• 한국정보컨버전스학회논문지
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• 제6권2호
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• pp.67-87
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• 2013

La France est un Etat unitaire $r{\acute{e}}agi$ par la Constitution. La $r{\acute{e}}forme$ de la $d{\acute{e}}centralisation$ a $d{\acute{e}}but{\acute{e}}$ par la $d{\acute{e}}claration$ 'des droits et $liber{\acute{e}}s$ des communes, des $d{\acute{e}}partements$ et des $r{\acute{e}}gions'$ qui influence plusieurs domaines de l' administration locale: la suppression du $contr\hat{o}le$ a priori et l' exercice du $contr\hat{o}le$ a posteriori par le commissaire de la Republique et par le Cour des comptes; le transfert des competences de l' Etat vers les communes, les $d{\acute{e}}partements$ et les $r{\acute{e}}gions$ avec la transmission du pouvoir de $d{\acute{e}}cision$; le transfert de moyens financiers pour financer les $d{\acute{e}}penses$ relatives aux $comp{\acute{e}}tences$ acquises; la $r{\acute{e}}forme$ du $syst{\acute{e}}me$ des fonctionnaires territoraux; le paiement des honoraires aux ${\acute{e}}lus$ locaux; la limitation du cumul des mandats.

• 응용통계연구
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• 제29권1호
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• pp.133-144
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• 2016

본 논문에서는 주기적 자기회귀(periodic autoregressive) 모형에서 모수의 수를 줄이기 위한 모수 절약 주기적 자기회귀 모형을 연구하였다. 제안된 모수 절약 모형은 실증분석에서 실업률을 이용하여 기존의 계절 시계열 모형과 비교를 통하여 그 성능을 평가하였다. 모수 절약 구조를 부여하기 위하여 계절성에서 공통된 패턴을 찾아내는 방법을 사용하였으며 기존 주기적 자기회귀 모형과의 통계적 차이 유무는 LR 검정을 통해 확인하였다. 그 결과, 중장기적으로 주기적 자기회귀 모형이 기존의 계절시계열 모형보다 우수한 예측성능을 보였으며, 특히 모수 절약 주기적 자기 회귀 모형의 사용은 기존의 주기적 자기회귀 모형보다 우수한 예측성능을 나타내는 것을 확인하였다.

• Natural Product Sciences
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• 제13권2호
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• pp.169-173
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• 2007

Luteolin is a major flavonoid of Lonicera japonica and has anti-inflammatory effect. The activation of proteinase-activated receptor (PAR)-2 and -4 by trypsin appears to play a role in inflammation, In the present study, we examined the inhibitory effects of luteolin on activation of trypsin-induced human leukemic mast cells (HMC-1). HMC-1 cells were stimulated with trypsin, PAR-2 and PAR-4 agonist, in the presence or absence of luteolin. The level of TNF-${\alpha}$ secretion was measured by enzyme-linked immunosorbent assay (ELISA). The expression of tryptase and phosphorylated-extracellular signal-regulated kinase (ERK) were assessed by Westem blot analysis. Moreover, trypsin activity was measured by the substrate Bz-DL-Arg-p-nitroanilide (BAPNA). TNF-${\alpha}$ secretion and Tryptase expression in trypsin-stimulated HMC-1 cells were markedly inhibited by pretreatment of luteolin. Furthermore, the pretreatment of luteolin resulted in the reduction of ERK phosphorylation and trypsin activity. These results suggest that luteolin might has the inhibitory effects on the PAR-2 and -4-dependent inflammation.

• 한국수산과학회지
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• 제47권3호
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• pp.247-254
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• 2014

To investigate the acquisition of quinolone resistance, we examined mutations in the quinolone resistance-determining region (QRDR) of type II topoisomerase genes in ciprofloxacin (CIP)-resistant clinical isolates and in vitro mutants of Streptococcus parauberis. The CIP-resistant clinical isolates had one base change responsible for a Ser-79${\rightarrow}$Thr in the QRDR of parC. However, the CIP-resistant in vitro mutants had an altered QRDR of parC (Ser-79${\rightarrow}$Ile) that differed from that of the isolates. None of the CIP-resistant S. parauberis clinical isolates or in vitro mutants exhibited amino acid changes in gyrA or gyrB. However, even though involvement in the increased resistance was not clear, an Arg-449${\rightarrow}$Ser mutation outside of the QRDR of parE was detected in CIP-resistant mutant 2P1. These results suggest that the topoisomerase IV gene, parC (and possibly parE, as well), is the primary ciprofloxacin target in S. parauberis. Additionally we established a high-resolution melting (HRM) assay capable of detecting the dominant mutation in four type II topoisomerase genes conferring ciprofloxacin resistance. These rapid and reliable assays may provide a convenient method of surveillance for genetic mutations conferring antibiotic resistance.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2006년도 춘계종합학술대회
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• pp.378-381
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• 2006

본 논문은 ISI가 존재하는 MIMO-OFDM 시스템에 사용되는 새로운 채널 추정 방법을 제안한다. 제안된 방법은 OFDM에서 문제가 되는 PAR를 일정하게 하고, IST의 영향을 제거하는 특별한 학습 신호를 사용한다. 이러한 학습 계열을 사용함으로서, LS(Least Square) 추정에서 문제가 되는 행렬의 특이를 피할 수 있다. 시뮬레이션 결과, SNR이 클 때 제안된 방법은 전통적인 방법보다 추정된 채널의 MSE가 20dB 이상 우수함을 확인할 수 있다.

• Journal of Ecology and Environment
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• 제47권3호
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• pp.85-102
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• 2023

Background: Ecophysiological characteristics of Rosa rugosa were analyzed under different environmental factors from May to October 2022. Photosynthesis, chlorophyll fluorescence, chlorophyll content, leaf water content (LWC), osmolality, carbohydrate content, and total ion content were measured to compare the physiological characteristics of R. rugosa at two study sites (i.e., in large pots and in the Goraebul coastal sand dune area). Results: When R. rugosa was exposed to high temperatures, photosynthetic parameters including net photosynthetic rate (P_N) and stomatal conductance (g_s) in both experiment areas declined. In addition, severe photoinhibition occurs when R. rugosa is continuously exposed to high photosynthetically active radiation (PAR), and because of this, relatively low Y(II) (i.e., the quantum yield of photochemical energy conversion in photosystem II [PSII]) and high Y(NO) (i.e., the quantum yield of non-regulated, non-photochemical energy loss in PSII) in the R. rugosa of the pot were observed. As the high Y(NPQ) (i.e., the quantum yield of regulated non-photochemical energy loss in PSII) of R. rugosa in the coastal sand dune, they dissipated the excessed photon energy through the non-photochemical quenching (NPQ) mechanism when they were exposed to relatively low PAR and low temperature. Rosa rugosa in the coastal sand dune has higher chlorophyll a and carotenoid content. The high chlorophyll a + b and low chlorophyll a/b ratios seemed to optimize light absorption in response to low PAR. High carotenoid content played an important role in NPQ. As a part of the osmotic regulation in response to low LWCs, R. rugosa exposed to high temperatures and continuously high PAR used soluble carbohydrates and ions to maintain high osmolality. Conclusions: We found that F_v/F_m was lower in the potted plants than in the coastal sand dune plants, indicating the vulnerability of R. rugosa to high temperatures and PAR levels. We expect that the suitable habitat range for R. rugosa will shrink and move to north under climate change conditions.

• 대한치과교정학회지
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• 제46권1호
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• pp.27-35
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• 2016

Objective: The aims of our study were to verify the validity of the T-Scan III system (Tekscan) as an objective occlusal evaluation tool, and to assess the differences between two occlusal indexes - the peer assessment rating (PAR) index and the American Board of Orthodontics objective grading system (OGS) - by comparing the scores derived from the T-Scan III system with the two occlusal indexes and analyzing the correlations between them. Methods: The final study sample included 48 adult volunteers (39 men and 9 women, mean age $24.14{\pm}3.16years$), after excluding 29 volunteers whose occlusion could not be evaluated by the T-Scan III system due to severe skeletal or occlusal problems. PAR index and OGS scores were assessed using dental study models, and measurements of centric occlusion, protrusive movement, and lateral excursion movement were obtained via the T-Scan III system. The results were analyzed to determine correlations. Results: Occlusal analysis by the T-Scan III system was clinically reliable (p < 0.05), and the PAR index and OGS scores were significantly correlated with several measurements obtained with the T-Scan III system (p < 0.05). Conclusions: The T-Scan III system is a quantitative and reliable method for occlusal evaluation, and represents a potential substitute for occlusal indexes. Compared to the PAR index, the OGS scores of more variables were significantly correlated with the T-Scan measurements.

• Journal of Microbiology and Biotechnology
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• 제15권6호
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• pp.1359-1367
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• 2005

The gene encoding Pyrobaculum arsenaticum DNA polymerase (Par DNA polymerase) was cloned and sequenced. The gene consists of 2,361 bp coding for a protein with 786 amino acid residues. The deduced amino acid sequence of Par DNA polymerase showed a high similarity to archaeal family B-type DNA polymerases (Group I), and contained all of the motifs conserved in the family B-type DNA polymerases for $3'{\rightarrow}5'$ exonuclease and polymerase activities. The Par DNA polymerase gene was expressed under the control of the T7lac promoter on the expression vector pET-22b(+) in Escherichia coli BL21-CodonPlus(DE3)-RP. The expressed enzyme was purified by heat treatment, and Cibacron blue 3GA and $Hirap^{TM}$ Heparin HP column chromatographies. The optimum pH of the purified enzyme was 7.5. The enzyme activity was activated by divalent cations, and was inhibited by EDTA and monovalent cations. The half-life of the enzyme at $95^{\circ}C$ was 6 h. Par DNA polymerase possessed associated $3'{\rightarrow}5'$ proofreading exonuclease activity, which is consistent with its deduced amino acid sequence. PCR experiment with Par DNA polymerase showed an amplified product, indicating that this enzyme might be useful in DNA amplification and PCR-based applications.

• 한국약용작물학회지
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• 제10권2호
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• pp.82-87
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• 2002

차광 및 광 강도별 맥문동의 광합성속도, 기공전도도 및 증산작용과 그 관련형질간의 상호연관성을 구명하였던 바는 다음과 같다. 맥문동의 광합성속도는 광 강도가 증가함에 따라 증가하였고 PAR $700-1000{\mu}mol/m^2/s$에서 최고치를 나타내었으며 차광에 의해 증가되는 경향이었다. 기공전도도는 광 강도가 증가함에 따라 증가되었고, 광합성속도, 증산작용 및 기공전도도의 일변화는 비슷한 경향의 양상을 띄었다. 광합성속도와 기공전도도와의 관계는 1차직선회귀관계로 고도의 정(正)의 상관이 인정되었으나 대조구와 차광구가 각각 다른 1차회귀직선을 보여 동일한 기공전도도에서 차광구의 광합성속도가 대조구보다 높은 경향으로 나타났다. 증산작용과 기공전도도 및 광합성속도와 증산작용의 관계는 양자간에 모두 1차회귀식의 정(正)의 상관관계가 인정되었다.

• 한국융합학회논문지
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• 제9권12호
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• pp.459-466
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• 2018

본 연구는 사업장과 지역사회에서 이루어진 PAR, CBPR을 중심으로 국내 외 문헌을 체계적 고찰을 하였다. 검토된 10개 논문의 연구 참여자는 보건전문가, 지역사회 네트워크, 근로자, 대학 연구자가 포함된 연구가 80%였고, 적용된 실행연구 기반 건강증진 프로그램은 안전 건강관리인식, 금연, 당뇨관리, 신체활동, 자기효능감 증진, 심혈관 질환, 근골격계 질환, 정신 건강 등 다양했다. 건강증진을 위해서는 지역사회 공동 작업을 통해 연구에 주도적으로 참여하는 것이 필수적이며, 이런 과정을 통하여 지역사회 차원의 문제를 해결할 수 있다. 또한 협력하며 건강증진프로그램을 개발하고 적용했을 때 지속가능한 효과를 확인할 수 있었다. PAR, CBPR은 개인과 조직, 지역사회, 제도적 차원의 범위를 조정하여 지속적인 변화를 추구할 것으로 사료되므로 다양한 사업장에서 근로자를 대상으로 활발히 수행되길 기대한다.