• The Journal of Internal Korean Medicine
• /
• v.42 no.5
• /
• pp.1082-1093
• /
• 2021

Objective: Alzheimer's disease is characterized by progressive, irreversible brain damage and cognitive decline. Although the diagnosis and treatment of the prodromal symptoms of dementia are important, no treatment for mild cognitive impairment has been currently established. Herein, we report the case of an 80-year-old female patient with memory complaints treated with Gugijihwang-tang, a traditional Korean medicine herbal formula, as an add-on medication. Case Presentation: The patient was diagnosed with mild cognitive impairment based on clinical examinations using the Mini-Mental State Examination (MMSE), the Consortium to Establish a Registry for Alzheimer's Disease (CERAD), Activities of Daily Living (ADL) Scale, Global Deterioration (GDR) Scale, and Clinical Dementia Rating (CDR) Scale. She was treated with Gugijihwang-tang bis in die for 12 months while continuing her original medications, including 5-mg donepezil and 590-mg acetyl-l-carnitine. The MMSE score in the Korean Version of the CERAD Assessment Packet increased from 21 to 27 during the 12-month treatment period, and the CERAD 2 score increased from 33 to 62. The instrumental ADL scale score improved from 11 to 5. Other clinical examination results also showed improvement. The patient was satisfied and experienced no significant adverse events related to the Gugijihwang-tang treatment. Conclusion: This case suggests that Gugijihwang-tang could be considered as a treatment method for patients with mild cognitive impairment.

• Journal of the Institute of Electronics and Information Engineers
• /
• v.52 no.3
• /
• pp.39-47
• /
• 2015

In this paper, we propose a new time synchronization algorithm using CoAP(constrained-application protocol) in sensor network environment, which handles a technique that synchronizes an explicit timestamp between sensor nodes not including an additional module for time-setting and sensor node gateway linked to internet time server. CoAP is a standard protocol for sensor data communication among sensor nodes and sensor node gateway to be built much less memory and power supply in constrained network surroundings including serious network jitter, packet losses, etc. We have supplied an exact time synchronization implementation among small and cheap IP-based sensor nodes or non-IP based sensor nodes and sensor node gateway in sensor network using CoAP message header's option extension. On behalf of conventional network time synchronization method, as our approach uses an exclusive protocol 'CoAP' in sensor network, it is not to become an additional burden for synchronization service to sensor nodes or sensor node gateway. This method has an average error about 2ms comparing to NTP service and offers a low-cost and robust network time synchronization algorithm.

• Journal of the Institute of Electronics and Information Engineers
• /
• v.53 no.4
• /
• pp.3-11
• /
• 2016

In the environment of Internet of Things (IoT), IoT devices are limited by physical components such as power supply and memory, and also limited to their network performance in bandwidth, wireless channel, throughput, payload, etc. Despite these limitations, resources of IoT devices are shared with other IoT devices. Especially, remote management of the information of devices and patients are very important for the IoT healthcare service, moreover, providing the interoperability between the healthcare device and healthcare platform is essential. To meet these requirements, format of the message and the expressions for the data information and data transmission need to comply with suitable international standards for the IoT environment. However, the ISO/IEEE 11073 PHD (Personal Healthcare Device) standards, the existing international standards for the transmission of health informatics, does not consider the IoT environment, and therefore it is difficult to be applied for the IoT healthcare service. For this matter, we have designed and implemented the IoT healthcare system by applying the oneM2M, standards for the Internet of Things, and ISO/IEEE 11073 DIM (Domain Information Model), standards for the transmission of health informatics. For the implementation, the OM2M platform, which is based on the oneM2M standards, has been used. To evaluate the efficiency of transfer syntaxes between the healthcare device and OM2M platform, we have implemented comparative performance evaluation between HTTP and CoAP, and also between XML and JSON by comparing the packet size and number of packets in one transaction.