• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2006.11a
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• pp.431-434
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• 2006

This study reviews the properties of coastal ocean and Seomjin River estuary spaces then define some MGIS(Marine Geographic Information System) related terminologies for clarifying the scope of MGIS boundaries. Therefore, we show the three-dimensional circulation of MGIS-based Seomjin River Estuary integrating three-dimensional POM model and observed data.

• IMMUNE NETWORK
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• v.21 no.3
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• pp.22.1-22.17
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• 2021

Chitinase-3-like-1 (CHI3L1) is known to induce inflammation in the progression of allergic diseases. Previous our studies revealed that 2-({3-[2-(1-cyclohexen-1-yl)ethyl]-6,7-dimethoxy-4-oxo-3,4-dihydro-2-quinazolinyl}sulfanyl)-N-(4-ethylphenyl)butanamide (K284-6111; K284), the CHI3L1 inhibiting compound, has the anti-inflammatory effect on neuroinflammation. In this study, we investigated that K284 treatment could inhibit the development of atopic dermatitis (AD). To identify the effect of K284, we used phthalic anhydride (5% PA)-induced AD animal model and in vitro reconstructed human skin model. We analyzed the expression of AD-related cytokine mediators and NF-κB signaling by Western blotting, ELISA and quantitative real-time PCR. Histological analysis showed that K284 treatment suppressed PA-induced epidermal thickening and infiltration of mast cells. K284 treatment also reduced PA-induced release of inflammatory cytokines. In addition, K284 treatment inhibited the expression of NF-κB activity in PA-treated skin tissues and TNF-α and IFN-γ-treated HaCaT cells. Protein-association network analysis indicated that CHI3L1 is associated with lactoferrin (LTF). LTF was elevated in PA-treated skin tissues and TNF-α and IFN-γ-induced HaCaT cells. However, this expression was reduced by K284 treatment. Knockdown of LTF decreased the expression of inflammatory cytokines in TNF-α and IFN-γ-induced HaCaT cells. Moreover, anti-LTF antibody treatment alleviated AD development in PA-induced AD model. Our data demonstrate that CHI3L1 targeting K284 reduces AD-like skin inflammation and K284 could be a promising therapeutic agent for AD by inhibition of LTF expression.

• Journal of Ocean Engineering and Technology
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• v.21 no.6
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• pp.87-94
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• 2007

This study used POM (Princeton ocean model) improved for applying to coastal area in order to predict the distribution of thermal waste water. This model was applied to the coastal circulation and the effect of thermal waste water of Cheonsu-Bay. So this study compared the discharge of thermal waste water with each layer and section. The tidal current was about 1.5 m/sec at surface level and 0.9 m/sec on bottom level at flood tide; tidal current was about 1.3 m/sec on surface level and 0.8 m/sec on bottom level at ebb tide. The method discharging the thermal waste water in the nearshore region (case 1) accelerates the diffusion of the thermal waste water in the north-south direction(longshore direction). However, the method discharge the thermal waster water in the offshore region (case 2) reduced the diffusion of the thermal waste water over the coastal region. According th the diffusion region of the thermal waste water with case 1 and case 2 at three different layers (surface, middle, bottom), the diffusion region by case 1 discharge method generally influenced wider region (twice) than the one by case 2 discharge method with lower temperature between $1^{\circ}C\;and\;2^{\circ}C$, whereas the case 2 discharge method influenced the deeper region (middle and botton layers) with higher change of the water temperature ($1{\sim}3^{\circ}C$).

• Journal of the korean society of oceanography
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• v.39 no.2
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• pp.119-135
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• 2004

A three-dimensional numerical model using POM (the Princeton Ocean Model) is established in order to understand the dispersion processes of the Yangtze River water in the Yellow and East China Seas. The circulation experiments for the seas are conducted first, and then on the bases of the results the dispersion experiments for the river water are executed. For the experiments, we focus on the tide effects and wind effects on the processes. Four cases of systematic experiments are conducted. They comprise the followings: a reference case with no tide and no wind, of tide only, of wind only, and of both tide and wind. Throughout this study, monthly mean values are used for the Kuroshio Current input in the southern boundary of the model domain, for the transport through the Korea Strait, for the river discharge, for the sea surface wind, and for the heat exchange rate across the air-sea interface. From the experiments, we obtained the following results. The circulation of the seas in winter is dependent on the very strong monsoon wind as several previous studies reported. The wintertime dispersion of the Yangtze River water follows the circulation pattern flowing southward along the east coast of China due to the strong monsoon wind. Some observed salinity distributions support these calculation results. In summertime, generally, low-salinity water from the river tends to spread southward and eastward as a result of energetic vertical mixing processes due to the strong tidal current, and to spread more eastward due to the southerly wind. The tide effect for the circulation and dispersion of the river water near the river mouth is a dominant factor, but the southerly wind is still also a considerable factor. Due to both effects, two major flow directions appear near the river mouth. One of them is a northern branch flow in the northeast area of the river mouth moving eastward mainly due to the weakened southerly wind. The other is a southern branch flow directed toward the southeastern area off the river mouth mostly caused by tide and wind effects. In this case, however, the tide effect is more dominant than the wind effect. The distribution of the low salinity water follows the circulation pattern fairly well.

• Fisheries and Aquatic Sciences
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• v.13 no.2
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• pp.167-181
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• 2010

To predict changes in the marine environment of the Beolgyo Stream Estuary in Jeonnam Province, South Korea, where cohesive tidal flats cover a broad area and a large bridge is under construction, this study conducted numerical simulations involving tidal flow and cohesive sediment transport. A wetting and drying (WAD) technique for tidal flats from the Princeton Ocean Model (POM) was applied to a large-scale-grid hydrodynamic module capable of evaluating the flow resistance of structures. Derivation of the eddy viscosity coefficient for wakes created by structures was accomplished through the explicit use of shear velocity and Chezy's average velocity. Furthermore, various field observations, including of tide, tidal flow, suspended sediment concentrations, bottom sediments, and water depth, were performed to verify the model and obtain input data for it. In particular, geologic parameters related to the evaluation of settling velocity and critical shear stresses for erosion and deposition were observed, and numerical tests for the representation of suspended sediment concentrations were performed to determine proper values for the empirical coefficients in the sediment transport module. According to the simulation results, the velocity variation was particularly prominent around the piers in the tidal channel. Erosion occurred mainly along the tidal channels near the piers, where bridge structures reduced the flow cross section, creating strong flow. In contrast, in the rear area of the structure, where the flow was relatively weak due to the formation of eddies, deposition and moderated erosion were predicted. In estuaries and coastal waters, changes in the flow environment caused by artificial structures can produce changes in the sedimentary environment, which in turn can affect the local marine ecosystem. The numerical model proposed in this study will enable systematic prediction of changes to flow and sedimentary environments caused by the construction of artificial structures.