• 보험의학회지
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• 제29권1호
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• pp.16-21
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• 2010

The measurement of prostate specific antigen (PSA) in screening for prostate cancer is recently performed as a routine check-up in clinical medicine and insurance medicine. Several factors may affect serum PSA levels. As prostate size increases with increasing age, the PSA concentration also rises. Increasing body mass index (BMI) is associated with a lower mean PSA concentration. Inhibitors of 5-alpha-reductase such as finasteride and dutasteride produce a 50 percent or greater decrease in serum PSA during the first three months of therapy, which persists as long as the drug is continued. Men who are regularly taking non-steroidal antiinflammatory drugs (NSAIDs) or acetaminophen have lower PSA levels. Emerging concepts regarding PSA testing that may help refine the interpretation of an elevated concentration include: PSA density, PSA velocity, and Free versus complexed or bound PSA. With many insurance companies, PSA level has become part of a standard battery of blood tests, along with HIV, cholesterol, liver enzymes, and other predictors of premature death. But, there is no clear proof of benefit, so we have to monitor the value of PSA test as a prostate cancer screening test in insurance medicine.

• Asian Pacific Journal of Cancer Prevention
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• 제13권11호
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• pp.5695-5699
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• 2012

We investigated the relationships between demographics, lifestyle characteristics, and serum total prostate specific antigen (PSA) concentration and examined the population-based distribution of total PSA by age among 2,246 Korean men with a median age of 45 years. We obtained data about demographic and lifestyle characteristics based on self-reporting using a quetionnaire. We also performed physical examinations, anthropometric measurements, and biochemical measurements. The PSA concentration increased with age and there was a significant difference in total PSA concentration between the age groups of 21-60 years and >60 years. Age >60 years, height ${\geq}1.8$ m, a low frequency of alcohol consumption, and taking nutritional supplements showed a significantly increased odds ratio for increased PSA when 3.0 ng/mL was chosen as the PSA cut-off level. Smoking status, BMI, percent body fat, diabetes mellitus, fatty liver, herbal medicine use, vitamin use, and diet were not significantly associated with total PSA regardless of the cut-off level. When interpreting a single PSA test, height, alcohol consumption, and nutritional supplement use should be considered, in addition to age.

• 대한화학회지
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• 제42권3호
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• pp.292-296
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• 1998

Amberlite IRC-718 킬레이트수지에서 Cu(Ⅱ)와 Fe(Ⅱ) 이온의 PSA(phenol sulfonic acid) 리간드에 의한 용리현상을 연구하였다. 여러 가지 농도의 PSA에 녹인 Cu(Ⅱ)와 Fe(Ⅱ) 용액 일정량을 수지에 흡착시키고 여러 가지 농도의 PSA로 용리하면 Cu(Ⅱ)와 Fe(Ⅱ) 이온이 각각 두 개의 봉우리로 용리되고, 이 두 개의 봉우리 면적을 PSA의 농도에 따라 변한다. 이를 이옹하여 두 이온과 PSA간의 착물의 안정도상수를 계산하였다. 그 값은 Cu(Ⅱ)는 7.0이고 Fe(Ⅱ)은 $4.5{\times}10^4$이었다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5261-5264
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• 2015

Purpose: To examine the effectiveness of serum free-to-total prostate specific antigen ratio (%fPSA) for the detection of prostate cancer (PCa) in men with different serum total PSA (tPSA) categories. Materials and Methods: From January 2010 to December 2013, a total of 225 patients with lower urinary tract symptoms (LUTS) underwent tPSA and %fPSA measurements. Histological examination with calculation of Gleason score and whole body bone scans were performed in identified cases of PCa. Results: PCa was diagnosed in 44 (19.6%) patients and the remaining 181 patients had benign prostate disease. PCa was detected in 5 (23.8%), 13 (8.7%) and 26 (47.3%) cases with tPSA level ranges ${\leq}4ng/ml$, 4 to 10 ng/ml and >10 ng/ml, respectively. The average Gleason score was $7.2{\pm}0.2$. Some 6 (13.6%) out of 44 PCa patients had bone metastases. The sensitivity was 80% and specificity was 81.3% at the cut-off %fPSA of 15% in PCa patients with a tPSA level below 4 ng/mL. A lower %fPSA was associated with PCa patients with Gleason score ${\geq}7$ than those with Gleason score ${\leq}6$ ($11.7{\pm}0.98$ vs. $16.5{\pm}2.25%$, P=0.029). No obvious relation of %fPSA to the incidence of bone metastasis was apparent in this study. Conclusions: The clinical application of %fPSA could help to discriminate PCa from benign prostate disease in men with a tPSA concentration below 4 ng/mL.

• 대한화학회지
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• 제39권5호
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• pp.379-383
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• 1995

Amberlite IRC-718 킬레이트 수지에서의 주석(II)이온의 PSA(phenol sulfonic acid) 리간드에 의한 용리현상을 연구하였다. 0.10 M $Sn^{2+}$ 용액 일정량을 흡착시키고 시료를 녹인 여러 가지 농도의 PSA 용리액으로 용리하면 $Sn^{2+}$이 두 개의 봉우리로 용리되고, 이 두 개의 봉우리 면적은 PSA의 농도에 따라 변한다. 이를 이용하여 $Sn^{2+}$와 PSA간의 착물의 안정도상수를 계산하였다. 그 값은 $2.0{\times}10^{-1}$이었다.

• 멤브레인
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• 제4권1호
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• pp.1-8
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• 1994

There are growing needs to produce relatively high purity(99.0% or higher) oxygen at low cost. For small scale production, both pressure swing adsorption(PSA) and membrane process are competitive and less expensive or more convenient than well known cryogenic fractionation technology. A continuous membrane column(CMC) combined with a PSA oxygen generator can be employed to produce high purity oxygen continuously. The oxygen enriched gas generated by a PSA unit, with a concentration of 93~94%, is fed to the CMC that consism of three modules of poly(imide) hollow fibers. Several experiments were conducted by varying parameters, such as feed flow rate, transmembrane pressure drop, stage cut, and feed location in order to obtain a high oxygen concentration above 99.0%. A two-series unit mode was also employed with CMC operation to optimize the given membrane area.

• 한국막학회:학술대회논문집
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• 한국막학회 1994년도 심포지움시리즈 Jan-94 기체분리막 기술 및 응용
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• pp.1-21
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• 1994

There are growing needs to produce relatively high purity (99.0% or higher) oxygen at low cost. For small scale production, both pressure swing adsorption (PSA) and membrane process are competitve and less expensive or more convient than well known crygenic fractionation technology. A continuous membrane colume (CMC) combined with a PSA oxygen generator can be employed to produce high purity oxygen continuosly. The oxygen-enriched gas generated by a PSA unit, with a concentration of 93-94%, is fed to the CMC that consists of three modules of poly(imide) hollow fibers. Several experiments were conducted by varying parameters, such feed flow rate, transmenbrane pressure drop, stage cut, and feed location in order to obtain a high oxygen concentration above 99.0%. A two-series unit mode was also employed with CMC operation to optimize the given membrane area.

• 대한의생명과학회지
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• 제3권2호
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• pp.107-114
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• 1997

전립선특이 항원 (PSA: Prostate Specific Antigen)은 전립선 세포에서 분비되는 단백질로서 장기 특이성이 높아 전립선암의 조기진단 및 치료의 예후를 판단하기 위해 임상에서 널리 사용되고 있는 혈청 종양표지검사의 대상항원이다. 그러나 혈청 PSA치는 전립선암 뿐 아니라 양성 전립선질환인 전립선비대증 (BPH), 전립선 경색, 전립선 염증 등에서도 상승될 수 있다. 혈청 내의 PSA는 여러 가지 분자형태로 이루어져 있으며 대표적으로 ${alpha}_1$-antichymotrypsin과 결합된 결합형 PSA(PSA-ACT)와 유리형 PSA (free PSA)로 나눌 수 있다. 전립선 암 환자의 혈청에는 결합형 PSA가 95% 이상으로 매우 높고 유리형 PSA의 분포는 매우 작은 반면 전립성비대증에서는 유리형 PSA의 농도가 높아지므로, 결합형 PSA와 동시에 유리형 PSA를 측정하면 종양표지검사로서의 특이성과 예민도를 높일 수 있다는 보고가 있어, 최근 혈청내의 유리형 PSA의 측정의 중요성이 임상적으로 대두되고 있다. 이에 본 연구에서는 sandwich 원리로 유리형 PSA 효소면역 측정법 (EIA) kit를 개발하고 그 유용성을 검토한 결과, 고, 저 농도에서의 일내, 일간 변이 계수 (CV)는 4% 이하였으며 상품화된 free PSA kit와 비교하였을 때 두 방법간의 상관계수는 0.9965으로 매우 양호하였다. 또한 농도가 높은 세 환자의 검체를 희석하여 직선성 검사를 하였을 때 상관계수가 모두 0.995이상으로 나타났다. 또한 microplate 법에서 문제될 수 있는 hook effect는 유리형 PSA농도가 40 ng/mL까지 나타나지 않았으며, 98.9%~104.1%의 회수율을 나타내었다. 따라서 본 연구에서 개발한 면역측정법 kit는 혈청 중의 유리형 PSA를 정확하고 간편하게 분석할 수 있으므로 임상 실험실에서 전립선암이나 전립선질환의 진단 및 치료효과의 판정에 유용하게 사용될 수 있을 것으로 기대된다.

• 아시안잔디학회지
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• 제11권1호
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• pp.59-72
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• 1997

The influence of respiration on photosythetic electron transport were investigated in the Wid type and psaB mutants from Syneehocystis sp. PCC6803. The amount of glucose uptake in the wild type was proportional to the glucose concentration added in wild type and less than that of psaB mutants in the dark. It was suggested that psaB mutants more depend on the glucose than the wild type. It was investigated how the activities of isocitrate dehydrogenase(IDH) and glucose-6-phos-phate dehydrogenase(G6PDH) were changed. The activities of IDH were very low. While, the ac-tivities of G6PDH were much higher than that of IDH. These results agree to the reports that ex-ogenous glucose was dismilated aerobically via Oxidative Pentose Phosphate Pathway in heterotrophic cyanobacteria. PsaB mutants showed high G6PDH activity in the presence of glucose as well as in the dark and high respiratory activities especially in the dark. It was also investigated how photosynthetic electron transport activities were changed. PsaB mutants showed higher photosynthetic electron tranasport activities than wild type in the presence of glucose as well as in the dark. In the results, it was proposed that photosynthetic electron transport between PS I and PS U was complemented by respiratory electron transport through the NADPH generated by Dxidative Pentose Phophate Pathway in psaB mutant from Synechocystis sp. PCC6803. Key words: Photosynthetic electron transport, Respiration, Synechoystis sp. PCC6803, psaB mutant, Glucose uptake, IDH, G6PDH, Respiratory electron transport activity.

• 공업화학
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• 제7권4호
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• pp.653-660
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• 1996

산소 PSA 장치 구성을 위하여, 여러 가지 흡착제에 대한 산소 및 질소의 평형흡착량을 측정하여 유효흡착량을 비교함으로써 산소 PSA에 적절한 흡착제를 선정하였고 Langmuir isotherm parameter를 구하였다. PSA 공정의 단계는 흡착, 탈착, 축압, 세정 및 균압 등으로 구성하고 흡착압력은 2atm을 기준으로 운전하였고 탈착압력은 120~400torr이며 cycle time은 2탑 80, 3탑 180초로 운전하였다. 2탑식과 3탑식 산소 PSA 장치의 운전특성과 경제성을 비교 분석하기 위하여, 운전조건에 따른 2탑식 및 3탑식 공정의 제품 생산성, 산소농도, 회수율을 비교하였고, 세정 및 축압단계의 영향을 분석하였으며, 대형화 하였을 경우의 투자비와 전력비를 추산하여 2탑식과 3탑식 산소 PSA의 경제성을 비교하여 $700Nm^3/hr$ 이하 규모에서는 2탑식이 유리함을 확인하였다.