• 대한수의학회지
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• 제27권2호
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• pp.191-200
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• 1987

Attempts were to produce porcine leukocyte interferon(PorLeIF) and porcine immune interferon (PorIIF) in the culture of porcine leukocytes. The interferons produced were tested for antiviral activity against vesicular stomatitis virus on poreine-derived PK(15) cells, human-derived FL cells, and Korean native black goat-derived BGK cells. The results were summarized as follws: 1. In the isolation of porcine leukocytes, the mean isolation rate by the buffy coat separation method (28.7%) was higher than that by the hydroxyethyl starch-RBC sedimentation method (9.2%). 2. When NDV(BI)-induced PorLeIFs were assyed on PK(15) cells and FL cells, the mean titers were 129 IU/ml and 72 IU/ml respectively, being 55.8% of the activity in homologous species system expressed in heterologous system. 3. The activities of PHA P-induced PorIIFs were 197 IU/ml on PK (15) cells and no activity on human FL cells. The mean antiviral activity of PorIIF was 1.5 times that of PorLeIF in PK (15) cells. 4. The cytopathic effect of vesicular stomatitis virus was observed in BGK cells derived from Korean native black goat kidney permitting interferon assay on the cells. While the cross-species antiviral activity of reference human ${\alpha},\;{\beta}-interferon$ was observed on the cells, PorLeIF and PorIIF did not show any activity.

• Clinical and Experimental Reproductive Medicine
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• 제47권2호
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• pp.135-139
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• 2020

Objective: In the present study, we aimed to retrospectively evaluate the cumulative live birth rate (LBR) after up to three consecutive embryo transfer (ET) cycles, either fresh or frozen, in women with expected poor ovarian response (ePOR). Methods: We selected 115 women who entered the first in vitro fertilization (IVF) cycle between August 2013 and July 2016. The women were divided into an ePOR group (37 women) and a non-ePOR group (78 women). All women in the ePOR group were ≥ 40 years old or had serum anti-Müllerian hormone levels of less than 1.1 ng/mL at the time of the first IVF cycle. Live birth outcomes were monitored until December 2017. The cumulative LBR (with both conservative and optimistic estimates) was calculated according to the serial number of ET cycles. Results: After up to three ET cycles, the overall cumulative LBR was significantly lower in the ePOR group than in the non-ePOR group (conservative estimate, 10.8% vs. 44.9%, respectively; optimistic estimate, 14.7% vs. 56.1%, respectively; log-rank test, p= 0.003). Conclusion: Women with ePOR exhibited a lower cumulative LBR than women in the non-ePOR group, and this information should be provided to ePOR women during counseling before starting IVF.

• Journal of Photoscience
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• 제11권2호
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• pp.83-87
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• 2004

A porphyrin compound containing a crown ether moiety (Por-Crown) and its zinc complex (ZnPor-Crown) have been prepared and the effect of the addition of alkali metal on their fluorescence has been investigated. As alkali metal cations were added, the absorption and fluorescence maxima did not change. However, the absorbance and intensity of fluorescence increased dramatically. Among the alkali metal cations tested, addition of K$^{+}$ and Cs$^{+}$ showed strongest enhancement of absorbance and fluorescence intensity of Por-Crown and ZnPor-Crown.own.

• Journal of Microbiology and Biotechnology
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• 제34권7호
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• pp.1419-1424
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• 2024

Secretin PilQ is an antigenically conserved outer membrane protein that is present in most meningococci and PorA is a major protein that elicits bactericidal immune response in humans following natural disease and immunization. In the present study, BALB/c mice were immunized subcutaneously with rPilQ406-770 or rPorA together with Freund's adjuvant (FA). Serum antibody responses to serogroup A and B Neisseria meningitides whole cells or purified proteins and functional activity of antibodies were determined by ELISA and serum bactericidal assay (SBA), respectively. Serum IgG responses were significantly increased in the immunized group with rPilQ406-770 or rPorA together with FA compared to control groups. IgG antibody response of mice immunized with rPilQ406-770 was significantly more than mice immunized with rPorA (OD at 450 nm was 1.6 versus 0.83). The booster injections were effective in increasing the responses of antirPilQ406-770 or anti-rPorA IgG significantly. Antisera produced against rPilQ406-770 or rPorA demonstrated strong surface reactivity to serogroup B N. meningitides in comparison with control groups. Antisera raised against rPorA or rPilQ406-770 and FA demonstrated SBA titers from 1/1024 to 1/2048 against serogroup B. The strongest bactericidal activity was detected in sera from mice immunized with rPilQ406-770 mixed with FA. These results suggest that rPilQ406-770 is a potential vaccine candidate for serogroup B N. meningitidis.

• Nuclear Engineering and Technology
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• 제24권3호
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• pp.285-296
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• 1992

가압경수로형 원전을 위한 운전조정기의 개념 설계를 수행하였다. 운전조정기는 디지탈 감시 제한 계통으로서, 원전의 주요 운전 인자들을 감지하여 운전 제한치를 벗어나지 않도록 조정한다. 이는 운전 유연성을 향상시켜서 원전이 전력망 요구에 효과적으로 대처할 수 있도록 한다. 운전 허용 범위를 넘어서는 전력망 요구에 대해서 이를 제한하거나 제어 체계를 변경함으로써 이용률에 영향을 주지 않으며 운전을 수행할 수 있도록 한다. 이 개념은 1000 MWe급 가압경수로인 영광 3,4호기의 거동 모의를 통하여 평가되었다. 그 모의 계산 결과 운전 조정기가 원전의 운전 유연성 향상을 위하여 유용하게 사용될 수 있음을 보여 주었다.

• Journal of Genetic Medicine
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• 제13권1호
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• pp.31-35
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• 2016

Antley-Bixler syndrome (ABS) is a rare form of syndromic craniosynostosis with additional systemic synostosis, including radiohumeral or radioulnar synostosis. Another characteristic feature of ABS is mid-facial hypoplasia that leads to airway narrowing after birth. ABS is associated with mutations in the FGFR2 and POR genes. Patients with POR mutations present with either skeletal manifestations or congenital adrenal hyperplasia with ambiguous genitalia. We report here two cases of ABS caused by mutations in FGFR2 and POR. Although the patients had craniosynostosis and radiohumeral synostosis in common and cranioplasty was performed in both cases, the male with POR mutations showed an elevated level of $17{\alpha}$-hydroxyprogesterone during newborn screening and was diagnosed with congenital adrenal hyperplasia by adrenocorticotropic hormone stimulation. This patient has been treated with hydrocortisone and fludrocortisone. He had no ambiguous genitalia but had bilateral cryptorchidism. On the other hand, the female with the FGFR2 mutation showed severe clinical manifestations: upper airway narrowing leading to tracheostomy, kyphosis of the cervical spine, and coccyx deformity. ABS shows locus heterogeneity, and mutations in two different genes can cause similar craniofacial and skeletal phenotypes. Because the long-term outcomes and inheritance patterns of the disease differ markedly, depending on the causative mutation, early molecular genetic testing is helpful.

• Journal of Radiation Protection and Research
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• 제44권3호
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• pp.110-117
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• 2019

Background: This study aimed to estimate occupational doses and patient peak skin doses (PSDs) during interventional radiology procedures. Materials and Methods: We examined data from brain embolization (n = 30), hepatic chemoembolization (n = 50), and uterine embolization (n = 12). The PSDs were measured using radiochromic film around the patient's head (group 1) or abdominal/pelvic region (group 2). Acquisition technical data and kerma-area products (KAP) were also recorded. Occupational doses were measured using $Instadose^{TM}$ dosimeters near the left eye region (LER), chest, and left ankle. Results and Discussion: The third quartile (median) KAP values were $408.1(235.3)Gy{\cdot}cm^2$ for group 1 and $584.4(449.4)Gy{\cdot}cm^2$ for group 2. The average PSDs were greatest during vascular procedures, reaching 1,004.4 (786.4) mGy, and the highest PSD was 2,352.6 mGy (during hepatic chemoembolization). The third quartile (median) occupational doses were 0.35 (0.21) mSv at the LER, 0.25 (0.15) mSv at the chest, and 1.47 (0.64) mSv at the left ankle. Occupational doses at the LER were higher than at the chest, which highlights the importance of protective glasses and suspended shields. The occupational doses at the ankle region were also high, which highlights the importance of using a lead-lined curtain attached to the table. Conclusion: The results indicate that physicians can reach, for eye region, the weekly occupational dose limit after around 15 procedures, even when using proper protection. The average PSD values were below the threshold for tissue reactions, although the complexity of these procedures emphasises the importance of considering related risks.

• 이베로아메리카
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• 제12권2호
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• pp.189-216
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• 2010

Después de los años 90, en la América Latina, nos llama la atención el surgimiento de los nuevos movimientos sociales que quieran superar o cambiar los caracteres del regimen neoliberalista, el cual nos obliga mantenernos aislados o dispersados. Sobre todo se trató así fuerte en la Argentina con los movimientos sociales de los desocupados pobres que se llaman 'piqueteros' en la segunda mitad de la década 90. En este estudio, he intentado de comprender y explicar cuáles motivos o contextos socio-culturales hayan movido esos movimientos sociales con la ayuda del marco teórico de 'habitus' de Pierre Bourdieu. Por ello, es muy importante interpretar la solidaridad entre la clase obrera y la media según la perspectiva de Bourdieu debido a la sugerencia de habitus de la clase obrera y la media latinoamericana basado en la cultura oral. Porque los movimientos piqueteros argentinos surgieron no desde la clase social ni del individuo abstracto-racional de la modernidad sino de los individuos reales. Y el concepto de habitus se penetra en el cuerpo de los individuos de manera inconsciente construido desde fuera de las condiciones histórico-sociales por mucho tiempo. Y también en la Argentina esa solidaridad ha desarrollado no sólo a superar la pobreza en sí misma sino a construir nuevas maneras sociales de los procesos de producción capitalista en forma del movimiento cooperativista, que se llama 'las empresas recuperadas por los trabajadores'. Por tanto, he analizado el proceso de cambio social en el ámbito de la América Latina relacionando el habitus con la estructura socio-cultural de la oralidad en dos sentidos; primero, se recalca la importancia de solidaridad entre las clases y la media segundo, fuerte resistencia social ante los crisis socio-económicos. Por ultimo, hay que valorar la importancia de la aparición de los nuevos sujetos sociales así como esos movimientos cooperativistas, socialización de los procesos de producción capitalista en renovar la democracia misma.

• Journal of Preventive Medicine and Public Health
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• 제32권3호
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• pp.297-305
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• 1999

Objectives: This study was conducted to evaluate factors related to the intention of participation in a worksite smoking cessation program. Methods: To explain the health behavior of participating intention in a worksite smoking cessation program, the health belief model(HBM) was used as study model, and 144 self-administered questionnaires were completed by electronic company workers. Variables of the health belief model were composed of perceived susceptibility to smokinginduced disease, perceived severity of smoking-induced disease, economical gain as perceived benefit of smoking cessation, and nicotine dependency as perceived barrier of smoking cessation. Variables of sociodemographics, smoking status, knowledge about adverse health effects of smoking, and cues to smoking cessation were used as modifying factors. Results: Perceived severity(POR=1.99, 95% CI: 1.03-3.83), perceived benefit(POR=2.11, 95% CI: 1.07-4.17), and perceived barrier(POR=0.29, 95% CI: 0.11-0.76) were significant variables to the intention of participation in a worksite smoking cessation program in the logistic regression analysis. The perceived severity was significantly affected by knowledge about adverse health effects of smoking(POR=2.17, 95% CI: 1.23-3.84). The perceived barrier was significantly affected by education level(POR=3.66, 95% CI: 1.17-11.44), age to first cigarette (POR=0.32, 95% CI: 0.10-0.98), pack-years(POR=5.47, 95% CI: 2.37-12.61). To the Perceived benefit, the model was not fitted. Conclusion: Our results found that counterplans improving the knowledge about adverse health effects of smoking, preventing early smoking, and decreasing smoking amount should be considered for an effective smoking ban policy.

• Clinical and Experimental Reproductive Medicine
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• 제44권4호
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• pp.224-231
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• 2017

Objective: We studied the association between sperm DNA fragmentation (SDF) and several clinical in vitro fertilization outcomes. Methods: We retrospectively analyzed 169 consecutive fresh IVF cycles. Semen was collected on the day of oocyte retrieval, and we assessed standard semen parameters and the SDF level (by terminal deoxynucleotidyl transferase dUTP nick-end labeling). Poor ovarian response (POR) was defined as the collection of three or fewer mature oocytes. Oocytes were inseminated by the conventional method or intracytoplasmic sperm injection. Results: SDF did not affect the fertilization or pregnancy rate, but did have a significant effect on the miscarriage rate. In the miscarriage group (n = 10), the SDF level was significantly higher (23.9% vs. 14.1%) and number of mature oocytes was significantly lower (4.3 vs. 7.6) than in the live birth group (n = 45). Multiple regression analysis showed that SDF was an independent predictor of miscarriage (odds ratio, 1.051; 95% confidence interval, 1.001-1.104). The cutoffs for the SDF level and number of mature oocytes that could predict miscarriage were > 13% and ${\leq}3$, respectively. In the low-SDF group (${\leq}13%$), the miscarriage rate was similar in POR patients and those with a normal ovarian response (NOR; 14.2% vs. 4.3%). In the high-SDF group ( > 13%), the miscarriage rate was significantly higher in the POR group than in the NOR group (60.0% vs. 13.3%, p= 0.045). Conclusion: Our study demonstrated that a high SDF level ( > 13%) was associated with a high miscarriage rate, and that it mainly contributed to miscarriage in the POR group. The results suggest that SDF measurements should be considered in couples with POR in order to predict the prognosis of the pregnancy.