• Korean Journal of Veterinary Research
• /
• v.27 no.2
• /
• pp.191-200
• /
• 1987

Attempts were to produce porcine leukocyte interferon(PorLeIF) and porcine immune interferon (PorIIF) in the culture of porcine leukocytes. The interferons produced were tested for antiviral activity against vesicular stomatitis virus on poreine-derived PK(15) cells, human-derived FL cells, and Korean native black goat-derived BGK cells. The results were summarized as follws: 1. In the isolation of porcine leukocytes, the mean isolation rate by the buffy coat separation method (28.7%) was higher than that by the hydroxyethyl starch-RBC sedimentation method (9.2%). 2. When NDV(BI)-induced PorLeIFs were assyed on PK(15) cells and FL cells, the mean titers were 129 IU/ml and 72 IU/ml respectively, being 55.8% of the activity in homologous species system expressed in heterologous system. 3. The activities of PHA P-induced PorIIFs were 197 IU/ml on PK (15) cells and no activity on human FL cells. The mean antiviral activity of PorIIF was 1.5 times that of PorLeIF in PK (15) cells. 4. The cytopathic effect of vesicular stomatitis virus was observed in BGK cells derived from Korean native black goat kidney permitting interferon assay on the cells. While the cross-species antiviral activity of reference human ${\alpha},\;{\beta}-interferon$ was observed on the cells, PorLeIF and PorIIF did not show any activity.

• Clinical and Experimental Reproductive Medicine
• /
• v.47 no.2
• /
• pp.135-139
• /
• 2020

Objective: In the present study, we aimed to retrospectively evaluate the cumulative live birth rate (LBR) after up to three consecutive embryo transfer (ET) cycles, either fresh or frozen, in women with expected poor ovarian response (ePOR). Methods: We selected 115 women who entered the first in vitro fertilization (IVF) cycle between August 2013 and July 2016. The women were divided into an ePOR group (37 women) and a non-ePOR group (78 women). All women in the ePOR group were ≥ 40 years old or had serum anti-Müllerian hormone levels of less than 1.1 ng/mL at the time of the first IVF cycle. Live birth outcomes were monitored until December 2017. The cumulative LBR (with both conservative and optimistic estimates) was calculated according to the serial number of ET cycles. Results: After up to three ET cycles, the overall cumulative LBR was significantly lower in the ePOR group than in the non-ePOR group (conservative estimate, 10.8% vs. 44.9%, respectively; optimistic estimate, 14.7% vs. 56.1%, respectively; log-rank test, p= 0.003). Conclusion: Women with ePOR exhibited a lower cumulative LBR than women in the non-ePOR group, and this information should be provided to ePOR women during counseling before starting IVF.

• Journal of Photoscience
• /
• v.11 no.32
• /
• pp.83-87
• /
• 2004

A porphyrin compound containing a crown ether moiety (Por-Crown) and its zinc complex (ZnPor-Crown) have been prepared and the effect of the addition of alkali metal on their fluorescence has been investigated. As alkali metal cations were added, the absorption and fluorescence maxima did not change. However, the absorbance and intensity of fluorescence increased dramatically. Among the alkali metal cations tested, addition of K$^{+}$ and Cs$^{+}$ showed strongest enhancement of absorbance and fluorescence intensity of Por-Crown and ZnPor-Crown.own.

• Nuclear Engineering and Technology
• /
• v.24 no.3
• /
• pp.285-296
• /
• 1992

The conceptual design of the Plant Operations Regulator (POR) is presented for the pressurized water reactor plants. The POR is a digital supervisory limitation control system The POR assures that the plant does not exceed the operating limits by regulating the plant operations through monitoring the operating margins of the critical parameters. The POR is aimed at increasing the operating flexibility which allows the nuclear plant to meet the grid demand in very efficient manner. It responds to the grid demand without penalizing plant availability by limiting the load demand or by modifying the plant control schemes when the operating limits are approached or violated. The POR design concepts were tested using simulation responses of the 1000 MWe pressurized water reactors, Yonggwang Units 3 & 4. The simulation results illustrate that the POR can be used to improve operating flexibility.

• Journal of Genetic Medicine
• /
• v.13 no.1
• /
• pp.31-35
• /
• 2016

Antley-Bixler syndrome (ABS) is a rare form of syndromic craniosynostosis with additional systemic synostosis, including radiohumeral or radioulnar synostosis. Another characteristic feature of ABS is mid-facial hypoplasia that leads to airway narrowing after birth. ABS is associated with mutations in the FGFR2 and POR genes. Patients with POR mutations present with either skeletal manifestations or congenital adrenal hyperplasia with ambiguous genitalia. We report here two cases of ABS caused by mutations in FGFR2 and POR. Although the patients had craniosynostosis and radiohumeral synostosis in common and cranioplasty was performed in both cases, the male with POR mutations showed an elevated level of $17{\alpha}$-hydroxyprogesterone during newborn screening and was diagnosed with congenital adrenal hyperplasia by adrenocorticotropic hormone stimulation. This patient has been treated with hydrocortisone and fludrocortisone. He had no ambiguous genitalia but had bilateral cryptorchidism. On the other hand, the female with the FGFR2 mutation showed severe clinical manifestations: upper airway narrowing leading to tracheostomy, kyphosis of the cervical spine, and coccyx deformity. ABS shows locus heterogeneity, and mutations in two different genes can cause similar craniofacial and skeletal phenotypes. Because the long-term outcomes and inheritance patterns of the disease differ markedly, depending on the causative mutation, early molecular genetic testing is helpful.

• Journal of Radiation Protection and Research
• /
• v.44 no.3
• /
• pp.110-117
• /
• 2019

Background: This study aimed to estimate occupational doses and patient peak skin doses (PSDs) during interventional radiology procedures. Materials and Methods: We examined data from brain embolization (n = 30), hepatic chemoembolization (n = 50), and uterine embolization (n = 12). The PSDs were measured using radiochromic film around the patient's head (group 1) or abdominal/pelvic region (group 2). Acquisition technical data and kerma-area products (KAP) were also recorded. Occupational doses were measured using $Instadose^{TM}$ dosimeters near the left eye region (LER), chest, and left ankle. Results and Discussion: The third quartile (median) KAP values were $408.1(235.3)Gy{\cdot}cm^2$ for group 1 and $584.4(449.4)Gy{\cdot}cm^2$ for group 2. The average PSDs were greatest during vascular procedures, reaching 1,004.4 (786.4) mGy, and the highest PSD was 2,352.6 mGy (during hepatic chemoembolization). The third quartile (median) occupational doses were 0.35 (0.21) mSv at the LER, 0.25 (0.15) mSv at the chest, and 1.47 (0.64) mSv at the left ankle. Occupational doses at the LER were higher than at the chest, which highlights the importance of protective glasses and suspended shields. The occupational doses at the ankle region were also high, which highlights the importance of using a lead-lined curtain attached to the table. Conclusion: The results indicate that physicians can reach, for eye region, the weekly occupational dose limit after around 15 procedures, even when using proper protection. The average PSD values were below the threshold for tissue reactions, although the complexity of these procedures emphasises the importance of considering related risks.

• Iberoamérica
• /
• v.12 no.2
• /
• pp.189-216
• /
• 2010

Después de los años 90, en la América Latina, nos llama la atención el surgimiento de los nuevos movimientos sociales que quieran superar o cambiar los caracteres del regimen neoliberalista, el cual nos obliga mantenernos aislados o dispersados. Sobre todo se trató así fuerte en la Argentina con los movimientos sociales de los desocupados pobres que se llaman 'piqueteros' en la segunda mitad de la década 90. En este estudio, he intentado de comprender y explicar cuáles motivos o contextos socio-culturales hayan movido esos movimientos sociales con la ayuda del marco teórico de 'habitus' de Pierre Bourdieu. Por ello, es muy importante interpretar la solidaridad entre la clase obrera y la media según la perspectiva de Bourdieu debido a la sugerencia de habitus de la clase obrera y la media latinoamericana basado en la cultura oral. Porque los movimientos piqueteros argentinos surgieron no desde la clase social ni del individuo abstracto-racional de la modernidad sino de los individuos reales. Y el concepto de habitus se penetra en el cuerpo de los individuos de manera inconsciente construido desde fuera de las condiciones histórico-sociales por mucho tiempo. Y también en la Argentina esa solidaridad ha desarrollado no sólo a superar la pobreza en sí misma sino a construir nuevas maneras sociales de los procesos de producción capitalista en forma del movimiento cooperativista, que se llama 'las empresas recuperadas por los trabajadores'. Por tanto, he analizado el proceso de cambio social en el ámbito de la América Latina relacionando el habitus con la estructura socio-cultural de la oralidad en dos sentidos; primero, se recalca la importancia de solidaridad entre las clases y la media segundo, fuerte resistencia social ante los crisis socio-económicos. Por ultimo, hay que valorar la importancia de la aparición de los nuevos sujetos sociales así como esos movimientos cooperativistas, socialización de los procesos de producción capitalista en renovar la democracia misma.

• Journal of Preventive Medicine and Public Health
• /
• v.32 no.3
• /
• pp.297-305
• /
• 1999

Objectives: This study was conducted to evaluate factors related to the intention of participation in a worksite smoking cessation program. Methods: To explain the health behavior of participating intention in a worksite smoking cessation program, the health belief model(HBM) was used as study model, and 144 self-administered questionnaires were completed by electronic company workers. Variables of the health belief model were composed of perceived susceptibility to smokinginduced disease, perceived severity of smoking-induced disease, economical gain as perceived benefit of smoking cessation, and nicotine dependency as perceived barrier of smoking cessation. Variables of sociodemographics, smoking status, knowledge about adverse health effects of smoking, and cues to smoking cessation were used as modifying factors. Results: Perceived severity(POR=1.99, 95% CI: 1.03-3.83), perceived benefit(POR=2.11, 95% CI: 1.07-4.17), and perceived barrier(POR=0.29, 95% CI: 0.11-0.76) were significant variables to the intention of participation in a worksite smoking cessation program in the logistic regression analysis. The perceived severity was significantly affected by knowledge about adverse health effects of smoking(POR=2.17, 95% CI: 1.23-3.84). The perceived barrier was significantly affected by education level(POR=3.66, 95% CI: 1.17-11.44), age to first cigarette (POR=0.32, 95% CI: 0.10-0.98), pack-years(POR=5.47, 95% CI: 2.37-12.61). To the Perceived benefit, the model was not fitted. Conclusion: Our results found that counterplans improving the knowledge about adverse health effects of smoking, preventing early smoking, and decreasing smoking amount should be considered for an effective smoking ban policy.

• Clinical and Experimental Reproductive Medicine
• /
• v.44 no.4
• /
• pp.224-231
• /
• 2017

Objective: We studied the association between sperm DNA fragmentation (SDF) and several clinical in vitro fertilization outcomes. Methods: We retrospectively analyzed 169 consecutive fresh IVF cycles. Semen was collected on the day of oocyte retrieval, and we assessed standard semen parameters and the SDF level (by terminal deoxynucleotidyl transferase dUTP nick-end labeling). Poor ovarian response (POR) was defined as the collection of three or fewer mature oocytes. Oocytes were inseminated by the conventional method or intracytoplasmic sperm injection. Results: SDF did not affect the fertilization or pregnancy rate, but did have a significant effect on the miscarriage rate. In the miscarriage group (n = 10), the SDF level was significantly higher (23.9% vs. 14.1%) and number of mature oocytes was significantly lower (4.3 vs. 7.6) than in the live birth group (n = 45). Multiple regression analysis showed that SDF was an independent predictor of miscarriage (odds ratio, 1.051; 95% confidence interval, 1.001-1.104). The cutoffs for the SDF level and number of mature oocytes that could predict miscarriage were > 13% and ${\leq}3$, respectively. In the low-SDF group (${\leq}13%$), the miscarriage rate was similar in POR patients and those with a normal ovarian response (NOR; 14.2% vs. 4.3%). In the high-SDF group ( > 13%), the miscarriage rate was significantly higher in the POR group than in the NOR group (60.0% vs. 13.3%, p= 0.045). Conclusion: Our study demonstrated that a high SDF level ( > 13%) was associated with a high miscarriage rate, and that it mainly contributed to miscarriage in the POR group. The results suggest that SDF measurements should be considered in couples with POR in order to predict the prognosis of the pregnancy.

• Journal of Preventive Medicine and Public Health
• /
• v.50 no.5
• /
• pp.320-327
• /
• 2017

Objectives: The purpose of our study was to evaluate the association between the intensity of physical activity (PA) and prevalence of cardiovascular disease (CVD) using Korean representative data. Methods: We analyzed 39 804 participant data from the Korea National Health and Nutrition Examination Survey, 2007-2013. Exposure variable was three levels of PA (low, medium, and high) in a week, and outcome variable was prevalence of CVD based on patient self-recognition and doctor's diagnosis. Complex logistic regression analysis was performed to evaluate the relationship between level of PA and CVD adjusted by body mass index, hypertension, hypercholesterolemia, diabetes mellitus, stress recognition, household income, smoking, and current drinking. The indices of association w ere estimated as crude prevalence odds ratio (POR), adjusted POR, and their 95% confidence interval (CI). All statistical analyzes were performed using complex sample analysis procedure of the SPSS version 23.0. Results: When all variables were adjusted, only high level PA in women showed a significant association with stroke (adjusted POR by patient's self-recognition, 0.57; 95% CI, 0.32 to 0.99, adjusted POR by doctor's diagnosis, 0.55; 95% CI, 0.34 to 0.87) and CVD (adjusted POR by doctor's diagnosis, 0.68; 95% CI, 0.48 to 0.96). Conclusions: High level PA in women has a significant reverse association with prevalence of stroke and CVD in Korea. Further study for elucidating the mechanism will be needed.