• BMB Reports
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• 제52권2호
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• pp.157-162
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• 2019

Our previous study found that two novel cancer-related genes, PRR11 and SKA2, constituted a classic gene pair that was regulated by p53 and NF-Y in lung cancer. However, their role and regulatory mechanism in breast cancer remain elusive. In this study, we found that the expression levels of PRR11 and SKA2 were upregulated and have a negative prognotic value in breast cancer. Loss-of-function experiments showed that RNAi-mediated knockdown of PRR11 and/or SKA2 inhibited proliferation, migration, and invasion of breast cancer cells. Mechanistic experiments revealed that knockdown of PRR11 and/or SKA2 caused dysregulation of several downstream genes, including CDK6, TPM3, and USP12, etc. Luciferase reporter assays demonstrated that wild type p53 significantly repressed the PRR11-SKA2 bidirectional promoter activity, but not NF-Y. Interestingly, NF-Y was only essential for and correlated with the expression of PRR11, but not SKA2. Consistently, adriamycin-induced (ADR) activation of endogenous p53 also caused significant repression of the PRR11 and SKA2 gene pair expression. Notably, breast cancer patients with lower expression levels of either PRR11 or SKA2, along with wild type p53, exhibited better disease-free survival compared to others with p53 mutations and/or higher expression levels of either PRR11 or SKA2. Collectively, our study indicates that the PRR11 and SKA2 transcription unit might be an oncogenic contributor and might serve as a novel diagnostic and therapeutic target in breast cancer.

• 한국산학기술학회논문지
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• 제13권11호
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• pp.5479-5486
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• 2012

본 논문에서는 Wi-Fi 환경에서 ZigBee 통신 시 채널별 특성 및 링크 품질을 나타내는 PRR, RSSI, LQI를 측정하고 평가하였다. Wi-Fi의 간섭에 의하여 Wi-Fi와 ZigBee의 겹치는 채널과 겹치지 않는 채널에서의 RSSI와 LQI 값이 PRR과 어떠한 관계가 있는지를 확인하기 위해 Wi-Fi 껐을 때와 켰을 때, 그리고 Wi-Fi를 이용하여 파일 다운로드 시 세 가지 경우에 대하여 실험하였다. Wi-Fi 간섭 환경에서 ZigBee 채널 특성 및 링크 품질 측정을 위해서 Wi-Fi와 ZigBee 수신단을 고정한 상태에서 ZigBee 수신단과 송신단 사이의 거리를 변화시켜가며 실험하였다. ZigBee 송신단은 ZigBee 수신단으로 매초 256 bits의 패킷을 보낸다. Wi-Fi 송신단과 ZigBee 수신단 위치에 따른 PRR값을 채널별로 측정하였고, ZigBee의 송, 수신단의 위치에 따른 RSSI와 PRR, LQI와 PRR을 역시 앞에서의 세 가지 경우에 대하여 측정하였다. 그 결과 Wi-Fi의 영향이 없을 때는 PRR 및 RSSI, LQI가 채널에 관계없이 비슷하였고, Wi-Fi의 영향이 커질수록 PRR의 값이 ZigBee와 겹치는 채널에서는 감소하였지만, 겹치지 않는 채널에서는 비슷하였다. 또한, RSSI와 LQI의 값은 Wi-Fi의 영향과 채널에 관계없이 비슷함을 확인하였다. 따라서 Wi-Fi 환경에서 ZigBee 통신의 간섭 탐지를 위해서 RSSI와 LQI의 사용은 적절하지 않으며, PRR을 이용해야 함을 알 수 있다.

• Molecules and Cells
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• 제26권1호
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• pp.5-11
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• 2008

Stalled DNA replication forks activate specific DNA repair mechanism called post-replication repair (PRR) pathways that simply bypass DNA damage. The bypassing of DNA damage by PRR prevents prolonged stalling of DNA replication that could result in double strand breaks (DSBs). Proliferating cell nuclear antigen (PCNA) functions to initiate and choose different bypassing pathways of PRR. In yeast, DNA replication forks stalled by DNA damage induces monoubiquitination of PCNA at K164, which is catalyzed by Rad6/Rad18 complex. PCNA monoubiquitination triggers the replacement of replicative polymerase with special translesion synthesis (TLS) polymerases that are able to replicate past DNA lesions. The PCNA interaction motif and/or the ubiquitin binding motif in most TLS polymerases seem to be important for the regulation of TLS. The TLS pathway is usually error-prone because TLS polymerases have low fidelity and no proofreading activity. PCNA can also be further polyubiquitinated by Ubc13/ Mms2/Rad5 complex, which adds an ubiquitin chain onto monoubiquitinated K164 of PCNA. PCNA polyubiquitination directs a different PRR pathway known as error-free damage avoidance, which uses the newly synthesized sister chromatid as a template to bypass DNA damage presumably through template switching mechanism. Mammalian homologues of all of the yeast PRR proteins have been identified, thus PRR is well conserved throughout evolution. Mutations of some PRR genes are associated with a higher risk for cancers in mice and human patients, strongly supporting the importance of PRR as a tumor suppressor pathway.

• 한국정보통신학회논문지
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• 제11권2호
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• pp.430-435
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• 2007

본 논문에서는 센서 네트워크의 원활한 전송을 위해 SOFM을 이용한 센서 네트워크의 지능적인 배치를 제안한다. 제안한 방법은 무선 채널 분석을 통해서 센서 노드 사이의 통신이 가능한 거리를 구하고, 신경회로망의 SOFM(Self-Organizing Feature Map)방식을 이용하여 지능적으로 최적의 센서 노드의 개수와 센서 노드가 배치할 최적 위치를 결정한다. Log-normal path loss 모델을 이용하여 거리에 따른 PRR(Packet Reception Rate)을 구하고, 이것으로부터 센서 노드의 통신 범위를 결정한다. 제안한 방식의 유용성을 확인하기 위하여 센서 노드의 지능적인 위치 탐색과 센서 네트워크의 연결 상태에 대한 시뮬레이션을 수행하였다.

• 전자공학회논문지
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• 제53권9호
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• pp.3-11
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• 2016

향상된 무선 통신 시스템을 이용하여 교통안전을 개선하기 위해 V2X (Vehicle to Everything) 통신에 대한 연구가 활발히 진행되고 있다. V2X 통신은 미래 교통안전 및 이동성의 발전을 위한 하나의 주요 솔루션이다. 본 논문에서는 LTE (Long Term Evolution) 기반 V2X 시스템 레벨 시뮬레이터 (SLS : System Level Simulator)를 개발하고 차량통신을 위한 적응적 전송 기법을 제안한다. 제안 기법은 시간 및 주파수 영역에서 랜덤하게 자원을 할당하고 전송 확률에 따라 메시지 전송을 결정한다. 성능 분석은 주기적 메시지 전송에서 고속도로의 경우에 대하여 이루어 졌다. 모의실험 결과, 제안한 기법에서 자원 충돌 및 간섭이 감소함 따라 PRR (Packet Reception Ratio)의 CDF (Cumulative Distribution Function) 및 평균 PRR이 향상 되는 것을 볼 수 있다.

• Safety and Health at Work
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• 제3권2호
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• pp.92-100
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• 2012

Objectives: The French National Occupational Diseases Surveillance and Prevention Network (RNV3P) is a French network of occupational disease specialists, which collects, in standardised coded reports, all cases where a physician of any specialty, referred a patient to a university occupational disease centre, to establish the relation between the disease observed and occupational exposures, independently of statutory considerations related to compensation. The objective is to compare the relevance of disproportionality measures, widely used in pharmacovigilance, for the detection of potentially new disease ${\times}$ exposure associations in RNV3P database (by analogy with the detection of potentially new health event ${\times}$ drug associations in the spontaneous reporting databases from pharmacovigilance). Methods: 2001-2009 data from RNV3P are used (81,132 observations leading to 11,627 disease ${\times}$ exposure associations). The structure of RNV3P database is compared with the ones of pharmacovigilance databases. Seven disproportionality metrics are tested and their results, notably in terms of ranking the disease ${\times}$ exposure associations, are compared. Results: RNV3P and pharmacovigilance databases showed similar structure. Frequentist methods (proportional reporting ratio [PRR], reporting odds ratio [ROR]) and a Bayesian one (known as BCPNN for "Bayesian Confidence Propagation Neural Network") show a rather similar behaviour on our data, conversely to other methods (as Poisson). Finally the PRR method was chosen, because more complex methods did not show a greater value with the RNV3P data. Accordingly, a procedure for detecting signals with PRR method, automatic triage for exclusion of associations already known, and then investigating these signals is suggested. Conclusion: This procedure may be seen as a first step of hypothesis generation before launching epidemiological and/or experimental studies.

• Molecules and Cells
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• 제39권11호
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• pp.777-782
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• 2016

The innate immune system has evolved to detect and destroy invading pathogens before they can establish systemic infection. To successfully eradicate pathogens, including viruses, host innate immunity is activated through diverse pattern recognition receptors (PRRs) which detect conserved viral signatures and trigger the production of type I interferon (IFN) and pro-inflammatory cytokines to mediate viral clearance. Viral persistence requires that viruses co-opt cellular pathways and activities for their benefit. In particular, due to the potent antiviral activities of IFN and cytokines, viruses have developed various strategies to meticulously modulate intracellular innate immune sensing mechanisms to facilitate efficient viral replication and persistence. In this review, we highlight recent advances in the study of viral immune evasion strategies with a specific focus on how Kaposi's sarcoma-associated herpesvirus (KSHV) effectively targets host PRR signaling pathways.

• Journal of Power Electronics
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• 제11권4호
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• pp.612-619
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• 2011

This paper presents a water treatment system for leachate from sewage-filled ground that uses a pulsed-power modulator developed based on semiconductor switches in order to realize a long life, a high repetition rate, and a fast rising time. The specifications of the developed pulsed-power modulator are the pulsed output voltage, the output current, the pulse repetition rate (PRR), the pulse width, and an average output power of $60\;kV_{max}$, $300\;A_{max}$, 3000, $50\;{\mu}s$, and 15 kW, respectively. The pulsed-power water treatment system was introduced and analyzed using an equivalent electrical circuit model to optimize the output voltage waveform. The experimental results verify that the proposed water treatment system can be effectively used for industrial applications.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2009년도 추계학술발표대회
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• pp.531-532
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• 2009

위치기반 라우팅 기법들은 소스에서 목적지노드로 데이터 패킷을 전송하기 위한 목적으로 널리 사용된다. 오리지널 그리디 포워딩 기법은 실제 무선링크의 신뢰성을 고려하지 않아 수많은 데이터 패킷 재전송이 발생한다. 이러한 문제를 해결하기 위해 PRR ${\times}$ Distance 기법이 제안되었지만 실제 무선링크의 비대칭성을 고려하지 않아 여전히 많은 재전송이 발생한다. 제안기법은 포워딩할 데이터 패킷을 가진 현재 노드의 전송 반경 내에서 전송 가능한 1-hop과 2-hop 라우팅 경로를 찾는다. 이들 라우팅 경로들 중 기대전송비용이 최소가 되는 경로를 선택하여 데이터와 ACK 패킷을 전송한다. 시뮬레이션을 결과를 통해 제안기법이 기존 기법들보다 높은 신뢰성과 에너지 효율을 가짐을 보인다.

• Journal of Preventive Medicine and Public Health
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• 제52권3호
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• pp.147-153
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• 2019

Objectives: The purpose of this study was to evaluate the association between body mass index (BMI) and severe lower urinary tract symptoms (LUTS) in Korean males. Methods: This study was conducted on males aged ${\geq}50years$ who participated in the 2011 Korean Community Health Survey. LUTS severity was assessed using the Korean version of the International Prostate Symptom Score (IPSS) questionnaire, and was dichotomized as severe (IPSS >19) and non-severe ($IPSS{\leq}19$). BMI was divided into 6 categories: <18.5, 18.5-22.9, 23.0-24.9, 25.0-27.4, 27.5-29.9, and ${\geq}30.0kg/m^2$. To evaluate the relationship between BMI and LUTS, a survey-weighted multivariate Poisson regression analysis was performed to estimate prevalence rate ratios (PRRs). Age, smoking status, alcohol intake, physical activity, educational level, household income, and comorbidities were adjusted for in the multivariate model. Results: A U-shaped relationship was detected between BMI and severe LUTS. Compared with a BMI of $23.0-24.9kg/m^2$, the PRR for a BMI < $18.5kg/m^2$ was 1.65 (95% confidence interval [CI], 1.35 to 2.02), that for a BMI of $18.5-22.9kg/m^2$ was 1.25 (95% CI, 1.09 to 1.44), that for a BMI of $25.0-27.4kg/m^2$ was 1.20 (95% CI, 1.00 to 1.45), that for a BMI of $27.5-29.9kg/m^2$ was 1.11 (95% CI, 0.83 to 1.47), and that for a BMI ${\geq}30.0kg/m^2$ was 1.85 (95% CI, 1.18 to 2.88). Conclusions: This study showed that both high and low BMI were associated with severe LUTS.