• Title/Summary/Keyword: Palmultang

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A Study on the Acute Toxicity of Palmultang and Fermented Palmultang Extract in ICR Mice (ICR 마우스를 이용한 팔물탕 및 발효팔물탕의 급성독성 연구)

  • Jung, Kiyoun;Hwang, Youn-Hwan;Jang, Doorye;Ha, Jeong-Ho;Ma, Jin Yeul
    • Journal of Society of Preventive Korean Medicine
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    • v.17 no.1
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    • pp.117-124
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    • 2013
  • Objectives : This study was carried out to investigate the acute toxicity and safety of Palmultang and Fermented Palmultang Extract in Mice. Methods : To evaluate their acute toxicity and safety, 0 (control group), 2000 mg/kg of Palmultang and Fermented Palmultang Extracts were orally administered to 15 male and 15 female ICR mice. After a single administration, we observed survival rates, behavioral pattern, clinical sign, body weight. The results of biochemical analysis and hematological analysis were no any significant change. Results : Compared with the control group, we could not find any toxic alteration in all treated mice. Conclusions : Overall, the results suggest that, the oral administration of Palmultang and Fermented Palmultang extracts did not produce significant toxic effect in mice. Hence, the fermented extract can be utilized for herbal therapy.

The Effect of Palmultang(八物湯) on the Ovarian Functions and Differential Gene Expression of Caspase-3, MAPK and MPG in Female Mice (팔물탕(八物湯)이 자성생쥐의 생식능력과 Caspase-3, MAPK 및 MPG 유전자 발현에 미치는 영향)

  • Joo, Jin-Man;Baek, Seung-Hee;Kim, Eun-Ha;Kim, Dong-Chul
    • The Journal of Korean Obstetrics and Gynecology
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    • v.20 no.3
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    • pp.91-110
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    • 2007
  • Purpose : These experiments were undertaken to evaluate the effect of administration of Palmultang on ovarian functions and differential gene expressions related cell viabilities caspase-3, MAPK and MPG in female mice. Materials and Methods : We administered the Palmultang to 6-week-old female ICR mice for 4, 8, or 12 days. The female mice were injected PMSG and hCG for ovarian hyperstimulation. And then recovered ovaries were minced and extracted mRNA and analyzed cell viability related gene expression. We chose the caspase-3 for cell apoptosis, MAPK and MPG genes for cell viability and DNA repair. To compare the differences, we set a control group treated with plain water at the same volume by the same way. Results : In case of administration of Palmultang, the mean number of total ovulated oocytes and the number of morphologically normal oocytes increased significantly compared to a control group. We were also examined the embryonic developmental competence in vitro. The administration of Palmultang in a concentration with 10 and 100 mg/ml were beneficial effect of embryonic development in preimplantation period. The administration of Palmultang play a role of prevention of cell apoptosis and DNA damages and also increased cell proliferation resulted in ovarian functions. Conclusion : From our results suggested that the medication of Palmultang has beneficial effect on reproductive functions of female mice via prevention of cell apoptosis and DNA damaging and promotion of cell proliferation.

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Subacute Toxicity Study on Palmultang(Bawu-Tang) in SD Rats (SD 랫트를 이용하여 팔물탕(八物湯)의 4주 반복투여 독성에 관한 연구)

  • Ma, Jin-Yeul;Yu, Young-Beob;Ha, Hye-Kyung;Huang, Dae-Sun;Shin, Hyun-Kyoo
    • The Korea Journal of Herbology
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    • v.22 no.4
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    • pp.59-64
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    • 2007
  • Objectives : Palmultang(Bawu-tang) has been traditionally prescribed as a restorative, The present study was undertaken to determine the possible toxic effects of Palmultang on SD rats. Methods : In this study, we investigated the subacute toxicity of water-extracted Palmultang(Bawu-tang) on SD rats. Twenty rats were orally adiministered Palmultang for 28 days at a dose of 0 mg/kg(control group) or 1500 mg/kg(treated group), respectively. Results : All of subjects was survived. No significant difference in abnormal clinical signs, related to hematological values, serum biochemical values, water and feed intake, coagulation time, autopsy analysis, organ weight, tissue microscopically, funduscopy, urine intake and urinalysis, was detected. Conclusions : Compared with the control group, we could not find any subacute toxic alteration in treated group (1500 mg/kg) for 28 days. This result suggests that Palmultang, a herbal medicine prescription, is a safe prescription to body.

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Effect of Palmultang on the Phagocytosis of Murine Peritoneal Macrophage (팔물탕이 복강 마크로파지의 탐식능에 미치는 영향)

  • Jeon, Hoon;Kim, Dae-Keun;Eun, Jae-Soon
    • Korean Journal of Pharmacognosy
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    • v.30 no.4
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    • pp.363-367
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    • 1999
  • Palmultang(PMT) consists of Ginseng Radix Alba, Atractylodis Rhizoma Alba, Hoelen, Glycyrrhizae Radix, Rehmanniae Radix Preparata, Paeoniae Radix, Cnidii Rhizoma and Angelicae Gigantis Radix. PMT enhanced the lucigenin chemiluminescence and the engulfment of fluorescein-conjugated E. coli particles and inhibited the production of nitric oxide in murine peritoneal macrophage. PMT enhanced the production of ${\gamma}-interferon$, interleukin-2 and the cell viability in murine thymocyte, but did not affect the production of interleukin-4. These results indicate that PMT enhances the phagocytosis of macrophage via the stimulation of ${\gamma}-interferon$ production in $T_H1$ cells and the reduction of nitric oxide production in peritoneal macrophage.

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A Study On Compositions, Dosages and Usages of Sagunjatang, Samultang, Palmultang, Sipjeondaebotang in Literature (사군자탕(四君子湯), 사물탕(四物湯), 팔물탕(八物湯) 및 십전대보탕(十全大補湯)의 처방 구성 및 용량 용법에 관한 연구)

  • Lee, Kyung-Goo;Huang, Dae-Sun;Yu, Young-Beob;Ma, Jin-Yeul;Ha, Hye-Kyeong;Shin, Hyeun-Kyoo
    • Journal of Korean Medical classics
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    • v.19 no.4
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    • pp.219-225
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    • 2006
  • The result is the followings after investigating composition, dosage and usage of Sagunjatang(四君子湯), Samultang(四物湯), Palmultang(八物湯), Sipjeondaebotang(十全大補湯) in literature by country and Era 1. Sagunjatang has become equal to Panax ginseng(人蔘), Atractylodes japonica(白朮), Poria cocos(복령) each for 2 Jeon(錢), Glycyrrhiza uralensis(甘草) 1 jeon since the Ming Dynasty in China and it is standardized by Panax ginseng, Atractylodes japonica, Poria cocos and Glycyrrhiza uralensis each for 1 Jeon 2 Pun(分) 5 Ri(里) since Dongeuibogam in Korea. 2. Samultang has become equal to Angelica gigas(當歸) and Rehmannia glutinosa(地黃) each three Jeon, Cnidium officinale(川芎) is 1 Jeon 2 Pun or 1 jeon and Paeonia lactiflora(芎藥) 2 Jeon since the Ming Dynasty in China and it is standardized by Angelica gigas, Cnidium officinale, Paeonia lactiflora and Rehmannia glutinosa each for 1 Jeon 2 Pun 5 Ri since Dongeuibogam in Korea. 3. In the case of Palmultang, compositional usage of medicine was different in the Ming Dynastry and the Ching(靑) Dynastry in China. Total dosage was increased and ratio of Angelica gigas and Rehmannia glutinosa was increased comparatively in the Ching Dynasty. All prescription of medicine was consisted of 1 Jeon 2 Pun and specific dosage was presented except Euirimchwalyo(醫林撮要) that dosage was not recorded in Korea. 4. Sipjeondaebotang tended to increase total dosage in the latter part in China. Dosage was mostly used 1 Jeon thus Dongeuibogam but Bangyakhap(方藥合編) used 1 Jeon 5 Pun differentially.

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Hereditary Retinitis Pigmentosa: Report of 1 Case Treated by Oriental Medicine (유전성 망막색소변성 한방 치험 1례)

  • Jung, Hyeon-A;Hong, Seok-Hun;Roh, Sek-Seun;Kim, Chang-Hun
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.19 no.3 s.31
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    • pp.224-231
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    • 2006
  • Retinitis pigmentosa(RP) is characterized by night-blindness, contraction of the visual field, distinct hereditary nature, wide-spread pigmentary in the midperiphery. We have experienced a case of retinitis pigmentosa treated by oriental medicine (Herbal medicaiton, Acupuncture & Electroacupuncture therapy). In the point of Differentiation of syndrome, this subject was diagnosed deficiency of both Gi & blood and Eum deficiency of Liver and Kidney. So we was administrated with Palmultang-Gamibang. After treatment of orient medicine, symptoms of patient were improved.

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Comparative Study of 12 Herbal Formulae Covered by the National Health Insurance Service in Korea (한방건강보험약 12종의 항산화 활성 및 신경세포 독성 스크리닝 연구)

  • Seo, Ji Eun;Lee, Hanul;Bae, Chang-Hwan;Yoon, Dong Hak;Kim, Hee-Young;Kim, Seungtae
    • Korean Journal of Acupuncture
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    • v.39 no.2
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    • pp.34-42
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    • 2022
  • Objectives : Parkinson's disease (PD) is a neurodegenerative disease caused by dopaminergic neuronal death in the substantia nigra pars compacta. PD is known to be linked with mitochondrial dysfunction and increased oxidative stress. In this study, anti-cytotoxic and anti-oxidative effect of 12 herbal formulae were compared. Methods : According to experts' advice, 12 types of herbal formulae (Gamisoyosan, Galgeuntang, Galgeunhaegitang, Banhabaekchoolcheonmatang, Bojungikgitang, Boheotang, Sihogyejitang, Sihosogantang, Sihocheonggantang, Ojeoksan, Cheongsanggyeontongtang and Palmultang) were selected from 56 types of herbal formulae covered by the National Health Insurance Service in Korea. To detect anti-oxidative effect, 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay was performed, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed to detect anti-cytotoxic effect of 12 herbal formulae using SH-SY5Y human neuroblastoma cells. Results : In DPPH assay, anti-oxidant activity was increased in a dose-dependent manner and half maximal inhibitory concentration was highest in the order of Galgeuntang, Gamisoyosan, Galgeunhaegitang, Ojeoksan, Palmultang, Sihogyejitang, Sihosogantang, Cheongsanggyeontongtang, Sihocheonggantang, Bojungikgitang, Boheotang and Banhabaekchoolcheonmatang. In MTT assay, concentration of 80% cell survival was highest in the order of Sihosogantang, Cheongsanggyeontongtang, Sihocheonggantang, Sihogyejitang, Bojungikgitang, Galgeuntang, Ojeoksan, Boheotang, Palmultang, Galgeunhaegitang, Banhabaekchoolcheonmatang and Gamisoyosan. Formulae with more than 50% DPPH radical scavenging activity at concentrations for 80% cell survival were Sihosogantang, Cheongsanggyeontongtang, Sihogyejitang, Galgeuntang and Sihocheonggantang. Conclusions : Sihosogantang, Cheongsanggyeontongtang, Sihogyejitang, Galgeuntang and Sihocheonggantang extracts can be candidate medicines for PD, but the effect should be validated in PD models.

The Protective Effect of Herbal Medicine on PC12 Cell Induced by $MPP^+$ and 6-OHDA Neurotoxicity ($MPP^+$와 6-OHDA에 대한 한약탕제의 보호효과 연구)

  • Kang, Bong-Joo;Hong, Seoung-Gil;Cho, Dong-Wuk
    • Korean Journal of Oriental Medicine
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    • v.5 no.1
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    • pp.119-131
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    • 1999
  • The effect of herbal medicine on 1-methyl-4-phenylpyridinium ion $(MPP^+)$ and 6-hydroxydopamine (6-OHDA) mediated neurotoxicity was studied in the rat phaeochromocytoma cell line PC12. The present study was designed to test the hypothesis that herbal medicine can protect cells from neurotoxiciy caused by $MPP^+$ and 6-OHDA. Exposure of PC12 cells to 0.2 mM $MPP^+$ and $50\;{\mu}M$ 6-OHDA for 24h resulted in a 50% cell death with respect to the control cells. $MPP^+$ induced cell death was reduced by Yollyounggobondan (延齡固本丹), Sagunjatang (四君子湯), Palmihwan (八味丸), and Palmultang (八物湯)(P<0.05). However, herbal medicines did not protect cells from degeneration caused by the 6-OHDA. Yollyounggobondan, Yungmijihwangwon (六味地黃元), Palmihwan, and Samultang (四物湯) were effective in protecting against $MPP^+$-induced ATP loss in PC12 cells (P<0.05). Yollyounggobondan and Palmultang were effect in neurite protection against 6-OHDA treatment in differentiated PC12 cells with NGF.

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A Case Study of Tremor Patient diagnosed as Cerebellar infarction (소뇌경색(小腦梗塞)으로 인한 진전환자(振顫患者)의 치험(治驗) 1례(例))

  • Hwang, Jin-Woo;Kang, Rae-Yeop;Shim, Hyo-Ju;Na, Yu-Jin;Kim, Byung-Chul;Song, Soo-Cheol;Lee, Won-Hui;Kim, Jin-Won;Seo, Ho-Seok;Kim, Yong-Ho
    • The Journal of Internal Korean Medicine
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    • v.28 no.4
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    • pp.929-936
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    • 2007
  • Tremor is a rhythmic, involuntary muscular contraction characterized by oscillations of a part of the body and is the most common movement disorder. Clinically, tremor isclassified into postural tremor, resting tremor, action tremor, or other kinds of tremor, and treated according to the causes. The appropriate treatment of tremor depends on accurate diagnosis of its cause. We have recently examined a number of tremor-patients diagnosed as cerebellar infarction. Based on traditional Korean medicine curative way, we diagnosed this patient as deficiency of Qi and blood(氣血兩虛). On this account, suitable treatment had been provided. Our results show the clinical symptoms had improved through treatment with herbal medicine (Palmultang-gamibang) and acupuncture, so we report it for better treatment.

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The bibliographical study on the treatment and drugs of Hu-Ro(虛勞) (허로(虛勞)의 치법(治法) 및 치방(治方)에 관(關)한 문헌적(文獻的) 고찰(考察))

  • Ryu, Gi-Won;Baek, Tae-Hyun
    • The Journal of Internal Korean Medicine
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    • v.13 no.1
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    • pp.117-123
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    • 1992
  • This study has been carried out to investigate the treatment and drugs of Hu-Ro(虛勞) by referring to 35 literatures. The results were as follows; 1. The treatment of Hu-Ro(虛勞) is as follows. basic treatment : hujeokboji (虛卽補之) nojaonji sonjaonji (勞者溫之 損者溫之) general treatment : onbo (溫補) - bojungikgiseongyang (補中益氣升陽) chungbo (淸補) - jaeomganghwa (滋陰降火) 2. The drugs of Gi-Su(氣嗽) is as follows. gihu (氣虛) : bojungikgitang (補中益氣湯), sagunjatang (四君子湯) hulhu (血虛) : samultang (四物湯), daebojineum (大補眞飮) yanghu (陽虛) : oogwieum (右歸嗽), jwagihwna (左歸丸) eumhu (陰虛) : yukmihwan (六味丸), jwagihwna (左歸丸) eumyangguhu (陰陽俱虛) : gojineumja (固眞飮子), palmultang (八物湯)

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