• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2005년도 BIOINFO 2005
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• pp.294-299
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• 2005

We have studied unbound docking for 12 protein-protein complexes using conformational space annealing (CSA) combined along with statistical pair potentials. The CSA, a powerful global optimization tool, is used to search the conformational space represented by a translational vector and three Euler amgles between two proteins. The energy function consists of three statistical pair-wise energy terms; one from the distance-scaled finite ideal-gas reference state (DFIRE) approach by Zhou and the other two derived from residue-residue contacts. The residue-residue contact terms describe both attractive and repulsive interactions between two residues in contact. The performance of the CSA docking is compared with that of ZDOCK, a well-established protein-protein docking method. The results show that the application of CSA to the protein-protein docking is quite successful, indicating that the CSA combined with a good scoring function is a promising method for the study of protein-protein interaction.

• 한국언어정보학회:학술대회논문집
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• 한국언어정보학회 2007년도 정기학술대회
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• pp.394-404
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• 2007

This paper explores the nature of multiple sluicing in English, which has two or more remnant wh-phrases in clause edge position. At the beginning part of the paper we argue against Nishigauchi's (1998) and Lasnik's (2007) Gapping analysis of multiple sluicing, which says that two remnant wh-phrases each actually occupies the left and right edge of a clause, with the in-between string of words undergoing Gapping. We rather argue that multiple sluicing in English is the same kind as found in Bulgarian and Serbo-Croatian. In other words, multiple sluicing in English is also derived by multiple wh-fronting which otherwise does not apply. We demonstrate that some important properties of the construction noted by Lmultiple sluicing, multiple wh-movement/fronting, sluicing, TP/IP-deletion, asnik (2007) under the Gapping approach to it can be accounted for in a principled way by our proposed analysis.

• Macromolecular Research
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• 제15권7호
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• pp.682-687
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• 2007

The equation of state developed herein is predicated on a hard-sphere reference with perturbations introduced via a potential function to account for electrostatic forces and for attraction between protein particles. During this process, the generalized Lennard-Jones (GLJ) pair potential function is employed. The GLJ pair potential function is employed to represent the protein-protein interaction in two-protein systems. Via the use of the relation between the equation of state and the chemical potential, the phase behavior in the aqueous two-protein system can be estimated. The partition coefficients can be obtained via these processes. The calculated values of the coefficients agree fairly well with the experimental data in the given pH and ionic strength range, with no additional adjustable model parameters.

• 한국컴퓨터정보학회논문지
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• 제21권1호
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• pp.115-123
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• 2016

In this study, we collect various side effect pairs which are appeared frequently at many drugs, and select side effect pairs that have higher severity. For every selected side effect pair, we extract common genetic networks which are shared by side effects' genes and drugs' target genes based on PPI(Protein-Protein Interaction) network. For this work, firstly, we gather drug related data, side effect data and PPI data. Secondly, for extracting common genetic network, we find shortest paths between drug target genes and side effect genes based on PPI network, and integrate these shortest paths. Thirdly, we develop a classification model which uses this common genetic network as a classifier. We calculate similarity score between the common genetic network and genetic network of a drug for classifying the drug. Lastly, we validate our classification model by means of AUC(Area Under the Curve) value.

• 한국가시화정보학회:학술대회논문집
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• 한국가시화정보학회 2006년도 추계학술대회 논문집
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• pp.55-58
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• 2006

The flow characteristics in a confined slot jet impinging on a flat plate were investigated by using cinematic Particle Image Velocimetry technique. The three different kinds of confined slot were applied to the jet with a view to evaluating the shape effect and the jet Reynolds number was varied from 250 to 1000 for a fixed jet-to-plate spacing of H/W=5. It was found that the vortex structures in the shear layer are developed with increase of Reynolds number and that the jet becomes unsteady by the interaction of vortex pairs between 500 and 750 of Reynolds number. Finally, the slot shape was proved to be related with the generation timing of vortex pair and the temporal vortex structure.

• Journal of the Korean Data and Information Science Society
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• 제24권6호
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• pp.1221-1229
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• 2013

이 연구의 목적은 교사와 가족의 상호작용이 자폐성장애 아동의 문제행동과 사회성 기술에 미치는 영향을 알아보는 것이다. 초등부에 재학하고 있는 자폐성장애 아동의 담임교사와 아동의 부모 각각 147명을 대상으로 상호작용의 수준에 따라 상호작용이 모두 높은 집단, 교사와 가족 중 한 집단이라도 상호작용이 높은 중간 집단, 상호작용이 모두 낮은 집단으로 나누어 문제행동, 사회성 기술에 미치는 영향을 분석하였다. 연구결과는 교사의 상호작용이 자폐성장애 아동의 사회성 기술과 상관관계가 있으며 통계적으로 유의한 것으로 나타났고, 교사와 가족의 상호작용이 모두 높은 집단이 중간 및 낮은 집단보다 자폐성장애 아동의 사회성 기술이 높음을 보여준다.

• 대한감각통합치료학회지
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• 제10권1호
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• pp.1-10
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• 2012

목적 : 본 연구에서는 그룹감각통합치료가 감각통합장애아동의 또래 및 치료사와의 상호작용에 어떠한 영향을 미치는지 알아보고자 하였다. 연구 방법 : 연구대상은 만 3~5세의 학령전기 아동 3명으로, 실험기간은 2011년 9월에서 12월까지였다. 그룹감각통합 치료는 주1회, 회기 당 80분씩 총 15회기로 실시하였다. 또래 및 치료사와의 상호작용을 관찰하기 위해 사회적 상호작용 행동관찰 표를 사용하였다. 그룹감각통합치료 사전/사후의 상호작용 차이는 윌콕슨 순위검정(Wilcoxon matched-pair signed rank test)을 사용하여 분석하였다. 결과 : 그룹감각통합치료 프로그램을 실시하기 전보다 후에 또래 및 치료사와의 긍정적 상호작용은 증가하고 부정적 상호작용은 감소하였으나 통계적으로 유의한 차이가 없었다. 결론 : 본 연구의 결과는 그룹감각통합치료가 감각통합장애아동의 또래와 치료사와의 상호작용 향상에 긍정적인 영향을 미친다고 결론짓기에는 한계가 있다. 그러나 프로그램이 적용되는 동안 다른 아동들을 관찰하고 기존의 놀이에 참여하려는 행동이 늘어났다. 그리고 거부하기나 물건 던지기와 같은 부정적인 행동은 줄어드는 등 아동의 개별행동에는 긍정적인 변화가 있었다. 향후 연구기간, 연구대상자 선정의 고려 및 표준 데이터를 제시해 줄 수 있는 평가도구를 통해 그룹감각통합치료를 적용한다면 상호작용에 향상에 대한 명확한 결과를 볼 수 있을 것으로 기대한다.

• Macromolecular Research
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• 제10권2호
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• pp.91-96
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• 2002

To explore the effects of intramolecular interactions within the copolymer on the phase separation behavior of polymer blends, copolymers having two different types of intramolecular interactions, i.e., intramolecular repulsion and intramolecular attraction were prepared . In this study, poly(styrene-co-methylmethacrylate) (P(S-MMA)) having intramolecular repulsion caused by positive interaction between styrene and MMA and poly(styrene-co-ethyl-methacrylate) (P(S-EMA)) and poly(styrene-co-cyclohexylmethacrylate) (P(S-CHMA)) having intramolecular attraction caused by negative interaction between styrene and methacrylate were blended with tetramethyl poly-carbonate (TMPC). The phase behavior of blends was examined as a function of copolymer composition and blend composition. TMPC formed miscible blends with styrenic copolymers containing less than certain amount of methacrylate. The phase separation temperature of TMPC blends with copolymer such as P(S-MMA) and P(S-EMA), first increases with methacrylate content, goes through a maximum and then decreases just prior to the limiting content of methacrylate for miscibility, while that of TMPC blends with P(S-CHMA) always decreases. The calculated interaction energy for TMPC-P(S-EMA) pair is negative and monotonically increases with EMA content of the copolymer. Such behavior contradicted the general notion that systems with more favorable energetic interactions have higher LCST, The detailed inspection of the lattice-fluid theory related to the phase behavior was performed to explain such behavior.

• 농촌계획
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• 제15권1호
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• pp.47-59
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• 2009

The aim of this study is to analyze the green-tourism centrality considering spatial interaction using Gravity Model and social network method. The degree centrality and prestige centrality were applied as green-tourism centrality index. The rural amenity resources and human resources were counted as attraction factors, and a distance among villages was used as friction factor in gravity model. The weights of rural tourism amenity resources were calculated using the analytic hierarchy process(AHP) method and applied to evaluate green-tourism potentiality. The distance was measured with the shortest path among villages using geographic information system(GIS) network analysis. The spatial interaction from gravity model were employed as link weights between nodal points; a pair villages. Using the spatial interaction, the degree-centrality and prestige-centrality indices were calculated by social network analysis and demonstrated possibility of developing integrated green-tourism region centered on high centrality villages.

• Bulletin of the Korean Chemical Society
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• 제16권9호
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• pp.873-885
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• 1995

The local structural and thermodynamical properties of blends A-B/H of a diblock copolymer A-B and a homopolymer H are studied using the polymer reference interaction site model (RISM) integral equation theory with the mean-spherical approximation closure. The random phase approximation (RPA)-like static scattering function is derived and the interaction parameter is obtained to investigate the phase transition behaviors in A-B/H blends effectively. The dependences of the microscopic interaction parameter and the macrophase-microphase separation on temperature, molecular weight, block composition and segment size ratio of the diblock copolymer, density, and concentration of the added homopolymer, are investigated numerically within the framework of Gaussian chain statistics. The numerical calculations of site-site interchain pair correlation functions are performed to see the local structures for the model blends. The calculated phase diagrams for A-B/H blends from the polymer RISM theory are compared with results by the RPA model and transmission electron microscopy (TEM). Our extended formal version shows the different feature from RPA in the microscopic phase separation behavior, but shows the consistency with TEM qualitatively. Scaling relationships of scattering peak, interaction parameter, and temperature at the microphase separation are obtained for the molecular weight of diblock copolymer. They are compared with the recent data by small-angle neutron scattering measurements.