• Journal of Gastric Cancer
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• 제17권3호
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• pp.204-211
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• 2017

Purpose: Recently, a nomogram predicting overall survival after gastric resection was developed and externally validated in Korea and Japan. However, this gastric cancer nomogram is derived from large-volume centers, and the applicability of the nomogram in smaller centers must be proven. The purpose of this study is to externally validate the gastric cancer nomogram using a dataset from a medium-volume center in Korea. Materials and Methods: We retrospectively analyzed 610 patients who underwent radical gastrectomy for gastric cancer from August 1, 2005 to December 31, 2011. Age, sex, number of metastatic lymph nodes (LNs), number of examined LNs, depth of invasion, and location of the tumor were investigated as variables for validation of the nomogram. Both discrimination and calibration of the nomogram were evaluated. Results: The discrimination was evaluated using Harrell's C-index. The Harrell's C-index was 0.83 and the discrimination of the gastric cancer nomogram was appropriate. Regarding calibration, the 95% confidence interval of predicted survival appeared to be on the ideal reference line except in the poorest survival group. However, we observed a tendency for actual survival to be constantly higher than predicted survival in this cohort. Conclusions: Although the discrimination power was good, actual survival was slightly higher than that predicted by the nomogram. This phenomenon might be explained by elongated life span in the recent patient cohort due to advances in adjuvant chemotherapy and improved nutritional status. Future gastric cancer nomograms should consider elongated life span with the passage of time.

• 설비공학논문집
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• 제17권10호
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• pp.898-906
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• 2005

The present study has been conducted to investigate convective heat/mass transfer in the cooling passage with bleed holes. The rotating square channel has 40.0 mm hydraulic diameter and the bleed holes on the leading surface of the channel. The hole diameter of bleed hole is 4.5mm and its spacing is ( p/d:4.9) about five times of hole diameter. Exit mass flow rate through bleed holes is $10\%$ of the main mass flow rate and relation number is changed form 0.0 to 0.4. A naphthalene sublimation technique is employed to determine the detailed local heat transfer coefficients using the heat and mass transfer analogy The cooling performance is influenced by exit mass flow rate through bleed holes and Coriolis force of rotating channel for fixed Reynolds number. The heat transfer on the leading surface is decreased due to Coriolis force. However the total heat transfer is enhanced around holes on the leading surface because of trapping flow by bleeding.

• 설비공학논문집
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• 제17권10호
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• pp.907-913
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• 2005

The present study has been conducted to investigate convective heat/mass transfer in the cooling passage with bleed holes. The rotating square channel has 40.0 mm hydraulic diameter and the bleed holes on the leading surface of the channel. The hole diameter of bleed hole is 4.5mm and its spacing is ( p/d:4.9) about five times of hole diameter. Exit mass flow rate through bleed holes is $0\%,\;10\%\;and\;20\%$ of the main mass flow rate respectively. rotation number is fixed 0.2. A naphthalene sublimation technique is employed to determine the detailed local heat transfer coefficients using the heat and mass transfer analogy. The cooling performance is influenced by exit mass flow rate through bleed holes and Coriolis force of rotating channel for fixed Reynolds number. The heat transfer on the leading surface is decreased due to Coriolis force. However the total heat transfer is enhanced around holes on the leading surface because of trapping flow by bleeding.

• 설비공학논문집
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• 제23권12호
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• pp.805-814
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• 2011

In the present study, the detailed flow structure and heat transfer characteristics in the newly-designed heat transfer surface geometry were investigated. The surface geometry proposed in the present study is a traditional dimple structure combining with a protrusion inside the dimple, which is named a protrusion-in-dimple in this study. The basic idea underlying the present surface geometry is to enhance the flow mixing and the corresponding heat transfer in the flow re-circulating region generated by a conventional dimple cavity. The present study was performed by the direct numerical simulation at a Reynolds number of 2800 based on mean velocity and channel height and Prandtl number of 0.71. Three different protrusion heights for protrusion-in-dimples were considered as the main design parameter of the present study. The calculated pressure drop and heat transfer capacity were assessed in terms of the Fanning friction factor and Colburn j factor. The overall performances estimated in terms of the volume and area goodness factor for protrusion-in-dimple cases were higher than the conventional dimple case.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2002년도 춘계학술발표논문집 (하)
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• pp.1563-1566
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• 2002

교통정체의 증가로 의하여 지불수단에 관한 관심이 증가되고 있다. 또한, 전자화폐 지불에 대한 수많은 프로젝트가 진행되고 있다. 교통시스템은 정보처리, 통신, 제어, 전자 등 다양한 첨단기술들로 구성되며 이러한 기술들을 교통관련에 접목함으로서 더욱 안전한 인명구조 및 시간과 경비절감을 더욱 효율적으로 추구 할 수가 있다. 특히, 운전자의 차량소통을 위해 접촉식으로 제공하는 시스템과 이로 인해 야기되는 문제점들을 해결하기 위한 제어에 관련된 전자화폐 시스템을 연구하였다. 이 논문에서는 전자지불 개념을 ATM 방식으로 도입하여 요구사항을 반영하고 기존에 개발되어 사용하고 있는 동전투입방식을 재구성하여 전체통합하여 새로운 ITS 개발에 사용하는 일련의 과정을 정리하였다. 그 결과 기존방식보다 차량대기속도 및 평균주행속도가 15% 에서 40% 가량 개선됨을 확인할 수가 있었다. 특히 이런 개념은 국내 ITS 개발의 특수상황에 적용하여 큰 효과를 얻을 수 있을 것으로 기대한다.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제23권4호
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• pp.77-84
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• 2017

Purpose: In terms of the flexibility in hospital architecture, there are fixed elements of hospital architecture: mechanical, electrical, aeration rooms and shafts, which are the main utility spaces. Thus, it is necessary to recognize the utility space as a system that helps internal functions and flexible internal changes. This study analyzes the notion of the main utility space in hospital architecture and the architectural planning features of the main utility spaces as the system in the design process of the recently built hospitals. Methods: The design factors are extracted comparing two hospitals' plans in each stage and the systematic characteristics of utility spaces are analyzed accordingly. The opinions gathered from interviews of practitioners, architects and facility planning experts directly involved in the architecture design process are analyzed and reflected in the results. Results: Planning for utility spaces should be accompanied by the architectural plan from the basic design process, and proceeded with recognizing utility spaces as a system, which is a fixed element. Utility spaces are highly organically connected. Horizontal and vertical distribution of air chambers can reduce the length and number of ducts, and thus save story height, and reduce the number of shafts, the vertical connection passage. This is advantageous in securing the variable area, which is the ultimate objective of the system-centered hospital architecture plan. Implications: Thereby aims to provide fundamental data on systematic utility space planning in the hospital architecture planning.

• 한국컴퓨터산업학회논문지
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• 제3권3호
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• pp.369-382
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• 2002

교통정체의 증가로 의하여 지불수단에 관한 관심이 증가되고 있다. 또한, 전자화폐 지불에 대한 수많은 프로젝트가 진행되고 있다. 교통시스템은 정보처리, 통신, 제어, 전자 등 다양한 첨단기술들로 구성되며 이러한 기술들을 교통관련에 접목함으로서 더욱 안전한 인명구조 및 시간과 경비절감을 더욱 효율적으로 추구할 수가 있다. 특히, 운전자의 차량소통을 위해 접촉식으로 제공하는 시스템과 이로 인해 야기되는 문제점들을 해결하기 위한 제어에 관련된 전자화폐 시스템을 연구하였다. 이 논문에서는 전자지불 개념을 ATM방식으로 도입하여 요구사항을 반영하고 기존에 개발되어 사용하고 있는 동전투입방식을 재구성하여 전체 통합하여 새로운 ITS개발에 사용하는 일련의 과정을 정리하였다. 그 결과 기존방식보다 차량대기속도 및 평균주행속도가 15%에서 40% 가량 개선됨을 확인할 수가 있었다. 특히 이런 개념은 국내ITS 개발의 특수상황에 적용하여 큰 효과를 얻을 수 있을 것으로 기대한다.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2022년도 춘계학술대회
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• pp.267-268
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• 2022

제주 연안 해역은 다수의 인명이 승선하는 국제크루즈선, 여객선, 유선 등이 통항하고 어선 조업도 많아 사고 위험성이 높은 해역이나 현재 운영 중인 제주항·민군 복합항과 인근해역에 국한되어 있으므로 제주도 연안 해역 통항 선박의 체계적인 안전관리를 위하여 제주·서귀포 연안에 VTS 시스템을 구축한다. 하지만 현재 해상교통관제센터 관제업무량 산정 기준이 없는 실정이다. 이에 본 연구는 효율적인 해상교통관제 업무량 산정을 위해 VTS 빅데이터를 활용하여 제주·서귀포 연안 관제석 필요 소요 운영인력을 산출하였다. 본 연구는 관제업무량 산정의 기준을 세우는 연구에 기초 자료로 활용될 수 있을 것으로 판단된다.

• 한국해양학회지:바다
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• 제15권3호
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• pp.97-109
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• 2010

하계 남강댐 방류수 유입에 의해 강하게 성층화된 남해 강진만에서 3차원 수치모델링 실험을 통해 태풍 통과시 염분장에 미치는 취송류의 영향과 성층 파괴에 대해 연구하였다. 조위와 유속장, 수온장, 염분장에 대해 각각 스킬 분석(skill analysis)을 이용하여 모델을 검증 하였고, 그 결과 대부분 90%가 넘는 재현율을 보였다. 모델은 조류, 담수유입에 의한 밀도류와 바람에 의한 취송류를 잘 재현했다. 대량 담수 유입이 있을 경우 바람의 영향은 강한 밀도류에 의해 상대적으로 큰 효과가 없으나, 담수유입이 감소하는 시기에는 바람이 수직 혼합작용을 촉진하여 바람을 부과하지 않은 모의 실험보다 2~3일 빠르게 성층을 파괴하였다. 담수 유입에 의한 성층과 바람에 의한 성층 파괴는 성층지수(Richardson 수(數), Ri)를 통하여 판단하였으며, 대량 방류시 성층지수는 급속도로 증가하여 Ri 수(數)가 7~20을 보였고, 방류가 중단된 이후에는 바람에 의한 혼합으로, 성층지수는 급격하게 감소하고 Ri 수(數)는 0~2까지 보였으며, 이 때 상하층간 염분은 일정하게 분포하였다.

• 한국발생생물학회:학술대회논문집
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• 한국발생생물학회 2003년도 제3회 국제심포지움 및 학술대회
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• pp.86-86
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• 2003

Research has been in progress for more than a decade to production of useful proteins by genetic modification in cattle. However, the levels of protein production in transgenic cattle have been reported very low. To enhance protein production in transgenic animal, we tried homologous recombination to donor cells for production of transgenic clone cattle through nuclear transfer procedure. Thus, we constructed the two targeting vectors of human thrombopoietin (TPO) at bovine $\beta$-casein locus using homologous recombination with 13.6 kb and 9.6 kb homology. In two targeting vectors, positive selection was through the neomycin resistance gene and negative selection was by the diphtheria toxin (DT). Gene targeting was attempted in bovine embryonic fibroblasts (bEF) and bovine ear skin fibroblasts (bESF). To determine the most appropriate concentration of neomycin for bEF and bESF, G4l8 resistance was confirmed by culturing the cells in various concentrations of the drug and both of the cells were optimally selected at $900 \mu g/ml$ of neomycin. The transfected bEF and bESF by the targeting vectors were colonized efficiently at the ratio of DNA to transfection reagent such as $4 \mu g$:2 ${mu}ell$ and $1 \mu g$:$2 \mu l$. Comparing number of healthy clones from passage 4 to passage 8, bESF (17%) persist in culture for much longer than bEF (6%). The two gene-targeted bESF clones of 30 random-integrated clones with 9.6 kb homology length were confirmed, however, nothing was out of 72 random integration clones with 13.6 kb homology length, The DT also worked more efficiently in clones transfected with the vector of 9.6 kb homology length. Our data suggests that the choice of donor cell for long culture period should be considered to obtain targeted cell clone, and the gene-targeting frequency and the DT working efficiency are dependent on the length of target homology.