• 대한한의학회지
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• 제32권6호
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• pp.74-84
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• 2011

Objectives: Palmul-tang (hachimotsu-to in Japanese and bawu-tang in Chinese) is a mixture of eight herbs. It is traditionally used for the treatment of anemia, anorexia, general weakness, and female infertility in China, Japan, and Korea. In this study, we investigated the protective effects of Palmul-tang water extract (PTE) against ethanol-induced acute gastric injury in rats. Material and Methods: Acute gastric lesions were induced by intragastric administration of 5mL/kg body weight of absolute ethanol to each rat. Control group rats were given PBS orally and the ethanol group (EtOH group) received absolute ethanol (5mL/kg) by oral gavage. The positive control group and the PTE group were given oral doses of omeprazole (50mg/kg) or PTE (400mg/kg), respectively, 2 h prior to the administration of absolute ethanol. The stomach of each animal was excised and examined for gastric mucosal lesions. To confirm the protective effects of PTE, we evaluated the degree of lipid peroxidation, the level of reduced glutathione (GSH), and the activities of the antioxidant enzymes catalase, glutathione-S-transferase, glutathione peroxidase, and glutathione reductase in the stomach. Results: PTE reduced ethanol-induced hemorrhage and hyperemia in the gastric mucosa. PTE reduced the increase in lipid peroxidation associated with ethanol-induced acute gastric lesions and increased mucosal GSH content and the activities of antioxidant enzymes. Conclusion: These results indicate that PTE protects gastric mucosa against ethanol-induced acute gastric injury by increasing antioxidant status. We suggest that PTE could be developed as an effective drug for the treatment of acute gastric injury.

• Journal of Nutrition and Health
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• 제49권2호
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• pp.72-79
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• 2016

Purpose: The initiation of mandatory folic acid fortification using pteroylmonoglutamic acid (PteGlu) has reduced the rate of congenital malformations. However, it also appears to be responsible for several adverse effects, including increased cancer incidence. This may be related to physicho-chemical characteristics of PteGlu. This study examines the potential effect of high concentrations of PteGlu on a population subjected to mandatory folic acid fortification using an in vitro model. Methods: Caco-2 (colorectal cancer) and MCF7 (breast cancer) cell lines were cultured at 6 different PteGlu concentrations (0, 0.1, 1, 50, 250, and $500{\mu}g/ml$) for 6 days. Cell growth was determined using thiazolyl blue tetrazolium bromide assay. The genotype of dihydrofolate reductase 19bp deletion/insertion (DHFR 19-del) was also scored in cell lines using a restriction fragment length polymorphism technique to examine whether genetic variations may factor in cell proliferation. Results: PteGlu exhibited differential growth promoting properties between cell lines. Caco-2 cells did not show a significant growth difference at low concentrations compared to control, however, at higher concentrations, the growth showed a contrasting trend in the early experimental period, while MCF7 showed enhanced cell growth at all concentrations. The DHFR 19-del genotype differed in the two cell lines. Conclusions: Altered response to PteGlu by Caco-2 and MCF7 may reflect a tissue specific disease aetiology or genotype specific differential enzyme activity, for example by DHFR, to critical levels of PteGlu. As folic acid fortification is a blanket intervention, and DHFR and other enzyme activities vary between individuals, PteGlu intake may have an as yet undefined effect on health. These findings may be relevant when considering mandatory folic acid fortification for disease prevention.

• 대한통합의학회지
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• 제4권4호
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• pp.101-108
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• 2016

Purpose : The purpose of this study was to determine the effect of selective thoracic extensor strengthening exercises in the sitting position using a foam-roller by investigating the electromyographic(EMG) activities of the thoracic and lumbar extensors. Methods : Eighteen healthy subjects with no medical history of back pain were recruited. EMG activity was recorded from thoracic extensor(TE) and lumbar extensor(LE) while subjects performed three thoracic extension exercises: prone thoracic extension(PTE), prone thoracic extension with abdominal draw-in maneuver(PTE-ADIM), and sitting thoracic extension using a foam-roller(STE). TE and LE EMG activity, and TE/LE EMG activity ratio were analyzed by one-way repeated-measures analysis of variance(ANOVA). Where a significant difference was identified, a Bonferroni correction was performed(p<.017, .05/3). Results : TE and LE EMG activity, and TE/LE EMG activity ratio differed significantly among the three exercises(p<.05). Post hoc pair-wise comparison with Bonferroni correction showed that TE muscle activity in the STE exercise was significantly different from PTE and PTE-ADIM exercises(p<.017). There was no significant difference between TE muscle activity for PTE and PTE-ADIM exercises(p>.017). LE muscle activity and TE/LE ratios were significantly different among the three exercises p<.017). Conclusion : TE/LE ratio showed superior selective thoracic extensor strengthening for the STE exercise than PTE and PTE-ADIM exercises. Therefore, we recommend STE exercise for selective thoracic extensor strengthening.

• 대한의생명과학회지
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• 제27권4호
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• pp.248-254
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• 2021

Ulcerative colitis (UC), chronic inflammatory bowel disease, is characterized by severe inflammation in the colon. Tea is one of the most popular beverages consumed worldwide. Pu-erh tea, a unique Chinese tea produced by microbial activities, possesses a broad range of health-promoting effects, including anti-aging, anti-Alzheimer's disease, antioxidation and anti-obesity. However, the inhibitory effect of Pu-erh tea on intestinal inflammation and the underlying mechanism remain unclear. The present study was designed to evaluate the regulatory effect of Pu-erh tea extract (PTE) on dextran sulfate sodium (DSS)-induced colitis clinical signs by analyzing the weight loss and colon length in mice. The inhibitory effects of PTE on inflammatory mediators, such as interleukin (IL)-6 and tumor necrosis factor (TNF)-α, and the activation of nuclear factor-κB (NF-κB) were also determined in DSS-treated colitis tissue. We observed that PTE treatment significantly inhibited the DSS-induced clinical symptoms of weight loss, decrease,in colon length, and colon tissue damage in mice. Moreover, PTE attenuated the DSS-induced levels of IL-6 and TNF-α in colon tissue. We also demonstrated the anti-inflammatory mechanism of PTE by suppressing the activation of NF-κB in DSS-treated colon tissues. Collectively, the findings provide experimental evidence that PTE may be effective in preventing and treatment of intestinal inflammatory disorders, including UC.

• 한국전문물리치료학회지
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• 제13권3호
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• pp.41-48
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• 2006

This study investigated therapeutic effects of pelvic tilt exercise (PTE) on weight bearing and body sway during sit-to-stand (STS) on 18 hemiplegic patients who had visited the Hanyang University Seoul Hospital and Injae University Sanggyebek Hospital physiotherapy rooms. The study compared the patients with 18 normal adults. The subjects were sampled out from those who could get up independently, maintain a standing posture more than 10 seconds, understand the movements of this study and have no difficulty in performing the tasks. By executing STS in a natural way with habitual movements before and after PTE, the weight bearing was measured by using Mediance II. In order to compare the difference of weight distribution, weight bearing and body sway on affected and nonaffected sides during STS before and after PTE, the Wilcoxon Signed Ranks Test was used. The statistical significance level was based on p<.05. The results revealed that the difference of weight distribution in the hemiplegic group was significantly decreased (p<.05), whereas there was no significant difference in the healthy group (p>.05). Weight bearing loaded on the affected side was $42.53{\pm}7.65%$ and $44.20{\pm}6.32%$, respectively, in the hemiplegic group during STS before and after PTE. Weight bearing during STS after PTE is increased significantly, as compared with weight bearing before PTE (p<.05). Body sway in the hemiplegic group was significantly decreased (p<.05). As mentioned, PTE proved to be effective for improvement in weight bearing on the affected side during STS of hemiplegic patients.

• 한국마이크로전자및패키징학회:학술대회논문집
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• 한국마이크로전자및패키징학회 2006년도 ISMP 2006
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• pp.21-35
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• 2006

• ETRI Journal
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• 제38권5호
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• pp.962-971
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• 2016

A wireless power transfer (WPT) system is generally designed with the optimum source and load impedance in order to achieve the maximum power transfer efficiency (PTE) at a specific coupling coefficient. Empirically or intuitively, however, it is well known that a high PTE can be attained by adjusting either the source or load impedance. In this paper, we estimate the maximum achievable PTE of WPT systems with the given load impedance, and propose the condition of source impedance for the maximum PTE. This condition can be reciprocally applied to the load impedance of a WPT system with the given source impedance. First, we review the transducer power gain of a two-port network as the PTE of the WPT system. Next, we derive two candidate conditions, the critical coupling and the optimum conditions, from the transducer power gain. Finally, we compare the two conditions carefully, and the results therefore indicate that the optimum condition is more suitable for a highly efficient WPT system with a given load impedance.

• Tuberculosis and Respiratory Diseases
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• 제59권6호
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• pp.644-650
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• 2005

배 경 : 만성 혈전색전성 폐고혈압(chronic thromboembolic pulmonary hypertension, CTEPH)의 치료에 약물치료를 포함한 고식적인 방법으로는 예후를 호전시킬 수 없고 폐동맥 혈전내막제거술(pulmonary thromboendarterectomy, PTE)을 통해서 증상과 혈역학적 호전 및 생존율의 향상을 기대할 수 있다. 이에 저자들은 PTE에 의한 효과를 고식적인 치료를 받은 환자들과 비교 분석하고자 하였다. 방 법 : 1995년부터 2003년까지 서울아산병원에서 CTEPH으로 진단 받은 24명의 환자를 대상으로 후향적으로 연구를 진행하였다. PTE를 시행 받았던 12명과 수술을 시행 받지 않았던 12명의 환자의 시간경과에 따른 호흡곤란 및 심초음파상 삼첨판역류 최고속도의 변화와 생존율을 비교분석 하였다. 결 과 : 호흡곤란은 수술군에서 1년후에는 통계적으로 유의하게 호전되었지만 비수술군에서는 유의한 호전은 없었다. 삼천판역류최고속도는 수술군에서 수술전 $4.23{\pm}0.54m/sec$에서 수술 1년후 및 2년후에는 각각 $3.23{\pm}0.77m/sec$와 $3.22{\pm}0.70m/sec$로 감소하였으나 비수술군에서는 진단시에는 $3.98{\pm}0.68m/sec$에서 진단 1년후에는 $4.27{\pm}0.95m/sec$로 변화가 없었다. 5년 생존율은 수술군과 비수술군이 각각 77.9%와 64.3%였으나 통계적으로 유의하지는 않았다. 결 론 : CTEPH은 비수술군에 비해 수술군에서 의미있는 증상 및 혈역학적 호전을 장기적으로 가져오므로 수술환자의 선택에 있어서 절대적 금기가 없다면 가능한 한 수술을 시행하는 것이 본 질환의 치료에 중요할 것으로 사료된다.

• 한국펄프종이공학회:학술대회논문집
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• 한국펄프종이공학회 2006년도 PAN PACIFIC CONFERENCE vol.2
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• pp.355-357
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• 2006

The application of specialty chemicals in a pulp mill system for the purpose of problem solving or process enhancement is often demonstrated and supported by data produced in laboratory testing. Hercules Chemical Solutions Pte Ltd., a major specialty chemical supplier to the Asian pulp and paper industry, partnered with the Asian Institute of Technology (AIT) on several occasions to provide insight into the efficacy of proposed chemical treatments designed for local operating conditions and wood species. This paper presents an example of a chemically-assisted deresination project. The resulting surfactant chemistry proved to be a superior deresinator for plantation grown acacia wood and has been successfully implemented in an Asian pulp and paper mill.

• Journal of Korean Neurosurgical Society
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• 제52권2호
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• pp.98-102
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• 2012

Objective : To study the clinical significance and relevant factors of radiation-induced intratumoral necrosis (RIN) and peritumoral edema (PTE) after Gamma knife radiosurgery (GKRS) for intracranial meningiomas. Methods : We retrospectively analyzed the data of 64 patients who underwent GKRS for intracranial meningioma. The mean lesion volume was 4.9 cc (range, 0.3-20), and the mean prescription dose of 13.4 Gy (range, 11-18) was delivered to the mean 49.9% (range, 45-50) isodose line. RIN was defined as newly developed or enlarged intratumoral necrosis after GKRS. Results : RIN and new development or aggravation of PTE were observed in 21 (32.8%) and 18 (28.1%) cases of meningioma, respectively during the median follow-up duration of $19.9{\pm}1.0$ months. Among various factors, maximum dose (>25 Gy) and target volume (>4.5 cc) were significantly related to RIN, and RIN and maximum dose (>24 Gy) were significantly related to the development or aggravation of PTE. In 21 meningiomas with development of RIN after GKRS, there was no significant change of the tumor volume itself between the times of GKRS and RIN. However, the PTE volume increased significantly compared to that at the time of GKRS (p=0.013). The median interval to RIN after GKRS was $6.5{\pm}0.4$ months and the median interval to new or aggravated PTE was $7.0{\pm}0.7$ months. Conclusion : A close observation is required for meningiomas treated with a maximum dose >24 Gy and showing RIN after GKRS, since following or accompanying PTE may deteriorate neurological conditions especially when the location involves adjacent critical structures.