• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.8 no.2
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• pp.199-206
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• 1997

Object：The purpose of this study was to investigate frequency and risk factor of violence toward parents seen in adolescents. We also want to apply this data toward developing a prevention program for adolescent violence. Method：A total of 1,345 students from 5 middle schools in Seoul, participated in this study：675 males, 670 females. We administered self-reporting questionnaire including violence toward parents, exposure to violence, family history of alcoholism, substance abuse of adolescetnt and dermographic data etc. Result：The frequency of boys’ violence toward parent was 2.8%, which was significantly higher than girls’(p<0.001). The frequency of violence toward the father was higher than the mother. The risk factors for violence toward parents were sex, parental alcohol problem, adolescent alcohol-smoking-drug problem, exposure to violence at home in the last year and exposure to violence in the life(p<0.0001). The grade, punishment, socioeconomic status, educational level of parent were not significantly related to violence toward parents. Conclusion：These suggest that adolescent violence toward parents is not rare problem any more and preventive intervention is needed for high-risk groups, that is related with experience domestic violence, substance abuse, alcoholic parent.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.12 no.2
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• pp.237-244
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• 2001

Objectives：Dysfunctional parent-child relationships have been associated with various mental and conduct disorders in adolescence and mental problems in adulthood as well. Most studies have done in clinical settings and little is known about the relationship between parenting and adolescent problem behaviors in community settings. This study is done to compare the perceived parenting and problem behaviors between problem behavior group and those of non-problem behavior group in male adolescents. Methods：The subjects of this study were 147 male high school students in Seoul, who do not have any known mental or conduct disorders and live with their real parents. Parental Bonding Instrument and Youth Self Report were administered to evaluate the perceived parenting and problem behaviors of adolescents. Results：There were significantly higher scores of mother overprotection in problem behavior group when comparing to non-problem behavior group. There was a significant association between mother overprotection and problem behavior when adjusting the number of family members, mother's job, parents' education level, grades, and religion. Conclusion：The parenting such as mother overprotection can be helpful to predict the problem behaviors in male adolescents, and appropriate parenting may prevent various problem behaviors in male adolescents.

• Korean Journal of Social Welfare
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• v.37
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• pp.33-66
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• 1999

The primary objectives of this research is to identify (1) demographic characteristics and job needs of women with disabilities in Korea and (2) factors that predicts the degrees of their job needs. This study uses the data based on interviews with 805 disabled women selected randomly from the registered disabled women in Seoul, Kuyngki-Do, Pusan, and Kuyngsangnam-Do. In the aspect of disabilities, this study showed that more than half of disabled women in our sample have very severe disabilities (1st degree and 2nd degree of disabilities) and needs others' help in their daily lives. In the demographic aspect, this study found that disabled women's education level is very low and their monthly income is also very low. This study also found that in spite of their disabilities and functional limitations, more than 3/4 of disabled women have needs about jobs. Finally, using logistic regression analysis, this study found that disabled women's type of disabilities, dependencies in daily life, age, job experiences, job training experiences, willingness for independence, and parental attitude about disabled women's future are statistically significant in predicting the degree of their job needs. This study will contribute to developing knowledge about disabled women's characteristics and provide practical implications for intervention strategies and assistance programs related to promoting their welfare.

• The Journal of Korea Assosiation for Disability and Oral Health
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• v.13 no.1
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• pp.33-36
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• 2017

Cerebral palsy(CP) is a motor disorder of the central nervous system resulting from irreversible brain injury due to congenital or acquired causes. Health-related quality of their life is associated with severity of impairment and socioeconomic factors. These patients are particularly easy to be neglected because they lack capacity to care themselves unless they have the help of caregiver from high socioeconomic status. A 11-year-old girl with severe motor impairment came with the chief complaint of severe calculus deposition on whole dentition. She was taken with bed-ridden state with pediatrician not her parents. Since brain was damaged at the age of two, she has been left alone in the city care hospitals without parental care. Main caregiver is her father with not high educational level. Oral hygiene was not performed at all. Severe calculus deposition, gingival swelling, and gingival redness around the whole dentition were observed. During the 1st and 2nd visit, scaling and extraction was performed. CP patients with low socioeconomic status and severe motor impairment tend to be neglected from dental treatment. Dental care, along with medical care, is crucial to the quality of CP patients' lives. Therefore it is important that they visit for regular dental check ups and receive preventative care.

• The Journal of the Korea Contents Association
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• v.16 no.3
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• pp.498-512
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• 2016

The purpose of this study was to raise validity of the result through using national data, to analyze the effect of children's smartphone addiction on aggression and moderating effect of parenting styles on the relationship between children's smartphone addiction and aggression. The data were obtained from 4th waves of KCYPS(Korean Children Youth Panel Study), and 1,686 4th graders in elementary schools who have smartphone were analysed. To achieve the purpose, this study executed frequency analysis, descriptive statistic, and hierarchical multiple regression analysis through SPSS 21.0. The results of this study are as follows: First, the higher children's smartphone addiction level, the higher children's aggression goes. Second, parents' supervision, affection, neglect have moderating effects on the relationship between children's smartphone addiction and aggression which means parenting styles could reduce children's aggression despite serious smartphone addiction. Based on these results, this study suggests that the combination of preventive discipline of smartphone addiction and parental education program is needed to reduce children's aggression which is main factor of bullying. In addition, this study suggests the establishment of special arrangement such as 'shut down' for smartphone addiction prevention.

• Biomedical Science Letters
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• v.11 no.2
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• pp.165-173
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• 2005

A potent demethylating agent, 5-Azacytidine (5-AzaC) has been widely used as in many studies on DNA methylation, regulation of gene expression, and cancer biology. The mechanisms of the demethylating activity were known to be formation of complex between DNA and DNA methyltransferase (MTase), which depletes cellular MTase activity. However, 5-AzaC can also induce hypermethylation of a transgene in a transgenic cell line, G12 cells and it was explained as a result of defense mechanisms to inactivate foreign gene(s) somehow. This finding evoked the question that whether the phenomenon of hypermethylation induced by 5-AzaC is limited to the transgene or it can be occurred in endogenous gene(s). In order to answer the question, mutagenicity test of 5-AzaC and molecular characterization of mutants obtained from the test were performed using an endogenous gene, thymidine kinase (tk) in Chinese hamster V79 cells. When V79 and V79-J3 subclone cells were treated with 1, 2.5 ,5, $10{\mu}M$ of 5-AzaC for 48 hours, their maximum mutant frequencies were revealed as $6\times10^{-3}\;at\;5{\mu}M$(350-fold induction over background) and $8\times10^{-3}\;at\;2.5{\mu}M$ (l,800-fold induction over background) respectively. Since the induction rates were too high to be induced by true mutations, many trifluorothymidine (TFT)-resistant $(TFT^R)$ cells were subjected to Northern blot analysis to check the presence of tk transcripts. Surprisingly, all clones tested possessed the transcripts in a similar level, that implicates the $TFT^R$ phenotype induced by 5-AzaC has not given rise to hypermethylation of the gene in spite of unusually high mutation frequency. In addition, it has shown that the TK activity in the pool of 5-AzaC-induced $TFT^R$ cells has about a half of that in spontaneously-induced $TFT^R$ cells or in non-selected parental V79-J3 cells. This result suggests that the mechanism(s) underlying the TFT-resistance between spontaneously occurred and 5-AzaC-induced cells may be different. These findings have shown that the $TFT^R$ phenotype induced by 5-AzaC has not given rise to hypermethylation of the tk gene, and 5-AzaC may be induced by one or combined pathways among many drug resistance mechanisms. The exact mechanisms for the 5-AzaC-induced $TFT^R$ phenotype remain to elucidate.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.9
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• pp.234-242
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• 2018

This descriptive study aims to examine the factors that influence nursing students' adaptation to clinical practice. Data was collected from 180 nursing students between April 26 and May 4, 2018. A self-reporting questionnaire was employed, which comprised of 17 questions regarding transition shock, 24 questions about social support, two questions regarding the levels of preparedness for clinical practice, and 14 questions about the degree of adaptation to clinical practice. Collected data was analyzed using t-test, one-way analysis of variance, and stepwise multiple regression, as well as by calculating the Pearson correlation coefficient. Subjects' degree of adaptation to clinical practice had a negative correlation with their transition shock. The degree of adaptation had a positive correlation with the levels of preparedness for clinical practice (r = 0.35) and the sub-variables of social support in the domains of friends (r = 0.24), parents (r = 0.32), and professors (r = 0.38). The smaller the transition shock (B = -0.409) and the greater the levels of preparedness (B = 0.766), professorial support (B = 0.228), and parental support (B = 0.163), the higher the degree of adaptation to clinical practice. Transition shock had the greatest influence on the degree of adaptation to clinical practice felt by subjects, followed by their level of preparedness for clinical practice and professorial support. Hence, to increase the degree of adaptation to clinical practice, not only should individual nursing students be better prepared to conduct clinical practice and professors provide greater support, but also there needs to be measures implemented to reduce transition shock.

• Clinical and Experimental Pediatrics
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• v.58 no.9
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• pp.330-335
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• 2015

Purpose: The clinical interpretation of children sensitized to allergens is challenging, particularly in children with food allergies. We aimed to examine clinical differences between children with monosensitization and those with polysensitization to common food allergens and to determine risk factors for polysensitization in young children <10 years of age with immediate-type food allergies. Methods: The study included children <10 years of age with signs and symptoms indicative of immediate-type food allergies. Serum total IgE level was measured, and ImmunoCAP analysis for food allergens was performed. Results: The mean age of the study subjects was $1.6{\pm}1.6$ years (75 boys and 51 girls). Thirty-eight children (30.2%) were monosensitized and 88 children (69.8%) were polysensitized. Multivariate logistic regression analysis showed that the development of polysensitization to common food allergens was positively associated with a parental history of allergic rhinitis (adjusted odds ratio [aOR], 6.28; 95% confidence interval [CI], 1.78-22.13; P=0.004), season of birth (summer/fall) (aOR, 3.10; 95% CI, 1.10-8.79; P=0.033), and exclusive breastfeeding in the first 6 months of age (aOR, 3.51; 95% CI, 1.20-10.25; P=0.022). Conclusion: We found significant clinical differences between children with monosensitization and those with polysensitization to common food allergens and identified risk factors for the development of polysensitization in young children with immediate-type food allergies. Clinicians should consider these clinical risk factors when evaluating, counseling, treating, and monitoring young children with food allergies.

• Journal of Preventive Medicine and Public Health
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• v.38 no.4
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• pp.391-400
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• 2005

Objective : This study examined the socioeconomic differentials for the health and health related behaviors among South Korean middle school students. Methods : A nationwide cross-sectional interview survey of 3,449 middle school second-grade students and their parents was conducted using a stratified multi-stage cluster sampling method. The response rate was 93.3%. The socioeconomic position indicators were based on self-reported information from the students and their parents: parental education, father's occupational class, monthly family income, out-of-pocket expenditure for education, housing ownership, educational expectations, educational performance and the perceived economic hardships. The outcome variables that were measured were also based on the self-reported information from the students. The health measures included self-rated health conditions, psychological or mental problems, the feelings of loneliness at school, the overall satisfaction of life and the perceived level of stress. The health related behaviors included were smoking, alcohol drinking, sexual intercourse, violence, bullying and verbal and physical abuse by parents. Results : Socioeconomic differences for the health and health related behaviors were found among the eighth grade boys and girls of South Korea. However, the pattern varied with gender, the socioeconomic position indicators and the outcome measures. The prevalence rates of the overall dissatisfaction with life for both genders differed according to most of the eight socioeconomic position indicators. All the health measures were significantly different according to the perceived economic hardship. However, the socioeconomic differences in the self-rated health conditions and the psychosocial or mental problems were not clear. The students having higher socioeconomic position tended to be a perpetrator of bullying while those students with lower socioeconomic position were more likely to be a victim. Conclusions : The perceived economic hardships predicted the health status among the eighth graders of South Korea. The overall satisfaction of life was associated with the socioeconomic position indicators. Further research efforts are needed to explore the mechanisms on how and why the socioeconomic position affects the health and health related behaviors in this age group.

• Journal of Aquaculture
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• v.19 no.3
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• pp.166-172
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• 2006

Induced androgenesis, a form of artificial parthenogenesis is an important tool for the generation and use of genetically isogenic or clonal fish strain. An optimized protocol for the genetic inactivation of mud loach (Misgurnus mizolepis) oocytes (i.e. production of androgenetic haploid) was developed using UV-irradiation. Various dose levels of UV significantly affected the fertilizing capacity of the eggs, hatchability of embryos and incidence of haploidy. Based on the extensive examinations of treatment conditions on embryo viability and haploid incidence, the optimum dose level of UV irradiation was turned out to be $10,800ergs/mm^2$ with 56.9% of hatching success and 94.6% of haploidy. The overall yield of putative androgen under optimized treatment condition was more than 50% out of total eggs inseminated. The success of androgenetic reproduction of haploid genome was verified by flow cytometry and PCR amplification of transgene that is exclusive to either one of parental sexes. However, a small portion $(8\sim11%)$ of presumed androgenetic haploid larvae was proven to contain residual DNA fragment(s) from maternal parent.