• Journal of Sasang Constitutional Medicine
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• v.22 no.4
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• pp.1-9
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• 2010

1. Objectives This paper investigates the origin, the progressive changes and the constructive principles of Palmulgunja-tang (八物君子湯). 2. Methods Palmulgunja-tang and other related prescriptions were analyzed in terms of their pathological indications, based on previous literature including "Donguisusebowon Chobongwon (東醫壽世保元 草本卷)", "Donguisusebowon Gabobon (東醫壽世保元 甲午本)", "Donguisusebowon Sinchukbon (東醫壽世保元 辛丑本)" and "Dongmuyugo (東武遺稿)". 3. Results and Conclusions 1) The Palmulgunja-tang most likely originates from Paljin-tang introduced in "Donguisusebowon Chobongwon (東醫壽世保元 草本卷)". Paljin-tang progressively transformed into Seungyangpalmul-tang ("Donguisusebowon Gabobon (東醫壽世保元 甲午本)") and ultimately into Palmulgunja-tang ("Donguisusebowon Sinchukbon (東醫壽世保元 辛丑本)"), a prescription appropriate for usage in the Ulgwang symptomatology (鬱狂證). Also, Seungyangikgi-tang in "Donguisusebowon Sinchukbon (東醫壽世保元 辛丑本)" can be presumed to have been affected by Seungyangpalmul-tang. 2) The variational prescriptions (變方) of Palmulgunja-tang shows increasing Seungyang (升陽) effect in order of Baekhaogunja-tang, Sipjeondaebo-tang, Palmulgunja-tang, and Doksampalmul-tang. 3) Palmulgunja-tang is composed of 8 herbs. Of these, Paeoniae Radix Alba (白芍藥), Glycyrrhizae Radix(甘草), Angelicae gigantis Radix (當歸), and Cnidii Rhizoma (川芎) fortify the Soeumin Spleen Element (脾元). Ginseng Radix (人蔘) and Astragali Radix (黃芪) support the ascension of Yang, whereas Atractlodis Rhizoma White (白朮) and Citrus unshiu (陳皮) encourage the descension of Yin.

• Journal of Sasang Constitutional Medicine
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• v.22 no.4
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• pp.98-105
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• 2010

1. Objectives The purpose of this case is to report that Soeumin patient diagnosed as Grave's disease was treated with Palmulgunja-tang and antithyroid drugs in combination. 2. Methods From April 7, 2010 to June 30, 2010, we treated him with Palmulgunja-tang and antithyroid drugs. We took his weight, pulse and checked visual analog scale(VAS) to evaluate the symptoms of Grave's disease. 3. Results After treatment, this patient's thyroid function test were improved faster than with western medicine treatment only in 2009. The symptoms also were improved. 4. Conclusions This case study showed an efficient results by giving Sasang Constitutional treatment in treatment of Grave's disease.

• Journal of Sasang Constitutional Medicine
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• v.32 no.2
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• pp.80-95
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• 2020

Introduction This study is the first case report to observe a significant improvement of clinical symptoms of both Recurrent Aphthous Stomatitis(RAS) and pompholyx treating with modified Palmulgunja-tang for Soeum-type. Case presentation A 37-year-old female patient complained of pain by ulcers on her mouth and tongue, and of itching caused by vesicles on her palms and soles was diagnosed with RAS, pompholyx, and, especially moderate pattern of 'Congestive Hyperpsychotic symptomatology' according to the theory of Sasang Constitutional Medicine(SCM). During inpatient and outpatient treatment, she took modified Palmulgunja-tang, and was treated with acupuncture, moxibustion, and cupping therapy. The effectiveness of these therapies was assessed with subjective Neumeral Rating Scale(NRS) and Dyshidotic Eczema Area and Severity Index(DASI). Conclusion After the treatment according to the theory of SCM, NRS, and DASI score about RAS and pompoholyx was decreased, and the general condition of the patient also has improved.

• Journal of Sasang Constitutional Medicine
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• v.28 no.2
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• pp.132-146
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• 2016

Objectives This study's object was to observe the comparative effects of Yangkyuksanhwa-tang, Palmulgunja-tang and Cheongpyesagan-tang on the chronic LT4(levothyroxine) induced hyperthyroidism in rats.Methods Six groups, each of 8 rats in group, were used in this study. Saline and distilled water treated rats are intact control group. Hyperthyroidism was induced by daily subcutaneous LT4 300 μg/kg treatment for 27 days(LT4 control). Since 12th LT4 treatment PTU(propylthiouracil) 10 mg/kg was intraperitoneal injected(PTU group) and aqueous extracts of Yangkyuksanhwa-tang, Palmulgunja-tang and Cheongpyesagan-tang(YS, PG and CS) 500 mg/kg were orally administrated(YS, PG, CS group), once a day for 15 days. The differences in the body, thyroid gland and epididymal fat pad weights, serum T3(tri-iodothyronine), T4(thyroxine), TSH(thyroid-stimulating hormone), thyroid gland and epididymal fat pad histopathology, liver weight, AST(asparte aminotransferase), ALT(alanine aminotransferase) concentrations, hepatic lipid peroxidation, GSH(glutathione), SOD(superoxide dismutase), CAT(catalase) activities, liver histopathology were observed to evaluate effects on hyperthyroidism, liver damages and antioxidant effects.Results As results of LT4 treatment, hyperthyroidism and related liver damages such as lower body, thyroid weights, higher serum T3, T4, AST, ALT levels, thinner follicular lining epithelium in thyroid glands were observed. However, these symptoms were inhibited by oral treatment of YS, PG and CS. As compared with PTU treatment, these herbal prescriptions showed lower overall efficacy on the hyperthyroidism, but YS showed more favorable effects on the hepatic antioxidant defense systems.Conclusions This results suggest that YS, PG and CS favorably control the LT4 induced hyperthyroidism and related liver damages in rats through modulation of the hepatic antioxidative defense systems.

• Journal of Sasang Constitutional Medicine
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• v.23 no.2
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• pp.254-262
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• 2011

1. Objectives: We report a case of Soeumin tidal fever patient presenting with pelvic pain who was successfully treated with Sasang therapy. The purpose of this case is to report that a Soeumin patients with tidal fever and pelvic pain who improved with Sasang Constitutional treatment 2. Methods: We treated a female Soeumin patient presenting with tidal fever and pelvic pain. We prescribed Palmulgunja-tang(八物君子湯) for her symptoms. Body temperature and physical symptoms were measured to assess improvement. 3. Results: The Soeumin patient's fever and pain improved with a dramatic drop in the highest body temperature from $39.1^{\circ}C$ to $36.6^{\circ}C$. Activities of daily living(ADL) improved from bed ridden to independently ambulatory state. 4. Conclusions: This case study shows that Palmulgunja-tang was in effective treating tidal fever and pain in this Soeumin patient.

• Journal of Sasang Constitutional Medicine
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• v.17 no.2
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• pp.64-73
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• 2005

1. Objectives The purpose of this study was to investigate the effects of the enzyme activity of Palmulgunja-tang with administered orally solution on cytochrome P450 isozyme 2. Methods This study was carried on through following methods. We treated the rat with the {3-naphthoflavone (${\beta}NF$) of 80mg/kg for 3 days i.p injection. Firstable, microsomal protein was separated and total intracellular protein test was done. Then GOT and GPT were measured and assay of cytochrome P450 IAI/2 enzyme activity was performed according to the method of EROD and MROD. (Ethoxyresorufin-O-deethylase(EROD) activity was used to measure cytochrome P450 lAI activity and methoxyresorufin O-demethylase(MROD) activity was used to measure cytochrome P450 lA2 activity. ) 3. Results and Conclusions 1) PGT recovered the liver damage on ${\beta}NF$ inducible CYP IAI/2 by pre-post and high-low condition. 2) At concentration of post-treated 50mg!kg of PGT, the inhibiting of $\betaNF$ metabolites to liver of rat cytochrome P450 lAl was inhibited by 53.0% respectively. 3) PGT showed 36.0% inhibition of ${\beta}NF$-induced lA2 activity at the concentration post-treated 50mg/kg.

• Journal of Sasang Constitutional Medicine
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• v.29 no.2
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• pp.116-127
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• 2017

Objectives The purpose of this study was to survey changes in symptoms caused by Sasang medicines. Methods We recruited 45 subjects who were classified 15 typical Soeumin, Soyangin, Taeumin and did a survey about symptoms. We split Soeumin into 3 groups and prescribed medicines Palmulgunja-tang, Yanggyuksanhwa-tang, Taeumjowi-tang. We did same process in Soyangin and Taeumin. After taking medicines for 4 weeks, we did a survey about physical changes. Results There was no consistent changes in symptoms. But medicines which were not suitable to their Sasang constitution induced known reactions. And medicines which were suitable to their Sasang constitution induced reactions. Conclusions Changes in symptoms appeared after taking medicine, but they can be induced by medicine.

• The Journal of Pediatrics of Korean Medicine
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• v.21 no.3
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• pp.1-10
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• 2007

Objectives The purpose of this study is to report a pediatric patient with bilateral facial nerve palsy. Methods The patient was treated by acupuncture, moxa, herb(Cheongungkyeoji-tang, Palmulgunja-tang) for 1 month. We described his progression and measured the degree by House-Brackmann scale and Yanagihara's scale. Results He started getting better from 7th day of the onset. During admission, the facial palsy had improved from Grade V/V(Rt/Lt) to Grade II/II(Rt/Lt) by House-Brackmann scale and from 0/0(Rt/Lt)score to 36/36(Rt/Lt)score by Yanagihara's scale. Conclusions Compared with unilateral facial nerve palsy cases, this case was not different from the time when it got better, and how much it improved. However, biased degree had increased and then decreased because of the time gap between the right facial improvements and left facial one.

• Journal of Sasang Constitutional Medicine
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• v.20 no.3
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• pp.107-117
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• 2008

1. Objective The aim of this study was to survey the adverse reactions by the prescriptions of Soeumin.Soyangin and to compare the tendency of their symptoms according to Sasang constitutional type. 2. Methods The clinical data for this study were based on the medical records of total 91 cases collected from an oriental clinic during 1996-2004. Their constitutional types were diagnosed by a specialist and then confirmed by drug reactions. To evaluate reliability of the analysis, we only analysed the cases above grade C. The target prescriptions were Palmulgunja-tang, Bojungikgi-tang, Hyangsayangwi-tang, Ijung-tang, Hyeongbangsabaek-san, Jeoryeongchajeonja-tang, Yanggyeoksanhwa-tang, Yangdokbaekho-tang and the sorts of Jihwang-tang. 3. Results and Conclusion The prescriptions which were not suitable for their Sasang constitutional type induced indigestion, stomachache and evacuation troubles basically. Besides, the prescriptions of Soeumin caused some fever of the upper body and skin on Taeeumin and Soyangin. And the prescriptions of Soyangin lead to more severe digestive and evacuation troubles on Taeeumin and Soeumin. 4. Conclusion: This study need to be compensated by additional clinical studies which are more systematic and continuous. This way we can make the firm evidence for approving the difference of drug susceptibility according to the Sasang constitutional type.

• The Journal of Korean Medical History
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• v.26 no.2
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• pp.23-29
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• 2013

Objectives : The purpose of this study is to extend indications of Four-Constitution Medicinal formulas by comparing with formulas on Dongeuibogam(東醫寶鑑), focusing on their composition. Methods : 1. We analyzed the composition of Four-Constitution Medicine formula which are mentioned on Donguisusebowon(東醫壽世保元), focusing on their composition. 2. We analyzed the composition of formulas on Dongeuibogam(東醫寶鑑) comparing with 24 formulas for So-Eum type, 17 formulas for So-Yang type, 24 formulas for Tae-Eum type, 2 formulas for Tae-Yang type. Results & Conclusions : 1. We finally selected 14 formulas and its effect as similar formulas with Bojungyikgi-tang, Insamjinpi-tang, Cheongunggyeji-tang, Palmulgunja-tang, Hwanggigyejibuja-tang, Hwanggigyeji-tang for So-Eum type. 2. We finally selected 4 formulas and its effect as similar formulas with Dokwaljihwang-tang, Sukjihwanggosam-tang for So-Yang type.