• Journal of Dental Anesthesia and Pain Medicine
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• 제22권4호
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• pp.277-287
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• 2022

Background: Inflammatory dental diseases that occur during pregnancy can cause preterm labor and/or intrauterine growth restriction. Therefore, proactive treatment of dental diseases is necessary during pregnancy. Dexmedetomidine (DEX) is a widely used sedative in the dental field, but research on the effect of DEX on pregnancy is currently insufficient. In this study, we investigated the effects of co-treatment with DEX and lipopolysaccharide (LPS) on inflammatory responses in human amnion-derived WISH cells. Methods: Human amnion-derived WISH cells were treated with 0.001, 0.01, 0.1, and 1 ㎍/mL DEX with 1 ㎍/mL LPS for 24 h. Cytotoxicity of WISH cells was evaluated by 3-(4,5-dimethylthiazol)-2,5-diphenyltetrazolium bromide (MTT) assay. The protein expression of cyclooxygenase-2 (COX-2), prostaglandin E₂ (PGE₂), p38, and nuclear factor kappa B (NF-𝜅B) was examined by western blot analysis. The mRNA expression of pro-inflammatory cytokines such as interleukin (IL)-1𝛽 and tumor necrosis factor (TNF)-𝛼 was analyzed by real-time quantitative polymerase chain reaction. Results: Co-treatment with DEX and LPS showed no cytotoxicity in the WISH cells. The mRNA expression of IL-1𝛽 and TNF-𝛼 decreased after co-treatment with DEX and LPS. DEX and LPS co-treatment decreased the protein expression of COX-2, PGE₂, phospho-p38, and phospho-NF-𝛋B in WISH cells. Conclusion: Co-treatment with DEX and LPS suppressed the expression of COX-2 and PGE₂, as well as pro-inflammatory cytokines such as IL-1𝛽 and TNF-𝛼 in WISH cells. In addition, the anti-inflammatory effect of DEX and LPS co-treatment was mediated by the inhibition of p38/NF-𝜅B activation.

• 한국산업보건학회지
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• 제33권3호
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• pp.298-307
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• 2023

Objectives: The purpose of this study is to analyze the recent trends in patients with work-related musculoskeletal disorders in South Korea and to check the major results by reviewing the literature on the risk factors and prevalence of musculoskeletal diseases related to work. Methods: Industrial disaster data from the Ministry of Employment and Labor from 2012 to 2021 were used, and the literature was reviewed regarding risk factors for musculoskeletal diseases related to work using PubMed and RISS. Results: The trend of patients with work-related musculoskeletal disorders has increased overall since 2017 after declining until 2016, with a particularly notable increase in the average annual number of patients with physical burden work. The average annual rate per ten thousand people for patients with body burden work, non-accidental lower back pain, and carpal tunnel syndrome among work-related diseases was high in the mining industry. The average annual rate per ten thousand people for patients with accidental lower back pain was the highest in the fishing industry. Within the manufacturing field, it was the highest in the shipbuilding and ship repair industry. As a result of the literature review, the search rate for work-related musculoskeletal disease papers in unstructured work was high. In addition, physical stress factors were high among risk factors, and pain areas showed a high rate for the waist. Conclusion: Even after the institutional implementation of a hazard investigation system related to musculoskeletal diseases is implemented, the number of patients with occupational musculoskeletal disorders continues to increase. Therefore, it is necessary to conduct regular surveys and implement effective improvement activities for vulnerable industries or occupations.

• Annals of Occupational and Environmental Medicine
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• 제35권
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• pp.21.1-21.11
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• 2023

Background: Recently, irregular working hours have become controversial issues in Korea. The health impact of irregular working hours on the work-related musculoskeletal pain (MSP) is scarcely researched before. We sought to investigate the association between irregular working hours and work-related MSP among South Korean workers. Methods: This study used data from the sixth Korean Working Conditions Survey in 2020. The prevalence of work-related MSP was analyzed using the χ² test. A multiple logistic regression analysis was conducted to assess the association between irregular working hours and work-related MSP. We conducted stratified analysis by gender, weekly working hours, and workers' control over their working hours. We calculated the adjusted odds ratios (ORs) of work-related MSP for irregular working hours combined with weekly working hours. Results: The OR for work-related MSP was significantly higher in the population with irregular working hours than in the population with regular working hours (OR: 1.43, 95% confidence interval [CI]: 1.29-1.58). Irregular and long (> 52 hours/week) working hours have the highest risk of work-related MSP in both genders (in men, OR: 3.48 [95% CI: 2.53-4.78]; in women, OR: 2.41 [95% CI: 1.46-4.00]). Conclusions: Irregular working hours were associated with work-related MSP in Korea. The association was magnified with long working hours. Reform of the Korean Labor Standards Act leading to increase irregular working hours may induce adverse health outcome.

• 한국임상수의학회지
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• 제21권3호
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• pp.319-322
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• 2004

Two bitches were presented to the Teaching Animal Hospital, Chonbuk National University with vagina prolapse along with prolapse of the bladder. Case 1 was a 2 years old, 38.5 kg, female Tosa dog which had slight shock and depression. She had a labor pain vagina prolapse since last 3 days. Case 2 was a 2 years old, 25 kg, female Rottweiler dog which was presented with the similar clinical signs with case 1. In both the dogs we performed plain radiography, CBC, blood chemistry and urine analysis. In case 1, we performed cesarean section along with the repositioning the vagina and the bladder. We found 13 fetuses among which 7 were alive. In case 2, we also performed cesarean section and recovered the fetuses. There were 7 fetuses but only one was alive. Among the 6 dead fetuses 3 were congenitally deformed. Then we reduced prolapsed vagina and bladder, and repositioned them. After that we performed ovariohysterectomy. Both the bitches become recovered from the prolapse of the vagina and bladder and there was no recurrence of the condition.

• 대한간호학회지
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• 제31권6호
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• pp.1088-1097
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• 2001

This study was formed to propose a theoretical background trying to create a positive delivery experience by understanding college women's subjective accounts (their view and attitude) on delivery. Method: Q- methodology was used to appreciate the highly abstract concept in an objective manner, since delivery can be assessed differently with each experience. Result: There were three types of opinions about the delivery in college women. The first type (matured type) understood delivery to be a precious experience that enables women to gain the value of life through labor pain, and granted then more appreciation to their own mothers. The second type (will type) recognizes delivery as an option rather than an obligation for women. They think women chooses whether or not to experience the process, especially since delivery requires a great deal of responsibility. The third type (positive type) takes delivery as a valuable, worthwhile, and marvelous process that they wish to experience. They are not even afraid of giving birth multiple times. Conclusion: The study explains and allows us to understand college women's overall opinion and attitudes about delivery. Thus this study aids the seizure of an opportunity to build a theoretical base for delivery management.

• Journal of Gastric Cancer
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• 제14권4호
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• pp.275-278
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• 2014

Gastric cancer is rare during pregnancy, and often advanced upon presentation. A Krukenberg tumor presents a diagnostic and therapeutic challenge in the pregnant patient. We present a case of a 38-year-old woman at 22 weeks' gestation who presented with worsening epigastric pain, and was found to have a left pelvic mass on ultrasound, which was confirmed by magnetic resonance imaging. She went into active labor and delivered a viable infant via vaginal delivery. An exploratory laparotomy revealed a large mass originating from her left ovary and diffuse thickening of the lesser curvature of the stomach. Frozen section investigation revealed the presence of signet cell adenocarcinoma. Subsequent upper endoscopy showed linitis plastica, while biopsy confirmed the presence of adenocarcinoma. In conclusion, the occurrence of gastric cancer in pregnancy is rare despite extremely common symptoms. The management poses a challenge because of the need for early treatment, and the continuation of the pregnancy.

• 근관절건강학회지
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• 제6권2호
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• pp.226-241
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• 1999

This study was undertaken to find out the causal perception of rheumatoid arthritis patients, and to understand the typology. The Q-population consisted of 236 statements of causal perception were collected. Thirty eight Q-samples of causal perception were selected. The P-sample for this study were made up of 28 first visiting female rheumatoid arthritis patients from a rheumatoid arthritis specialty hospital. Each respondent responded Q-set of causal perception according to 9-point scale. The result of Q-sorting were coded and analyzed using QUANL PC program. 1) Typological Observation on Causal Perception (1) Physical Fatigue Type : Type 1 perceived that the illness occurred due to excessive work requiring physical labor or strain that had occurred from not resting after excessive physical labor, therefore, thinking the origin of the illness was from physical strain. (2) Physical origin Type : Type 2 perceived that the major cause for the illness is not only excessive physical labour but also fecundity and old age. (3) Causality to Environment Type : Type 3 perceived that rheumatoid arthritis occurred from injury to the joints or bad and humid weather. (4) Conscience of Guilty Type : Type 4 consisted of people with guilty conscience for lack of religious commitment. They perceived that the illness was a punishment from God for not praying or because of bad luck. (5) Rationally Perceiving Type : People who belong in type 5 perceived the cause of illness in light of scientific facts such as genetics, unbalanced diet or lack of exercise. (6) Psychological Stress Type : People who belong in type 6 believed that excessive stress was the cause of the illness. 2) Emotions of Rheumatoid arthritis patients Rheumatoid arthritis patients' positive emotions included determination, courage, coping, acceptance, hope, and adoption ; and their negative emotions were prostration, worry, stupor, conflicts, grievance, giving-up, resignation, depression, loss, solitariness, fear, anxiety, avoidance, anger and loneliness. Rheumatoid arthritis patients experience different level of emotions from their suffering experience from the severe pains. Rheumatoid arthritis patients also experience negative emotions when they could not perform self-care and lose their self-esteem from painful suffering ; however, they regain positive emotions when they recover from pain with the use of drugs, physical therapy or exercise. Their emotional states are closely connected to level of and presence of pain.

• 한국보건간호학회지
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• 제18권1호
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• pp.39-49
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• 2004

The purpose of this study was to investigate the effect of moxibustion heat therapy(Koryo hand acupuncture) on menstrual cramps. dysmenorrhea and ADL. The experiment was carried out during the period from March 24 to April 30, 2003. The subjects in the study were drawn from female students attending two colleges in Chungcheongbuk-do and Kyunggi-do. Of all those subjects. 19 and 14 subjects were assigned to the experimental and the control groups respectively. The moxibustion heat therapy were performed three times a week, subjects were treated twice a time. Data was analyzed using SPSS/WIN10.0 by $x^2$test. Wilcoxon sign rank. and Wilcoxon rank sum test. The result of this study were as follows : 1) After moxibustion heat therapy. the graphic rating score of menstrual cramps was decreased significantly from 7.79(SD=1.22) to 4.47(SD=2.25) in experimental group(z=-3.731. p=.000). And there was significant difference in the change of graphic rating score of menstrual cramps between both groups(z=-3.637. p=.000). 2) After moxibustion heat therapy. the score of face rating scale of menstrual cramps was decreased significantly from 3.95(SD=0.71) to 2.32(SD=1.00) in experimental group(z=-3.457. p=.000). And there was significant difference in the change of face rating score between both groups(z=-2.713. p=.007). 3) After moxibustion heat therapy. the score of adjective labor pain rating scale rank (ALPRS) of menstrual cramps was decreased significantly from 23.63(SD=4.19) to 17.27(SD=6.34) in experimental group(z=-2.941. p=.001). But there was no significant difference in the change of adjective labor pain rating score(ALPRS) of menstrual cramps between both groups(z=-1.918. p=.059). 4) After moxibustion heat therapy. the score of dysmenorrhea was decreased significantly from 7.0(SD=2.89) to 5.26(SD=3.54) in experimental group(z=-2.183. p=.029). But there was no significant difference in the change of the score of dysmenorrhea between both groups(z =-1.555. p=.125). 5) After moxibustion heat therapy, the score of ADL difficulty was decreased significantly from 33.26(SD=4.58) to 28.83(SD=9.44) in experimental group(z=-3.552. p=.000). And there was significant difference in the change of score of difficulty of ADL between both groups(z=-4.110. p=.000). The above finding indicated that the moxibustion heat therapy showed a practical effect on reducing menstrual cramps, dysmenorrhea and ADL difficulty in female. Accordingly. we can adopt the moxibustion heat therapy as a useful intervention in the community nursing.

• 대한간호학회지
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• 제10권2호
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• pp.1-12
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• 1980

The process of having baby including pregnancy, labor and birth; is considered as crises of life cycle. It is noted that most pregnat women experience fear and anxiety through the gestational period and this may effect to the health of the baby and the mother. Therefore, we, nurses must focuse on this fear and anxiety of pregnant women and make an effort to relieve their emotional discomfort. This study was conducted to determine the pregnant women's intensity of fear and anxiety during pregnancy thus to provide some information for maternal care in terms of antenatal care. The specific objectives of this study are : 1. to determine what are the most frequently experienced fear and anxiety and how frequently the pregnant women perceive them as a fearful and anxious experience. 2. to find out the relations between the intensity of fear and anxiety of pregnancy and the demographic characteristics of the subjected women During the period May 15,1980 to June 4,1980,212 pregnant were asked to question are by trained student mures who visited to 4 obstetric clinic for antenatal care in C-city. The questionare were designed and and scheduled by author which covers 38 items about fears and anxiety during pregnancy and each item was answered by 5 seales according to it's intensity. The result analysed as percentile , mean and S.D. statistically and obtained as rollows 1) The mean age was 27,4 years, the proportion of women completed high school are 45.3%, and 51.4% has no religion 2）68.6% seplied“positive”response about fears and anxiety during pregnancy. 3) Fear relevant to pain, particularly during labor noted most frequent rate. 4) Social factors may relate to the intensity of the fears or anxiety further more socioeconomic problem take important role and affects to the expectant women, 5) Primigravida noted more fears and anxiety about pregnancy compared to multigravida and more in-tensity during aerly half gestational period than late. Majority of pregnant women have experienced fear and anxiety attendant upon pregnancy and so nurse can help the patient to be able experience 1ha difficult adjustment to be course of pregnancy and be able to get good result both fetus and mother through antenatal care.

• 여성건강간호학회지
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• 제6권1호
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• pp.34-45
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• 2000

The study was to find whether the educational program contributed to increase of knowledge and self-efficacy of the postpartal primiparas. This study aimed at improvement of the educational effect for postpartal primiparas. The Subjects were 34 primiparas who were admitted to the obstetric ward in a University hospital from November 15th to December 9th, 1999. The Subjects were those who had no labor pain at the admission time, had no complications during labor and delivery and, gave birth to a healthy baby. They were tested on knowledge and self-efficacy two times, one at the admission time and prior to discharge. After the first test nurses in a maternity ward taught them on postpartal care. Two tools were developed by authors based on literature review. The test tool fr knowledge of postpartal car consisted of 23 items. The test tool for self-efficacy of postpartal care consisted of 16 items. Analysis of demographic data were analyzed with calculation of percentage. Score differences between the first test and the second test were analyzed with paired t-test. The Spss (Win 8.0) program was used for data analysis. The results are as follows. 1. There were not significant influencing general characteristics of primiparous to pre-educational knowledge. There were significant influencing general characteristics of primiparous to post-educational knowledge : occupation(t=13.04, p=0.00), postpartal education(t=5.51, p=0.02). 2. There were not significant influencing general characteristics of primiparous to pre-educational self-efficacy. There were significant influencing general characteristics of primiparous to post-educational self-efficacy : antenatal education(t=5.53, p=0.02) 3. Primiparas' knowledge of postpartal care increased significantly after education(t=13.04, p=0.00). 4. Primiparas' self-efficacy of postpartal care increased significantly after education(t=5.51, p=0.02). 5. Correlation between knowledge and self-efficacy was r=.360(p=0.03). We suggest follow-up studies to find whether primiparas' self-efficacy will last after discharge or not.