• Trans-
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• v.14
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• pp.35-63
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• 2023

Parkinson's disease is a degenerative neurological disease that affects even basic daily life movements due to impairment of body function caused by a lack of dopamine, which is charge of the body movement. Presently, it is hard to cure Parkinson's disease entirely with medical technology, so movement therapy as a solution to delay and prevent disease is getting more attention. Therefore, this study aims at desiging and disseminating a body movement program that concentrates on individual self-care and balacing the state of body and mind by applying the Feldenkrais Method® to patients with Parkinson's disease. The Feldenkrais Method® is a mind-body perceptual learning method using body movements. It is a methodology that re-educates the nervous system by connecting the brain and behavior as a function of neuroplasticity. In this study, the body movement program developed and verified by the researcher was modified and supplemented with a focus on the self-awareness of the Feldenkrais Method®. A 24-session physical exercise program was composed of 5 stages to improve the self-management ability of patients with Parkinson's disease. The stages include self-awareness, self-observation, self-organization, self-control, and self-care. The overall changes recognize one's condition and improve one's ability to detect modifications in the internal sense and external environment. In conclusion, the body movement program improves the body movement program improves mental and physical functions and self-care for Parkinson's disease patients through the Feldenkrais method. The availability of the program's on-site applicability remains a follow-up task. Furthermore, it is necessary to establish a systematic structure to spread it more widely through convergent cooperation with the scientific field applied with metaverse as a reference for the wellness of the elderly.

• Korean Journal of Acupuncture
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• v.31 no.1
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• pp.40-47
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• 2014

Objectives : Postural instability and gait difficulty(PIGD) can develop in all Parkinson's disease patients, especially late in the disease course, but does not respond well to conventional dopamine treatment. This study aimed to report three cases of PIGD in Parkinson's disease patients treated with Korean and Western medicine treatment. Methods : We used acupuncture, bee venom acupuncture, herbal medicine and moxibustion to treat patients during hospitalization. They continued Western medication and received rehabilitation treatment. We observed the changes of PIGD using the Unified Parkinson's Disease Rating Scale(UPDRS). Results : After treatment, PIGD symptoms improved and UPDRS scores were decreased. Especially, scores of falling, walking, gait and postural stability subsections related with PIGD were decreased. In addition, general conditions of patients were improved. Conclusions : This study suggests that Korean medicine treatment could be effective in the treatment of PIGD in Parkinson's disease patients.

• Journal of Biomedical Engineering Research
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• v.30 no.2
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• pp.142-146
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• 2009

The purpose of this study is to investigate the angular velocity of forearm pronation/supination movement in Parkinson's disease patients, as a quantitative measure of the bradykinesia. Thirteen Parkinson's disease patients ($64{\pm}11.0$ yrs, male:6, female:7) participated in the experiments. The subjects' both right and left forearms were scored by a rater according to rapid alternating movement of hands category in the UPDRS (unified Parkinson's disease rating scale) and the angular velocity of forearm pronation/supination was measured at the same time. As analysis parameters, RMS (root mean square) angular velocity and RMS angle were used. The parameters showed negative correlation with the clinical score (RMS angular velocity: r= - 0.914, RMS angle: r= -0.749). The RMS angular velocity of all clinical scales were significantly different one another except for the non significant difference between those of scale 3 and 4. RMS angle of scale 0 was significantly different from those of scale 2, 3, 4 and that of scale 1 was significantly different from those of scale 3 and 4. This suggests that RMS angular velocity can be used for a quantitative measure of bradykinesia in motor examination.

• Korean Journal of Applied Biomechanics
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• v.26 no.3
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• pp.309-314
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• 2016

Objective: There are no guidelines for choosing appropriate gait assistive devices. The aim of this study was to evaluate gait assistive devices in patients with Parkinson's disease. Method: We evaluated 15 individuals with Parkinson's disease who did or did not use one of two different devices including canes and two-wheeled walkers. Data were collected using the GAITRite system. Results: Participants in the group using canes and two-wheeled walkers had significantly increased double support time and decreased gait velocity, normalized gait velocity, and stride length compared with those who did not. Participants who used a two-wheeled walker had significantly decreased gait velocity, normalized gait velocity, and stride length compared with those who used a cane. Furthermore, participants who used a two-wheeled walker had significantly decreased coefficients of variation for step time, stride length, and swing time compared with those who used a cane. Conclusion: Our results indicated that the two-wheeled walker offered the most consistent advantages for decreasing the risk of falling.

• BMB Reports
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• v.43 no.4
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• pp.233-244
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• 2010

Parkinson's disease (PD) is the second most common neurodegenerative disease, and 5-10% of the PD cases are genetically inherited as familial PD (FPD). LRRK2 (leucine-rich repeat kinase 2) was first reported in 2004 as a gene corresponding to PARK8, an autosomal gene whose dominant mutations cause familial PD. LRRK2 contains both active kinase and GTPase domains as well as protein-protein interaction motifs such as LRR (leucine-rich repeat) and WD40. Most pathogenic LRRK2 mutations are located in either the GTPase or kinase domain, implying important roles for the enzymatic activities in PD pathogenic mechanisms. In comparison to other PD causative genes such as parkin and PINK1, LRRK2 exhibits two important features. One is that LRRK2's mutations (especially the G2019S mutation) were observed in sporadic as well as familial PD patients. Another is that, among the various PD-causing genes, pathological characteristics observed in patients carrying LRRK2 mutations are the most similar to patients with sporadic PD. Because of these two observations, LRRK2 has been intensively investigated for its pathogenic mechanism (s) and as a target gene for PD therapeutics. In this review, the general biochemical and molecular features of LRRK2, the recent results of LRRK2 studies and LRRK2's therapeutic potential as a PD target gene will be discussed.

• Korean Journal of Applied Biomechanics
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• v.19 no.2
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• pp.257-264
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• 2009

The purpose of this study was to investigate the lower extremity kinematics and muscle activities of adductor longus(AL), gluteus medius(GME), gluteus maximus(GMA), biceps femoris(BF), rectus femoris(RF), gastrocnemius(GA), and tibialis anterior(TA) using three dimensional and Noraxon 8 channels EMG system during turn 0, 60, 90 and 120 degrees in patients with Parkinson's disease. Seven parkinson's patients and five healthy subjects were participated in the study. Participants with Parkinson's disease demonstrated significant differences in reduction of stride length and stride width. Also, they showed ill difference in muscle activities. The strength and balance of the lower extremity muscles may help to improve cutting movement and to prevent falling in parkinson's patients.

• The Journal of Internal Korean Medicine
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• v.44 no.5
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• pp.846-854
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• 2023

Objectives: The purpose of this study is to report the case of a patient with Parkinson's disease experiencing anxiety and insomnia treated with Korean medicine therapies. Methods: A patient diagnosed with Parkinson's disease with anxiety and insomnia was treated with Korean medicine therapies, including herbal medication (Gyejigayonggolmolye-tang), acupuncture, electro-acupuncture, and moxibustion, for 18 days. To evaluate the therapeutic effect, we checked the Beck Anxiety Inventory (BAI) and Insomnia Severity Index (ISI) scores to monitor anxiety and insomnia. Results: After treatment, the patient's BAI and ISI scores for anxiety and insomnia decreased. Further, the patient and her protector mentioned that their quality of life had improved. Conclusion: These results suggest that Korean medicine therapies with Gyejigayonggolmolye-tang have a beneficial effect on anxiety and insomnia in patients with Parkinson's disease.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.13 no.3
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• pp.390-400
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• 2006

Purpose: To develop & to examine the effect of a Tailored Exercise Program (TEP) on physical fitness in patients with Parkinson's disease (PD). Method: In a two-group pre-and post-test design, from a total 41 participants. 21 were assigned th the experimental group find the remainder to the control group. The experimental group participated in a 4-day a week, 8 week program in which one session a week was by direct instruction with the self-help group and two sessions a week were by videotaped instruction at home by themselves. The control group did not receive any intervention. Results: The eight week TEP in patients with PD was found to be significantly effective in enhancing muscle strength, ankle flexibility, and balance. However instrumental activities of daily living was not changed by the intervention. Conclusion: These results suggest that TEP can have an effect on physical fitness in patients with PD. Further research with a larger sample and for a longer follow up period is needed to expand our understanding of the effects of TEP for patients with PD.

• Journal of Society of Preventive Korean Medicine
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• v.28 no.1
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• pp.69-87
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• 2024

Objectives : This study is to investigate the current National Health Insurance Database cohort studies related to complications of Parkinson's Disease (PD) and suggest the design of Korean medical epidemiological studies of PD. Methods : Nationwide longitudinal studies of PD patients in South Korea were collected through Pubmed and the Korea Citation Index (KCI). We selected cohort studies that used the National Health Insurance Database in Korea and targeted Parkinson's disease patients. Studies published before February 2024 were categorized according to study designs. We examined variables and covariates, enroll dates and matching methods. Results : Of a total of 536 studies, 18 studies met the inclusion criteria. All studies used the National Health Insurance (NHI) Research Database and among them, 5 used sample data and one senior database. Studies can be classified into two types. 11 cohort studies were comparing PD patients and non-PD patients. Another type was 4 PD patients cohort studies. Most studies used two diagnostic codes (G20 and V124) for inclusion criteria. Enroll periods were from 2002 to 2017, and follow-up periods were from 7 to 14 years. 16 studies considered age and sex as covariates. 15 studies used the propensity score matching method to increase the level of causality. There was only one study related to the Korean medical treatment. Conclusion : In future cohort studies on Korean medical treatment, more attempts should be made to reveal the effect of the treatments on PD patients by defining inclusion criteria for patient groups, covariates, exposure variables, and assessment indicators more operatively.

• Journal of the Korean Society of Physical Medicine
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• v.7 no.3
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• pp.259-265
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• 2012

Purpose : Patients with Parkionson's disease have a temporal and spatial restriction for their's exercise treatment. The aim of this study is to verify the effectiveness of e-exercise program on balance, gait, and endurance ability in people with Parkinson's disease. Methods : Eighteen participants, with Parkinson's disease that ranged from stage to on the Hoehn & Yahr scale, were assigned to two group. Two group were divided into on-line group that exercised in home by computer video, and off-line group that exercised in clinical center. Exercise program that included 3 sections (warm-up, main exercise, cool down)-5 parts(stretch, strength, balance, gait, stretch) was used to train for participants. We used the functional reach test for balance ability, timed up and go test for gait ability, 6 minute walking test for endurance ability. Wilkoxon sign lank tests were used to assess the difference of balance, gait, and endurance ability in pre-and post test each groups. Mann-whitney tests were used to assess the difference of balance, gait, and endurance ability between groups. Results : Wilkoxon sign lank tests revealed that both group were improved the balance, gait and endurance agility by e-exercise program intervention. Mann-whitney tests showed that there were no differences between groups in the variation of balance, gait, endurance ability. Conclusion : We believe that exercise program with on-line(e-exercise program) is an effective intervention for people with Parkinson's disease and is no different than off-line exercise group in the variation of balance, gait, endurance ability.