• 제목/요약/키워드: Park Chung-Hee

검색결과 3,083건 처리시간 0.035초

Effects of ellagitannin on IL-12 expression.

  • Kwon, Hee-Seung;Park, Jung-Hwan;Lee, Do-lk
    • 대한약학회:학술대회논문집
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    • 대한약학회 2001년도 Proceedings of International Convention of the Pharmaceutical Society of Korea
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    • pp.199.1-199.1
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    • 2001
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Synthesis of 6-Formyl-pyridine-2-carboxylate Derivatives and their Telomerase Inhibitory Activities

  • Jew, Sang-Sup;Park, Boon-Saeng;Lim, Doo-Yeon;Kim, Myoung-Goo;Chung, In-Kwon;Kim, Joo-Hee;Hong, Chung-Il;Kim, Joon-Kyum;Park, Hong-Jun;Lee, Jun-Hee;Park, Hong-Jun;Lee, Jun-Hee;Park, Hyeung-Geun
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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    • pp.181.4-182
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    • 2003
  • Telomeres are DNA-protein complexes at the ends of chromosomes, which play an essential protective role against DNA degradation and aberrant recombination during cell divisions. Several telomerase inhibitors have been reported as candidates for new antitumor drugs. Among them, 2-thiobenzylpyridines, developed by Geron. Co Ltd. as a telomerase inhibitor, were chosen as lead compounds. Twenty-one pyridine-2- carboxylate derivatives were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol, thiophenol, and aniline, substituted with various functional groups. (omitted)

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