• 한국방송∙미디어공학회:학술대회논문집
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• 한국방송공학회 2008년도 추계학술대회
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• pp.27-30
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• 2008

본 논문에서는 지상파DTV 방송프로그램 보호를 위한 하드웨어 PPI 전송서버를 제안한다. 제안한 하드웨어 PPI 전송서버는 방송환경에서의 안정성을 보장하기 위하여 소프트웨어의 PPI 스케줄러와 하드웨어의 PPI MUX로 구성하였다. PPI 스케줄러는 EPG를 PPI 보호신호와 프로그램 ID와 함께 편성하여 시간순서로 스케줄링하는 기능을 제공하며, PPI MUX는 EPG, PPI 보호신호, 프로그램 ID를 PSIP로 부호화한 후, 이를 MPEG-2 TS로 패킷화하여 실시간 출력하는 기능을 제공한다. 또한 하드웨어 PPI 전송서버는 기존의 방송 송출 시스템의 변경 없이 유연하게 연동시킬 수 있는 장점이 있다. 본 논문에서 제안한 하드웨어 PPI 전송서버는 PPI 보호신호를 방송프로그램에 삽입하여 송출함으로써, 지상파DTV 방송프로그램의 무단복제, 불법배포를 제한하는 기능을 제공한다.

• 한국식품조리과학회지
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• 제7권2호
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• pp.97-104
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• 1991

This study was carried out in order to study the protein functionality such as foaming and emulsifying properties by succinylation of peanut protein isolates. Succinylated and unsuccinylated peanut protein isolate was tested for to find out the effect of pH, heat treatment and sodium chloride concentration on the solubility, foam expansion, foam stability, emulsion capacity and emulsion stability. The results are summarized as follows; 1. Succinylation enhanced the solubility of peanut protein isotate (PPI). The solubility of succinylated PPI markedly increased at pH 4.5. When the protein solutions was heated, the solubility of succinylated PPI greatly increased than PPI at pH 3. With addition of NaCl, solubility of succinylated PPI increased at pH 7 and pH 9. 2. The foam expansion of PPI and succinylated PPI on pH was no difference between both proteins. Addition of NaCl and heat treatment caused steeply increased in foam expansion at pH 3. 3. The foam stability of PPI and succinylated PPI showed the lowest value at pH 4.5. When PPI and succinylated PPI was heated, foam stability of two proteins incensed at pH 3 and showed similar aspects between PPI and succinylated PPI. However, at pH 9 stability of succinylated PPI decreased by heat treatment over $60^{\circ}C$. 4. Emulsion capacity of succinylated PPI on pH was markedly increased and showed the highest value at pH 11. At pH 4.5 which is isoelectric point of PPI, emulsion capacity of PPI by succinylation improved than that of PPI. When succinylated PPI was heated, emulsion capacity was greatly increased at pH 2 and pH 7. With NaCl was added, emulsion capacity of succinylated PPI increased than that of PPI. 5. Emulsion stability of PPI and succinylated PPI was affected by pH and showed its highest value at pH 11. At pH 4.5, emulsion stability of succinylated PPI increased than that of PPI. Addition of NaCl and heat treatment caused slightly increased in emulsion stability of succinylated PPI.

• 인터넷정보학회논문지
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• 제25권2호
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• pp.29-38
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• 2024

경피적 대동맥 판막 치환술(TAVR) 후에는 인공 심박동기 삽입술(PPI)을 비롯한 TAVR 이후 합병증에 대한 철저한 관리가 필요하며 그에 따라 정확한 예측 모델에 대한 필요성이 점점 증가하고 있다. 본 연구는 기존의 이미지 의존적 방법론에서 벗어나 ECG 정보를 중심으로 예측하는 XGBoost 기반의 최적의 PPI 예측 모델을 개발했다. 이 모델은 심전도상의 특정 신호들인 DeltaPR, DeltaQRS 등을 주요 지표로 삼아, 환자의 전도 장애 및 PPI와의 연관성을 파악하며, 기존의 이미지와 ECG 데이터를 결합한 모델과 ECG 기반의 모델 보다 뛰어난 AUC 0.91 성능을 달성하였다. 본 연구에서 제안하는 모델은 두 병원의 데이터를 기반으로 최적의 PPI 예측 모델을 구현 및 검증하였으며, 검증 결과 ECG 데이터의 특성이 PPI 예측에 큰 영향을 미치며 95.28%의 높은 유사도를 보였다. 이로써 본 연구의 예측 모델이 다양한 병원 데이터에도 효과적으로 적용될 수 있음을 확인하였다. 최적의 머신러닝 알고리즘을 사용하여 PPI와 각 특성 간의 상관관계를 명확히 했으며, 고비용의 의료 이미지에 의존하지 않고 ECG 데이터를 사용하여 높은 정확도로 PPI를 예측할 수 있음을 입증하였다. 이는 의료 결정 과정에서 인간 개입의 의존도를 줄이며, 신뢰할 수 있고 실용적인 PPI 예측 모델 개발로의 중요한 진전을 의미한다.

• BMB Reports
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• 제51권10호
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• pp.526-531
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• 2018

Protein-Protein Interactions (PPIs) play essential roles in diverse biological processes and their misregulations are associated with a wide range of diseases. Especially, the growing attention to PPIs as a new class of therapeutic target is increasing the need for an efficient method of cell-based PPI analysis. Thus, we newly developed a robust PPI assay (SeePPI) based on the co-translocation of interacting proteins to the discrete subcellular compartment 'processing body' (p-body) inside living cells, enabling a facile analysis of PPI by the enriched fluorescent signal. The feasibility and strength of SeePPI (${\underline{S}}ignal$ ${\underline{e}}nhancement$ ${\underline{e}}xclusively$ on ${\underline{P}}-body$ for ${\underline{P}}rotein-protein$ ${\underline{I}}nteraction$) assay was firmly demonstrated with FKBP12/FRB interaction induced by rapamycin within seconds in real-time analysis of living cells, indicating its recapitulation of physiological PPI dynamics. In addition, we applied p53/MDM2 interaction and its dissociation by Nutlin-3 to SeePPI assay and further confirmed that SeePPI was quantitative and well reflected the endogenous PPI. Our SeePPI assay will provide another useful tool to achieve an efficient analysis of PPIs and their modulators in cells.

• KDI Journal of Economic Policy
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• 제46권2호
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• pp.21-43
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• 2024

This paper provides a new theoretical rationale for public procurement for innovation (PPI), a unique policy encouraging public procurers to purchase innovative products. In contrast to existing studies that primarily emphasize the advantages of PPI, this paper takes a comprehensive approach, examining both the costs and risks associated with PPI, alongside its benefits. It finds a general condition under which PPI outperforms traditional public procurement. Under this condition, this paper demonstrates that PPI enhances social welfare by facilitating optimal risk-sharing between public procurers and the general economy. Additionally, it draws policy implications from a comparative analysis between the current PPI policy in Korea and an optimal PPI policy.

• 한국정보과학회논문지:시스템및이론
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• 제33권5호
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• pp.267-281
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• 2006

단백질-단백질 상호작용(PPI : Protein-Protein Interaction) 데이타는 생물체가 어떠한 메커니즘으로 생명을 유지하는지에 대한 정보를 담고 있다. 질병 연구나 신약 연구를 위해서 PPI 데이타를 이용한 많은 연구들이 이루어지고 있다. 이러한 PPI 데이타의 크기는 Yeast-two-hybrid, Mass spectrometry과 Correlated mRNh expression과 같은 방법들로 인하여 점차 그 증가량이 커지고 있다. 따라서 단백질-단백질 상호작용 데이타의 방대한 양과 복잡한 구조로 인하여 사람이 직접 분석하는 것은 불가능하다. 다행히도 PPI 데이타는 단백질은 노드로, 상호작용은 에지로 표현함으로써 전산학의 그래프 구조로 추상화될 수 있다. 본 논문에서는 방대한 단백질-단백질 상호작용 데이타를 연구자가 다양한 방법으로 손쉽게 분석할 수 있는 워크벤치(workbench) 시스템인 Proteinca (PROTEin INteraction CAbaret)에 대하여 소개한다. Proteinca는 다앙한 데이타베이스의 PPI 데이타를 그래프이론 기반의 분석 기능들을 제공하며, 그래프로 가시화하여 사용자가 직관적으로 이해할 수 있도록 도와준다. 또한, 중력 모델 기반의 간략화 방법을 제공하여 사용자에게 중요 단백질 중심의 가시화를 제공한다.

• Clinical and Experimental Pediatrics
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• 제62권10호
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• pp.400-404
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• 2019

Background: An increase in the numbers of patients with gastrointestinal symptoms has recently been observed. Purpose: To investigate the effects of proton pump inhibitor (PPI) therapy on intestinal inflammation in children and adolescents as confirmed by clinical manifestations and objectively assessed by fecal calprotectin (FC) level measurement. Methods: Consecutive children (aged 3-18 years) who presented with gastrointestinal symptoms and were treated with or without PPI for at least 1 month were enrolled. Patients were divided into PPI and non-PPI groups. The PPI group was further subdivided by treatment duration and type of PPI used. Stool samples were collected for FC evaluation at baseline and after treatment and clinical data and FC levels were compared between the groups. Results: Fifty-one patients (15 boys, 36 girls) were enrolled in the study. The PPI group included 37 patients, while the non-PPI group included 14 patients. Clinical symptoms were not significantly different. FC levels and laboratory results, including C-reactive protein levels, white blood cell count, and absolute neutrophil count, were not statistically different before versus after PPI treatment. After treatment, FC levels decreased to 8.1 mg/kg (-575.4 to 340.3 mg/kg) in the PPI group and increased to 5.6 mg/kg (-460.0 to 186.9 mg/kg) in the non-PPI group compared to those before treatment (P=0.841). The number of patients with increased FC levels was not significantly different between the 2 groups (48.6% vs. 64.3%, P=0.363), similar to that observed in patients with an FC level > 50 mg/kg (24.3% and 7.1%, P=0.250). PPI therapy type and duration did not affect the FC levels (P=0.811 and P=0.502, respectively). Conclusion: Although we aimed to confirm the evidence of intestinal inflammation due to PPI use in children and adolescents through clinical symptoms and FC measurement, no significant changes were observed.

• 한국농공학회:학술대회논문집
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• 한국농공학회 2001년도 학술발표회 발표논문집
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• pp.220-223
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• 2001

This study was carried out to developed that appraisement model of Potential Productivity Index (PPI). PPI model was used Farmland Productivity Index(FPI) and Labor Productivity Index(LPI) by GIS, and PPI model applied to farm land consolidation region which has been completed recently. FPI was determined by overlapping Poly Grid of the soil properties at the analyzed project region. LPI was estimated by addition productive wages ratio of total direct productive cost. Addition productive wages was determined by GIS Network analysis of working distance between farm house to paddy and each paddy. PPI variation of each the analyzed paddy of Masu and Weoncheon region was $0.967{\sim}0.712,\;0.986{\sim}0.780$ respectively, and could be showed relative largely PPI value. PPI will provide basic element for large scaling and gathering of farm land and a substitute lot of farm land consolidation, and will be maximize productivity of paddy.

• 대한불안의학회지
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• 제10권2호
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• pp.157-162
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• 2014

Objective : This study was conducted to evaluate the validity of the Korean Inventory of Interpersonal Problems (K-IIP) with Psychopathic Personality Inventory-Revised (PPI-R) to assess interpersonal problems in Korean criminal offenders with schizophrenia. Methods : The sample consisted of 187 inpatients with schizophrenia who had committed crimes. All participants filled out self-report questionnaires ofPPI-R and K-IIP. Results : The result showed that all scales of K-IIP were correlated highly with the PPI-R total score (r range=0.25-0.65). Correlations with K-IIP scales were highest for Blame Externalization, Rebellious Nonconformity, and Machiavellian Egocentricity scales (r range=0.50-0.66, 0.43-0.64, 0.39-0.58, respectively). All scales of K-IIP exhibited a negative correlation with Social Influences, Stress Immunity, Coldheartedness (C) scale ofPPI-R. Cold/Distant scale ofK-IIP was not correlated with C scale of PPI-R. All scales of K-IIP was highly correlated with PPI-R-factor-2 (r range=0.44-0.71) and negatively correlated with PPI-R-factor-l (r range=-0.03-0.38). Conclusions : Despite of strong correlation between PPI-R total score and K-IIP total score, K-IIP was not correlated with PPI-R-I that represents affective and interpersonal deficits. It suggests K-IIP may not proper for measuring the interpersonal problems of criminal offenders with schizophrenia. It will be needed other assessment scale for measuring the interpersonal problems of psychopathy in criminal schizophrenia.

• Spatial Information Research
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• 제9권2호
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• pp.341-352
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• 2001

이 연구는 지리정보시스템(GIS)로 구한 토지생산성지수(FPI)와 노동생산성지수(LPI)를 적용하여 농지의 잠재생산성지수(PPI)를 산정할 수 있는 모형을 개발하였고, 최근 경지정리사업이 완료된 지구에 적용하여 개발된 모형의 적용성을 검토하였다. 토지 생산성지수(FPI)는 분석대상지역의 토양 특성 Poly Grid를 중첩하여 결정하였으며, 노동생산성 지수(LPI)는 직접생산비중 GIS Network 분석으로 구한 통작거리와 논지분포에 따른 노력비 추가분을 전체 직접생산비에 대하 비율로 환산하였다. 마수지구와 원천지구의 개별 농지에 대한 전체생산성지수(PPI)는 각각 0.967∼0.712, 0.986∼0.780으로 비교적 큰 변이를 나타낼 수 있어 농지 평가에 대한 객관적인 자료로 적용할 수 있을 것이다. 농지의 잠재생산성지수를 경지정리 사업의 환지사업, 농민상호간에 농지교환 및 합병사업에 적용함으로써 농지의 규모화 및 집단화을 유도하고 농지생산성을 극대화할 수 있을 것이다.