• BMB Reports
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• v.52 no.2
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• pp.157-162
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• 2019

Our previous study found that two novel cancer-related genes, PRR11 and SKA2, constituted a classic gene pair that was regulated by p53 and NF-Y in lung cancer. However, their role and regulatory mechanism in breast cancer remain elusive. In this study, we found that the expression levels of PRR11 and SKA2 were upregulated and have a negative prognotic value in breast cancer. Loss-of-function experiments showed that RNAi-mediated knockdown of PRR11 and/or SKA2 inhibited proliferation, migration, and invasion of breast cancer cells. Mechanistic experiments revealed that knockdown of PRR11 and/or SKA2 caused dysregulation of several downstream genes, including CDK6, TPM3, and USP12, etc. Luciferase reporter assays demonstrated that wild type p53 significantly repressed the PRR11-SKA2 bidirectional promoter activity, but not NF-Y. Interestingly, NF-Y was only essential for and correlated with the expression of PRR11, but not SKA2. Consistently, adriamycin-induced (ADR) activation of endogenous p53 also caused significant repression of the PRR11 and SKA2 gene pair expression. Notably, breast cancer patients with lower expression levels of either PRR11 or SKA2, along with wild type p53, exhibited better disease-free survival compared to others with p53 mutations and/or higher expression levels of either PRR11 or SKA2. Collectively, our study indicates that the PRR11 and SKA2 transcription unit might be an oncogenic contributor and might serve as a novel diagnostic and therapeutic target in breast cancer.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.11
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• pp.5479-5486
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• 2012

In this paper, we have measured PRR, RSSI and LQI of ZigBee channels under Wi-Fi environment and have assessed channel characteristic and link quality. To confirm any relationship among RSSI, LQI values and PRR under Wi-Fi interference in overlapping and non-overlapping channels of Wi-Fi and ZigBee, the experiments were performed without Wi-Fi, with Wi-Fi and file download through Wi-Fi. Under Wi-Fi interference, We perfomed experiments to ensure channel characteristics and link quality by fixing Wi-Fi and ZigBee receiver and varying the distance between ZigBee receiver and transmitter. ZigBee transmitter sends packet of 256 bits every second to ZigBee receiver. PRR was measured from ZigBee with variance of distance between fixed Wi-Fi and ZigBee. RSSI, LQI, PRR were measured from ZigBee with fixed Wi-Fi, fixed ZigBee receiver and variance of distance of ZigBee transmitter. As a result, we confirmed decrease of PRR under Wi-Fi interference but RSSI, LQI values similar regardless of overlapped or non-overlapped channel and Wi-Fi interference. Therefore, PRR should be used for interference detection in ZigBee communication under Wi-Fi environment but RSSI and LQI are not appreciate.

• Molecules and Cells
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• v.26 no.1
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• pp.5-11
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• 2008

Stalled DNA replication forks activate specific DNA repair mechanism called post-replication repair (PRR) pathways that simply bypass DNA damage. The bypassing of DNA damage by PRR prevents prolonged stalling of DNA replication that could result in double strand breaks (DSBs). Proliferating cell nuclear antigen (PCNA) functions to initiate and choose different bypassing pathways of PRR. In yeast, DNA replication forks stalled by DNA damage induces monoubiquitination of PCNA at K164, which is catalyzed by Rad6/Rad18 complex. PCNA monoubiquitination triggers the replacement of replicative polymerase with special translesion synthesis (TLS) polymerases that are able to replicate past DNA lesions. The PCNA interaction motif and/or the ubiquitin binding motif in most TLS polymerases seem to be important for the regulation of TLS. The TLS pathway is usually error-prone because TLS polymerases have low fidelity and no proofreading activity. PCNA can also be further polyubiquitinated by Ubc13/ Mms2/Rad5 complex, which adds an ubiquitin chain onto monoubiquitinated K164 of PCNA. PCNA polyubiquitination directs a different PRR pathway known as error-free damage avoidance, which uses the newly synthesized sister chromatid as a template to bypass DNA damage presumably through template switching mechanism. Mammalian homologues of all of the yeast PRR proteins have been identified, thus PRR is well conserved throughout evolution. Mutations of some PRR genes are associated with a higher risk for cancers in mice and human patients, strongly supporting the importance of PRR as a tumor suppressor pathway.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.11 no.2
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• pp.430-435
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• 2007

In this paper, we propose an intelligent deployment of sensor network for reliable communication. The proposed method determines optimal transmission range based on the wireless channel characteristics, and searches the optimal number of sensor nodes, and optimal locations with SOFM. We calculate PRR against a distance uses the log-normal path loss model, and decide the communication range of sensor node from PRR. In order to verify the effectiveness of the proposed method, we performed simulations on the searching for intelligent deployment and checking for link condition of sensor network.

• Journal of the Institute of Electronics and Information Engineers
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• v.53 no.9
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• pp.3-11
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• 2016

Vehicle to Everything (V2X) communication has been growing to enhance traffic safety by employing advanced wireless communication systems. V2X communication is one core solution for governing and advancing future traffic safety and mobility. In this paper, we design the system level simulator (SLS) of Long Term Evolution (LTE)-based V2X and propose the adaptive transmission scheme for vehicle communication. The proposed scheme allocates the resource randomly in time and frequency domain, and transmit the message according to probability of transmission. The performance analysis is based on freeway case in periodic message transmission. Simulation results show that proposed scheme can improve the cumulative distribution function (CDF) of packet reception ratio (PRR) and average PRR.

• Safety and Health at Work
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• v.3 no.2
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• pp.92-100
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• 2012

Objectives: The French National Occupational Diseases Surveillance and Prevention Network (RNV3P) is a French network of occupational disease specialists, which collects, in standardised coded reports, all cases where a physician of any specialty, referred a patient to a university occupational disease centre, to establish the relation between the disease observed and occupational exposures, independently of statutory considerations related to compensation. The objective is to compare the relevance of disproportionality measures, widely used in pharmacovigilance, for the detection of potentially new disease ${\times}$ exposure associations in RNV3P database (by analogy with the detection of potentially new health event ${\times}$ drug associations in the spontaneous reporting databases from pharmacovigilance). Methods: 2001-2009 data from RNV3P are used (81,132 observations leading to 11,627 disease ${\times}$ exposure associations). The structure of RNV3P database is compared with the ones of pharmacovigilance databases. Seven disproportionality metrics are tested and their results, notably in terms of ranking the disease ${\times}$ exposure associations, are compared. Results: RNV3P and pharmacovigilance databases showed similar structure. Frequentist methods (proportional reporting ratio [PRR], reporting odds ratio [ROR]) and a Bayesian one (known as BCPNN for "Bayesian Confidence Propagation Neural Network") show a rather similar behaviour on our data, conversely to other methods (as Poisson). Finally the PRR method was chosen, because more complex methods did not show a greater value with the RNV3P data. Accordingly, a procedure for detecting signals with PRR method, automatic triage for exclusion of associations already known, and then investigating these signals is suggested. Conclusion: This procedure may be seen as a first step of hypothesis generation before launching epidemiological and/or experimental studies.

• Molecules and Cells
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• v.39 no.11
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• pp.777-782
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• 2016

The innate immune system has evolved to detect and destroy invading pathogens before they can establish systemic infection. To successfully eradicate pathogens, including viruses, host innate immunity is activated through diverse pattern recognition receptors (PRRs) which detect conserved viral signatures and trigger the production of type I interferon (IFN) and pro-inflammatory cytokines to mediate viral clearance. Viral persistence requires that viruses co-opt cellular pathways and activities for their benefit. In particular, due to the potent antiviral activities of IFN and cytokines, viruses have developed various strategies to meticulously modulate intracellular innate immune sensing mechanisms to facilitate efficient viral replication and persistence. In this review, we highlight recent advances in the study of viral immune evasion strategies with a specific focus on how Kaposi's sarcoma-associated herpesvirus (KSHV) effectively targets host PRR signaling pathways.

• Journal of Power Electronics
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• v.11 no.4
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• pp.612-619
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• 2011

This paper presents a water treatment system for leachate from sewage-filled ground that uses a pulsed-power modulator developed based on semiconductor switches in order to realize a long life, a high repetition rate, and a fast rising time. The specifications of the developed pulsed-power modulator are the pulsed output voltage, the output current, the pulse repetition rate (PRR), the pulse width, and an average output power of $60\;kV_{max}$, $300\;A_{max}$, 3000, $50\;{\mu}s$, and 15 kW, respectively. The pulsed-power water treatment system was introduced and analyzed using an equivalent electrical circuit model to optimize the output voltage waveform. The experimental results verify that the proposed water treatment system can be effectively used for industrial applications.

• Proceedings of the Korea Information Processing Society Conference
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• 2009.11a
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• pp.531-532
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• 2009

위치기반 라우팅 기법들은 소스에서 목적지노드로 데이터 패킷을 전송하기 위한 목적으로 널리 사용된다. 오리지널 그리디 포워딩 기법은 실제 무선링크의 신뢰성을 고려하지 않아 수많은 데이터 패킷 재전송이 발생한다. 이러한 문제를 해결하기 위해 PRR ${\times}$ Distance 기법이 제안되었지만 실제 무선링크의 비대칭성을 고려하지 않아 여전히 많은 재전송이 발생한다. 제안기법은 포워딩할 데이터 패킷을 가진 현재 노드의 전송 반경 내에서 전송 가능한 1-hop과 2-hop 라우팅 경로를 찾는다. 이들 라우팅 경로들 중 기대전송비용이 최소가 되는 경로를 선택하여 데이터와 ACK 패킷을 전송한다. 시뮬레이션을 결과를 통해 제안기법이 기존 기법들보다 높은 신뢰성과 에너지 효율을 가짐을 보인다.

• Journal of Preventive Medicine and Public Health
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• v.52 no.3
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• pp.147-153
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• 2019

Objectives: The purpose of this study was to evaluate the association between body mass index (BMI) and severe lower urinary tract symptoms (LUTS) in Korean males. Methods: This study was conducted on males aged ${\geq}50years$ who participated in the 2011 Korean Community Health Survey. LUTS severity was assessed using the Korean version of the International Prostate Symptom Score (IPSS) questionnaire, and was dichotomized as severe (IPSS >19) and non-severe ($IPSS{\leq}19$). BMI was divided into 6 categories: <18.5, 18.5-22.9, 23.0-24.9, 25.0-27.4, 27.5-29.9, and ${\geq}30.0kg/m^2$. To evaluate the relationship between BMI and LUTS, a survey-weighted multivariate Poisson regression analysis was performed to estimate prevalence rate ratios (PRRs). Age, smoking status, alcohol intake, physical activity, educational level, household income, and comorbidities were adjusted for in the multivariate model. Results: A U-shaped relationship was detected between BMI and severe LUTS. Compared with a BMI of $23.0-24.9kg/m^2$, the PRR for a BMI < $18.5kg/m^2$ was 1.65 (95% confidence interval [CI], 1.35 to 2.02), that for a BMI of $18.5-22.9kg/m^2$ was 1.25 (95% CI, 1.09 to 1.44), that for a BMI of $25.0-27.4kg/m^2$ was 1.20 (95% CI, 1.00 to 1.45), that for a BMI of $27.5-29.9kg/m^2$ was 1.11 (95% CI, 0.83 to 1.47), and that for a BMI ${\geq}30.0kg/m^2$ was 1.85 (95% CI, 1.18 to 2.88). Conclusions: This study showed that both high and low BMI were associated with severe LUTS.