• KSBB Journal
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• v.26 no.3
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• pp.217-222
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• 2011

Itraconazole is a triazole antifungal agent to inhibit most fungal pathogens. To improve the oral absorption and dissolution of poorly water-soluble itraconazole, microsponge system composed of $Eudragit^{(R)}$ E100 and polyvinyl alcohol(PVA) formulated by quasi-emulsion solvent diffusion method, and its physicochemical properties and pharmacokinetic parameters of itraconazole were studied. The microsponge of itraconazole were discrete free flowing micro sized particles with perforated orange peel like morphology as visualized by scanning electron microscope (SEM). Results showed that the drug loading efficiency, production yield, and particle size of itraconazole microsponge were affected by drug to polymer ratio, the volume of internal phase containing methylene chloride, stirring rate and the concentration of PVA used. Also, the results showed that the dissolution rate of itraconazole from the microsponges was affected by drug to polymer ratio. In other words, the release rate of itraconazole from microsponges was increased from at least 27.43% to 64.72% after 2 h. The kinetics of dissolution mechanism showed that the dissolution data followed Korsmeyer-Peppas model. Therefore, these results suggest that microsponge system can be useful for the oral delivery of itraconazole by manipulating the release profile.

• Applied Chemistry for Engineering
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• v.26 no.2
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• pp.229-233
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• 2015

In this study, we examined the removal characteristics of suspended particulate matters which are one of carcinogens to cause lung cancer. The fine dust capture by a pilot scale filtration system depends on several important variables such as humidity, initial fine dust injection volume, and flow rate. The average concentration of particulate matters in the test chamber decreased, but the ultimate collection efficiency did not change during the filtration under high humidity, compared to those of using ambient conditions The initial injection amount of fine dust did not influence the particle capturing efficiency. When the flow rate reduced from 0.6 m/s to 0.3 m/s, the dust collection time increased approximately 1.4 times. Among all variables tested, the flow rate showed the most significant effect on the removal efficiency of fine particulate matter.

• Carbon letters
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• v.7 no.2
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• pp.87-96
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• 2006

This paper describes the physical properties of filled Nylon6 composites resin with nano-sized carbon black particle and graphite nanofibers prepared by melt extrusion method. In improving adhesions between resin and fillers, the surface of the carbon filler materials were chemically modified by thermo-oxidative treatments and followed by treatments of silane coupling agent. Crystallization temperature and rate of crystallization increased with increases in filler concentration which would act as nuclei for crystallization. The silane treatments on the filler materials showed effect of reduction in crystallization temperature, possibly from enhancement in wetting property of the surface of the filler materials. Percolation transition phenomenon at which the volume resistivity was sharply decreased was observed above 9 wt% of carbon black and above 6 wt% of graphite nanofiber. The graphite nanofibers contributed to more effectively in an increase in electrical conductivity than carbon black did, on the other hand, the silane coupling agent negatively affected to the electrical conductivity due to the insulating property of the silane. Positive temperature coefficient (PTC) phenomenon, was observed as usual in other composites, that is, temperature increase results conductivity increase. The dispersity of the fillers were excellently approached by melt extrusion of co-rotational twin screw type and it could be illustrated by X-ray diffraction and SEM.

• Proceedings of the Korean Society of Marine Engineers Conference
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• 2005.11a
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• pp.254-255
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• 2005

The effect of surrounding air velocity on the soot deposition process from a diffusion flame to a solid wall was investigated in a microgravity environment to attain in-situ observations of the process. An ethylene($C_2H_4$) diffusion flame was formed around a cylindrical rod burner in surrounding air velocity of $v_{air}$=2.5, 5, and 10 cm/s with oxygen concentration of 35 % and wall temperature of 300 K. Laser extinction was adopted to determine the soot volume fraction distribution between the flame and burner wall. The experimental results show that the soot particle distribution region moves closer to the surface of the wall with increasing surrounding air velocity. A numerical simulation was also performed to understand the motion of soot particles in the flame and the characteristics of the soot deposition to the wall. The results successfully predicted the differences in the motion of soot particles by different surrounding air velocity near the burner surface and are in good agreement with observed soot behavior in microgravity. A comparison of the calculations and experimental results led to the conclusion that a consideration of the thermophoretic effect is essential to understand the soot deposition on walls.

• Journal of the Korean Society for Precision Engineering
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• v.10 no.1
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• pp.134-141
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• 1993

Electro-Rheological(ER) fluids undergo a phase-change when subjected to an external electic field, and this phase-change typically manifests itself as a many-order-of-magnitude change in the rheological behavior. This phenomenon permits the global stiffness and energy- dissipation properties of the beam structures to be tuned in order to synthesize the desired vibration characteristics. This paper reports on a proof-of-concept experimental investigation focussed on evaluation the vibration properties of hollow cantilevered beams filled with an ER fluid. and consequently deriving an empirical model for predicting field-dependent vibration characteristics. A hydrous-based ER fluid consisting of corn starch and silicone oil is employed. The beams are considered to be uniform viscoelastic materials and modelled as a viscously-damped harmonic oscillator. Natural frequency, damping ratio and elastic modulus are evaluated with respect to the electric field and compared among three different beams: two types of different volume fraction of ER fluid and one type of different particle concentration of ER fluid by weight. Transient and forced vibration responses are examined in time domain to demonstrate the validity of the proposed empirical model and to evaluate the feasibility of using the ERfluid as an actuator in a closed-loop control system.

• Transactions of the Korean Society of Mechanical Engineers
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• v.17 no.7 s.94
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• pp.1649-1657
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• 1993

This paper reports on a proof-of-concept experimental investigation focused on evaluating the vibration characteristics and control of smart hollow cantilever beams filled with an electro-rheological(ER) fluid. The beams are considered to be of uniform viscoelastic materials and modelled as a viscously-damped harmonic oscillator. Electric field-dependent natural frequencies, loss factors and complex moduli are evaluated and compared among three different beams : two types of different volume fraction of ER fluid and one type of different particle concentration of ER fluid by weight. Modal characteristics of the beams are observed in both the absence and the presence of electric potentials. It is also shown that by constructing active control algorithm the removal of structural resonances and the suppression of tip deflection are obtained. This result provides the feasiblility of ER fluids as an active vibration control element.

• YAKHAK HOEJI
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• v.34 no.3
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• pp.206-211
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• 1990

Total suspended particles were collected and size-fractionated by an Andersen high-volume air sampler at Chungang University located near the Han River, Seoul, Korea, during the period form March, 1986 to August, 1986 and from March, 1987 to February, 1988. The concentrations and the particle size distributions of anions such as chloride, nitrate and sulfate were determined by ion chromatography. The averages of concentrations were $125.43\;{\mu}g/m^3$ in 1986 and $189.19\;{\mu}g/m^3$ in 1987 for total suspended particles (TSP), $2.12\;{\mu}g/m^3$ in 1986 and $4.14\;{\mu}g/m^3$ in 1987 for chloride, $4.39\;{\mu}g/m^3$ in 1986 and $5.95\;{\mu}g/m^3$ in 1987 for nitrate and $11.98\;{\mu}g/m^3$ in 1986 and $19.29\;{\mu}g/m^3$ in 1987 for sulfate. Size distribution of TSP was found to be generally bimodal. Chloride exhibited a seasonal variation in the distribution; fine particles were predominant in the winter whereas the concentration of coarse ones was almost same through four seasons. Nitrate showed a distribution similar to that of chloride. Such variation was less significant for sulfate. For chloride and nitrate, the relationship between the monthly averaged distribution pattern and air temperature was analyzed in terms of fine fraction (FF). The FF decreased with increasing air temperature.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.21 no.9
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• pp.496-504
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• 2009

In order to investigate the feasibility of a direct ice slurry transporting system for the purpose of district cooling, a case study of field application is performed. The research aims include the field measurement of ice packing factor, the performance of coldness delivery, and the branching characteristics of ice slurry. Two representative types of pipe branch are dealt with in this work. For the slurry flow with ice volume fraction of 0.16 or less, the pipe blocking due to aggregation is not observed. Based on the time-wise variation of temperature in the storage tank, a calculating method of ice packing factor is newly developed, which seems to be useful when the brine concentration is unknown. It is confirmed that the mass flow rate of ice slurry per unit cooling load is markedly reduced with increasing the ice content. The pumping power also decreases, but remains unchanged for high ice fractions. The distribution of ice particle before and after branching shows a good uniformity within the range of 5% difference, but yields a unique trend depending on the flow rate.

• Wind and Structures
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• v.29 no.1
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• pp.65-75
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• 2019

A heated square cylinder (with height $A^*$) is kept parallel to the cold wall at a fixed gap height $0.5A^*$ from the wall. Another adiabatic rectangular cylinder (of same height $A^*$ and width $0.5A^*$) is placed upstream in an inline tandem arrangement. The spacing between the two cylinders is fixed at $3.0A^*$. The inlet flow is taken as Couette-Poiseuille flow based non-linear velocity profile. The conventional fluid (also known as base fluid) is chosen as water (W) whereas the nanoparticle material is selected as $Al_2O_3$. Numerical simulations are performed by using SIMPLE algorithm based Finite Volume approach with staggered grid arrangement. The dependencies of hydrodynamic and heat transfer characteristics of the cylinder on non-dimensional parameters governing the nanofluids and the fluid flow are explored here. A critical discussion is made on the mechanism of improvement/reduction (due to the presence of the upstream cylinder) of heat transfer and drag coefficient, in comparison to those of an isolated cylinder. It is observed that the heat transfer increases with the increase in the non-linearity in the incident velocity profile at the inlet. For the present range studied, particle concentration has a negligible effect on heat transfer.

• Carbon letters
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• v.8 no.4
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• pp.274-279
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• 2007

In order to understand the breakthrough behaviour of iodine vapours on impregnated carbon systems, an active carbon, 80 CTC grade, $12{\times}30$ BSS particle size and $1104\;m^2/g$ surface area, was impregnated with metal salts such Cu, Cr, Ag, Mo and Zn, and an organic compound Triethylene diamine (TEDA) to prepare different carbon systems such as whetlerite, whetlerite/TEDA, whetlerite/KI/KOH and ASZMT. The prepared adsorbents along with active carbon were characterized for surface area and pore volume by $N_2$ adsorption at liquid nitrogen temperature. These carbon systems were compared for their CT (concentration X time) values at 12.73 to 53.05 cm/sec space velocities and 2 to 5 cm carbon column bed heights. The carbon column of 5.0 cm bed height and 1.0 cm diameter was found to be providing protection against iodine vapours up to 5.5 h at 3.712 mg/L iodine vapour concentration and 12.73 cm/sec space velocity. The study clearly indicated the adsorption capacities of carbon systems to be directly proportional to their surface area values. Dead layer with all the prepared carbon systems was found to be less than 2.0 cm indicating it to be minimum bed height to have protection against $I_2$ vapours. Effect of carbon bed height and flow rate was also studied. The active carbon showed maximum protection at all bed heights and flow rates in comparison to all other impregnated carbon systems, showing that only physical adsorption is responsible for the removal of iodine vapours.