• BMB Reports
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• 제41권9호
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• pp.640-644
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• 2008

The preS1 surface protein of the hepatitis B virus (HBV) is a key factor involved in initial viral entry into hepatocytes. It has been long postulated that an anti-HBV effect should be achievable using peptide fragments of the preS1. Recent reports demonstrated that several preS1-derived lipo-peptides in genotype D HBV exhibit nano to picomolar inhibitory activity against HBV infection. In this study, an acylated analog of a preS1 fragment, a 21-residue lipo-peptide (named 7524 BVS7) with a sequence of palmitoyl-GMGTNLSVPNPLGFFPDHQLDC-$NH_2$, from genotype C HBV was produced base upon a previous structural study and was shown potently inhibits HBV infection with an $IC_{50}$ of $\approx$ 20 nM.

• 한국시뮬레이션학회:학술대회논문집
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• 한국시뮬레이션학회 2003년도 춘계학술대회논문집
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• pp.101-105
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• 2003

본 논문은 고리 1호기 원자력발전소를 기준발전소로 하여 개발된 PRE-MARK 소개 및 PRE-MARK을 기반으로 개발된 노심모델의 결과를 제시하고자 하는 것을 주된 목적으로 하고 있다. 노심 모델개발에는 REMARK 모델 프로그램을 기반으로 개발된 PRE-MARK를 이용하였으며, PRE-MARK의 주요 특징으로는 노심모델 입력자료를 노심설계코드 및 Lattice 코드로부터 자동으로 생성하며여 GUI 기반으로 변경된 REMARK으로 입력하여 노심모델을 구동함과 동시에 실시간으로 중요 변수의 현재 값들을 그래프로 도시해줌으로 조율 (Tuning) 상수를 용이하게 결정할 수 있도록 하는 것이다. 또한 BOL 및 EOL에서 HFP 평형 Xenon조건에서의 제어봉 위치에 따른 제어봉가(Rod worth)를 고리 1호기 20주기 NDR (Nuclear Design Report)과 비교하고, 원자로정지 이후 BOL, MOL 및 EOL에서의 시간에 따른 Xenon의 반응도 영향을 비교함으로 개발된 모델의 건전성을 입증하였다.

• 대한금속재료학회지
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• 제49권6호
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• pp.448-453
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• 2011

Pre-aging heat treatment after solution heat treatment (SHT) of Al-0.4 wt%Mg-1.2 wt%Si-0.1 wt%Mn alloy sheets for auto-bodies was carried out to investigate the effect of pre-aging and its conditions on the bake-hardening response. Mechanical properties were evaluated by a tensile and Vickers hardness test. Microstructural observation was also performed using a transmission electron microscope (TEM). It was revealed that pre-aging treatments play a great role in the bake-hardening response. In addition, it was found that the sphere-shaped nanosized clusters that can directly transit to the needle-shaped ${\beta}$" phase during the paint-bake process, not being dissolved into the matrix, are formed at 343 K. The result, reveals that the dominant factor of the bake-hardening response is the pre-aging temperature rather than the pre-aging time.

• Environmental Engineering Research
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• 제19권1호
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• pp.59-66
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• 2014

The aim of this study was to assess the effect of pre-aeration on sludge solubilization and the behaviors of nitrogen, dissolved sulfide, sulfate, and siloxane. The results of this study showed that soluble chemical oxygen demand in sewage sludge could be increased through pre-aeration. The pre-aeration process resulted in a higher methane yield compared to the anaerobic condition (blank). The pre-aeration of sewage sludge, therefore, was shown to be an effective method for enhancing the digestibility of the sewage sludge. In addition, this result confirms that the pre-aeration of sewage sludge prior to its anaerobic digestion accelerates the growth of methanogenic bacteria. Removal rates for $NH_3$-N and T-N increased simultaneously during pre-aeration, indicating simultaneous nitrification and denitrification. The siloxane concentration in sewage sludge decreased by 40% after 96 hr of pre-aeration; in contrast, the sulfide concentration in sewage sludge did not change. Therefore, pre-aeration can be employed as an efficient treatment option to achieve higher methane yield and lower siloxane concentration in sewage sludge. In addition, reduction of nitrogen loading by pre-aeration can reduce operating costs to achieve better effluent water quality in wastewater treatment plant and benefit the anaerobic process by minimizing the toxic effect of ammonia.

• Korean Journal of Acupuncture
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• 제26권3호
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• pp.121-132
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• 2009

Objectives : The purpose of this study is to review the prevention of pre- or syncope by acupuncture of "Geum Chim Mae Hwa Si Cho" Methods : 1. The authors reviewed "Geum Chim Mae Hwa Si Cho" and several literatures related with pre- or syncope by acupuncture. 2. We investigated the causes and signs of pre- or syncope by acupuncture, and the mechanism and clinical usefulness of the prevention of pre- or syncope by acupuncture. Results and Conclusions : 1. Pre- or syncope by acupuncture is a kind of Myung Hyun phenomenon resulted from patients' failure of reception of acupuncture treatment. 2. "Geum Chim Mae Hwa Si Cho" said not to be confused by pre- or syncope, and suggested 8 items for prevention of pre- or syncope by acupuncture. 3. "Geum Chim Mae Hwa Si Cho" especially argued to give doctor's whole mind to patients, and relax the mental tension of patients. 4. Yang Myoung meridian occupies the biggest part in acupoints used for the first aid.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2023년도 학술발표회
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• pp.158-158
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• 2023

Characterizing the performance of precipitation (hereafter PRE) products in estimating the uncertainties in daily PRE in the era of global warming is of great value to the ecosystem's sustainability and human survival. This study intercompares the performance of different PRE products (gauge-based, satellite and reanalysis) sourced from the Frequent Rainfall Observations on GridS (FROGS) database over diverse climate zones in Africa and identifies regions where they depict minimal uncertainties in order to build optimal maps as a guide for different climate users. This is achieved by utilizing various techniques, including the triple collection (TC) approach, to assess the capabilities and limitations of different PRE products over nine climatic zones over the continent. For daily scale analysis, the uncertainties in light PRE (0.1 5mm/day) are prevalent over most regions in Africa during the study duration (2001-2016). Estimating the occurrence of extreme PRE events based on daily PRE 90th percentile suggests that extreme PRE is mainly detected over central Africa (CAF) region and some coastal regions of west Africa (WAF) where the majority of uncorrected satellite products show good agreement. The detection of PRE days and non-PRE days based on categorical statistics suggests that a perfect POD/FAR score is unattainable irrespective of the product type. Daily PRE uncertainties determined based on quantitative metrics show that consistent, satisfactory performance is demonstrated by the IMERG products (uncorrected), ARCv2, CHIRPSv2, 3B42v7.0 and PERSIANN_CDRv1r1 (corrected), and GPCC, CPC_v1.0, and REGEN_ALL (gauge) during the study period. The optimal maps that show the classification of products in regions where they depict reliable performance can be recommended for various usage for different stakeholders.

• 호남수학학술지
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• 제33권1호
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• pp.61-71
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• 2011

The notion of a complicated pre-logic is introduced and investigated some properties of it. A special set in a pre-logic is established and some related its properties are discussed. Also more extended special sets in a pre-logic are introduced and some relations with deductive systems are obtained.

• Asia Marketing Journal
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• 제18권3호
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• pp.1-18
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• 2016

The purpose of this paper is to examine empirically how to balance advertising expenditure before and after launch with regard to the direction of word of mouth in the motion picture industry. The vector auto-regression model is applied to assess the dynamic impact of advertising and word of mouth on sales. Empirical data, including advertising, word of mouth, and sales (the number of entries) of 83 movies are used for analysis. The research results show that for a movie having more positive word of mouth in the pre- and post-launch periods, it is worthwhile to spend the advertising budget in the pre-launch period only and to spare it in post-launch period. However, it is worthwhile to spare the advertising budget in the pre-launch period for movies having less positive word of mouth before and after launch, and to concentrate spending in post-launch period instead. Mangers who handle products and services facing shortened lifecycles, such as games, eBooks, and digital music contents, need to check the quality of pre-launch word of mouth for their advertising budget decisions in the pre- and post-launch periods and spend more of the advertising budget in the post- (pre-) launch period if pre-launch word of mouth is negative (positive). For products and services with a shortened lifecycle, it is recommended to spend more of the advertising budget in the post- (pre-) launch period if pre-launch word of mouth is negative (positive).

• 한국압력기기공학회 논문집
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• 제14권1호
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• pp.1-7
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• 2018

Materials in nuclear power plants can be embrittled by neutron irradiation. According to existing studies, the effect of the material property by irradiation embrittlement can be approximately simulated by cold working (pre-strain). In this study, finite element damage analysis method using the stress-modified fracture strain model is proposed to predict J-Resistance curves of irradiated SUS316 stainless steel. Experimental data of pre-strained SUS316 stainless steel material are obtained from literature and the damage model is determined by simulating the tensile and fracture toughness tests. In order to consider damage caused by the pre-strain, a pre-strain constant is newly introduced. Experimental J-Resistance curves for various degrees of pre-strain are well predicted.

• 한국전기전자재료학회논문지
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• 제23권1호
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• pp.18-23
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• 2010

We demonstrated that the solution processed organic light-emitting diodes (OLEDs) have the high efficiency with pre-treated indium-tin-oxide (ITO). ITO surface was pre-treated with four methods and compared each other. The pre-treatment of ITO surface improves the chemical and physical characteristics of ITO such as the surface roughness, adhesion property, and the hole injection ability. These properties were analyzed by the contact angle, atomic force microscope (AFM) image, and the current flow character in device. As a results, the device with ITO pre-treated by $O_2$ plasma shows the current efficiency of 5.93 cd/A, which is 1.5 times the device without pre-treatment.