectively. Furthermore, the maximum amplitude of AE was detected at low values of 28 dB, 31.3 dB, and 30.3 dB.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2004.05a
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• pp.153-158
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• 2004

The coupling phenomenon between stress and magnetic induction, known as magnetostriction, has been successfully applied to generate and measure elastic waves. Most applications of this phenomenon thus far, however, are rather limited to cylindrical ferromagnetic waveguides. The main objective of this work is to develop a new patch-type, orientation-adjustable magnetostrictive transducer that is applicable for non-cylindrical, non-ferromagnetic waveguides. The existing patch-type transducer consisting of a ferromagnetic patch and a racetrack coil is useful to generate elastic waves only in one specific direction once the patch is bonded to a test specimen. However, the proposed transducer can transmit and receive elastic waves in any direction only with one patch at a given location. The proposed magnetostrictive transducer consists of a circular nickel patch, a figure-of-eight coil, and a couple of bias permanent magnets. Because of the unique configuration of the transducer, the propagating direction of the generated waves can be freely controlled since the set of bias magnets and the coil is not bonded to the magnetostrictive patch. In this work, the characteristics of the proposed transducer were investigated experimentally.

• YAKHAK HOEJI
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• v.47 no.2
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• pp.120-124
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• 2003

Due to its profound intestinal first-pass metabolism, oral eperisone hydrochloride produces a very low bioavailability and a very short muscle relaxant activity. To improve the efficacy and compliance of eperisone, we designed a new dosage form, the transdermal patch and evaluated the muscle relaxant effects of this patch in rats. The muscle relaxant activity was assessed by measurement of forelimb grip strength and hanging test in rats. The transdermal patch of eperisone hydrochloride showed significant muscle relaxant activity at 0.5, 1.5 and 3 cm$^2$/200 g rat (1.39, 4.17 and 8.33 mg of eperisone hydrochloride/kg, respectively) in a dose-dependent manner and the effects were lasted over 24 hours. The oral eperisone hydrochloride showed significant activity at 12.5, 25 and 50 mg/kg in a dose-dependent manner but the activity was within 1 or 2 hours after administration. These results suggest that the eperisone hydrochloride is absorbed efficiently from transdermal patch and the patch can exert potent and long-lasting muscle relaxant activity. This transdermal patch will increase the efficacy and compliance in the clinical use of eperisone hydrochloride.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.10
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• pp.3642-3667
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• 2021

Texture synthesis technology has the advantages of repairing texture and structure at the same time. However, during the filling process, the size of the patch is fixed, and the content of the filling is not fully considered. In order to be able to adaptively change the patch size, we used the exemplar-based inpainting technique as the test algorithm, considering the image structure and texture, calculated the image structure patch size and texture patch size, and comprehensively determined the image patch size. This can adaptively change the patch size according to the filling content. In addition, we use multi-layer images to calculate the priority, so that the order of image repair was more stable. The proposed repair algorithm is compared with other image repair algorithms. The experimental results showed that the proposed adaptive image repair algorithm can better repair the texture and structure of the image, which proved the effectiveness of the proposed algorithm.

• International Journal of Highway Engineering
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• v.14 no.6
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• pp.45-55
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• 2012

PURPOSES : Skid resistance and noise of roads highly depend on the characteristics of pavement texture. Therefore, estimation of texture characteristics may give useful information for the skid resistance and noise of road. Generally, Sand Patch Test is performed in order to estimate MTD(Mean Texture Depth). However, it is time-consuming and needs traffic control. This study aimed to investigate the effectiveness of measurement texture depth using the Portable Laser Profiler that give the MPD(Mean Profile Depth). METHODS : MTD and MPD were collected on the number of expressway sections including Central Inland Test Road sections in Korea. Statistical analysis are performed to establish the relationship between MTD data based on Sand Patch Test and MPD data obtained by the Portable Laser Profiler. RESULTS : Linear relationship MPD and MTD is observed for both of asphalt pavement and concrete pavement such as R-square of 0.51 to 0.58. CONCLUSIONS : Even though, the test method and definition of MPD and MTD are different. EMTD(Estimated Mean Texture Depth) can be obtained by using the correlationship between MPD with MTD.

• Biomolecules & Therapeutics
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• v.5 no.3
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• pp.260-264
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• 1997

The bioequivalence of two nicotine patches was evaluated in 16 normal male volunteers (age 21 ~ 27 yrs) following single transdermal application. Test product was "Nicostop patch" made by Sam Yang Co. and reference product was "Nicotinell TTS patch" made by Korean Searle Ciba-Geigy Co. After nicotine patches were applied onto the inside of the forearm, blood was taken at predetermined time intervals and the nicotine concentration in plasma was determined with a sensitive GC method using NPD detector. AUC and Cm\ulcorner were calculated and statistically analyzed for the bioequivalence of the two products. The results showed that the differences in AUC and $C_{msx}$between two products were 5.47% and 2.70%, respectively. The powers (1-$\beta$) for AUC and $C_{max}$. were >90% and 88.76%, respectively. Detectable differences($\Delta$) and confidence intervals were all less than 20%. All of these parameters met the criteria of KFDA for bioequivalence, indicating that "Nicostop patch" is bioequivalent to "Nicotinell TTS patch" . . .

• Journal of Institute of Control, Robotics and Systems
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• v.14 no.2
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• pp.156-160
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• 2008

A localization system to estimate the position as well as movement direction of mobile robots is proposed in this paper. This system implements a camera fixed on a robot and color patches evenly distributed and mounted on the planar ceiling. Different permutations of patch colors code information about robot localization. Thus, extraction of color information from patch images leads to estimation of robot position. Additionally, simple geometric indicators are combined with patch colors to estimate robot's movement direction. Since only the distribution of patch colors has to be known, the analysis of patch images to is relatively fast and simple. The proposed robot localization system has been successfully tested for navigation of sample mobile robot. Obtained test results indicate the robustness and reliability of proposed technique for robot navigation.