• 대한관절경학회지
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• 제16권1호
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• pp.60-65
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• 2012

외측 원판형 연골판은 비교적 흔히 관찰할 수 있으나, 내측 원판형 연골판은 매우 드문 반월상 연골판 기형이다. 외측 원판형 연골판의 발생율은 1.4%에서 15.5%이며, 내측 원판형 연골판의 발생율은 0.06%에서 0.3%로 외측에 비해 현저히 낮게 보고되고 있다. 저자들은 좌측 슬관절은 증상이 있고 우측은 증상이 없는 양측성 내측 원판형 연골판 1명과 환측 슬관절에만 파열을 동반한 일측성 내측 원판형 연골판 1명을 자기공명영상 검사 및 관절경 검사로 발견하여, 증상이 있는 내측 원판형 연골판을 부분 절제술로 치료하여 증상 호전을 보였다. 저자들은 2명, 3예의 내측 원판형 연골판을 경험하였기에 보고하고자 한다.

• Imaging Science in Dentistry
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• 제44권4호
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• pp.307-314
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• 2014

Primitive neuroectodermal tumor (PNET), which belongs to the Ewing's sarcoma (ES) family of tumors, is mainly seen in children and young adults. PNETs are extremely rare in the maxilla. Here, we report a case of PNET of the left maxillary sinus in an elderly male. Magnetic resonance imaging (MRI) revealed a slightly enhanced solid mass occupying the left maxillary sinus and infiltrating into the retroantral space. A partial maxillectomy was performed. Despite postoperative chemotherapy, follow-up computed tomography (CT) and MRI revealed a nodal metastasis in the submandibular space. Neck dissection was performed. However, the patient died 10 months after the second surgery because of distant metastasis to the liver. MRI and CT were particularly useful in detecting the extent of the tumor, recurrence, and metastasis. Further, a literature review of the previously reported PNET cases of the maxilla was carried out. In this paper, we also discuss the current approach for the diagnosis and management of these tumors.

• Journal of Animal Science and Technology
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• 제62권3호
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• pp.321-333
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• 2020

Beef quality is influenced by the fattening period. Therefore, meat metabolomics profiles from the different fattening periods (e.g., short-term vs. long-term) were analyzed for identify potential indicators using nuclear magnetic resonance. Additionally, blood, free fatty acid, sensory, and mineral compositions in Korean steers were determined. Blood, free fatty acid, and mineral concentrations showed significant differences between short-term and long-term groups that were fed different diets. However, there were no sensory differences in the two fattening groups. Additionally, the metabolic profiles of meats were clearly separated based on multivariate orthogonal partial least square discriminant analysis. Six metabolites of variable importance in the projection plot were identified and showed high sensitivity as candidate markers for meat characteristics. In particular, lactate, carnosine, and creatine could be directly linked to scientific indicators of the fattening stage (31 vs. 28 mo) of meat. Our findings suggest that the metabolomics approach could be a powerful method for the detection of novel signatures underlying the managing period of beef.

• 한국자기공명학회논문지
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• 제20권3호
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• pp.95-101
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• 2016

Apolipoprotein B-100 (Apo-B100) is a major component of low density lipoprotein (LDL). Apo B-100 protein has 4,536 amino acid sequence and these amino acids are classified into peptide groups A to G with subsequent 20 amino acids (P1-P302). The peptide groups were act as immunoglobulin (Ig) antigens which oxidized via malondialdehyde (MDA). The mimetic peptide P1 (EEEMLENVSLVCPKDAT RFK) out of D-group peptides carrying the highest value of IgG antigens were selected for structural studies that may provide antigen specificity. Circular Dichroism (CD) spectra were measured for peptide secondary structure in the range of 190-250 nm. Experimental results show that P1 exhibit partial of ${\beta}-sheet$ and random coil structure. Homonuclear (COSY, TOCSY, NOESY) 2D-NMR experiments were carried out for NMR signal assignments and structure determination for P1. On the basis of these completely assigned NMR spectra and distance data, distance geometry (DG) and Molecular dynamics (MD) were carried out to determine the structures of P1. The proposed structure was selected by comparisons between experimental NOE spectra and back calculated 2D NOE results from determined structure showing acceptable agreement. The total Root-Mean-Square-Deviation (RMSD) value of P1 obtained upon superposition of all atoms was in the range $0.33{\AA}$. The solution state P1 has mixed structure of ${\beta}-sheet$ (Glu[1] to Cys[12]) and random coil (Pro[13] to Lys[20]). These NMR results are well consistent with secondary structure from experimental results of circular dichroism. Structural studies based on NMR may contribute to the studies of atherosclerosis and observed conformational characteristics of apo B-100 in LDL using monoclonal antibodies.

• Animal Bioscience
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• 제34권12호
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• pp.1930-1939
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• 2021

Objective: The aim of the study was to conduct metabolic profiling of dairy cattle serum and urine using proton nuclear magnetic resonance (¹H-NMR) spectroscopy and to compare the results obtained with those of other dairy cattle herds worldwide so as to provide a basic dataset to facilitate research on metabolites in serum and urine. Methods: Six dairy cattle were used in this study; all animals were fed the same diet, which was composed of total mixed ration; the fed amounts were based on voluntary intake. Blood from the jugular neck vein of each steer was collected at the same time using a separate serum tube. Urine samples were collected by hand sweeping the perineum. The metabolites were determined by ¹H-NMR spectroscopy, and the obtained data were statistically analyzed by performing principal component analysis, partial least squares-discriminant analysis, variable importance in projection scores, and metabolic pathway data using Metaboanalyst 4.0. Results: The total number of metabolites in the serum and urine was measured to be 115 and 193, respectively, of which 47 and 81, respectively were quantified. Lactate (classified as an organic acid) and urea (classified as an aliphatic acylic compound) exhibited the highest concentrations in serum and urine, respectively. Some metabolites that have been associated with diseases such as ketosis, bovine respiratory disease, and metritis, and metabolites associated with heat stress were also found in the serum and urine samples. Conclusion: The metabolites measured in the serum and urine could potentially be used to detect diseases and heat stress in dairy cattle. The results could also be useful for metabolomic research on the serum and urine of ruminants in Korea.

• Animal Bioscience
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• 제34권2호
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• pp.213-222
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• 2021

Objective: The metabolites that constitute the rumen fluid and milk in dairy cattle were analyzed using proton nuclear magnetic resonance (1H-NMR) spectroscopy and compared with the results obtain for other dairy cattle herds worldwide. The aim was to provide basic dataset for facilitating research on metabolites in rumen fluid and milk. Methods: Six dairy cattle were used in this study. Rumen fluid was collected using a stomach tube, and milk was collected using a pipeline milking system. The metabolites were determined by 1H-NMR spectroscopy, and the obtained data were statistically analyzed by principal component analysis, partial least squares discriminant analysis, variable importance in projection scores, and metabolic pathway data using Metaboanalyst 4.0. Results: The total numbers of metabolites in rumen fluid and milk were measured to be 186 and 184, and quantified as 72 and 109, respectively. Organic acid and carbohydrate metabolites exhibited the highest concentrations in rumen fluid and milk, respectively. Some metabolites that have been associated with metabolic diseases (acidosis and ketosis) in cows were identified in rumen fluid, and metabolites associated with ketosis, somatic cell production, and coagulation properties were identified in milk. Conclusion: The metabolites measured in rumen fluid and milk could potentially be used to detect metabolic diseases and evaluate milk quality. The results could also be useful for metabolomic research on the biofluids of ruminants in Korea, while facilitating their metabolic research.

• Journal of Korean Neurosurgical Society
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• 제50권2호
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• pp.103-108
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• 2011

Objective : There are few studies comparing small and large craniotomies for the initial treatment of chronic subdural hematoma (CSDH) which had non-liquefied hematoma, multilayer intrahematomal loculations, or organization/calcification on computed tomography and magnetic resonance imaging. These procedures were compared to determine which would produce superior postoperative results. Methods : Between 2001 and 2009, 317 consecutive patients were surgically treated for CSDH at our institution. Of these, 16 patients underwent a small craniotomy with partial membranectomy and 42 patients underwent a large craniotomy with extended membranectomy as the initial treatment. A retrospective review was performed to compare the postoperative outcomes of these two techniques, focusing on improvement of neurological status, complications, reoperation rate, and days of post-operative hospitalization. Results : The mean ages were $69.4{\pm}12.1$ and $55.6{\pm}9.3$ years in the small and large craniotomy groups, respectively. The recurrence of hematomas requiring reoperation occurred in 50% and 10% of the small and large craniotomy patients, respectively (p<0.001). There were no significant differences in postoperative neurological status, complications, or days of hospital stay between these two groups. Conclusion : Among the cases of CSDH initially requiring craniotomy, the large craniotomy with extended membranectomy technique reduced the reoperation rate, compared to that of the small craniotomy with partial membranectomy technique.

• 전력전자학회논문지
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• 제12권6호
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• pp.465-471
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• 2007

본 논문에서는 새로운 소프트 스위칭형 PFC 벅-부스트 AC-DC 컨버터에 대해 연구된다. 제안된 컨버터에 사용된 제어스위치의 턴-온과 턴-오프는 부분공진 동작에 의해 소프트 스위칭으로 되어 스위칭 손실을 줄이고, 입력전류는 듀티율 일정제어에 의한 교류 입력전압의 크기에 비례된 불연속적 유사 펄스열의 정현파 형태를 가진다. 그 결과 컨버터는 효율이 증대되고 입력역률이 증대되는 효과를 가진다. 또한 제안된 컨버터의 출력전압은 제어스위치의 PWM 제어에 의해 조정되고 벅-부스트용 인덕터에 흐르는 전류는 불연속모드로 제어되어 제어회로와 제어기법이 간단한 장점이 주어진다. 제안된 PFC 벅-부스트 컨버터는 기존의 PFC 벅-부스트 컨버터와 비교되어 해석되고 컴퓨터 시뮬레이션과 실험을 통해 그 해석적 타당성이 입증된다.

• 전력전자학회논문지
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• 제12권5호
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• pp.394-399
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• 2007

본 논문에서는 소프트 스위칭에 의한 새로운 고효율의 벅-부스트 DC-DC 컨버터에 대해 연구된다. 제안된 벅-부스트 컨버터는 기존의 벅-부스트 DC-DC 컨버터에서 문제가 되는 제어용 스위치의 스위칭 손실증대를 해결하기 위해 새로운 소프트 스위칭 기법이 적용된다. 소프트 스위칭 회로는 구조적으로 기존의 컨버터에 사용되는 벅-부스트용 인덕터와 스너버 회로를 변형 설계한 구조로써 회로구성이 간단하다. 제안된 컨버터에 사용된 제어스위치들은 부분공진의 동작에 의해 소프트 스위칭을 이룬다. 또한 컨버터의 출력전압은 제어스위치의 PWM 제어에 의해 조정되고 벅-부스트용 인덕터에 흐르는 전류는 불연속모드로 제어되어 제어회로와 제어기법이 간단한 장점이 주어진다. 제안된 벅-부스트 컨버터는 기존의 벅-부스트 컨버터와 비교되어 해석되고 컴퓨터 시뮬레이션과 실험을 통해 그 해석적 타당성이 입증된다.

• 구강회복응용과학지
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• 제18권2호
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• pp.113-118
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• 2002

Long bridge가 필요한 구강암종환자에게 자기공명영상을 촬영하여야 하는 경우, fiber reinforced polymer ceramics로 잠정보철물을 제작해준 경우 충분한 파절 저항성과 심미성을 얻을 수 있었다. 하지만, 여기에 대한 장기간의 연구와 관찰이 필요하리라 사료된다.