• Biotechnology and Bioprocess Engineering:BBE
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• v.6 no.1
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• pp.42-50
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• 2001

The activity of immobilized cell-support particle aggregates is influenced by physical and biochemical elements, mass transfer, and physiology. Accordingly, the mathematical model discussed in this study is capable of predicting the steady state and transient concentration profiles of the cell mass and substrate, plus the effects of the substrate and product inhibition in an immobilized cell-support aggregate. The overall mathematical model is comprised of material balance equations for the cell mass, major carbon source, dissolved oxygen, and non-biomass products in a bulk suspension along with a single particle model. A smaller bead size and higher substrate concentration at the surface of the particle, resulted in a higher supply of the substrate into the aggregate and consequently a higher biocatalyst activity.

• Journal of Korean Society for Atmospheric Environment
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• v.12 no.3
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• pp.243-254
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• 1996

The main purpose of this study is to investigate the collection efficiency characteristics of a cylindrical ESP. To do that, it is necessary to analyze the electric field, gas flow field, and mechanism of particle movement by numerical simulation based on EHD model. For a gas flow field, Navier-Stokes equation involving the electric source term was solved by SIMPLE algorithm. In case of the electric field, the current continuity and electric field equations were solved by S.O.R. method. The analysis of particle movement was performed on the basis of PSI-CELL model from the Lagrangian viewpoint. The results showed that the influence on the gas flow field by the electric field is almost negligible in a cylindrical ESP. The particle drift velocity $V_P$ toward the collection surface is increased continuously by the electrostatic force due to the rise of particle charge as the particle is moving to the flow direction and the particle size becomes larger. The collection efficiency is to quitely higher with the increase of applied voltage for the same particle size, while becomes smaller as the inlet velocity is increased.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.23 no.6
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• pp.778-787
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• 1999

In this study, the autoignition process of liquid fuel, injected into hot and stagnant air in a 2-D axisymmetric confined cylindrical combustor, has been investigated. Eulerian-Lagrangian scheme was adopted to analyze the two-phase flow and combustion. The unsteady conservation equations were used to solve the transition of the gas field. Interactions between two phases were accounted by using the particle source in cell (PSI-Cell) model, which was used for detailed consideration of the finite rates of transports between phases. And infinite conduction model was adopted for the vaporization of droplets. The results have shown that the process of the autoignition consists of heating up of droplets, vaporization, mixing and ignition. The ignition criteria could be determined by the temporal variations of temperature, reaction rate and species mass fraction. And the effects of various parameters on ignition phenomena are examined. These have shown that the increasing the reaction rate and/or the vaporization rate can reduce the ignition delay time.

• 한국전산유체공학회:학술대회논문집
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• 2002.10a
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• pp.41-46
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• 2002

A numerical simulation was made to determine the motion of particles in the fluid. The simulation is based on the Eulerian-Lagrangian method. The fluid motion was solved using a PISO-based finite-element method and a $\kappa-\epsilon$ model of turbulence. In the Lagrangian method for the solid phase, the trajectories of particles are calculated by integrating the equations of motion of a single Particle, and the collision between particles are taken into account. The influence of particles on the fluid phase is taken into account by introducing source terms in the Eulerian equations govering the fluid flow. It is known as the particle-source-in-cell (PSIC) method. Also, the turbulent effect in the particles and fluid notion is considered. The numerical results were compared with the experiment for a two-phase flow in a vertical pipe.

• Environmental Analysis Health and Toxicology
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• v.19 no.4
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• pp.335-344
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• 2004

Diesel exhaust particle (<2.5 ${\mu}{\textrm}{m}$, DEP$_{2.5}$) is known to be probarbly carcinogenic (IARC group 2A). DEP$_{2.5}$ contains organic compounds such as polycyclicaromatic hydrocarbon (PAH), heterocyclic compounds, phenols, and nitroarenes. Reactive oxygen species (ROS) are generated by DEP$_{2.5}$ without any biological activation system. Therefore, an alternative mechanism by which DEP$_{2.5}$ could be carcinogenic is known by the generation of oxidative DNA damage. The aim of this study was to investigate genotoxic effects of DEP$_{2.5}$ using single cell gel electrophoresis. In order to evaluate the mechanisms of DEP$_{2.5}$ genotoxicity, the rat micro-some mediated and DNA repair enzyme treated comet assays together with routine comet assay were performed. DEP$_{2.5}$ was collected from diesel engine bus and dichloromethane extract was obtained. The organic extract of DEP$_{2.5}$ revealed DNA damage itself in NIH/3T3 cells. And it showed both oxidative and microsome mediated DNA damages. Vitamin C as an model antioxidant reduced DNA damage in endonuclase III treated comet assay. One of flavonoid, galangin as a CYP1A1 inhibitor reduced DNA damage in the presence of S-9 mixture. Our results show that DEP$_{2.5}$ are genotoxic and a great source of oxidative stress, but antioxidants can significantly reduce oxidative DNA damages. And DEP$_{2.5}$ may contain indirect mutagens which can be inhibited by CYP inhibitors.d by CYP inhibitors.

• Transactions of the Korean Society of Mechanical Engineers
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• v.15 no.6
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• pp.2073-2082
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• 1991

The vaporization and combustion of liquid spray in a cylindrical shape combustor was studied numerically. Mixture of liquid drops and air was assumed to be ejected from the center-hole and assisting air from the concentric annulus with swirling. Eulerian-Lagrangian scheme was adopted for the two phase calculation, and the interactions between the phases were considered with the PSIC model. Also adopted were the infinite conductivity model for drop vaporization, the equation of Arrhenius and the eddy break-up model for reaction rate, and the k-epsilon model for turbulence calculations. Gas flow patterns, drop trajectories and contours of temperature and mass fractions of the gas species were predicted with swirl number, drop diameter, and equivalence ratio taken as parameters. Calculations show that the vaporization and the consequent combustion efficiency enhance with the increase of the swirl number and/or with the decrease of drop size, and the higher maximum temperature is attained with the higher equivalence ratio.

• Transactions of the Korean Society of Mechanical Engineers
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• v.14 no.3
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• pp.702-715
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• 1990

This paper describes behaviors of two-phase open channel flow inside the flash chamber of a horizontal Multi-Stage-Flash evaporator numerically along with the experimental observations. Bubble trajectories and the velocity and temperature distributions of the liquid phase were predicted by using the particle-source-in-cell(PSI-Cell) method with the appropriate bubble motion/growth equations. Size and number of bubble nuclei embedded in the incoming liquid(brine) were taken into account as important parameters in addition to the conventional ones such as the velocity, degree of inlet superheat, inlet opening height, and the liquid level. Bubble motions, which are unsteady, appeared to be mostly determined by the buoyancy and the drag forces. The calculations, though a number of simplifying assumptions were made, reasonably simulated the hydrodynamic behaviors of the two-phase horizontal stream observed in the experiments. The simulated temperature distributions also agreed fairly well with the other's measurements. Non-equilibrium allownaces, evaluated from the simulated temperature distributions, were within the range of those obtained from the existing correlations, and reduced with the increases of the number and size of incoming bubble nuclei due to vigorous flashing.