• Toxicological Research
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• v.29 no.2
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• pp.81-86
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• 2013

Toxicoproteomics integrates the proteomic knowledge into toxicology by enabling protein quantification in biofluids and tissues, thus taking toxicological research to the next level. Post-translational modification (PTM) alters the three-dimensional (3D) structure of proteins by covalently binding small molecules to them and therefore represents a major protein function diversification mechanism. Because of the crucial roles PTM plays in biological systems, the identification of novel PTMs and study of the role of PTMs are gaining much attention in proteomics research. Of the 300 known PTMs, protein acylation, including lysine formylation, acetylation, propionylation, butyrylation, malonylation, succinylation, and crotonylation, regulates the crucial functions of many eukaryotic proteins involved in cellular metabolism, cell cycle, aging, growth, angiogenesis, and cancer. Here, I reviewed recent studies regarding novel types of lysine acylation, their biological functions, and their applicationsin toxicoproteomics research.

• 전기의세계
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• v.29 no.5
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• pp.321-328
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• 1980

The Q-switching oscillator of TE $M_{00}$ mode was constructed in order to improve the properties of energy focusing and amplification, and prevent laser materials from breakdown. The Q-switching was done by means of electro-optical effect using Glan prism and KDP Pockels cell. Sharp laser pulse of risetime-1 ns and variable pulse width 2-10 ns was obtained from Q-switching laser pulse by PTM method using a laser triggered spark gap (LTSG), Glan prism and Pockels cell. A single ultra-short pulse (picosec order in pulse width) was obtained from mode-locked pulse train in combination of a mode-locked oscillator using saturable dye cell with pulse shaping system using PTM method.d.

• Proceedings of the Korean Geotechical Society Conference
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• 2001.03a
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• pp.591-596
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• 2001

The purpose of this paper Is to present and discuss some of evaporation and desiccation observed in laboratory experiments under controlled conditions, and is to improve PTM(Progressive Trenching Method) operating technique. PTM is the technically feasible and economically justifiable dewatering and desiccation technique for dredged material containment areas. A series of laboratory experiments with large model test were carried out to get evaporation rate and strength increase. Surface desiccation of dredged material is basically changed by evaporation characteristics which is controlled by weather and trench type, etc. This study shows that trench depth and rain fall are important factors in desiccation of dredged soft clay.

• Proceedings of the Korea Information Processing Society Conference
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• 2000.10b
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• pp.1121-1124
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• 2000

본 논문은 기존의 IPv4 인터넷 망에 새로 도입될 IPv6 망을 어떻게 연동할 것인가에 대한 구체적인 연동 방안으로 Application 레벨의 Translation Proxy를 구현하였다. 구현된 PTM(Proxy based IPv4/IPv6 Translation Mechanism)은 응용 계층에서 연동을 지원하므로 기존 인터넷 망에서 특별한 Network 구조나 사용자 Application의 수정 없이 IPv6 망과의 연동을 할 수 있게 하였다. 또한 본 논문에서는 기본적인 성능 실험을 통하여 PTM의 Capability를 도출하였다. 본 논문의 결과는 IPv6를 도입함에 있어서 상당 기간동안 IPv4 망과의 병존이 예상되므로, IPv4 망과의 유연한 연동 없이는 성공적인 IPv6로의 진화가 불가능하다는 관점에서 그 중요성이 강조된다.

• Mycobiology
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• v.47 no.2
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• pp.154-164
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• 2019

Four strains of Penicillium and Talaromyces species are described and illustrated in an inventory of fungal species belonging to Eurotiales. The strains, CNUFC-DDS17-1, CNUFC-DDS27-1, CNUFC-PTM72-1, and CNUFC-YJW3-31, were isolated from soil and freshwater samples from South Korea. Based on their morphological characteristics and sequence analyses by the combined b-tubulin and calmodulin gene, the CNUFC-DDS17-1, CNUFC-DDS27-1, CNUFC-PTM72-1, and CNUFC-YJW3-31 isolates were identified as Penicillium pasqualense, Penicillium sanguifluum, Talaromyces apiculatus, and Talaromyces liani, respectively. The designated strains were found to represent a previously undescribed species of Korean fungal biota. In this study, detailed morphological descriptions and phylogenetic relationships of these species are provided.

• Proceedings of the Korea Information Processing Society Conference
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• 2010.11a
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• pp.1834-1836
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• 2010

프로테오믹스는 세포 안 또는 개체 안의 모든 단백질을 총체적으로 연구하는 분야이다. 단백질 동정은 단백질이 어떤 아미노산의 서열로 구성되었는지를 확인하는 것이다. 하지만 Post-translational modification과 같은 단백질 변형을 고려하게 되면 단백질 동정은 매우 어렵게 된다. $MOD^i$ 알고리즘은 단백질 동정을 할 때 Post-translational modification의 종류나 개수에 제한 없이 단백질 동정을 정확하게 수행한다. 하지만, 대용량 단백질 서열 데이터베이스를 사용하면 수행시간이 많이 걸리는 단점이 있다. 본 논문에서는 $MOD^i$를 보완하기 위해 대용량 데이터베이스에서 후보 단백질을 선정하는 알고리즘을 통해서 개선된 $MOD^f$ 알고리즘을 제안하고 Target-decoy search strategy를 적용하여 정확성을 분석한다. 후보 단백질 선정 알고리즘과 Target-decoy search strategy 적용 결과 $MOD^f$는 $MOD^i$에 비해 정확도를 희생하지 않으면서 수행속도는 약 2배 향상되었다.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.18 no.1
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• pp.57-63
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• 2012

Background: The number of old people with degenerative osteoarthritis one of the chronic disease, were constantly increased. Many researchers have made a great effort to verify the effects of ultrasound and laser therapy in degenerative osteoarthritis treatment. This study applied ultrasound-laser integration therapy on knee joint degenerative osteoarthritis and compared its effect with ultrasound and laser. Methods: We assigned 60 patients age 65 to 85 who had been diagnosed as knee joint degenerative osteoarthritis in G nursing home in Daejeon city. Randomization was done in blocks of three, holding twenty people per each group to receive either ultrasound, laser, ultrasound-laser integration therapy. This study carried out the experiment for 6 weeks to from April 17, 2010. We measured variables using visual analog scale (VAS) and pressure threshold meter (PTM) of the effects by before and after exercise. Results: It has been found that VAS was reduced and PTM was increased in all three groups. Compare with the other groups, Ultrasound-laser integration therapy group had lower VAS and higher PTM than ultrasound therapy and laser therapy group. Conclusions: These results lead us to the conclusion that ultrasound-laser integration have influenced the pain reduction of the knee degenerative osteoarthritis.

• Korean Journal of Mineralogy and Petrology
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• v.33 no.1
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• pp.11-18
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• 2020

High-pressure synchrotron X-ray powder diffraction experiments were performed on natural illite (K_0.65Al₂(Al_0.65Si_3.35)O₁₀(OH)₂) using diamond anvil cell (DAC) under two different pressure transmitting media (PTM), i.e., water and ME41 (methanol:ethanol = 4:1 by volume). When using water as PTM, occasional heating was applied up to about 250℃ while reaching pressure up to 2.7 GPa in order to promote both hydrostatic conditions and intercalation of water molecules into the layer. When using ME41, pressure was reached up to 6.9 GPa at room temperature. Under these conditions, illite did not show any expansion of interlayer distance or phase transitions. Pressure-volume data were used to derive bulk moduli (K₀) of 45(3) GPa under water and 51(3) GPa under ME41 PTM. indicating no difference in compressibility within the analytical error. Linear compressibilities were then calculated to be β^a = 0.0025, β^b = 0.0029, β^c = 0.0144 under ME41 PTM showing the c-axis is ca. six times more compressible than a- and b-axes. These elastic behaviors of illite were compared to muscovite, one of its structural analogues.

• The korean journal of orthodontics
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• v.33 no.3 s.98
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• pp.157-167
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• 2003

The purpose of this study was to find whether there is a correlation between tooth size and jaw size. Dental stone models and cephalometric radiographic films of 87 untreated individuals were evaluated. Repeated measurements of the maximum mesiodistal width of the teeth were taken by means of a digital vernier caliper. Linear measurements of jaw size were assessed by means of a digitizer and Visual C++ program. All measurements were taken separately according to the subject's gender. To determine the relationship between jaw and tooth size, the Pearson correlation was used. The results were as follows: 1. Male and female subjects showed a statistical difference in regard to tooth size and jaw size 2. In contrast to the results of the male subjects, there were no statistically significant correlations between maxillary size and maxillary teeth size in female subjects 3. In male subjects, the two maxillary sizes of PTM vert-ANS vert (FH plane) and PTM vert-A yen (palatal plane) were significantly correlated with themaxillary teeth size. Especially, the size of the upper central incisor showed significant correlation with all maxillary sizes. 4. In both male and female subjects, mandibular size B vert- Point J vert (mandibular plane) showed significant correlation with mandibular teeth size. As gleaned kom the results of this study, the relationship between jaw size and tooth size was fair or little in natural occurring good occlusion.

• BMB Reports
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• v.48 no.3
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• pp.131-138
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• 2015

Cardiac hypertrophy is a form of global remodeling, although the initial step seems to be an adaptation to increased hemodynamic demands. The characteristics of cardiac hypertrophy include the functional reactivation of the arrested fetal gene program, where histone deacetylases (HDACs) are closely linked in the development of the process. To date, mammalian HDACs are divided into four classes: I, II, III, and IV. By structural similarities, class II HDACs are then subdivided into IIa and IIb. Among class I and II HDACs, HDAC2, 4, 5, and 9 have been reported to be involved in hypertrophic responses; HDAC4, 5, and 9 are negative regulators, whereas HDAC2 is a pro-hypertrophic mediator. The molecular function and regulation of class IIa HDACs depend largely on the phosphorylation-mediated cytosolic redistribution, whereas those of HDAC2 take place primarily in the nucleus. In response to stresses, posttranslational modification (PTM) processes, dynamic modifications after the translation of proteins, are involved in the regulation of the activities of those hypertrophy-related HDACs. In this article, we briefly review 1) the activation of HDAC2 in the development of cardiac hypertrophy and 2) the PTM of HDAC2 and its implications in the regulation of HDAC2 activity.