• Annals of Clinical Neurophysiology
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• 제7권2호
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• pp.138-140
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• 2005

Strumpell, in 1880, was the first to describe familial case of spastic paraplegia characterized by progressive weakness and spasticity of the lower limbs with little or no involvement of the upper extremities. This syndrome is heterogeneous in inheritance, age of onset, severity and associated signs. We present one family with autosomal dominant hereditary spastic paraplegia (HSP) due to SPG4 (spastin) gene mutation which is confirmed by genomic DNA isolated from peripheral blood.

• 한국임상수의학회지
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• 제15권2호
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• pp.255-262
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• 1998

Lateral laminectomy was performed far spinal decompression in 7 thoracolumbar disc herniated dogs. These dogs showed upper motor neurologic signs including kyphosisi urinary dysfunction, and paraplegia or paralysis in hindlimbs. The lesions were evaluated with myelographic findings and predominated in $T_{12}-T_{13}, T_{13}-L_{1} and L_{1}-L_{2}$ discs. Five dogs which were operated within 48 hours after the onset of paraplegia were recovered from kyphosis and sustained the normal gait and walkings furthermore normal urination and defecation were presented within 3 days of postoperation. One dog was expired with steroid induced intestinal bleeding. The other dog operated on 96 hours after the onset of paraplegia was not recovered from neurologic deficits. Spinal decompression technique was considered to be useful method fur improving neurological problems resulted firom thoracolumbar disc herniation, if dogs are operated on early stage of the onset of paraplegia.

• The Korean Journal of Pain
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• 제10권2호
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• pp.304-307
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• 1997

Continuous epidural infusion, a combination of local anesthetic and opioid, have been widely administered for treatment of chronic cancer pain. A serious complications of epidural block is paraplegia which can also be caused by : direct spinal cord injury, epidural hematoma, epidural abscess, ischemic change, neurotoxicity, preexisting disease. Continuous epidural block for pain control of patient with cervical cancer was performed at $T_{12}/L_1$ interspace. A 4 cm catheter was inserted cephalad into the epidural space. After four months, back pain and motor weariless of lower extremities progressively developed. Spine CT showed bony destruction and soft mass-like lesion at $T_9$ & $T_{12}$ spine. We propose paraplegia was caused by spinal cord compression which resulted from vertebral metastasis of cervical cancer.

• The Korean Journal of Pain
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• 제6권1호
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• pp.122-128
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• 1993

Two cases are described transient unilateral paraplegia following a splanchnic nerve block (SNB) among 683 procedures in 708 patients from 1968 to 1992. The first case, 64 year-old male, had bilteral splanchnic nerve block twice with pure alcohol 4 months and 2month ago. The paraparesis of right leg was developed 4 minutes after the pure alcohol injection during the third SNB and was completely recovered after 37 minutes. The second case, 60 year-old male, had also a first SNB with temporary relief of pain for a week. The Second SNB with 95% alcohol was followed by paraplegia of left leg. He showed almost complete improvement but expired 18 days later. The probable cause was the spread of alcohol onto the lumbar plexus or paravertebral space unilaterally, because of adhesion or paravertebral space due to previous alcohol injections.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2010년도 춘계학술대회 논문집
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• pp.327-328
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• 2010

• The Korean Journal of Pain
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• 제28권2호
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• pp.148-152
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• 2015

The goal of cancer treatment is generally pain reduction and function recovery. However, drug therapy does not treat pain adequately in approximately 43% of patients, and the latter may have to undergo a nerve block or neurolysis. In the case reported here, a 42-year-old female patient with lung cancer (adenocarcinoma) developed paraplegia after receiving T8-10 and $11^{th}$ intercostal nerve neurolysis and T9-10 interlaminar epidural steroid injections. An MRI results revealed extensive swelling of the spinal cord between the T4 spinal cord and conus medullaris, and T5, 7-11, and L1 bone metastasis. Although steroid therapy was administered, the paraplegia did not improve.

• 대한한방내과학회지
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• 제45권1호
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• pp.75-86
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• 2024

Spinal cord infarction is one of the rare strokes with no clear signs of serious nerve damage or after-effects. This study reports on the effectiveness of a combined treatment of Korean medicine and acupuncture on bilateral paraplegia, dysuria, and constipation in a patient with sudden-onset spinal cord infarction. An 84-year-old male patient was diagnosed with spinal cord infarction in August 2022. After diagnosis by whole spine MRI, he received treatment for two months at another hospital, but the improvement was insignificant. He then received Korean medicine treatment, and during this period, his lower extremity manual muscle test grade improved from 3 to 4 and his modified Rivermead mobility index score increased by 13 points, compared with hospitalization. Dysuria improved with acupuncture, and constipation improved with herbal medicine treatment. A combination of herbal medicine and acupuncture can be used to treat paraplegia, dysuria, and constipation caused by spinal cord infarction.

• Journal of Korean Neurosurgical Society
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• 제48권6호
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• pp.544-546
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• 2010

Paraplegia following spinal epidural anesthesia is extremely rare. Various lesions for neurologic complications have been documented in the literature. We report a 66-year-old female who developed paraplegia after left knee surgery for osteoarthritis under spinal epidural anesthesia. In the recovery room, paraplegia and numbness below T4 vertebra was checked. A magnetic resonance image (MRI) scan showed a spinal thoracic intradural extramedullary (IDEM) tumor. After extirpation of the tumor, the motor weakness improved to the grade of 3/5. If a neurologic deficit following spinal epidural anesthesia does not resolve, a MRI should be performed without delay to accurately diagnose the cause of the deficit and optimal treatment should be rendered for the causative lesion.

• Annals of Clinical Neurophysiology
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• 제22권2호
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• pp.121-124
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• 2020

The most common form of autosomal recessive hereditary spastic paraplegia (HSP) is caused by mutations in SPG11/KIAA1840 gene, which encodes for spatacsin. The clinical presentation of SPG11 is characterized by cognitive impairment, peripheral neuropathy and a thin corpus callosum in brain magnetic resonance imaging. We identified a novel homozygous nonsense mutation (c.6082C>T [p.Q2028]) in exon 32 of SPG11 in Korean siblings. Our findings suggest that this novel homozygous mutation in SPG11 is associated with HSP and with dysgenesis of the corpus callosum.

• 한방재활의학과학회지
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• 제31권1호
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• pp.175-185
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• 2021

The objective of this study was to purpose korean medicine treatment for paraplegia and hypoesthesia after spinal cord infarction, and report its effectiveness. We treated a 74-year-old male patient diagnosed with spinal cord infarction using various methods, including acupuncture, herbal medication, moxibustion, physical therapy, western medication. We evaluated patient's motor ability using the manual muscle test (MMT), active range of motion (AROM), walking index for spinal cord injury II( WISCI II) and sense ability using International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI). After treatment, motor and sense ability of patient was improved after treatment. The MMT, AROM, WISCI II scores and ISNCSCI scores were numerically improved. According to these results, this study suggested effectiveness of combined Korean medical treatment for spinal cord infarction. However, More studies are required in the future.